Incidental Mutation 'R5098:Ugt2b37'
ID 388123
Institutional Source Beutler Lab
Gene Symbol Ugt2b37
Ensembl Gene ENSMUSG00000057425
Gene Name UDP glucuronosyltransferase 2 family, polypeptide B37
Synonyms 0610033E06Rik
MMRRC Submission 042687-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R5098 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 87388351-87402647 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87390812 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 352 (T352S)
Ref Sequence ENSEMBL: ENSMUSP00000075255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075858]
AlphaFold Q8VCN3
Predicted Effect probably damaging
Transcript: ENSMUST00000075858
AA Change: T352S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000075255
Gene: ENSMUSG00000057425
AA Change: T352S

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:UDPGT 24 527 5.5e-256 PFAM
Pfam:Glyco_tran_28_C 328 449 2.5e-9 PFAM
Meta Mutation Damage Score 0.8911 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 100% (54/54)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b T C 11: 109,847,944 (GRCm39) I784V probably benign Het
Agxt A G 1: 93,065,029 (GRCm39) H146R probably benign Het
Art5 A G 7: 101,747,177 (GRCm39) F201L probably damaging Het
Bcl2a1b T A 9: 89,081,432 (GRCm39) M7K probably benign Het
Card10 G A 15: 78,660,917 (GRCm39) A1030V probably benign Het
Ccdc66 G A 14: 27,220,750 (GRCm39) T58M probably damaging Het
Cd72 C T 4: 43,452,610 (GRCm39) G74R probably damaging Het
Cdc27 T C 11: 104,398,113 (GRCm39) K749R probably damaging Het
Commd3 A T 2: 18,678,988 (GRCm39) T102S possibly damaging Het
Cyp2f2 A G 7: 26,829,304 (GRCm39) T270A possibly damaging Het
Dclre1b A G 3: 103,716,452 (GRCm39) probably benign Het
Dennd1b T A 1: 139,061,459 (GRCm39) D380E probably damaging Het
Dhx58 T C 11: 100,585,999 (GRCm39) E674G probably benign Het
Dnaaf9 A G 2: 130,640,101 (GRCm39) S128P probably damaging Het
Ecpas T C 4: 58,877,048 (GRCm39) D129G probably damaging Het
Exoc5 T C 14: 49,286,304 (GRCm39) T108A possibly damaging Het
Fat4 T C 3: 38,942,438 (GRCm39) S444P probably benign Het
Gm3327 A T 14: 44,362,292 (GRCm39) I64F unknown Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
Gpr15 T A 16: 58,538,890 (GRCm39) R66S probably damaging Het
Hmga1b T C 11: 120,654,018 (GRCm39) S102P probably benign Het
Kat6b G A 14: 21,669,083 (GRCm39) probably benign Het
Kdm1b A G 13: 47,216,467 (GRCm39) Y279C probably damaging Het
Krtap9-3 C A 11: 99,488,816 (GRCm39) C22F probably benign Het
Map3k14 T A 11: 103,115,185 (GRCm39) D817V probably damaging Het
Mybpc1 T C 10: 88,381,926 (GRCm39) D588G probably damaging Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or2t6 A G 14: 14,175,683 (GRCm38) V133A probably benign Het
Or5g29 A G 2: 85,420,976 (GRCm39) I31V probably benign Het
Pcdhb20 A G 18: 37,637,858 (GRCm39) D128G probably damaging Het
Pgap6 A T 17: 26,337,902 (GRCm39) N429Y probably damaging Het
Ppil6 A G 10: 41,366,616 (GRCm39) E47G probably null Het
Rad17 A T 13: 100,754,154 (GRCm39) *689K probably null Het
Scin A T 12: 40,127,541 (GRCm39) Y416* probably null Het
Serf1 A G 13: 100,245,575 (GRCm39) T18A probably benign Het
Sik2 T C 9: 50,906,891 (GRCm39) probably benign Het
Slc39a8 C A 3: 135,563,918 (GRCm39) N254K probably benign Het
Spint3 A G 2: 164,411,821 (GRCm39) F63L probably damaging Het
Suox A T 10: 128,507,027 (GRCm39) S334T probably damaging Het
Tas2r119 A G 15: 32,178,228 (GRCm39) M265V probably benign Het
Tmem126b A G 7: 90,118,850 (GRCm39) L146P probably damaging Het
Trpc3 G T 3: 36,717,047 (GRCm39) D330E probably benign Het
Ugt2a2 T C 5: 87,612,040 (GRCm39) E290G possibly damaging Het
Vmn1r40 T C 6: 89,691,930 (GRCm39) V249A probably damaging Het
Zc3h18 A G 8: 123,113,608 (GRCm39) D200G probably damaging Het
Zfp652 T C 11: 95,643,762 (GRCm39) V140A probably damaging Het
Other mutations in Ugt2b37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00401:Ugt2b37 APN 5 87,390,340 (GRCm39) missense possibly damaging 0.90
IGL00567:Ugt2b37 APN 5 87,401,933 (GRCm39) missense probably damaging 1.00
