Incidental Mutation 'R5068:Myo9b'
| ID |
388452 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo9b
|
| Ensembl Gene |
ENSMUSG00000004677 |
| Gene Name |
myosin IXb |
| Synonyms |
|
| MMRRC Submission |
042658-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.770)
|
| Stock # |
R5068 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
71272714-71360713 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 71349055 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 1275
(Y1275H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148316
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071935]
[ENSMUST00000168839]
[ENSMUST00000170242]
[ENSMUST00000212935]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000071935
AA Change: Y1274H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000071827
Gene: ENSMUSG00000004677
AA Change: Y1274H
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
15 |
114 |
3.7e-30 |
SMART |
|
MYSc
|
140 |
954 |
N/A |
SMART |
|
IQ
|
955 |
977 |
1.2e-3 |
SMART |
|
IQ
|
978 |
1000 |
1.6e-5 |
SMART |
|
IQ
|
1001 |
1022 |
4.3e-5 |
SMART |
|
IQ
|
1023 |
1045 |
8.4e-5 |
SMART |
|
low complexity region
|
1050 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1127 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1211 |
1222 |
N/A |
INTRINSIC |
|
low complexity region
|
1232 |
1246 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1247 |
1323 |
3e-19 |
BLAST |
|
low complexity region
|
1348 |
1359 |
N/A |
INTRINSIC |
|
coiled coil region
|
1563 |
1590 |
N/A |
INTRINSIC |
|
C1
|
1591 |
1639 |
1.7e-14 |
SMART |
|
RhoGAP
|
1668 |
1843 |
4.7e-71 |
SMART |
|
coiled coil region
|
1901 |
1925 |
N/A |
INTRINSIC |
|
low complexity region
|
1940 |
1952 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168839
AA Change: Y1285H
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000131635
Gene: ENSMUSG00000004677
AA Change: Y1285H
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
15 |
114 |
5.79e-28 |
SMART |
|
MYSc
|
140 |
954 |
N/A |
SMART |
|
IQ
|
955 |
977 |
2.46e-1 |
SMART |
|
IQ
|
978 |
1000 |
3.35e-3 |
SMART |
|
IQ
|
1001 |
1022 |
8.84e-3 |
SMART |
|
IQ
|
1023 |
1045 |
1.77e-2 |
SMART |
|
low complexity region
|
1050 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1127 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1211 |
1222 |
N/A |
INTRINSIC |
|
low complexity region
|
1234 |
1257 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1258 |
1334 |
3e-19 |
BLAST |
|
low complexity region
|
1361 |
1372 |
N/A |
INTRINSIC |
|
low complexity region
|
1581 |
1601 |
N/A |
INTRINSIC |
|
C1
|
1605 |
1653 |
3.58e-12 |
SMART |
|
RhoGAP
|
1682 |
1857 |
7.78e-69 |
SMART |
|
coiled coil region
|
1915 |
1939 |
N/A |
INTRINSIC |
|
low complexity region
|
1954 |
1966 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170242
AA Change: Y1285H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129220
Gene: ENSMUSG00000004677
AA Change: Y1285H
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
15 |
114 |
5.79e-28 |
SMART |
|
MYSc
|
140 |
954 |
N/A |
SMART |
|
IQ
|
955 |
977 |
2.46e-1 |
SMART |
|
IQ
|
978 |
1000 |
3.35e-3 |
SMART |
|
IQ
|
1001 |
1022 |
8.84e-3 |
SMART |
|
IQ
|
1023 |
1045 |
1.77e-2 |
SMART |
|
low complexity region
|
1050 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1127 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1211 |
1222 |
N/A |
INTRINSIC |
|
low complexity region
|
1234 |
1257 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1258 |
1334 |
3e-19 |
BLAST |
|
low complexity region
|
1361 |
1372 |
N/A |
INTRINSIC |
|
low complexity region
|
1581 |
1601 |
N/A |
INTRINSIC |
|
C1
|
1605 |
1653 |
3.58e-12 |
SMART |
|
RhoGAP
|
1682 |
1857 |
7.78e-69 |
SMART |
|
coiled coil region
|
1931 |
1955 |
N/A |
INTRINSIC |
|
low complexity region
|
1970 |
1982 |
N/A |
INTRINSIC |
|
low complexity region
|
1992 |
2003 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000212412
AA Change: Y82H
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000212935
AA Change: Y1275H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutants breed normal, but shows defect in macrophage motility and chemotaxis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 110 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210010C04Rik |
A |
C |
6: 41,032,436 (GRCm38) |
Y155D |
probably benign |
Het |
| 3425401B19Rik |
A |
G |
14: 32,661,792 (GRCm38) |
S739P |
possibly damaging |
Het |
| 6030468B19Rik |
A |
G |
11: 117,802,875 (GRCm38) |
Y56C |
possibly damaging |
Het |
| Actn2 |
A |
G |
13: 12,288,522 (GRCm38) |
I464T |
possibly damaging |
Het |
| Add2 |
T |
A |
6: 86,107,458 (GRCm38) |
L496Q |
probably damaging |
Het |
| Akt1s1 |
T |
C |
7: 44,850,008 (GRCm38) |
|
probably null |
Het |
| Als2 |
G |
T |
1: 59,211,274 (GRCm38) |
P437Q |
probably benign |
Het |
| Ankar |
T |
C |
1: 72,680,210 (GRCm38) |
|
probably null |
Het |
| Ankrd17 |
T |
C |
5: 90,254,808 (GRCm38) |
R1464G |
probably damaging |
Het |
| Ankrd24 |
T |
C |
10: 81,639,865 (GRCm38) |
S121P |
possibly damaging |
Het |
| Arvcf |
A |
G |
16: 18,398,986 (GRCm38) |
Y412C |
probably damaging |
Het |
| Birc6 |
C |
T |
17: 74,565,972 (GRCm38) |
R409C |
probably damaging |
Het |
| Bnip3l |
T |
C |
14: 66,999,632 (GRCm38) |
E57G |
possibly damaging |
Het |
| Calcoco1 |
A |
G |
15: 102,711,092 (GRCm38) |
L354P |
probably damaging |
Het |
| Cc2d1b |
T |
C |
4: 108,623,464 (GRCm38) |
V27A |
possibly damaging |
Het |
| Cdc37 |
T |
C |
9: 21,149,803 (GRCm38) |
T19A |
probably damaging |
Het |
| Cep152 |
T |
C |
2: 125,571,816 (GRCm38) |
I1199V |
probably benign |
Het |
| Chd6 |
G |
T |
2: 160,966,369 (GRCm38) |
L1642I |
possibly damaging |
Het |
| Chst13 |
T |
C |
6: 90,309,569 (GRCm38) |
E137G |
possibly damaging |
Het |
| Cnrip1 |
A |
G |
11: 17,054,687 (GRCm38) |
D79G |
probably damaging |
Het |
| Dars2 |
A |
T |
1: 161,041,913 (GRCm38) |
C589S |
probably benign |
Het |
| Dhx15 |
T |
G |
5: 52,170,067 (GRCm38) |
I102L |
possibly damaging |
Het |
| Dip2a |
A |
G |
10: 76,318,043 (GRCm38) |
L151P |
possibly damaging |
Het |
| Dlc1 |
T |
C |
8: 36,938,030 (GRCm38) |
T202A |
probably benign |
Het |
| Dlg1 |
G |
T |
16: 31,684,295 (GRCm38) |
|
probably null |
Het |
| Dlgap4 |
T |
C |
2: 156,707,111 (GRCm38) |
F464L |
probably benign |
Het |
| Dnah3 |
T |
C |
7: 120,032,790 (GRCm38) |
H1314R |
probably benign |
Het |
| Dsp |
A |
C |
13: 38,197,123 (GRCm38) |
T2615P |
possibly damaging |
Het |
| Dthd1 |
C |
A |
5: 62,818,716 (GRCm38) |
D244E |
probably benign |
Het |
| Dtl |
A |
T |
1: 191,568,373 (GRCm38) |
D126E |
probably damaging |
Het |
| Ell2 |
A |
G |
13: 75,763,618 (GRCm38) |
N341S |
probably benign |
Het |
| Enpp2 |
T |
C |
15: 54,864,054 (GRCm38) |
Y513C |
probably damaging |
Het |
| Erbb4 |
A |
T |
1: 68,043,902 (GRCm38) |
|
probably null |
Het |
| Erc2 |
A |
T |
14: 28,302,943 (GRCm38) |
H593L |
possibly damaging |
Het |
| Ercc6 |
T |
C |
14: 32,570,063 (GRCm38) |
V1128A |
probably benign |
Het |
| Fyn |
A |
G |
10: 39,526,843 (GRCm38) |
K204E |
probably damaging |
Het |
| Gm14685 |
T |
C |
X: 73,127,971 (GRCm38) |
I323T |
probably damaging |
Het |
| Gm4847 |
A |
T |
1: 166,638,384 (GRCm38) |
F212Y |
possibly damaging |
Het |
| Gpc5 |
T |
C |
14: 115,417,264 (GRCm38) |
*499R |
probably null |
Het |
| Hcn4 |
T |
C |
9: 58,860,021 (GRCm38) |
L955P |
unknown |
Het |
| Hook2 |
C |
A |
8: 84,993,399 (GRCm38) |
L111I |
possibly damaging |
Het |
| Hook3 |
C |
T |
8: 26,095,757 (GRCm38) |
|
probably null |
Het |
| Hvcn1 |
T |
C |
5: 122,233,481 (GRCm38) |
F28S |
probably damaging |
Het |
| Igkv6-32 |
A |
G |
6: 70,074,283 (GRCm38) |
F30L |
possibly damaging |
Het |
| Inpp5b |
G |
A |
4: 124,742,649 (GRCm38) |
|
probably null |
Het |
| Itgb2 |
G |
A |
10: 77,548,761 (GRCm38) |
A239T |
probably damaging |
Het |
| Kcnrg |
T |
C |
14: 61,607,817 (GRCm38) |
L102P |
probably damaging |
Het |
| Kif16b |
A |
T |
2: 142,711,707 (GRCm38) |
M1068K |
probably benign |
Het |
| Kifc3 |
T |
C |
8: 95,110,216 (GRCm38) |
R109G |
possibly damaging |
Het |
| Klhl28 |
A |
T |
12: 64,957,712 (GRCm38) |
M9K |
probably benign |
Het |
| Kptn |
T |
C |
7: 16,123,102 (GRCm38) |
Y172H |
probably damaging |
Het |
| Mib1 |
A |
G |
18: 10,793,002 (GRCm38) |
E646G |
probably damaging |
Het |
| Mmp14 |
T |
A |
14: 54,439,113 (GRCm38) |
Y372N |
probably damaging |
Het |
| Mrc1 |
T |
A |
2: 14,306,516 (GRCm38) |
M868K |
probably benign |
Het |
| Mterf1a |
T |
C |
5: 3,891,854 (GRCm38) |
N5D |
probably benign |
Het |
| Muc5b |
T |
C |
7: 141,858,608 (GRCm38) |
S1764P |
unknown |
Het |
| Nek1 |
T |
C |
8: 61,016,296 (GRCm38) |
I129T |
probably damaging |
Het |
| Net1 |
G |
A |
13: 3,886,740 (GRCm38) |
A221V |
probably benign |
Het |
| Nuak2 |
A |
T |
1: 132,331,771 (GRCm38) |
D429V |
probably benign |
Het |
| Nup98 |
T |
C |
7: 102,145,655 (GRCm38) |
T882A |
probably benign |
Het |
| Olfr599 |
A |
T |
7: 103,338,022 (GRCm38) |
|
probably null |
Het |
| Olfr648 |
T |
A |
7: 104,180,241 (GRCm38) |
S56C |
probably damaging |
Het |
| Olfr744 |
T |
A |
14: 50,618,740 (GRCm38) |
C173S |
probably damaging |
Het |
| Olfr749 |
C |
A |
14: 50,737,074 (GRCm38) |
L29F |
probably benign |
Het |
| Olfr901 |
T |
C |
9: 38,430,464 (GRCm38) |
Y61H |
probably damaging |
Het |
| Otx1 |
C |
A |
11: 21,997,037 (GRCm38) |
A91S |
probably damaging |
Het |
| Pcdh7 |
T |
C |
5: 57,722,166 (GRCm38) |
V1021A |
probably damaging |
Het |
| Pclo |
G |
C |
5: 14,679,073 (GRCm38) |
|
probably benign |
Het |
| Pds5a |
A |
C |
5: 65,615,272 (GRCm38) |
D1329E |
probably damaging |
Het |
| Pex5 |
A |
G |
6: 124,413,596 (GRCm38) |
S97P |
probably benign |
Het |
| Pias3 |
A |
G |
3: 96,703,855 (GRCm38) |
K431E |
probably damaging |
Het |
| Piwil1 |
T |
C |
5: 128,741,614 (GRCm38) |
S158P |
probably damaging |
Het |
| Plxnc1 |
A |
T |
10: 94,799,377 (GRCm38) |
I1329N |
possibly damaging |
Het |
| Pnkp |
C |
T |
7: 44,862,403 (GRCm38) |
S113L |
probably damaging |
Het |
| Pnpla1 |
T |
A |
17: 28,879,423 (GRCm38) |
|
probably null |
Het |
| Prdm10 |
T |
C |
9: 31,359,047 (GRCm38) |
Y827H |
probably damaging |
Het |
| Psma2 |
G |
A |
13: 14,616,028 (GRCm38) |
V20I |
probably benign |
Het |
| Rgl3 |
A |
G |
9: 21,988,044 (GRCm38) |
|
probably null |
Het |
| Rnf17 |
T |
C |
14: 56,505,928 (GRCm38) |
V1317A |
probably damaging |
Het |
| Rpp40 |
T |
C |
13: 35,898,698 (GRCm38) |
N254D |
probably benign |
Het |
| Scin |
T |
A |
12: 40,124,700 (GRCm38) |
H128L |
probably damaging |
Het |
| Sh3bp2 |
A |
T |
5: 34,556,967 (GRCm38) |
M225L |
probably benign |
Het |
| Shisa9 |
C |
A |
16: 12,267,548 (GRCm38) |
H324Q |
possibly damaging |
Het |
| Sipa1l1 |
A |
G |
12: 82,437,827 (GRCm38) |
D1585G |
probably damaging |
Het |
| Slc11a1 |
G |
A |
1: 74,385,184 (GRCm38) |
A434T |
probably damaging |
Het |
| Slc5a8 |
A |
T |
10: 88,886,598 (GRCm38) |
I98F |
possibly damaging |
Het |
| Slc6a13 |
T |
C |
6: 121,333,342 (GRCm38) |
L320P |
probably damaging |
Het |
| Spats2l |
A |
G |
1: 57,943,221 (GRCm38) |
T421A |
probably benign |
Het |
| Spryd3 |
A |
T |
15: 102,128,611 (GRCm38) |
D207E |
probably benign |
Het |
| Srrt |
T |
C |
5: 137,296,541 (GRCm38) |
N392S |
possibly damaging |
Het |
| Stk36 |
G |
T |
1: 74,622,345 (GRCm38) |
R510S |
probably benign |
Het |
| Sucnr1 |
A |
G |
3: 60,086,867 (GRCm38) |
Y272C |
probably damaging |
Het |
| Taar7b |
T |
G |
10: 24,000,461 (GRCm38) |
S175A |
probably benign |
Het |
| Tmem131 |
A |
G |
1: 36,854,905 (GRCm38) |
I139T |
probably damaging |
Het |
| Tph2 |
T |
A |
10: 115,151,174 (GRCm38) |
Y237F |
probably benign |
Het |
| Trim35 |
C |
T |
14: 66,308,972 (GRCm38) |
|
probably benign |
Het |
| Tsc22d1 |
T |
C |
14: 76,418,310 (GRCm38) |
I661T |
probably benign |
Het |
| Ttc27 |
T |
A |
17: 74,799,342 (GRCm38) |
H541Q |
probably damaging |
Het |
| Uap1 |
G |
T |
1: 170,161,463 (GRCm38) |
P130Q |
probably damaging |
Het |
| Ube3c |
T |
C |
5: 29,601,354 (GRCm38) |
|
probably null |
Het |
| Umad1 |
A |
T |
6: 8,401,157 (GRCm38) |
|
probably null |
Het |
| Usp34 |
T |
C |
11: 23,460,665 (GRCm38) |
V2705A |
possibly damaging |
Het |
| Vps13a |
T |
C |
19: 16,746,058 (GRCm38) |
S259G |
probably benign |
Het |
| Vwa7 |
G |
A |
17: 35,024,190 (GRCm38) |
V615I |
probably benign |
Het |
| Wdfy3 |
T |
C |
5: 101,894,937 (GRCm38) |
T1983A |
probably benign |
Het |
| Wdr24 |
T |
G |
17: 25,825,779 (GRCm38) |
F203V |
possibly damaging |
Het |
| Xlr4c |
T |
A |
X: 73,238,684 (GRCm38) |
K121M |
probably damaging |
Het |
| Zfc3h1 |
T |
A |
10: 115,418,783 (GRCm38) |
C1427* |
probably null |
Het |
| Zfp282 |
A |
C |
6: 47,877,703 (GRCm38) |
Q11P |
probably benign |
Het |
| Zfp750 |
T |
A |
11: 121,512,195 (GRCm38) |
T576S |
probably benign |
Het |
|
| Other mutations in Myo9b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00163:Myo9b
|
APN |
8 |
71,348,735 (GRCm38) |
missense |
probably benign |
|
|
IGL01020:Myo9b
|
APN |
8 |
71,352,000 (GRCm38) |
missense |
probably benign |
|
|
IGL01479:Myo9b
|
APN |
8 |
71,359,342 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01704:Myo9b
|
APN |
8 |
71,359,642 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01761:Myo9b
|
APN |
8 |
71,349,152 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL01766:Myo9b
|
APN |
8 |
71,290,517 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01834:Myo9b
|
APN |
8 |
71,355,257 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL01834:Myo9b
|
APN |
8 |
71,356,318 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01838:Myo9b
|
APN |
8 |
71,334,390 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02318:Myo9b
|
APN |
8 |
71,354,124 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02333:Myo9b
|
APN |
8 |
71,358,993 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
IGL02340:Myo9b
|
APN |
8 |
71,291,045 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02514:Myo9b
|
APN |
8 |
71,291,006 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02593:Myo9b
|
APN |
8 |
71,290,773 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03075:Myo9b
|
APN |
8 |
71,354,527 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03332:Myo9b
|
APN |
8 |
71,348,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
avantgarde
|
UTSW |
8 |
71,344,162 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Freaky
|
UTSW |
8 |
71,290,819 (GRCm38) |
missense |
probably damaging |
1.00 |
|
iconoclastic
|
UTSW |
8 |
71,290,475 (GRCm38) |
missense |
probably benign |
0.37 |
|
unconventional
|
UTSW |
8 |
71,348,597 (GRCm38) |
missense |
probably benign |
0.00 |
|
PIT4418001:Myo9b
|
UTSW |
8 |
71,322,947 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4651001:Myo9b
|
UTSW |
8 |
71,342,812 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R0023:Myo9b
|
UTSW |
8 |
71,333,768 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0103:Myo9b
|
UTSW |
8 |
71,323,849 (GRCm38) |
splice site |
probably benign |
|
|
R0103:Myo9b
|
UTSW |
8 |
71,323,849 (GRCm38) |
splice site |
probably benign |
|
|
R0144:Myo9b
|
UTSW |
8 |
71,346,043 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0207:Myo9b
|
UTSW |
8 |
71,355,225 (GRCm38) |
splice site |
probably benign |
|
|
R0226:Myo9b
|
UTSW |
8 |
71,353,832 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0227:Myo9b
|
UTSW |
8 |
71,344,162 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0244:Myo9b
|
UTSW |
8 |
71,321,813 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0277:Myo9b
|
UTSW |
8 |
71,355,952 (GRCm38) |
splice site |
probably benign |
|
|
R0362:Myo9b
|
UTSW |
8 |
71,347,770 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0689:Myo9b
|
UTSW |
8 |
71,330,756 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0844:Myo9b
|
UTSW |
8 |
71,290,475 (GRCm38) |
missense |
probably benign |
0.37 |
|
R1051:Myo9b
|
UTSW |
8 |
71,355,822 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1469:Myo9b
|
UTSW |
8 |
71,291,036 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1469:Myo9b
|
UTSW |
8 |
71,291,036 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1526:Myo9b
|
UTSW |
8 |
71,355,764 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1544:Myo9b
|
UTSW |
8 |
71,290,976 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1565:Myo9b
|
UTSW |
8 |
71,315,192 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R1645:Myo9b
|
UTSW |
8 |
71,322,978 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1745:Myo9b
|
UTSW |
8 |
71,354,047 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1820:Myo9b
|
UTSW |
8 |
71,333,358 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2037:Myo9b
|
UTSW |
8 |
71,290,866 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2050:Myo9b
|
UTSW |
8 |
71,290,550 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2056:Myo9b
|
UTSW |
8 |
71,359,690 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R2129:Myo9b
|
UTSW |
8 |
71,333,699 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2423:Myo9b
|
UTSW |
8 |
71,327,940 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2869:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2869:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2871:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2871:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2872:Myo9b
|
UTSW |
8 |
71,290,966 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2872:Myo9b
|
UTSW |
8 |
71,290,966 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2873:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2874:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2920:Myo9b
|
UTSW |
8 |
71,325,857 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2926:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2939:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2940:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3033:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3040:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3689:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3691:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3735:Myo9b
|
UTSW |
8 |
71,348,597 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4194:Myo9b
|
UTSW |
8 |
71,359,624 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R4258:Myo9b
|
UTSW |
8 |
71,355,765 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4457:Myo9b
|
UTSW |
8 |
71,290,999 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4478:Myo9b
|
UTSW |
8 |
71,291,081 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4496:Myo9b
|
UTSW |
8 |
71,334,337 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4544:Myo9b
|
UTSW |
8 |
71,327,941 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4580:Myo9b
|
UTSW |
8 |
71,315,135 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4736:Myo9b
|
UTSW |
8 |
71,356,592 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5124:Myo9b
|
UTSW |
8 |
71,355,839 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5194:Myo9b
|
UTSW |
8 |
71,349,089 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5296:Myo9b
|
UTSW |
8 |
71,333,388 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R5528:Myo9b
|
UTSW |
8 |
71,323,274 (GRCm38) |
missense |
probably benign |
0.06 |
|
R5664:Myo9b
|
UTSW |
8 |
71,359,882 (GRCm38) |
missense |
probably benign |
0.13 |
|
R5677:Myo9b
|
UTSW |
8 |
71,343,686 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5680:Myo9b
|
UTSW |
8 |
71,290,372 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5982:Myo9b
|
UTSW |
8 |
71,348,396 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6344:Myo9b
|
UTSW |
8 |
71,327,914 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6352:Myo9b
|
UTSW |
8 |
71,348,411 (GRCm38) |
missense |
probably benign |
|
|
R6352:Myo9b
|
UTSW |
8 |
71,348,410 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6411:Myo9b
|
UTSW |
8 |
71,322,955 (GRCm38) |
nonsense |
probably null |
|
|
R6425:Myo9b
|
UTSW |
8 |
71,333,628 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6505:Myo9b
|
UTSW |
8 |
71,355,857 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6743:Myo9b
|
UTSW |
8 |
71,352,159 (GRCm38) |
splice site |
probably null |
|
|
R6811:Myo9b
|
UTSW |
8 |
71,356,578 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6813:Myo9b
|
UTSW |
8 |
71,323,305 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6954:Myo9b
|
UTSW |
8 |
71,290,819 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7124:Myo9b
|
UTSW |
8 |
71,333,701 (GRCm38) |
nonsense |
probably null |
|
|
R7255:Myo9b
|
UTSW |
8 |
71,290,891 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7293:Myo9b
|
UTSW |
8 |
71,325,905 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7342:Myo9b
|
UTSW |
8 |
71,355,774 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7451:Myo9b
|
UTSW |
8 |
71,352,188 (GRCm38) |
missense |
probably benign |
0.28 |
|
R7482:Myo9b
|
UTSW |
8 |
71,342,798 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7508:Myo9b
|
UTSW |
8 |
71,354,801 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7957:Myo9b
|
UTSW |
8 |
71,354,761 (GRCm38) |
missense |
probably benign |
0.12 |
|
R8062:Myo9b
|
UTSW |
8 |
71,321,813 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8108:Myo9b
|
UTSW |
8 |
71,348,342 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8197:Myo9b
|
UTSW |
8 |
71,290,963 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8274:Myo9b
|
UTSW |
8 |
71,359,836 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8686:Myo9b
|
UTSW |
8 |
71,334,322 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8731:Myo9b
|
UTSW |
8 |
71,353,842 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8924:Myo9b
|
UTSW |
8 |
71,349,031 (GRCm38) |
missense |
probably benign |
|
|
R9056:Myo9b
|
UTSW |
8 |
71,352,262 (GRCm38) |
missense |
probably benign |
0.17 |
|
R9117:Myo9b
|
UTSW |
8 |
71,347,807 (GRCm38) |
missense |
probably benign |
0.03 |
|
R9151:Myo9b
|
UTSW |
8 |
71,355,227 (GRCm38) |
splice site |
probably benign |
|
|
R9315:Myo9b
|
UTSW |
8 |
71,349,167 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R9332:Myo9b
|
UTSW |
8 |
71,359,602 (GRCm38) |
missense |
probably benign |
0.07 |
|
R9364:Myo9b
|
UTSW |
8 |
71,355,839 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9569:Myo9b
|
UTSW |
8 |
71,358,985 (GRCm38) |
missense |
probably benign |
|
|
R9581:Myo9b
|
UTSW |
8 |
71,359,899 (GRCm38) |
missense |
probably benign |
0.19 |
|
R9600:Myo9b
|
UTSW |
8 |
71,290,431 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
X0066:Myo9b
|
UTSW |
8 |
71,323,898 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Myo9b
|
UTSW |
8 |
71,290,709 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTTCAAAGCAGGCACAGGTTG -3'
(R):5'- TGCCCTCAACCCTGCATAATG -3'
Sequencing Primer
(F):5'- TCCCAGTCCCGTGCAGAG -3'
(R):5'- CCCTGCATAATGGATAGGCTTAC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation