Incidental Mutation 'R5096:Fam181b'
ID 388042
Institutional Source Beutler Lab
Gene Symbol Fam181b
Ensembl Gene ENSMUSG00000051515
Gene Name family with sequence similarity 181, member B
Synonyms A830059I20Rik
MMRRC Submission 042685-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.226) question?
Stock # R5096 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 92729087-92730929 bp(+) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) T to G at 92730452 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000146473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051179]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000051179
Predicted Effect noncoding transcript
Transcript: ENSMUST00000098303
SMART Domains Protein: ENSMUSP00000095904
Gene: ENSMUSG00000054061

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
low complexity region 41 62 N/A INTRINSIC
low complexity region 111 143 N/A INTRINSIC
low complexity region 167 195 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181886
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191246
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.6%
Validation Efficiency 95% (61/64)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal fertility and morphology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acin1 A T 14: 54,916,679 (GRCm39) probably benign Het
Adar T A 3: 89,654,598 (GRCm39) *728C probably null Het
Ap3b1 A G 13: 94,616,357 (GRCm39) R753G unknown Het
Atp9b C T 18: 80,805,399 (GRCm39) V720I probably benign Het
AY358078 A C 14: 52,063,575 (GRCm39) D407A probably benign Het
Ccdc185 A G 1: 182,576,354 (GRCm39) S112P possibly damaging Het
Cir1 A G 2: 73,134,105 (GRCm39) S155P probably damaging Het
Colq C T 14: 31,274,911 (GRCm39) E76K possibly damaging Het
Cthrc1 T A 15: 38,947,815 (GRCm39) I104N probably damaging Het
D930020B18Rik A T 10: 121,503,709 (GRCm39) I92L probably benign Het
Eif3i C T 4: 129,494,237 (GRCm39) E21K probably damaging Het
Fam114a1 T A 5: 65,137,234 (GRCm39) M59K probably benign Het
Fam163b A G 2: 27,002,761 (GRCm39) S79P probably benign Het
Fsip2 G A 2: 82,821,460 (GRCm39) S5731N probably benign Het
Fzd9 C T 5: 135,278,713 (GRCm39) V391I probably damaging Het
Gbp5 A G 3: 142,207,122 (GRCm39) D97G probably damaging Het
Gm10715 T C 9: 3,038,157 (GRCm39) probably benign Het
Grhl1 A T 12: 24,653,049 (GRCm39) K418M probably damaging Het
H2-Q4 T A 17: 35,598,689 (GRCm39) probably benign Het
Hmcn1 C A 1: 150,486,420 (GRCm39) A4329S probably damaging Het
Hspa8 T C 9: 40,714,197 (GRCm39) probably benign Het
Ica1l T C 1: 60,067,313 (GRCm39) T26A possibly damaging Het
Ifi209 T A 1: 173,472,300 (GRCm39) N380K probably benign Het
Inpp5e G T 2: 26,289,537 (GRCm39) N482K probably damaging Het
Iqsec3 C T 6: 121,363,657 (GRCm39) V866M probably damaging Het
Kbtbd2 A G 6: 56,756,260 (GRCm39) V492A probably benign Het
Kcnb2 A G 1: 15,781,068 (GRCm39) R647G probably benign Het
Lcmt1 T G 7: 123,000,691 (GRCm39) V75G probably damaging Het
Lrp4 A G 2: 91,316,137 (GRCm39) I752V possibly damaging Het
Mmp17 C A 5: 129,682,627 (GRCm39) P422Q probably damaging Het
Myo3a A T 2: 22,464,254 (GRCm39) H165L probably benign Het
Nos3 C T 5: 24,576,955 (GRCm39) T494I probably damaging Het
Or1ak2 T C 2: 36,827,815 (GRCm39) V228A possibly damaging Het
Or4p22 C T 2: 88,317,646 (GRCm39) T190I possibly damaging Het
Or51q1c T C 7: 103,652,667 (GRCm39) Y68H probably benign Het
Or8u8 A G 2: 86,012,276 (GRCm39) Y60H probably damaging Het
Pkn2 A C 3: 142,545,092 (GRCm39) V27G probably damaging Het
Scube2 T C 7: 109,398,451 (GRCm39) probably benign Het
Skint7 A G 4: 111,839,152 (GRCm39) I149V probably damaging Het
Smc4 T A 3: 68,928,612 (GRCm39) I412K probably damaging Het
Snx19 T A 9: 30,340,082 (GRCm39) C407S probably benign Het
Speer3 C G 5: 13,846,394 (GRCm39) A238G possibly damaging Het
Sytl2 T A 7: 90,025,290 (GRCm39) I426N possibly damaging Het
Tbce A T 13: 14,203,990 (GRCm39) probably benign Het
Tdpoz2 T C 3: 93,559,819 (GRCm39) E51G possibly damaging Het
Tmem221 A G 8: 72,011,353 (GRCm39) L34P probably damaging Het
Tmem92 T C 11: 94,669,862 (GRCm39) T90A probably benign Het
Tpr A G 1: 150,321,953 (GRCm39) D42G probably damaging Het
Wt1 A G 2: 104,973,470 (GRCm39) T237A probably damaging Het
Other mutations in Fam181b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1328:Fam181b UTSW 7 92,729,437 (GRCm39) missense probably damaging 0.96
R1447:Fam181b UTSW 7 92,729,368 (GRCm39) missense probably damaging 0.99
R2055:Fam181b UTSW 7 92,729,634 (GRCm39) missense probably benign
R4086:Fam181b UTSW 7 92,729,788 (GRCm39) missense probably benign
R4600:Fam181b UTSW 7 92,729,992 (GRCm39) missense possibly damaging 0.73
R5048:Fam181b UTSW 7 92,729,147 (GRCm39) utr 5 prime probably benign
R7171:Fam181b UTSW 7 92,729,943 (GRCm39) missense possibly damaging 0.49
R7429:Fam181b UTSW 7 92,729,403 (GRCm39) missense probably benign 0.17
R7430:Fam181b UTSW 7 92,729,403 (GRCm39) missense probably benign 0.17
R8555:Fam181b UTSW 7 92,729,296 (GRCm39) missense probably damaging 0.99
R9001:Fam181b UTSW 7 92,730,356 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TGACCTTGAACGAGCCTGTG -3'
(R):5'- GCTGTGATTAAAACAATCCTCACTTCG -3'

Sequencing Primer
(F):5'- TGTACCCCACAGCCTTGGAC -3'
(R):5'- AGATCCTTTATTAAATGGATTGAGGG -3'
Posted On 2016-06-06