Incidental Mutation 'R5067:Marchf10'
ID 388381
Institutional Source Beutler Lab
Gene Symbol Marchf10
Ensembl Gene ENSMUSG00000078627
Gene Name membrane associated ring-CH-type finger 10
Synonyms Rnf190, 4933417C16Rik, OTTMUSG00000002847, March10
MMRRC Submission 042657-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R5067 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 105251624-105347561 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 105280933 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 451 (T451S)
Ref Sequence ENSEMBL: ENSMUSP00000121919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049995] [ENSMUST00000138977]
AlphaFold E9PX79
Predicted Effect possibly damaging
Transcript: ENSMUST00000049995
AA Change: T451S

PolyPhen 2 Score 0.511 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000063198
Gene: ENSMUSG00000078627
AA Change: T451S

DomainStartEndE-ValueType
low complexity region 36 49 N/A INTRINSIC
low complexity region 56 71 N/A INTRINSIC
low complexity region 114 130 N/A INTRINSIC
low complexity region 292 304 N/A INTRINSIC
RINGv 638 695 7.45e-22 SMART
low complexity region 728 737 N/A INTRINSIC
low complexity region 767 781 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000138977
AA Change: T451S

PolyPhen 2 Score 0.511 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000121919
Gene: ENSMUSG00000078627
AA Change: T451S

DomainStartEndE-ValueType
low complexity region 36 49 N/A INTRINSIC
low complexity region 56 71 N/A INTRINSIC
low complexity region 114 130 N/A INTRINSIC
low complexity region 292 304 N/A INTRINSIC
RINGv 638 695 7.45e-22 SMART
low complexity region 728 737 N/A INTRINSIC
low complexity region 767 781 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153672
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 91.3%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak2 T C 12: 112,748,936 (GRCm39) N304D probably benign Het
Akr7a5 T C 4: 139,038,333 (GRCm39) S90P probably damaging Het
Aplnr T A 2: 84,967,128 (GRCm39) V51E probably damaging Het
Arhgap21 A T 2: 20,884,848 (GRCm39) H776Q probably damaging Het
Asxl3 C G 18: 22,658,356 (GRCm39) A2122G possibly damaging Het
Bsn T A 9: 107,989,152 (GRCm39) Y2200F probably damaging Het
Btbd10 A T 7: 112,925,043 (GRCm39) D268E probably damaging Het
Cacna1h T C 17: 25,616,782 (GRCm39) N113D probably damaging Het
Cfap54 T C 10: 92,902,628 (GRCm39) N175D probably benign Het
Cfap61 A G 2: 145,943,956 (GRCm39) D134G probably damaging Het
Clybl A T 14: 122,616,701 (GRCm39) I239L possibly damaging Het
Defb11 A T 8: 22,396,352 (GRCm39) F15Y probably damaging Het
Dlc1 A G 8: 37,051,647 (GRCm39) S695P probably benign Het
Fbxl5 T C 5: 43,916,114 (GRCm39) K432E probably benign Het
Fryl T C 5: 73,215,098 (GRCm39) E2226G probably benign Het
Gm10337 T A 15: 102,412,306 (GRCm39) probably null Het
Gm5828 A G 1: 16,839,516 (GRCm39) noncoding transcript Het
Gm8674 A T 13: 50,053,870 (GRCm39) noncoding transcript Het
Ighv6-5 T C 12: 114,380,191 (GRCm39) probably null Het
Insyn2a A T 7: 134,520,284 (GRCm39) V82E probably benign Het
Ints14 C A 9: 64,871,694 (GRCm39) L11M probably damaging Het
Kcp G A 6: 29,492,107 (GRCm39) P153L probably benign Het
Lrrk2 A C 15: 91,649,993 (GRCm39) N1710T probably benign Het
Mcf2l T G 8: 12,965,959 (GRCm39) probably benign Het
Mfng C T 15: 78,648,588 (GRCm39) R163H probably benign Het
Neurod2 T A 11: 98,218,063 (GRCm39) H367L possibly damaging Het
Nfatc4 A T 14: 56,069,875 (GRCm39) Q681L probably damaging Het
Nkx3-2 T C 5: 41,919,220 (GRCm39) N256S probably damaging Het
Ntng1 G A 3: 110,042,661 (GRCm39) T55M possibly damaging Het
Snd1 C A 6: 28,888,239 (GRCm39) N891K probably damaging Het
Syt7 T C 19: 10,420,222 (GRCm39) V382A possibly damaging Het
Trim72 T C 7: 127,609,139 (GRCm39) S314P possibly damaging Het
Ttc41 T C 10: 86,580,408 (GRCm39) S785P probably damaging Het
Ube2z C T 11: 95,953,835 (GRCm39) V128I probably benign Het
Vps26c T A 16: 94,327,263 (GRCm39) probably benign Het
Wdr43 T C 17: 71,933,849 (GRCm39) Y149H probably benign Het
Wnk4 T A 11: 101,153,682 (GRCm39) V248E probably damaging Het
Zcchc2 A T 1: 105,958,694 (GRCm39) N1055I probably damaging Het
Zdhhc23 T C 16: 43,794,134 (GRCm39) Y180C probably benign Het
Other mutations in Marchf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Marchf10 APN 11 105,293,014 (GRCm39) missense possibly damaging 0.82
IGL01461:Marchf10 APN 11 105,280,431 (GRCm39) missense probably damaging 1.00
IGL01473:Marchf10 APN 11 105,280,431 (GRCm39) missense probably damaging 1.00
Forward UTSW 11 105,273,063 (GRCm39) missense probably damaging 1.00
PIT4142001:Marchf10 UTSW 11 105,281,346 (GRCm39) missense probably benign 0.17
R0195:Marchf10 UTSW 11 105,276,351 (GRCm39) missense probably damaging 1.00
R0520:Marchf10 UTSW 11 105,280,708 (GRCm39) missense probably benign
R0628:Marchf10 UTSW 11 105,280,986 (GRCm39) missense probably benign 0.00
R1087:Marchf10 UTSW 11 105,281,488 (GRCm39) missense probably damaging 1.00
R1440:Marchf10 UTSW 11 105,281,409 (GRCm39) missense probably damaging 1.00
R1802:Marchf10 UTSW 11 105,280,741 (GRCm39) missense probably benign 0.00
R1855:Marchf10 UTSW 11 105,281,218 (GRCm39) missense probably benign
R1860:Marchf10 UTSW 11 105,287,904 (GRCm39) missense probably damaging 0.99
R2504:Marchf10 UTSW 11 105,276,398 (GRCm39) missense probably damaging 1.00
R3788:Marchf10 UTSW 11 105,287,905 (GRCm39) missense probably damaging 1.00
R4629:Marchf10 UTSW 11 105,280,664 (GRCm39) missense probably benign 0.28
R4755:Marchf10 UTSW 11 105,255,302 (GRCm39) intron probably benign
R4776:Marchf10 UTSW 11 105,280,863 (GRCm39) missense probably benign 0.42
R5192:Marchf10 UTSW 11 105,262,752 (GRCm39) missense possibly damaging 0.68
R5436:Marchf10 UTSW 11 105,292,991 (GRCm39) missense possibly damaging 0.92
R5541:Marchf10 UTSW 11 105,280,957 (GRCm39) missense probably damaging 1.00
R5888:Marchf10 UTSW 11 105,292,972 (GRCm39) missense possibly damaging 0.92
R5908:Marchf10 UTSW 11 105,281,065 (GRCm39) missense probably benign 0.00
R5914:Marchf10 UTSW 11 105,276,308 (GRCm39) missense probably damaging 1.00
R6038:Marchf10 UTSW 11 105,292,877 (GRCm39) missense probably damaging 0.96
R6178:Marchf10 UTSW 11 105,280,440 (GRCm39) missense probably damaging 1.00
R6300:Marchf10 UTSW 11 105,273,063 (GRCm39) missense probably damaging 1.00
R6612:Marchf10 UTSW 11 105,287,904 (GRCm39) missense probably damaging 0.99
R6894:Marchf10 UTSW 11 105,287,787 (GRCm39) missense possibly damaging 0.94
R6921:Marchf10 UTSW 11 105,280,603 (GRCm39) missense probably benign 0.00
R7134:Marchf10 UTSW 11 105,299,502 (GRCm39) missense probably benign
R7199:Marchf10 UTSW 11 105,281,532 (GRCm39) missense probably damaging 0.99
R7546:Marchf10 UTSW 11 105,280,906 (GRCm39) missense not run
R7792:Marchf10 UTSW 11 105,281,054 (GRCm39) missense probably benign
R8241:Marchf10 UTSW 11 105,280,741 (GRCm39) missense probably benign 0.00
R8467:Marchf10 UTSW 11 105,280,979 (GRCm39) nonsense probably null
R8843:Marchf10 UTSW 11 105,292,802 (GRCm39) missense possibly damaging 0.83
R8962:Marchf10 UTSW 11 105,280,815 (GRCm39) nonsense probably null
R9214:Marchf10 UTSW 11 105,281,100 (GRCm39) missense probably benign 0.02
R9323:Marchf10 UTSW 11 105,280,581 (GRCm39) missense probably damaging 0.98
Z1088:Marchf10 UTSW 11 105,281,185 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACCCTGGGCTTCATCACTG -3'
(R):5'- TGAGAAGACCCCTGTTCTAGG -3'

Sequencing Primer
(F):5'- AGCAGCGGCCAATGGATTTC -3'
(R):5'- CCTGTTCTAGGGGATGCGAAATC -3'
Posted On 2016-06-06