Incidental Mutation 'R5097:Igkv4-80'
ID388080
Institutional Source Beutler Lab
Gene Symbol Igkv4-80
Ensembl Gene ENSMUSG00000076540
Gene Nameimmunoglobulin kappa variable 4-80
SynonymsGm16729
MMRRC Submission 042686-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.097) question?
Stock #R5097 (G1)
Quality Score225
Status Not validated
Chromosome6
Chromosomal Location69016560-69017080 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 69016665 bp
ZygosityHeterozygous
Amino Acid Change Serine to Alanine at position 81 (S81A)
Ref Sequence ENSEMBL: ENSMUSP00000100142 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103341]
Predicted Effect probably benign
Transcript: ENSMUST00000103341
AA Change: S81A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000100142
Gene: ENSMUSG00000076540
AA Change: S81A

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
IGv 40 111 1.7e-19 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts3 C A 5: 89,693,050 V805F probably damaging Het
Adgrb3 G A 1: 25,826,084 T226M probably damaging Het
Ak5 A G 3: 152,481,633 S406P probably damaging Het
Akt3 C G 1: 177,248,688 V12L probably benign Het
Arhgef40 A C 14: 51,989,689 S397R probably damaging Het
Atp5c1 A G 2: 10,063,512 V144A probably benign Het
Ccser1 A G 6: 61,312,160 S436G probably benign Het
Clgn G T 8: 83,410,523 V290F possibly damaging Het
Dis3l T A 9: 64,319,216 D261V probably damaging Het
Dnah11 T A 12: 118,017,700 Y2577F probably damaging Het
Evi5l A G 8: 4,193,317 E371G probably damaging Het
Fat2 A G 11: 55,310,704 S515P probably damaging Het
Fsip2 A G 2: 82,991,985 I6021V probably benign Het
Gm813 A C 16: 58,613,864 N163K probably benign Het
Gstm5 A T 3: 107,895,942 probably benign Het
H2-Oa G A 17: 34,093,835 D29N probably damaging Het
Ireb2 A G 9: 54,895,384 I434M probably benign Het
Klk14 G A 7: 43,692,077 C51Y probably damaging Het
Micall1 A G 15: 79,129,878 T658A probably benign Het
Mitf C T 6: 97,996,462 A252V possibly damaging Het
Mpzl1 A G 1: 165,605,716 I122T probably damaging Het
Mtus2 G A 5: 148,295,582 V146I probably damaging Het
Myh11 C T 16: 14,205,906 probably null Het
Myrfl A G 10: 116,817,704 I486T probably damaging Het
N4bp2 T C 5: 65,817,218 V1477A probably damaging Het
Ndc1 T A 4: 107,374,161 S100T probably benign Het
Nek10 T A 14: 14,857,851 N433K probably benign Het
Noc4l C T 5: 110,651,346 S190N probably benign Het
Nprl2 A G 9: 107,543,532 E122G probably damaging Het
Olfr1 G C 11: 73,395,293 S243C probably damaging Het
Olfr430 C T 1: 174,069,529 T77I probably benign Het
Olfr525 A G 7: 140,323,095 Y132C probably damaging Het
Osbpl1a T C 18: 12,763,537 I324V probably damaging Het
Otx1 C A 11: 21,997,037 A91S probably damaging Het
Peg3 C T 7: 6,710,027 R732H probably damaging Het
Rfc4 A G 16: 23,114,296 I297T possibly damaging Het
Rpl3l T A 17: 24,733,461 D218E probably damaging Het
Rufy4 T C 1: 74,147,663 C537R probably damaging Het
Sesn2 C T 4: 132,496,898 V400I probably benign Het
Syt11 C T 3: 88,747,924 V51I probably benign Het
Tas2r115 A C 6: 132,737,253 L245R probably damaging Het
Tmem115 G A 9: 107,534,860 V128I probably benign Het
Trim47 A G 11: 116,106,434 V499A probably benign Het
Trpm7 A T 2: 126,796,336 probably null Het
Zfp143 A G 7: 110,088,791 D479G probably damaging Het
Zfp292 T C 4: 34,839,878 T91A possibly damaging Het
Other mutations in Igkv4-80
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02452:Igkv4-80 APN 6 69016832 missense probably benign 0.01
IGL02630:Igkv4-80 APN 6 69016696 nonsense probably null
IGL02711:Igkv4-80 APN 6 69016817 missense probably damaging 1.00
IGL02934:Igkv4-80 APN 6 69016856 missense probably benign 0.32
R4584:Igkv4-80 UTSW 6 69016736 missense probably damaging 1.00
R4873:Igkv4-80 UTSW 6 69016665 missense probably benign
R4875:Igkv4-80 UTSW 6 69016665 missense probably benign
R4925:Igkv4-80 UTSW 6 69016665 missense probably benign
R4934:Igkv4-80 UTSW 6 69016665 missense probably benign
R4991:Igkv4-80 UTSW 6 69016665 missense probably benign
R4992:Igkv4-80 UTSW 6 69016665 missense probably benign
R5020:Igkv4-80 UTSW 6 69016665 missense probably benign
R5061:Igkv4-80 UTSW 6 69016665 missense probably benign
R5063:Igkv4-80 UTSW 6 69016665 missense probably benign
R5164:Igkv4-80 UTSW 6 69016665 missense probably benign
R5165:Igkv4-80 UTSW 6 69016665 missense probably benign
R5169:Igkv4-80 UTSW 6 69016665 missense probably benign
R5170:Igkv4-80 UTSW 6 69016665 missense probably benign
R5171:Igkv4-80 UTSW 6 69016665 missense probably benign
R5172:Igkv4-80 UTSW 6 69016665 missense probably benign
R5203:Igkv4-80 UTSW 6 69016665 missense probably benign
R5204:Igkv4-80 UTSW 6 69016665 missense probably benign
R5205:Igkv4-80 UTSW 6 69016665 missense probably benign
R5257:Igkv4-80 UTSW 6 69016827 missense probably benign 0.01
R5258:Igkv4-80 UTSW 6 69016827 missense probably benign 0.01
R5380:Igkv4-80 UTSW 6 69016665 missense probably benign
R5381:Igkv4-80 UTSW 6 69016665 missense probably benign
R5382:Igkv4-80 UTSW 6 69016665 missense probably benign
R5383:Igkv4-80 UTSW 6 69016665 missense probably benign
R5415:Igkv4-80 UTSW 6 69016665 missense probably benign
R5416:Igkv4-80 UTSW 6 69016665 missense probably benign
R6778:Igkv4-80 UTSW 6 69016561 nonsense probably null
R7385:Igkv4-80 UTSW 6 69016715 missense probably damaging 1.00
R7507:Igkv4-80 UTSW 6 69016693 missense probably benign 0.02
Predicted Primers
Posted On2016-06-06