Mutagenetix > Incidental Mutations

Incidental Mutation 'R5064:Vmn1r55'

388258

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r55

Ensembl Gene

ENSMUSG00000074402

Gene Name

vomeronasal 1 receptor 55

Synonyms

LOC236535, LOC384522, V1rd5

MMRRC Submission

042654-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R5064 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

5146218-5147501 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 5146929 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 165 (M165K)

Ref Sequence

ENSEMBL: ENSMUSP00000096443 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098844]

Predicted Effect

probably benign
Transcript: ENSMUST00000098844
AA Change: M165K

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000096443
Gene: ENSMUSG00000074402
AA Change: M165K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	286	3.7e-14	PFAM
Pfam:7tm_1	20	279	4e-8	PFAM
Pfam:V1R	31	286	5.5e-17	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.3%
20x: 92.1%

Validation Efficiency

100% (44/44)

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932431P20Rik	A	G	7: 29,535,655		noncoding transcript	Het
Abca12	A	G	1: 71,300,960	V1082A	probably damaging	Het
Adamts7	T	A	9: 90,195,830	Y1496N	probably damaging	Het
Ascl2	T	C	7: 142,968,259	N151D	possibly damaging	Het
Asxl3	G	T	18: 22,516,019	S355I	probably benign	Het
Cttnbp2	T	C	6: 18,448,279	Q127R	probably damaging	Het
Efhc1	T	A	1: 20,974,963	I401N	possibly damaging	Het
Eml6	C	T	11: 29,749,300	V1818I	probably benign	Het
Fam129a	A	G	1: 151,689,659	I247V	probably benign	Het
Grin1	G	T	2: 25,303,831		probably benign	Het
Ints2	C	T	11: 86,249,274	R244H	probably damaging	Het
Mfng	C	T	15: 78,764,388	R163H	probably benign	Het
Mllt6	C	A	11: 97,673,949	A527E	probably damaging	Het
Msh5	G	T	17: 35,043,783		probably benign	Het
Mypn	T	A	10: 63,123,371	D1057V	possibly damaging	Het
Nasp	A	G	4: 116,611,970		probably null	Het
Nat8l	T	C	5: 33,996,869	V9A	probably damaging	Het
Nr1h2	G	A	7: 44,551,649	A219V	possibly damaging	Het
Nup155	C	A	15: 8,135,870	H663Q	probably damaging	Het
Pikfyve	A	G	1: 65,253,407	Y1339C	probably damaging	Het
Plppr1	A	T	4: 49,319,974	H200L	probably benign	Het
Por	T	C	5: 135,733,795	V421A	probably benign	Het
Pxylp1	T	G	9: 96,854,800		probably benign	Het
Serpina3a	G	A	12: 104,116,189	V74I	probably benign	Het
Sfxn1	T	C	13: 54,085,569	I37T	probably benign	Het
Thsd7a	G	T	6: 12,330,952	T1397N	possibly damaging	Het
Tnrc6a	T	C	7: 123,186,723		probably null	Het
Vmn2r58	A	T	7: 41,837,110	M787K	probably damaging	Het
Vta1	G	T	10: 14,705,478		probably benign	Het
Zfp236	A	G	18: 82,691,576		probably null	Het

Other mutations in Vmn1r55

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1771:Vmn1r55	UTSW	7	5146920	missense	probably benign	0.01
R2063:Vmn1r55	UTSW	7	5147049	missense	possibly damaging	0.91
R2064:Vmn1r55	UTSW	7	5147049	missense	possibly damaging	0.91
R2066:Vmn1r55	UTSW	7	5147049	missense	possibly damaging	0.91
R2068:Vmn1r55	UTSW	7	5147049	missense	possibly damaging	0.91
R3737:Vmn1r55	UTSW	7	5147196	missense	probably damaging	0.99
R4409:Vmn1r55	UTSW	7	5147076	missense	probably benign	0.40
R4410:Vmn1r55	UTSW	7	5147076	missense	probably benign	0.40
R4700:Vmn1r55	UTSW	7	5146587	missense	probably damaging	1.00
R4700:Vmn1r55	UTSW	7	5146588	missense	probably damaging	0.98
R4755:Vmn1r55	UTSW	7	5147026	missense	probably damaging	1.00
R4945:Vmn1r55	UTSW	7	5147106	missense	probably damaging	1.00
R5186:Vmn1r55	UTSW	7	5146986	missense	probably damaging	0.99
R5394:Vmn1r55	UTSW	7	5146996	missense	probably damaging	1.00
R6487:Vmn1r55	UTSW	7	5146555	missense	probably benign	0.23
R7855:Vmn1r55	UTSW	7	5146624	missense	probably benign
R8204:Vmn1r55	UTSW	7	5147286	missense	possibly damaging	0.48
R8376:Vmn1r55	UTSW	7	5146870	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TTTCAGCATGGCCTCTGTTG -3'
(R):5'- GGCACAAACATGTGTTCTACC -3'

Sequencing Primer
(F):5'- CAGCATGGCCTCTGTTGCTTTG -3'
(R):5'- GCACAAACATGTGTTCTACCTGTGTC -3'

Posted On

2016-06-06