Incidental Mutation 'R0432:Myo6'
| ID |
38838 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo6
|
| Ensembl Gene |
ENSMUSG00000033577 |
| Gene Name |
myosin VI |
| Synonyms |
Myo6, Tlc, rsv |
| MMRRC Submission |
038634-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0432 (G1)
|
| Quality Score |
185 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
80072313-80219011 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to C
at 80181256 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139019
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035889]
[ENSMUST00000076140]
[ENSMUST00000113266]
[ENSMUST00000113268]
[ENSMUST00000127779]
[ENSMUST00000184480]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000035889
|
| SMART Domains |
Protein: ENSMUSP00000036181
Gene: ENSMUSG00000033577
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
51 |
772 |
N/A |
SMART |
|
IQ
|
812 |
834 |
8.58e-1 |
SMART |
|
low complexity region
|
909 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
982 |
1002 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1003 |
1113 |
3e-29 |
BLAST |
|
PDB:3H8D|D
|
1134 |
1262 |
1e-74 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000076140
|
| SMART Domains |
Protein: ENSMUSP00000075501
Gene: ENSMUSG00000033577
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
51 |
772 |
N/A |
SMART |
|
IQ
|
812 |
834 |
8.58e-1 |
SMART |
|
low complexity region
|
909 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
982 |
1002 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1003 |
1126 |
2e-27 |
BLAST |
|
PDB:3H8D|D
|
1138 |
1266 |
8e-75 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113266
|
| SMART Domains |
Protein: ENSMUSP00000108891
Gene: ENSMUSG00000033577
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
51 |
772 |
N/A |
SMART |
|
IQ
|
812 |
834 |
8.58e-1 |
SMART |
|
low complexity region
|
909 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
982 |
1002 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1003 |
1113 |
3e-29 |
BLAST |
|
PDB:3H8D|D
|
1125 |
1253 |
9e-75 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113268
|
| SMART Domains |
Protein: ENSMUSP00000108893
Gene: ENSMUSG00000033577
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
51 |
772 |
N/A |
SMART |
|
IQ
|
812 |
834 |
8.58e-1 |
SMART |
|
low complexity region
|
909 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
982 |
1002 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1003 |
1135 |
2e-26 |
BLAST |
|
Pfam:Myosin-VI_CBD
|
1167 |
1257 |
1.4e-46 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000127779
|
| SMART Domains |
Protein: ENSMUSP00000139228
Gene: ENSMUSG00000033577
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
51 |
772 |
N/A |
SMART |
|
IQ
|
812 |
834 |
8.58e-1 |
SMART |
|
low complexity region
|
909 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
982 |
1002 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1003 |
1136 |
1e-26 |
BLAST |
|
PDB:3H8D|D
|
1157 |
1285 |
9e-75 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184480
|
| SMART Domains |
Protein: ENSMUSP00000139019
Gene: ENSMUSG00000033577
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
51 |
772 |
N/A |
SMART |
|
IQ
|
812 |
834 |
8.58e-1 |
SMART |
|
low complexity region
|
909 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
982 |
1002 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1003 |
1145 |
1e-25 |
BLAST |
|
PDB:3H8D|D
|
1166 |
1294 |
8e-75 |
PDB |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.9%
|
| Validation Efficiency |
99% (91/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
PHENOTYPE: Homozygous mutant mice exhibit deafness and related behavioral characteristics such as circling, head tossing and hyperactivity. Progressive degeneration of the cochlear hair cells and the organ of Corti is observed with one mutation. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(13) : Targeted, other(2) Gene trapped(6) Spontaneous(3) Chemically induced(2) |
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310061I04Rik |
A |
G |
17: 36,206,708 (GRCm39) |
L110P |
probably damaging |
Het |
| 4930522L14Rik |
A |
T |
5: 109,884,785 (GRCm39) |
C358S |
probably damaging |
Het |
| Abca8b |
C |
A |
11: 109,870,841 (GRCm39) |
V104F |
possibly damaging |
Het |
| Afap1l2 |
T |
C |
19: 56,905,551 (GRCm39) |
|
probably benign |
Het |
| Ahctf1 |
A |
C |
1: 179,611,726 (GRCm39) |
I548R |
probably damaging |
Het |
| Alox12b |
G |
T |
11: 69,060,382 (GRCm39) |
G646V |
probably damaging |
Het |
| Aoah |
C |
T |
13: 21,095,368 (GRCm39) |
|
probably benign |
Het |
| Arhgap39 |
C |
T |
15: 76,619,086 (GRCm39) |
D833N |
probably damaging |
Het |
| Atxn1l |
A |
G |
8: 110,458,325 (GRCm39) |
W646R |
probably damaging |
Het |
| Cabp2 |
T |
C |
19: 4,134,903 (GRCm39) |
I28T |
possibly damaging |
Het |
| Cacna1b |
G |
A |
2: 24,577,716 (GRCm39) |
T719I |
probably damaging |
Het |
| Camk1d |
A |
T |
2: 5,449,946 (GRCm39) |
H70Q |
probably damaging |
Het |
| Car1 |
T |
C |
3: 14,835,236 (GRCm39) |
T170A |
probably benign |
Het |
| Ccdc162 |
T |
C |
10: 41,417,856 (GRCm39) |
T2113A |
probably benign |
Het |
| Cdc5l |
G |
A |
17: 45,726,610 (GRCm39) |
R321W |
probably damaging |
Het |
| Cdh17 |
T |
A |
4: 11,771,273 (GRCm39) |
C18* |
probably null |
Het |
| Cdk17 |
A |
T |
10: 93,073,652 (GRCm39) |
|
probably benign |
Het |
| Chd9 |
T |
A |
8: 91,721,078 (GRCm39) |
|
probably benign |
Het |
| Chrm5 |
T |
A |
2: 112,310,000 (GRCm39) |
K372M |
possibly damaging |
Het |
| Clasp2 |
A |
G |
9: 113,738,487 (GRCm39) |
T423A |
probably benign |
Het |
| Col11a1 |
A |
G |
3: 113,999,550 (GRCm39) |
|
probably benign |
Het |
| Col27a1 |
T |
C |
4: 63,143,848 (GRCm39) |
M512T |
possibly damaging |
Het |
| Dclk3 |
A |
G |
9: 111,314,003 (GRCm39) |
D693G |
probably damaging |
Het |
| Dcun1d3 |
T |
A |
7: 119,457,173 (GRCm39) |
K180* |
probably null |
Het |
| Dmxl2 |
T |
C |
9: 54,324,235 (GRCm39) |
R876G |
probably benign |
Het |
| Dnmbp |
A |
T |
19: 43,843,296 (GRCm39) |
Y432* |
probably null |
Het |
| Elapor2 |
G |
T |
5: 9,490,966 (GRCm39) |
G659* |
probably null |
Het |
| Eml2 |
C |
T |
7: 18,913,456 (GRCm39) |
Q125* |
probably null |
Het |
| Faap100 |
A |
C |
11: 120,264,702 (GRCm39) |
|
probably benign |
Het |
| Foxp2 |
T |
C |
6: 15,254,278 (GRCm39) |
|
probably benign |
Het |
| Gda |
A |
G |
19: 21,394,471 (GRCm39) |
Y129H |
probably damaging |
Het |
| Gga3 |
G |
A |
11: 115,481,350 (GRCm39) |
R207C |
probably damaging |
Het |
| Glg1 |
T |
C |
8: 111,909,201 (GRCm39) |
I496M |
probably damaging |
Het |
| Glt6d1 |
C |
A |
2: 25,684,739 (GRCm39) |
|
probably null |
Het |
| Gm10322 |
A |
T |
10: 59,452,030 (GRCm39) |
H49L |
possibly damaging |
Het |
| Golga5 |
G |
T |
12: 102,442,467 (GRCm39) |
V269F |
possibly damaging |
Het |
| Gramd2b |
G |
A |
18: 56,607,141 (GRCm39) |
C85Y |
probably benign |
Het |
| Grhl1 |
C |
T |
12: 24,632,918 (GRCm39) |
P153L |
probably benign |
Het |
| Hdac9 |
T |
C |
12: 34,487,221 (GRCm39) |
Q60R |
probably damaging |
Het |
| Hdlbp |
T |
C |
1: 93,353,054 (GRCm39) |
I414V |
probably damaging |
Het |
| Itpk1 |
C |
T |
12: 102,572,337 (GRCm39) |
|
probably benign |
Het |
| Itsn1 |
T |
A |
16: 91,612,408 (GRCm39) |
Y266N |
probably damaging |
Het |
| Lipe |
G |
A |
7: 25,097,913 (GRCm39) |
P10L |
probably benign |
Het |
| Lrrc8a |
A |
G |
2: 30,147,079 (GRCm39) |
E631G |
probably damaging |
Het |
| Lvrn |
T |
A |
18: 47,038,366 (GRCm39) |
N973K |
possibly damaging |
Het |
| Man2c1 |
T |
A |
9: 57,042,881 (GRCm39) |
H250Q |
probably damaging |
Het |
| Mup3 |
T |
C |
4: 62,003,519 (GRCm39) |
T117A |
probably benign |
Het |
| Nbn |
T |
A |
4: 15,983,951 (GRCm39) |
|
probably benign |
Het |
| Ncapg |
T |
A |
5: 45,829,770 (GRCm39) |
N157K |
probably damaging |
Het |
| Or4p7 |
C |
T |
2: 88,222,377 (GRCm39) |
T262I |
probably damaging |
Het |
| Or5an1 |
T |
A |
19: 12,261,267 (GRCm39) |
M285K |
probably damaging |
Het |
| Or5m12 |
T |
A |
2: 85,734,501 (GRCm39) |
N299I |
probably damaging |
Het |
| Or5w14 |
G |
A |
2: 87,541,774 (GRCm39) |
H159Y |
probably benign |
Het |
| Or9m1 |
T |
C |
2: 87,733,304 (GRCm39) |
T239A |
probably damaging |
Het |
| P4ha1 |
T |
A |
10: 59,184,079 (GRCm39) |
Y180* |
probably null |
Het |
| Pcdhb19 |
T |
A |
18: 37,632,588 (GRCm39) |
F794L |
probably benign |
Het |
| Pdxdc1 |
T |
A |
16: 13,672,264 (GRCm39) |
I379F |
probably damaging |
Het |
| Psme3 |
T |
A |
11: 101,211,268 (GRCm39) |
S185T |
possibly damaging |
Het |
| Ptgr1 |
A |
G |
4: 58,978,045 (GRCm39) |
S116P |
probably damaging |
Het |
| Ptpn23 |
A |
T |
9: 110,218,078 (GRCm39) |
|
probably null |
Het |
| Rabgap1l |
A |
C |
1: 160,549,775 (GRCm39) |
I277R |
probably benign |
Het |
| Rapgef1 |
C |
T |
2: 29,569,828 (GRCm39) |
T93I |
possibly damaging |
Het |
| Rbp3 |
A |
T |
14: 33,676,730 (GRCm39) |
D226V |
probably damaging |
Het |
| Rnf144a |
A |
T |
12: 26,389,328 (GRCm39) |
C38S |
probably damaging |
Het |
| Rptor |
C |
T |
11: 119,671,379 (GRCm39) |
Q281* |
probably null |
Het |
| Rragd |
T |
C |
4: 33,004,332 (GRCm39) |
L208S |
probably damaging |
Het |
| Slc12a4 |
T |
C |
8: 106,686,120 (GRCm39) |
E41G |
probably damaging |
Het |
| Slc16a1 |
G |
T |
3: 104,560,735 (GRCm39) |
V347F |
probably benign |
Het |
| Slit1 |
G |
A |
19: 41,731,732 (GRCm39) |
T39I |
probably damaging |
Het |
| Sra1 |
T |
C |
18: 36,810,556 (GRCm39) |
N98S |
probably benign |
Het |
| Ssx2ip |
T |
C |
3: 146,132,184 (GRCm39) |
L215P |
probably damaging |
Het |
| Syne2 |
A |
T |
12: 75,995,838 (GRCm39) |
H2126L |
probably damaging |
Het |
| Tep1 |
TTTCTTCTTCTT |
TTTCTTCTT |
14: 51,104,280 (GRCm39) |
|
probably benign |
Het |
| Tgfbi |
T |
C |
13: 56,780,004 (GRCm39) |
|
probably benign |
Het |
| Tmem232 |
T |
C |
17: 65,563,498 (GRCm39) |
M632V |
probably damaging |
Het |
| Tmem81 |
C |
G |
1: 132,435,567 (GRCm39) |
I124M |
probably damaging |
Het |
| Tnnt3 |
T |
G |
7: 142,065,823 (GRCm39) |
D153E |
probably benign |
Het |
| Tnrc6b |
T |
A |
15: 80,807,647 (GRCm39) |
|
probably benign |
Het |
| Tpsab1 |
A |
G |
17: 25,562,798 (GRCm39) |
|
probably benign |
Het |
| Usp34 |
T |
A |
11: 23,351,505 (GRCm39) |
V1431D |
probably damaging |
Het |
| Wdr49 |
G |
T |
3: 75,357,329 (GRCm39) |
R285S |
possibly damaging |
Het |
| Wdr7 |
A |
G |
18: 63,929,320 (GRCm39) |
Y1052C |
probably damaging |
Het |
| Zan |
A |
T |
5: 137,380,578 (GRCm39) |
|
probably benign |
Het |
| Zfp652 |
G |
A |
11: 95,654,565 (GRCm39) |
V323I |
possibly damaging |
Het |
| Zfp740 |
A |
G |
15: 102,121,094 (GRCm39) |
T136A |
possibly damaging |
Het |
| Zfp82 |
C |
T |
7: 29,755,754 (GRCm39) |
E443K |
probably damaging |
Het |
| Zfp874b |
A |
G |
13: 67,629,955 (GRCm39) |
S10P |
probably damaging |
Het |
| Zmynd19 |
A |
G |
2: 24,848,134 (GRCm39) |
Y110C |
probably benign |
Het |
|
| Other mutations in Myo6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00493:Myo6
|
APN |
9 |
80,199,754 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00584:Myo6
|
APN |
9 |
80,149,555 (GRCm39) |
splice site |
probably benign |
|
|
IGL00596:Myo6
|
APN |
9 |
80,189,025 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL00778:Myo6
|
APN |
9 |
80,190,868 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01667:Myo6
|
APN |
9 |
80,197,175 (GRCm39) |
missense |
unknown |
|
|
IGL01939:Myo6
|
APN |
9 |
80,168,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02123:Myo6
|
APN |
9 |
80,171,554 (GRCm39) |
splice site |
probably benign |
|
|
IGL02271:Myo6
|
APN |
9 |
80,168,113 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02512:Myo6
|
APN |
9 |
80,199,801 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02716:Myo6
|
APN |
9 |
80,176,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02888:Myo6
|
APN |
9 |
80,177,013 (GRCm39) |
splice site |
probably benign |
|
|
IGL02890:Myo6
|
APN |
9 |
80,173,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02951:Myo6
|
APN |
9 |
80,171,516 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL02990:Myo6
|
APN |
9 |
80,183,685 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03060:Myo6
|
APN |
9 |
80,168,159 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03145:Myo6
|
APN |
9 |
80,207,947 (GRCm39) |
nonsense |
probably null |
|
|
IGL03306:Myo6
|
APN |
9 |
80,153,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
agnostic
|
UTSW |
9 |
80,190,816 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
knownothing
|
UTSW |
9 |
80,210,583 (GRCm39) |
critical splice donor site |
probably null |
|
|
mayday_circler
|
UTSW |
9 |
80,153,733 (GRCm39) |
nonsense |
probably null |
|
|
torticollis
|
UTSW |
9 |
80,195,499 (GRCm39) |
critical splice donor site |
probably null |
|
|
toss
|
UTSW |
9 |
80,207,949 (GRCm39) |
critical splice donor site |
probably null |
|
|
truths
|
UTSW |
9 |
80,177,321 (GRCm39) |
nonsense |
probably null |
|
|
unbiased
|
UTSW |
9 |
80,181,257 (GRCm39) |
splice site |
probably benign |
|
|
IGL03134:Myo6
|
UTSW |
9 |
80,199,749 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0023:Myo6
|
UTSW |
9 |
80,190,816 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R0023:Myo6
|
UTSW |
9 |
80,190,816 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R0124:Myo6
|
UTSW |
9 |
80,215,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0133:Myo6
|
UTSW |
9 |
80,181,257 (GRCm39) |
splice site |
probably benign |
|
|
R0207:Myo6
|
UTSW |
9 |
80,195,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0295:Myo6
|
UTSW |
9 |
80,190,861 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0389:Myo6
|
UTSW |
9 |
80,199,748 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0526:Myo6
|
UTSW |
9 |
80,190,823 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0791:Myo6
|
UTSW |
9 |
80,169,656 (GRCm39) |
splice site |
probably benign |
|
|
R0885:Myo6
|
UTSW |
9 |
80,149,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1082:Myo6
|
UTSW |
9 |
80,195,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1113:Myo6
|
UTSW |
9 |
80,152,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Myo6
|
UTSW |
9 |
80,193,664 (GRCm39) |
nonsense |
probably null |
|
|
R1308:Myo6
|
UTSW |
9 |
80,152,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1498:Myo6
|
UTSW |
9 |
80,214,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1609:Myo6
|
UTSW |
9 |
80,195,499 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1615:Myo6
|
UTSW |
9 |
80,215,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1771:Myo6
|
UTSW |
9 |
80,193,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1772:Myo6
|
UTSW |
9 |
80,177,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1789:Myo6
|
UTSW |
9 |
80,207,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1962:Myo6
|
UTSW |
9 |
80,168,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1978:Myo6
|
UTSW |
9 |
80,136,207 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2011:Myo6
|
UTSW |
9 |
80,215,004 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2092:Myo6
|
UTSW |
9 |
80,152,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2098:Myo6
|
UTSW |
9 |
80,188,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2206:Myo6
|
UTSW |
9 |
80,165,737 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2286:Myo6
|
UTSW |
9 |
80,173,494 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R2429:Myo6
|
UTSW |
9 |
80,210,583 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2696:Myo6
|
UTSW |
9 |
80,168,176 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2897:Myo6
|
UTSW |
9 |
80,176,893 (GRCm39) |
splice site |
probably null |
|
|
R2898:Myo6
|
UTSW |
9 |
80,176,893 (GRCm39) |
splice site |
probably null |
|
|
R3881:Myo6
|
UTSW |
9 |
80,171,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4424:Myo6
|
UTSW |
9 |
80,195,320 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4718:Myo6
|
UTSW |
9 |
80,153,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4893:Myo6
|
UTSW |
9 |
80,136,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4936:Myo6
|
UTSW |
9 |
80,214,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Myo6
|
UTSW |
9 |
80,190,792 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5073:Myo6
|
UTSW |
9 |
80,195,290 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5101:Myo6
|
UTSW |
9 |
80,177,321 (GRCm39) |
nonsense |
probably null |
|
|
R5137:Myo6
|
UTSW |
9 |
80,149,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5200:Myo6
|
UTSW |
9 |
80,183,656 (GRCm39) |
nonsense |
probably null |
|
|
R5510:Myo6
|
UTSW |
9 |
80,152,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5579:Myo6
|
UTSW |
9 |
80,125,002 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5693:Myo6
|
UTSW |
9 |
80,173,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5701:Myo6
|
UTSW |
9 |
80,165,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6693:Myo6
|
UTSW |
9 |
80,153,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7151:Myo6
|
UTSW |
9 |
80,152,418 (GRCm39) |
missense |
unknown |
|
|
R7399:Myo6
|
UTSW |
9 |
80,169,573 (GRCm39) |
missense |
unknown |
|
|
R7492:Myo6
|
UTSW |
9 |
80,195,328 (GRCm39) |
nonsense |
probably null |
|
|
R7651:Myo6
|
UTSW |
9 |
80,171,548 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7698:Myo6
|
UTSW |
9 |
80,124,938 (GRCm39) |
missense |
unknown |
|
|
R7743:Myo6
|
UTSW |
9 |
80,183,611 (GRCm39) |
missense |
unknown |
|
|
R7888:Myo6
|
UTSW |
9 |
80,203,947 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8161:Myo6
|
UTSW |
9 |
80,124,991 (GRCm39) |
missense |
unknown |
|
|
R8245:Myo6
|
UTSW |
9 |
80,162,229 (GRCm39) |
missense |
unknown |
|
|
R8375:Myo6
|
UTSW |
9 |
80,162,206 (GRCm39) |
missense |
unknown |
|
|
R8387:Myo6
|
UTSW |
9 |
80,183,632 (GRCm39) |
missense |
unknown |
|
|
R8467:Myo6
|
UTSW |
9 |
80,136,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8669:Myo6
|
UTSW |
9 |
80,173,531 (GRCm39) |
missense |
unknown |
|
|
R8770:Myo6
|
UTSW |
9 |
80,171,481 (GRCm39) |
missense |
unknown |
|
|
R8807:Myo6
|
UTSW |
9 |
80,207,949 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9006:Myo6
|
UTSW |
9 |
80,136,140 (GRCm39) |
missense |
unknown |
|
|
R9018:Myo6
|
UTSW |
9 |
80,159,086 (GRCm39) |
missense |
unknown |
|
|
R9038:Myo6
|
UTSW |
9 |
80,162,285 (GRCm39) |
missense |
unknown |
|
|
R9124:Myo6
|
UTSW |
9 |
80,195,353 (GRCm39) |
missense |
unknown |
|
|
R9190:Myo6
|
UTSW |
9 |
80,195,384 (GRCm39) |
missense |
unknown |
|
|
R9194:Myo6
|
UTSW |
9 |
80,153,836 (GRCm39) |
missense |
unknown |
|
|
R9281:Myo6
|
UTSW |
9 |
80,162,164 (GRCm39) |
nonsense |
probably null |
|
|
Z1191:Myo6
|
UTSW |
9 |
80,149,509 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCATTTTGCATGATGCTGCC -3'
(R):5'- CATCCTGAACCTCGTGCTTACCAG -3'
Sequencing Primer
(F):5'- ATGCTGCCTGTTCCAGAG -3'
(R):5'- agcaccccatcccatttc -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation