Incidental Mutation 'R5093:Or2n1c'
ID 387965
Institutional Source Beutler Lab
Gene Symbol Or2n1c
Ensembl Gene ENSMUSG00000057801
Gene Name olfactory receptor family 2 subfamily N member 1C
Synonyms MOR256-48, GA_x6K02T2PSCP-2656648-2657586, Olfr135
MMRRC Submission 042682-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R5093 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 38519138-38520076 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 38519208 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Alanine at position 24 (E24A)
Ref Sequence ENSEMBL: ENSMUSP00000150535 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076245] [ENSMUST00000213217]
AlphaFold Q8VEY4
Predicted Effect possibly damaging
Transcript: ENSMUST00000076245
AA Change: E24A

PolyPhen 2 Score 0.916 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000075595
Gene: ENSMUSG00000057801
AA Change: E24A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 7.6e-50 PFAM
Pfam:7tm_1 41 290 9.2e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213217
AA Change: E24A

PolyPhen 2 Score 0.916 (Sensitivity: 0.81; Specificity: 0.94)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.1%
Validation Efficiency 99% (90/91)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik C T 13: 119,610,573 (GRCm39) probably benign Het
Abca9 A T 11: 110,032,358 (GRCm39) L753Q probably damaging Het
Acvrl1 A G 15: 101,032,628 (GRCm39) probably null Het
Adgrv1 A T 13: 81,740,704 (GRCm39) N141K probably damaging Het
Aftph C T 11: 20,659,619 (GRCm39) probably null Het
Aifm1 C T X: 47,571,637 (GRCm39) G371S probably benign Het
Aldh3b2 A G 19: 4,029,433 (GRCm39) M269V probably benign Het
Ankrd44 T C 1: 54,802,877 (GRCm39) Y207C probably damaging Het
Arhgap15 G T 2: 44,212,767 (GRCm39) M412I probably damaging Het
Auts2 A C 5: 131,468,296 (GRCm39) L783R probably damaging Het
Baiap2l1 A T 5: 144,215,363 (GRCm39) Y381N probably damaging Het
Baiap3 T C 17: 25,469,243 (GRCm39) D180G probably damaging Het
Cant1 T C 11: 118,302,038 (GRCm39) Y93C probably damaging Het
Catsperg2 T C 7: 29,416,423 (GRCm39) S330G probably benign Het
Ccdc73 A T 2: 104,848,111 (GRCm39) probably benign Het
Cdc5l A T 17: 45,703,967 (GRCm39) F752L possibly damaging Het
Celsr2 G T 3: 108,320,689 (GRCm39) H708N possibly damaging Het
Cep170 T A 1: 176,596,896 (GRCm39) K487M possibly damaging Het
Cerkl A T 2: 79,163,867 (GRCm39) N66K probably damaging Het
Cilk1 G A 9: 78,047,303 (GRCm39) V68I probably benign Het
Clec11a C T 7: 43,954,150 (GRCm39) A268T probably damaging Het
Ctnna2 C A 6: 77,091,912 (GRCm39) probably null Het
Diaph3 C A 14: 87,222,236 (GRCm39) R416L probably damaging Het
Dnmbp T A 19: 43,838,315 (GRCm39) N1170I probably damaging Het
Erbb2 G T 11: 98,318,279 (GRCm39) C505F probably damaging Het
Ercc6 T A 14: 32,289,479 (GRCm39) F904L probably damaging Het