IGL00787:Ugt2b37 APN 5 87,390,288 (GRCm39) missense probably benign 0.00
IGL01560:Ugt2b37 APN 5 87,399,698 (GRCm39) missense probably damaging 1.00
IGL01617:Ugt2b37 APN 5 87,399,738 (GRCm39) missense probably damaging 1.00
IGL01982:Ugt2b37 APN 5 87,390,291 (GRCm39) missense probably damaging 1.00
IGL02299:Ugt2b37 APN 5 87,390,174 (GRCm39) missense probably benign 0.00
IGL02323:Ugt2b37 APN 5 87,398,423 (GRCm39) splice site probably benign
IGL02326:Ugt2b37 APN 5 87,388,861 (GRCm39) missense probably benign 0.25
IGL02516:Ugt2b37 APN 5 87,388,741 (GRCm39) missense probably damaging 1.00
IGL03285:Ugt2b37 APN 5 87,388,734 (GRCm39) missense probably damaging 1.00
R0076:Ugt2b37 UTSW 5 87,402,080 (GRCm39) missense probably benign 0.31
R0141:Ugt2b37 UTSW 5 87,388,842 (GRCm39) missense probably damaging 1.00
R0312:Ugt2b37 UTSW 5 87,398,524 (GRCm39) missense probably damaging 1.00
R0359:Ugt2b37 UTSW 5 87,398,443 (GRCm39) missense probably benign 0.10
R0523:Ugt2b37 UTSW 5 87,399,691 (GRCm39) missense possibly damaging 0.91
R1938:Ugt2b37 UTSW 5 87,388,716 (GRCm39) missense probably damaging 1.00
R1962:Ugt2b37 UTSW 5 87,402,193 (GRCm39) missense probably damaging 1.00
R2496:Ugt2b37 UTSW 5 87,402,569 (GRCm39) missense probably damaging 0.97
R3704:Ugt2b37 UTSW 5 87,390,846 (GRCm39) missense possibly damaging 0.55
R4430:Ugt2b37 UTSW 5 87,401,951 (GRCm39) missense probably benign 0.00
R4825:Ugt2b37 UTSW 5 87,398,498 (GRCm39) missense possibly damaging 0.91
R5043:Ugt2b37 UTSW 5 87,399,719 (GRCm39) nonsense probably null
R5174:Ugt2b37 UTSW 5 87,399,739 (GRCm39) missense probably benign 0.00
R5522:Ugt2b37 UTSW 5 87,388,759 (GRCm39) missense probably benign 0.14
R5879:Ugt2b37 UTSW 5 87,402,265 (GRCm39) missense probably benign
R5999:Ugt2b37 UTSW 5 87,402,036 (GRCm39) missense probably benign 0.25
R6374:Ugt2b37 UTSW 5 87,390,279 (GRCm39) missense probably damaging 1.00
R6454:Ugt2b37 UTSW 5 87,388,836 (GRCm39) missense probably damaging 1.00
R6857:Ugt2b37 UTSW 5 87,388,705 (GRCm39) missense probably damaging 0.98
R6875:Ugt2b37 UTSW 5 87,390,288 (GRCm39) missense probably benign 0.00
R6916:Ugt2b37 UTSW 5 87,402,459 (GRCm39) missense probably benign 0.07
R7099:Ugt2b37 UTSW 5 87,388,848 (GRCm39) missense probably benign 0.00
R7239:Ugt2b37 UTSW 5 87,402,590 (GRCm39) missense probably benign
R7470:Ugt2b37 UTSW 5 87,401,971 (GRCm39) missense probably benign 0.24
R7810:Ugt2b37 UTSW 5 87,402,118 (GRCm39) missense probably damaging 1.00
R7841:Ugt2b37 UTSW 5 87,398,489 (GRCm39) missense probably benign 0.05
R7860:Ugt2b37 UTSW 5 87,402,189 (GRCm39) missense probably damaging 1.00
R7861:Ugt2b37 UTSW 5 87,390,299 (GRCm39) nonsense probably null
R8200:Ugt2b37 UTSW 5 87,388,750 (GRCm39) nonsense probably null
R8211:Ugt2b37 UTSW 5 87,390,235 (GRCm39) missense probably benign 0.07
R8282:Ugt2b37 UTSW 5 87,402,440 (GRCm39) missense probably benign 0.01
R8312:Ugt2b37 UTSW 5 87,390,799 (GRCm39) missense probably benign 0.15
R8520:Ugt2b37 UTSW 5 87,388,714 (GRCm39) missense probably benign 0.04
R8688:Ugt2b37 UTSW 5 87,390,240 (GRCm39) missense possibly damaging 0.52
R8695:Ugt2b37 UTSW 5 87,390,243 (GRCm39) missense probably benign 0.00
R8772:Ugt2b37 UTSW 5 87,402,345 (GRCm39) missense probably benign 0.00
R8839:Ugt2b37 UTSW 5 87,402,415 (GRCm39) missense probably damaging 1.00
R9087:Ugt2b37 UTSW 5 87,401,996 (GRCm39) missense probably benign 0.01
R9139:Ugt2b37 UTSW 5 87,399,636 (GRCm39) missense probably benign 0.09
R9424:Ugt2b37 UTSW 5 87,402,217 (GRCm39) missense probably damaging 0.99
R9432:Ugt2b37 UTSW 5 87,402,046 (GRCm39) missense probably damaging 0.97
R9498:Ugt2b37 UTSW 5 87,402,244 (GRCm39) missense probably benign 0.07
R9711:Ugt2b37 UTSW 5 87,402,532 (GRCm39) missense possibly damaging 0.85
R9718:Ugt2b37 UTSW 5 87,390,802 (GRCm39) missense probably benign 0.11
R9783:Ugt2b37 UTSW 5 87,388,840 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTAAGAAAAGACCAAATCCATGTC -3'
(R):5'- ATCTATCCTATGGGAGATGTTCAGATC -3'

Sequencing Primer
(F):5'- AGACCAAATCCATGTCATAACTTG -3'
(R):5'- CATAAGCATGCCCCCTTGG -3'
Posted On 2016-06-06