Incidental Mutation 'R5064:Wdr87-ps'
| ID |
388259 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wdr87-ps
|
| Ensembl Gene |
ENSMUSG00000074224 |
| Gene Name |
WD repeat domain 87, pseudogene |
| Synonyms |
4932431P20Rik |
| MMRRC Submission |
042654-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5064 (G1)
|
| Quality Score |
119 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
29223968-29237480 bp(+) (GRCm39) |
| Type of Mutation |
exon |
| DNA Base Change (assembly) |
A to G
at 29235080 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000098602
|
| SMART Domains |
Protein: ENSMUSP00000096202
Gene: ENSMUSG00000074224
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
233 |
239 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141713
|
| SMART Domains |
Protein: ENSMUSP00000120285
Gene: ENSMUSG00000074224
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:WD40
|
94 |
134 |
1e-9 |
BLAST |
|
WD40
|
139 |
176 |
1.59e1 |
SMART |
|
WD40
|
228 |
269 |
9.51e1 |
SMART |
|
WD40
|
272 |
311 |
3.33e-1 |
SMART |
|
Blast:WD40
|
354 |
393 |
4e-15 |
BLAST |
|
Blast:WD40
|
445 |
490 |
2e-22 |
BLAST |
|
Blast:WD40
|
493 |
538 |
8e-15 |
BLAST |
|
WD40
|
595 |
634 |
1.68e-6 |
SMART |
|
low complexity region
|
701 |
710 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
1135 |
1168 |
N/A |
INTRINSIC |
|
low complexity region
|
1211 |
1230 |
N/A |
INTRINSIC |
|
low complexity region
|
1239 |
1273 |
N/A |
INTRINSIC |
|
coiled coil region
|
1347 |
1375 |
N/A |
INTRINSIC |
|
coiled coil region
|
1399 |
1433 |
N/A |
INTRINSIC |
|
low complexity region
|
1435 |
1453 |
N/A |
INTRINSIC |
|
low complexity region
|
1497 |
1519 |
N/A |
INTRINSIC |
|
coiled coil region
|
1612 |
1707 |
N/A |
INTRINSIC |
|
coiled coil region
|
1731 |
1989 |
N/A |
INTRINSIC |
|
coiled coil region
|
2034 |
2072 |
N/A |
INTRINSIC |
|
coiled coil region
|
2127 |
2154 |
N/A |
INTRINSIC |
|
coiled coil region
|
2220 |
2302 |
N/A |
INTRINSIC |
|
coiled coil region
|
2357 |
2561 |
N/A |
INTRINSIC |
|
low complexity region
|
2993 |
2999 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0869 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.3%
- 20x: 92.1%
|
| Validation Efficiency |
100% (44/44) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca12 |
A |
G |
1: 71,340,119 (GRCm39) |
V1082A |
probably damaging |
Het |
| Adamts7 |
T |
A |
9: 90,077,883 (GRCm39) |
Y1496N |
probably damaging |
Het |
| Ascl2 |
T |
C |
7: 142,521,996 (GRCm39) |
N151D |
possibly damaging |
Het |
| Asxl3 |
G |
T |
18: 22,649,076 (GRCm39) |
S355I |
probably benign |
Het |
| Cttnbp2 |
T |
C |
6: 18,448,278 (GRCm39) |
Q127R |
probably damaging |
Het |
| Efhc1 |
T |
A |
1: 21,045,187 (GRCm39) |
I401N |
possibly damaging |
Het |
| Eml6 |
C |
T |
11: 29,699,300 (GRCm39) |
V1818I |
probably benign |
Het |
| Grin1 |
G |
T |
2: 25,193,843 (GRCm39) |
|
probably benign |
Het |
| Ints2 |
C |
T |
11: 86,140,100 (GRCm39) |
R244H |
probably damaging |
Het |
| Mfng |
C |
T |
15: 78,648,588 (GRCm39) |
R163H |
probably benign |
Het |
| Mllt6 |
C |
A |
11: 97,564,775 (GRCm39) |
A527E |
probably damaging |
Het |
| Msh5 |
G |
T |
17: 35,262,759 (GRCm39) |
|
probably benign |
Het |
| Mypn |
T |
A |
10: 62,959,150 (GRCm39) |
D1057V |
possibly damaging |
Het |
| Nasp |
A |
G |
4: 116,469,167 (GRCm39) |
|
probably null |
Het |
| Nat8l |
T |
C |
5: 34,154,213 (GRCm39) |
V9A |
probably damaging |
Het |
| Niban1 |
A |
G |
1: 151,565,410 (GRCm39) |
I247V |
probably benign |
Het |
| Nr1h2 |
G |
A |
7: 44,201,073 (GRCm39) |
A219V |
possibly damaging |
Het |
| Nup155 |
C |
A |
15: 8,165,354 (GRCm39) |
H663Q |
probably damaging |
Het |
| Pikfyve |
A |
G |
1: 65,292,566 (GRCm39) |
Y1339C |
probably damaging |
Het |
| Plppr1 |
A |
T |
4: 49,319,974 (GRCm39) |
