Incidental Mutation 'R5067:Ighv6-5'
ID388383
Institutional Source Beutler Lab
Gene Symbol Ighv6-5
Ensembl Gene ENSMUSG00000096407
Gene Nameimmunoglobulin heavy variable V6-5
Synonyms
MMRRC Submission 042657-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.258) question?
Stock #R5067 (G1)
Quality Score225
Status Not validated
Chromosome12
Chromosomal Location114416596-114417053 bp(-) (GRCm38)
Type of Mutationsplice site (28 bp from exon)
DNA Base Change (assembly) T to C at 114416571 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000136790 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000179796] [ENSMUST00000193936]
Predicted Effect probably null
Transcript: ENSMUST00000179796
SMART Domains Protein: ENSMUSP00000136790
Gene: ENSMUSG00000096407

DomainStartEndE-ValueType
IGv 17 99 9.45e-23 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000193936
SMART Domains Protein: ENSMUSP00000141679
Gene: ENSMUSG00000096407

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IGv 36 119 3.4e-29 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 91.3%
Validation Efficiency 100% (54/54)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak2 T C 12: 112,785,316 N304D probably benign Het
Akr7a5 T C 4: 139,311,022 S90P probably damaging Het
Aplnr T A 2: 85,136,784 V51E probably damaging Het
Arhgap21 A T 2: 20,880,037 H776Q probably damaging Het
Asxl3 C G 18: 22,525,299 A2122G possibly damaging Het
Bsn T A 9: 108,111,953 Y2200F probably damaging Het
Btbd10 A T 7: 113,325,836 D268E probably damaging Het
Cacna1h T C 17: 25,397,808 N113D probably damaging Het
Cfap54 T C 10: 93,066,766 N175D probably benign Het
Cfap61 A G 2: 146,102,036 D134G probably damaging Het
Clybl A T 14: 122,379,289 I239L possibly damaging Het
Defb11 A T 8: 21,906,336 F15Y probably damaging Het
Dlc1 A G 8: 36,584,493 S695P probably benign Het
Dscr3 T A 16: 94,526,404 probably benign Het
Fam196a A T 7: 134,918,555 V82E probably benign Het
Fbxl5 T C 5: 43,758,772 K432E probably benign Het
Fryl T C 5: 73,057,755 E2226G probably benign Het
Gm10337 T A 15: 102,503,871 probably null Het
Gm5828 A G 1: 16,769,292 noncoding transcript Het
Gm8674 A T 13: 49,899,834 noncoding transcript Het
Ints14 C A 9: 64,964,412 L11M probably damaging Het
Kcp G A 6: 29,492,108 P153L probably benign Het
Lrrk2 A C 15: 91,765,790 N1710T probably benign Het
March10 T A 11: 105,390,107 T451S possibly damaging Het
Mcf2l T G 8: 12,915,959 probably benign Het
Mfng C T 15: 78,764,388 R163H probably benign Het
Neurod2 T A 11: 98,327,237 H367L possibly damaging Het
Nfatc4 A T 14: 55,832,418 Q681L probably damaging Het
Nkx3-2 T C 5: 41,761,877 N256S probably damaging Het
Ntng1 G A 3: 110,135,345 T55M possibly damaging Het
Snd1 C A 6: 28,888,240 N891K probably damaging Het
Syt7 T C 19: 10,442,858 V382A possibly damaging Het
Trim72 T C 7: 128,009,967 S314P possibly damaging Het
Ttc41 T C 10: 86,744,544 S785P probably damaging Het
Ube2z C T 11: 96,063,009 V128I probably benign Het
Wdr43 T C 17: 71,626,854 Y149H probably benign Het
Wnk4 T A 11: 101,262,856 V248E probably damaging Het
Zcchc2 A T 1: 106,030,964 N1055I probably damaging Het
Zdhhc23 T C 16: 43,973,771 Y180C probably benign Het
Other mutations in Ighv6-5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02532:Ighv6-5 APN 12 114416804 missense probably benign 0.04
IGL02928:Ighv6-5 APN 12 114416792 missense probably benign 0.42
IGL03117:Ighv6-5 APN 12 114416700 missense possibly damaging 0.95
IGL02991:Ighv6-5 UTSW 12 114416695 missense probably benign
R0020:Ighv6-5 UTSW 12 114416621 missense probably null 1.00
R4386:Ighv6-5 UTSW 12 114416717 missense possibly damaging 0.84
R6154:Ighv6-5 UTSW 12 114416742 missense probably benign 0.04
R7133:Ighv6-5 UTSW 12 114416775 missense probably benign 0.00
R7617:Ighv6-5 UTSW 12 114417006 critical splice donor site probably benign
R8047:Ighv6-5 UTSW 12 114416571 splice site probably null
Predicted Primers
Posted On2016-06-06