Incidental Mutation 'R5066:Or6c204'
ID 388333
Institutional Source Beutler Lab
Gene Symbol Or6c204
Ensembl Gene ENSMUSG00000096000
Gene Name olfactory receptor family 6 subfamily C member 204
Synonyms Olfr773-ps1, GA_x6K02T2PULF-10872859-10871923, MOR114-15, Olfr773
MMRRC Submission 042656-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R5066 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129022353-129023288 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129022433 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 286 (I286V)
Ref Sequence ENSEMBL: ENSMUSP00000072743 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072976]
AlphaFold F6VS78
Predicted Effect possibly damaging
Transcript: ENSMUST00000072976
AA Change: I286V

PolyPhen 2 Score 0.884 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000072743
Gene: ENSMUSG00000096000
AA Change: I286V

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.6e-48 PFAM
Pfam:7tm_1 38 287 4.4e-22 PFAM
Meta Mutation Damage Score 0.1459 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 100% (45/45)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930544D05Rik A T 11: 70,507,417 (GRCm39) Y154F probably benign Het
Abca5 A T 11: 110,200,176 (GRCm39) probably benign Het
Agtpbp1 T A 13: 59,622,364 (GRCm39) D11V probably damaging Het
Aldh1a2 G A 9: 71,188,982 (GRCm39) A299T possibly damaging Het
Apc T A 18: 34,449,158 (GRCm39) V1984D probably damaging Het
Asxl3 C G 18: 22,658,356 (GRCm39) A2122G possibly damaging Het
Atp13a2 G A 4: 140,732,449 (GRCm39) V905M probably damaging Het
Atp1a1 C T 3: 101,489,420 (GRCm39) G731R probably damaging Het
Atrn T C 2: 130,836,113 (GRCm39) V1131A possibly damaging Het
Bcl2l13 T A 6: 120,863,982 (GRCm39) V312E possibly damaging Het
Chic2 A G 5: 75,187,817 (GRCm39) V81A possibly damaging Het
Drg1 A T 11: 3,209,353 (GRCm39) I122N possibly damaging Het
Efcab3 A G 11: 104,611,490 (GRCm39) D444G probably benign Het
Flt4 A G 11: 49,524,990 (GRCm39) N612S possibly damaging Het
Hadhb T C 5: 30,369,094 (GRCm39) probably benign Het
Heg1 G T 16: 33,559,041 (GRCm39) R856S probably benign Het
Ice2 A C 9: 69,315,573 (GRCm39) N143T probably benign Het
Igkv8-21 G A 6: 70,292,427 (GRCm39) Q4* probably null Het
Lrfn2 T C 17: 49,403,448 (GRCm39) S524P probably damaging Het
Mndal C A 1: 173,703,229 (GRCm39) A59S probably damaging Het
Mpp7 T C 18: 7,513,002 (GRCm39) E33G possibly damaging Het
Msantd5l A G 11: 51,145,251 (GRCm39) F112S probably damaging Het
Nedd4 T A 9: 72,617,801 (GRCm39) D187E probably damaging Het
Nfx1 A G 4: 40,991,868 (GRCm39) I519V probably benign Het
Or10p22 G A 10: 128,826,660 (GRCm39) R293Q probably damaging Het
Padi1 T C 4: 140,556,748 (GRCm39) N153S probably damaging Het
Parp10 A G 15: 76,125,146 (GRCm39) probably benign Het
Setbp1 A T 18: 78,900,514 (GRCm39) M1051K probably damaging Het
Slc2a7 T A 4: 150,244,573 (GRCm39) M347K probably damaging Het
Slc45a2 C A 15: 11,012,693 (GRCm39) T232K probably benign Het
Snd1 C A 6: 28,888,239 (GRCm39) N891K probably damaging Het
Spata13 T C 14: 60,987,538 (GRCm39) Y899H possibly damaging Het
Sult1c2 T A 17: 54,281,026 (GRCm39) I26F probably damaging Het
Sybu A G 15: 44,541,040 (GRCm39) C341R probably damaging Het
Syk T A 13: 52,796,018 (GRCm39) S538T possibly damaging Het
Syne2 A G 12: 76,013,325 (GRCm39) T2840A probably benign Het
Thsd4 A G 9: 59,883,615 (GRCm39) C924R probably damaging Het
Tle1 A G 4: 72,076,504 (GRCm39) S175P probably benign Het
Tmbim4 C T 10: 120,053,537 (GRCm39) T112M probably benign Het
Tmprss11a A G 5: 86,567,859 (GRCm39) probably null Het
Tnc C A 4: 63,893,466 (GRCm39) D1698Y probably damaging Het
Ypel1 A G 16: 16,927,539 (GRCm39) Y18H probably benign Het
Other mutations in Or6c204
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01539:Or6c204 APN 10 129,022,804 (GRCm39) missense probably benign 0.04
R1924:Or6c204 UTSW 10 129,023,044 (GRCm39) missense possibly damaging 0.78
R4171:Or6c204 UTSW 10 129,022,453 (GRCm39) missense probably benign 0.39
R4688:Or6c204 UTSW 10 129,022,514 (GRCm39) missense probably damaging 0.99
R4952:Or6c204 UTSW 10 129,022,466 (GRCm39) missense probably benign 0.12
R5610:Or6c204 UTSW 10 129,022,426 (GRCm39) missense probably damaging 0.96
R5633:Or6c204 UTSW 10 129,022,718 (GRCm39) missense probably benign 0.02
R6953:Or6c204 UTSW 10 129,022,474 (GRCm39) missense probably benign 0.01
R9644:Or6c204 UTSW 10 129,022,738 (GRCm39) missense possibly damaging 0.94
RF007:Or6c204 UTSW 10 129,022,562 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGTTAGCACACATGAAAGG -3'
(R):5'- AGACAGTTCTTAGATTCCCTTCTGC -3'

Sequencing Primer
(F):5'- CTGTTAGCACACATGAAAGGATGTC -3'
(R):5'- TTAGATTCCCTTCTGCCCAACAAAAG -3'
Posted On 2016-06-06