H200L |
probably benign |
Het |
| Por |
T |
C |
5: 135,762,649 (GRCm39) |
V421A |
probably benign |
Het |
| Pxylp1 |
T |
G |
9: 96,736,853 (GRCm39) |
|
probably benign |
Het |
| Serpina3a |
G |
A |
12: 104,082,448 (GRCm39) |
V74I |
probably benign |
Het |
| Sfxn1 |
T |
C |
13: 54,239,588 (GRCm39) |
I37T |
probably benign |
Het |
| Thsd7a |
G |
T |
6: 12,330,951 (GRCm39) |
T1397N |
possibly damaging |
Het |
| Tnrc6a |
T |
C |
7: 122,785,946 (GRCm39) |
|
probably null |
Het |
| Vmn1r55 |
A |
T |
7: 5,149,928 (GRCm39) |
M165K |
probably benign |
Het |
| Vmn2r58 |
A |
T |
7: 41,486,534 (GRCm39) |
M787K |
probably damaging |
Het |
| Vta1 |
G |
T |
10: 14,581,222 (GRCm39) |
|
probably benign |
Het |
| Zfp236 |
A |
G |
18: 82,709,701 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Wdr87-ps |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00272:Wdr87-ps
|
APN |
7 |
29,237,047 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL00505:Wdr87-ps
|
APN |
7 |
29,233,608 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL00557:Wdr87-ps
|
APN |
7 |
29,235,227 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL00569:Wdr87-ps
|
APN |
7 |
29,233,565 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL00966:Wdr87-ps
|
APN |
7 |
29,236,888 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL01668:Wdr87-ps
|
APN |
7 |
29,236,855 (GRCm39) |
exon |
noncoding transcript |
|
|
K7371:Wdr87-ps
|
UTSW |
7 |
29,230,417 (GRCm39) |
exon |
noncoding transcript |
|
|
P0037:Wdr87-ps
|
UTSW |
7 |
29,233,039 (GRCm39) |
exon |
noncoding transcript |
|
|
R0179:Wdr87-ps
|
UTSW |
7 |
29,235,365 (GRCm39) |
exon |
noncoding transcript |
|
|
R0357:Wdr87-ps
|
UTSW |
7 |
29,235,007 (GRCm39) |
exon |
noncoding transcript |
|
|
R0358:Wdr87-ps
|
UTSW |
7 |
29,231,636 (GRCm39) |
exon |
noncoding transcript |
|
|
R0412:Wdr87-ps
|
UTSW |
7 |
29,229,995 (GRCm39) |
exon |
noncoding transcript |
|
|
R0530:Wdr87-ps
|
UTSW |
7 |
29,229,545 (GRCm39) |
exon |
noncoding transcript |
|
|
R0600:Wdr87-ps
|
UTSW |
7 |
29,232,690 (GRCm39) |
exon |
noncoding transcript |
|
|
R0675:Wdr87-ps
|
UTSW |
7 |
29,231,942 (GRCm39) |
exon |
noncoding transcript |
|
|
R1118:Wdr87-ps
|
UTSW |
7 |
29,233,669 (GRCm39) |
exon |
noncoding transcript |
|
|
R1395:Wdr87-ps
|
UTSW |
7 |
29,230,812 (GRCm39) |
exon |
noncoding transcript |
|
|
R1444:Wdr87-ps
|
UTSW |
7 |
29,229,380 (GRCm39) |
exon |
noncoding transcript |
|
|
R1476:Wdr87-ps
|
UTSW |
7 |
29,234,315 (GRCm39) |
exon |
noncoding transcript |
|
|
R1534:Wdr87-ps
|
UTSW |
7 |
29,229,854 (GRCm39) |
exon |
noncoding transcript |
|
|
R1535:Wdr87-ps
|
UTSW |
7 |
29,229,004 (GRCm39) |
exon |
noncoding transcript |
|
|
R2023:Wdr87-ps
|
UTSW |
7 |
29,230,959 (GRCm39) |
exon |
noncoding transcript |
|
|
R2127:Wdr87-ps
|
UTSW |
7 |
29,236,565 (GRCm39) |
exon |
noncoding transcript |
|
|
R2141:Wdr87-ps
|
UTSW |
7 |
29,230,935 (GRCm39) |
exon |
noncoding transcript |
|
|
R2198:Wdr87-ps
|
UTSW |
7 |
29,226,697 (GRCm39) |
exon |
noncoding transcript |
|
|
R2201:Wdr87-ps
|
UTSW |
7 |
29,235,950 (GRCm39) |
exon |
noncoding transcript |
|
|
R2262:Wdr87-ps
|
UTSW |
7 |
29,231,987 (GRCm39) |
exon |
noncoding transcript |
|
|
R2263:Wdr87-ps
|
UTSW |
7 |
29,231,987 (GRCm39) |
exon |
noncoding transcript |
|
|
R4874:Wdr87-ps
|
UTSW |
7 |
29,235,608 (GRCm39) |
exon |
noncoding transcript |
|
|
R5130:Wdr87-ps
|
UTSW |
7 |
29,228,699 (GRCm39) |
exon |
noncoding transcript |
|
|
R5366:Wdr87-ps
|
UTSW |
7 |
29,232,964 (GRCm39) |
exon |
noncoding transcript |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CAAATGAGAAGGCTGAGCACT -3'
(R):5'- TTCCTCTCCCTCCACTTGTTC -3'
Sequencing Primer
(F):5'- GGGAGCACTATTCTTTAAAAGGCTGC -3'
(R):5'- ACTTGTTCTTTCTCCTCTTTCCAC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation