Incidental Mutation 'R5065:Ighg2c'
ID 388303
Institutional Source Beutler Lab
Gene Symbol Ighg2c
Ensembl Gene ENSMUSG00000076612
Gene Name immunoglobulin heavy constant gamma 2C
Synonyms
MMRRC Submission 042655-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R5065 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 113251009-113252552 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 113251708 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 140 (I140V)
Gene Model predicted gene model for transcript(s):
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000103416
AA Change: I140V
SMART Domains Protein: ENSMUSP00000100212
Gene: ENSMUSG00000076612
AA Change: I140V

DomainStartEndE-ValueType
IGc1 21 91 2.4e-15 SMART
IG_like 143 218 1.64e-2 SMART
IGc1 249 322 1.97e-34 SMART
transmembrane domain 350 372 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000195192
AA Change: I140V
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 100% (36/36)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310009B15Rik T A 1: 138,779,893 (GRCm39) N120Y probably damaging Het
A930011G23Rik G A 5: 99,382,432 (GRCm39) T272M probably benign Het
Aldh9a1 A G 1: 167,180,128 (GRCm39) E74G probably damaging Het
Asxl3 C G 18: 22,658,356 (GRCm39) A2122G possibly damaging Het
Bcl2l10 A T 9: 75,255,261 (GRCm39) E26V possibly damaging Het
Cspg4b T A 13: 113,457,453 (GRCm39) H1166Q probably benign Het
Dennd2a C A 6: 39,472,110 (GRCm39) probably null Het
Dock3 A G 9: 106,832,883 (GRCm39) F129L probably damaging Het
Gm4847 A T 1: 166,462,359 (GRCm39) I377N probably damaging Het
Gm8674 T C 13: 50,056,613 (GRCm39) noncoding transcript Het
Hhipl2 A T 1: 183,207,580 (GRCm39) H433L probably benign Het
Hsfy2 G A 1: 56,675,626 (GRCm39) Q304* probably null Het
Kmt2a T C 9: 44,753,997 (GRCm39) probably benign Het
Map3k5 A G 10: 19,958,213 (GRCm39) E671G probably damaging Het
Map6 A G 7: 98,985,917 (GRCm39) D607G probably benign Het
Mroh4 C T 15: 74,500,119 (GRCm39) probably null Het
Or10g6 A G 9: 39,934,546 (GRCm39) I286V probably benign Het
Pcsk6 A G 7: 65,560,047 (GRCm39) D124G possibly damaging Het
Pkhd1l1 T A 15: 44,445,689 (GRCm39) N3790K possibly damaging Het
Polr3b C A 10: 84,468,402 (GRCm39) N129K probably benign Het
Ptpn23 A T 9: 110,227,256 (GRCm39) L31Q possibly damaging Het
Sema3c A G 5: 17,932,615 (GRCm39) N706S possibly damaging Het
Sipa1l2 T C 8: 126,218,324 (GRCm39) I338V probably benign Het
Slc39a7 A G 17: 34,250,033 (GRCm39) probably benign Het
Snd1 C A 6: 28,888,239 (GRCm39) N891K probably damaging Het
Sntg1 A G 1: 8,433,663 (GRCm39) probably benign Het
Stxbp5 A T 10: 9,646,295 (GRCm39) L780Q probably damaging Het
Tacr1 G A 6: 82,531,859 (GRCm39) V252M possibly damaging Het
Tdrp T C 8: 14,003,791 (GRCm39) E182G probably damaging Het
Vmn1r58 A G 7: 5,413,834 (GRCm39) I132T probably benign Het
Wap A T 11: 6,586,840 (GRCm39) N86K probably damaging Het
Other mutations in Ighg2c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02087:Ighg2c APN 12 113,248,986 (GRCm39) unclassified probably benign
IGL02560:Ighg2c APN 12 113,251,504 (GRCm39) missense unknown
IGL03339:Ighg2c APN 12 113,251,614 (GRCm39) missense unknown
R0047:Ighg2c UTSW 12 113,251,788 (GRCm39) splice site probably benign
R0047:Ighg2c UTSW 12 113,251,788 (GRCm39) splice site probably benign
R0415:Ighg2c UTSW 12 113,251,530 (GRCm39) missense unknown
R0571:Ighg2c UTSW 12 113,252,382 (GRCm39) nonsense probably null
R0634:Ighg2c UTSW 12 113,251,584 (GRCm39) missense unknown
R0893:Ighg2c UTSW 12 113,251,053 (GRCm39) missense unknown
R1169:Ighg2c UTSW 12 113,249,572 (GRCm39) unclassified probably benign
R3895:Ighg2c UTSW 12 113,251,278 (GRCm39) missense unknown
R6407:Ighg2c UTSW 12 113,252,271 (GRCm39) missense unknown
R6846:Ighg2c UTSW 12 113,251,930 (GRCm39) missense unknown
R7052:Ighg2c UTSW 12 113,252,343 (GRCm39) missense
R7231:Ighg2c UTSW 12 113,251,636 (GRCm39) missense
R7513:Ighg2c UTSW 12 113,252,471 (GRCm39) missense
R8783:Ighg2c UTSW 12 113,252,412 (GRCm39) missense
R9175:Ighg2c UTSW 12 113,252,499 (GRCm39) missense
R9419:Ighg2c UTSW 12 113,251,015 (GRCm39) critical splice donor site probably benign
Z1177:Ighg2c UTSW 12 113,251,300 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- AGTCAGGATGCAGCTCTCAC -3'
(R):5'- AGTCACTAGACCAGAGCTCC -3'

Sequencing Primer
(F):5'- AGGATGCAGCTCTCACCTCTG -3'
(R):5'- AGCTCCACTCCAGGGAGAATG -3'
Posted On 2016-06-06