Incidental Mutation 'R5094:Olfr1051'
ID 387977
Institutional Source Beutler Lab
Gene Symbol Olfr1051
Ensembl Gene ENSMUSG00000075193
Gene Name olfactory receptor 1051
Synonyms GA_x6K02T2Q125-47756192-47755266, MOR187-5
MMRRC Submission 042683-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R5094 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 86273814-86279088 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 86276040 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 149 (Y149F)
Ref Sequence ENSEMBL: ENSMUSP00000150061 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099898] [ENSMUST00000216432] [ENSMUST00000217245] [ENSMUST00000217294]
AlphaFold Q7TR76
Predicted Effect probably damaging
Transcript: ENSMUST00000099898
AA Change: Y149F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097482
Gene: ENSMUSG00000075193
AA Change: Y149F

Pfam:7tm_4 31 308 1.8e-53 PFAM
Pfam:7tm_1 41 290 2.7e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216432
AA Change: Y149F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217245
AA Change: Y149F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217294
AA Change: Y149F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 92.9%
Validation Efficiency 91% (40/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik G T 15: 82,062,682 (GRCm38) G260V possibly damaging Het
Agap3 T C 5: 24,451,321 (GRCm38) probably benign Het
Bicra A G 7: 15,975,371 (GRCm38) S1173P probably damaging Het
C3 A T 17: 57,225,033 (GRCm38) probably null Het
Cdh18 G A 15: 22,714,539 (GRCm38) probably benign Het
Cep290 A G 10: 100,567,030 (GRCm38) K2274E probably damaging Het
Cfap54 T C 10: 92,898,999 (GRCm38) probably benign Het
Chat T A 14: 32,408,939 (GRCm38) I582F probably damaging Het
Chrnb4 T C 9: 55,035,313 (GRCm38) I226V probably benign Het
Dnajc2 T C 5: 21,776,732 (GRCm38) T139A probably damaging Het
Eml1 T C 12: 108,536,311 (GRCm38) F712S probably benign Het
Fgfr1 C T 8: 25,570,165 (GRCm38) S524L probably damaging Het
Gimap3 T C 6: 48,765,372 (GRCm38) E208G probably damaging Het
Gm12185 T A 11: 48,907,548 (GRCm38) D706V probably benign Het
Gucy1a2 T A 9: 3,865,443 (GRCm38) V639D probably damaging Het
Hivep2 T C 10: 14,132,149 (GRCm38) F1497S probably benign Het
Hunk A G 16: 90,496,666 (GRCm38) D612G probably benign Het
Ifit3b T A 19: 34,612,548 (GRCm38) S375T possibly damaging Het
Mucl1 A G 15: 103,755,403 (GRCm38) S13P possibly damaging Het
Olfr1135 C T 2: 87,671,830 (GRCm38) C179Y possibly damaging Het
Pah T A 10: 87,538,219 (GRCm38) Y78* probably null Het
Pex13 A G 11: 23,655,441 (GRCm38) V263A probably benign Het
Pfdn2 T A 1: 171,356,499 (GRCm38) probably benign Het
Phip C T 9: 82,871,844 (GRCm38) V1616I probably benign Het
Pigg A G 5: 108,336,257 (GRCm38) S457G possibly damaging Het
Ppp1r13b A G 12: 111,843,610 (GRCm38) S97P probably benign Het
Slc22a6 T C 19: 8,626,177 (GRCm38) L535P probably damaging Het
Slc5a1 A G 5: 33,158,280 (GRCm38) T548A probably damaging Het
Smtnl2 T A 11: 72,400,385 (GRCm38) S346C probably damaging Het
Spata31d1a A G 13: 59,705,044 (GRCm38) probably null Het
Tlcd2 T C 11: 75,469,814 (GRCm38) S228P probably benign Het
Tmem135 A G 7: 89,143,793 (GRCm38) L411P probably damaging Het
Tnrc6c T C 11: 117,721,046 (GRCm38) V170A probably benign Het
Other mutations in Olfr1051
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01578:Olfr1051 APN 2 86,275,741 (GRCm38) missense probably damaging 0.99
IGL02263:Olfr1051 APN 2 86,276,202 (GRCm38) missense probably benign 0.01
IGL03143:Olfr1051 APN 2 86,276,236 (GRCm38) missense probably benign 0.03
R1182:Olfr1051 UTSW 2 86,276,268 (GRCm38) missense probably damaging 0.98
R1475:Olfr1051 UTSW 2 86,275,561 (GRCm38) makesense probably null
R1712:Olfr1051 UTSW 2 86,275,993 (GRCm38) missense probably damaging 0.97
R1903:Olfr1051 UTSW 2 86,275,846 (GRCm38) missense probably benign 0.00
R2097:Olfr1051 UTSW 2 86,276,039 (GRCm38) nonsense probably null
R4680:Olfr1051 UTSW 2 86,276,173 (GRCm38) missense possibly damaging 0.88
R4879:Olfr1051 UTSW 2 86,275,763 (GRCm38) nonsense probably null
R6448:Olfr1051 UTSW 2 86,276,347 (GRCm38) missense probably benign 0.07
R8250:Olfr1051 UTSW 2 86,276,154 (GRCm38) missense probably damaging 1.00
R9525:Olfr1051 UTSW 2 86,276,140 (GRCm38) missense probably benign 0.22
R9761:Olfr1051 UTSW 2 86,275,806 (GRCm38) missense probably benign 0.06
X0064:Olfr1051 UTSW 2 86,276,118 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2016-06-06