Exo5 C T 4: 120,779,514 (GRCm39) G117D probably damaging Het
F2 CAGAAAG CAG 2: 91,465,302 (GRCm39) probably benign Het
Fbxl5 A G 5: 43,930,896 (GRCm39) Y64H probably damaging Het
Gabra4 T A 5: 71,798,207 (GRCm39) M207L probably damaging Het
Galnt15 T C 14: 31,771,786 (GRCm39) L277P probably damaging Het
Gclm T C 3: 122,049,261 (GRCm39) probably null Het
Gm5493 T A 17: 22,966,201 (GRCm39) C29S possibly damaging Het
Grik3 A G 4: 125,564,382 (GRCm39) T455A probably benign Het
Grm3 A G 5: 9,639,766 (GRCm39) V93A probably benign Het
Hdgfl2 C T 17: 56,406,217 (GRCm39) A535V possibly damaging Het
Hfm1 A T 5: 107,049,597 (GRCm39) S455T probably damaging Het
Hmcn1 T A 1: 150,613,007 (GRCm39) D1424V probably benign Het
Hsd3b6 C T 3: 98,715,120 (GRCm39) V91I probably benign Het
Igdcc4 G A 9: 65,030,039 (GRCm39) S363N possibly damaging Het
Intu T C 3: 40,647,347 (GRCm39) V740A probably benign Het
Itga2 C T 13: 114,992,717 (GRCm39) V838I probably benign Het
Kif9 A G 9: 110,318,965 (GRCm39) E143G probably damaging Het
Kmt2c T A 5: 25,614,205 (GRCm39) I172F probably benign Het
Kmt2d G A 15: 98,754,043 (GRCm39) R21W probably damaging Het
Mdh1b A T 1: 63,750,620 (GRCm39) D449E probably benign Het
Meis1 T C 11: 18,831,785 (GRCm39) I418V probably benign Het
Nags T A 11: 102,037,395 (GRCm39) M162K probably damaging Het
Nufip1 A G 14: 76,348,413 (GRCm39) D14G probably benign Het
Or2l13 T A 16: 19,306,227 (GRCm39) I213N probably damaging Het
Or7g28 T G 9: 19,272,274 (GRCm39) I126L probably damaging Het
Osmr A C 15: 6,850,560 (GRCm39) V681G probably damaging Het
Paxip1 G T 5: 27,971,282 (GRCm39) Q356K unknown Het
Pcdhac1 T A 18: 37,223,595 (GRCm39) F136Y probably damaging Het
Pla2g6 A G 15: 79,171,328 (GRCm39) V699A probably benign Het
Plcb3 A T 19: 6,943,578 (GRCm39) V107E probably damaging Het
Plch1 T A 3: 63,681,136 (GRCm39) I164F probably damaging Het
Plpp3 A T 4: 105,052,077 (GRCm39) I73F probably damaging Het
Plscr5 G A 9: 92,080,574 (GRCm39) R20Q probably benign Het
Prdm10 G A 9: 31,252,779 (GRCm39) R504Q probably damaging Het
Prss58 T C 6: 40,874,751 (GRCm39) Y30C probably damaging Het
Psg19 T A 7: 18,530,894 (GRCm39) T87S probably benign Het
Ptpn22 T G 3: 103,789,418 (GRCm39) M294R probably benign Het
Rai1 T A 11: 60,079,482 (GRCm39) M1182K probably benign Het
Sez6 T A 11: 77,867,388 (GRCm39) V795D possibly damaging Het
Shcbp1 A G 8: 4,789,214 (GRCm39) V535A possibly damaging Het
Skint9 A G 4: 112,246,447 (GRCm39) Y222H probably benign Het
Slc13a3 T A 2: 165,253,816 (GRCm39) I446F probably damaging Het
Slc2a3 C T 6: 122,714,196 (GRCm39) R57H probably damaging Het
Slc44a4 A G 17: 35,140,219 (GRCm39) D208G probably benign Het
Spata31d1b A T 13: 59,863,838 (GRCm39) N329Y possibly damaging Het
Strbp C T 2: 37,517,499 (GRCm39) R192K probably damaging Het
Tctn3 A T 19: 40,600,548 (GRCm39) L14Q probably damaging Het
Tenm2 T A 11: 36,834,989 (GRCm39) D2V probably damaging Het
Tln2 T G 9: 67,241,596 (GRCm39) K1003T probably benign Het
Tmem63b T C 17: 45,971,800 (GRCm39) E805G probably damaging Het
Trhr A T 15: 44,060,980 (GRCm39) N167Y probably damaging Het
Trpc2 A G 7: 101,744,390 (GRCm39) R721G probably benign Het
Ttn C A 2: 76,701,267 (GRCm39) probably benign Het
Wdr91 A G 6: 34,869,288 (GRCm39) I412T probably damaging Het
Zcchc4 T A 5: 52,953,952 (GRCm39) S211T probably benign Het
Other mutations in Or2n1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00978:Or2n1c APN 17 38,519,873 (GRCm39) missense probably damaging 0.99
IGL01316:Or2n1c APN 17 38,519,388 (GRCm39) missense probably damaging 0.98
IGL01666:Or2n1c APN 17 38,519,780 (GRCm39) missense probably benign 0.11
IGL02096:Or2n1c APN 17 38,520,074 (GRCm39) makesense probably null
R0255:Or2n1c UTSW 17 38,519,286 (GRCm39) missense probably benign
R0630:Or2n1c UTSW 17 38,519,304 (GRCm39) missense probably damaging 0.97
R1185:Or2n1c UTSW 17 38,520,074 (GRCm39) makesense probably null
R1185:Or2n1c UTSW 17 38,520,074 (GRCm39) makesense probably null
R1185:Or2n1c UTSW 17 38,520,074 (GRCm39) makesense probably null
R1279:Or2n1c UTSW 17 38,519,678 (GRCm39) missense probably benign 0.01
R1878:Or2n1c UTSW 17 38,519,265 (GRCm39) missense probably benign 0.03
R1969:Or2n1c UTSW 17 38,519,355 (GRCm39) missense probably damaging 1.00
R2374:Or2n1c UTSW 17 38,519,958 (GRCm39) missense probably damaging 0.97
R3708:Or2n1c UTSW 17 38,519,174 (GRCm39) missense probably benign 0.01
R5025:Or2n1c UTSW 17 38,519,334 (GRCm39) missense probably damaging 1.00
R5095:Or2n1c UTSW 17 38,519,208 (GRCm39) missense possibly damaging 0.92
R5103:Or2n1c UTSW 17 38,519,208 (GRCm39) missense possibly damaging 0.92
R5104:Or2n1c UTSW 17 38,519,208 (GRCm39) missense possibly damaging 0.92
R5105:Or2n1c UTSW 17 38,519,208 (GRCm39) missense possibly damaging 0.92
R5149:Or2n1c UTSW 17 38,519,208 (GRCm39) missense possibly damaging 0.92
R5150:Or2n1c UTSW 17 38,519,208 (GRCm39) missense possibly damaging 0.92
R5344:Or2n1c UTSW 17 38,519,995 (GRCm39) missense probably damaging 1.00
R6608:Or2n1c UTSW 17 38,519,370 (GRCm39) missense probably damaging 1.00
R7300:Or2n1c UTSW 17 38,519,588 (GRCm39) missense possibly damaging 0.76
R7324:Or2n1c UTSW 17 38,519,607 (GRCm39) missense probably benign
R7580:Or2n1c UTSW 17 38,519,934 (GRCm39) missense probably benign 0.11
R8062:Or2n1c UTSW 17 38,520,065 (GRCm39) missense probably benign 0.01
R8371:Or2n1c UTSW 17 38,519,189 (GRCm39) missense probably benign 0.01
R8984:Or2n1c UTSW 17 38,519,304 (GRCm39) missense probably damaging 0.97
R9002:Or2n1c UTSW 17 38,519,555 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GTAGAATGCCAACCCTGGATTC -3'
(R):5'- CACCTCAAGTAGCTGATGGTC -3'

Sequencing Primer
(F):5'- GAATGCCAACCCTGGATTCTATAG -3'
(R):5'- TCTTTGTAGAGCCCCAAAGG -3'
Posted On 2016-06-06