Incidental Mutation 'R5069:Ankar'
ID 388514
Institutional Source Beutler Lab
Gene Symbol Ankar
Ensembl Gene ENSMUSG00000039342
Gene Name ankyrin and armadillo repeat containing
Synonyms 4932422E22Rik
MMRRC Submission 042659-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R5069 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 72642980-72700579 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 72680210 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148640 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053499] [ENSMUST00000053499] [ENSMUST00000211837] [ENSMUST00000211837] [ENSMUST00000212573] [ENSMUST00000212573]
AlphaFold A2RT91
Predicted Effect probably null
Transcript: ENSMUST00000053499
SMART Domains Protein: ENSMUSP00000054056
Gene: ENSMUSG00000039342

DomainStartEndE-ValueType
low complexity region 46 51 N/A INTRINSIC
low complexity region 484 496 N/A INTRINSIC
ANK 532 561 1.25e2 SMART
ANK 582 611 3.49e0 SMART
ANK 615 644 4.44e2 SMART
ANK 651 680 3.8e-1 SMART
ANK 684 714 9.87e0 SMART
ARM 744 784 5.96e-3 SMART
ARM 785 825 4.09e0 SMART
Blast:ARM 827 865 1e-15 BLAST
ARM 867 907 8.34e0 SMART
ARM 909 949 8.34e0 SMART
Blast:ARM 951 991 2e-13 BLAST
ARM 1034 1077 4.82e1 SMART
ARM 1084 1123 1.3e1 SMART
ARM 1257 1297 6.01e0 SMART
Predicted Effect probably null
Transcript: ENSMUST00000053499
SMART Domains Protein: ENSMUSP00000054056
Gene: ENSMUSG00000039342

DomainStartEndE-ValueType
low complexity region 46 51 N/A INTRINSIC
low complexity region 484 496 N/A INTRINSIC
ANK 532 561 1.25e2 SMART
ANK 582 611 3.49e0 SMART
ANK 615 644 4.44e2 SMART
ANK 651 680 3.8e-1 SMART
ANK 684 714 9.87e0 SMART
ARM 744 784 5.96e-3 SMART
ARM 785 825 4.09e0 SMART
Blast:ARM 827 865 1e-15 BLAST
ARM 867 907 8.34e0 SMART
ARM 909 949 8.34e0 SMART
Blast:ARM 951 991 2e-13 BLAST
ARM 1034 1077 4.82e1 SMART
ARM 1084 1123 1.3e1 SMART
ARM 1257 1297 6.01e0 SMART
Predicted Effect probably null
Transcript: ENSMUST00000211837
Predicted Effect probably null
Transcript: ENSMUST00000211837
Predicted Effect probably null
Transcript: ENSMUST00000212573
Predicted Effect probably null
Transcript: ENSMUST00000212573
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A G 14: 32,661,792 (GRCm38) S739P possibly damaging Het
9330182L06Rik T A 5: 9,440,897 (GRCm38) C636S probably damaging Het
Actn2 A G 13: 12,288,522 (GRCm38) I464T possibly damaging Het
Adcy7 T C 8: 88,327,697 (GRCm38) L1060P probably damaging Het
Aff3 A G 1: 38,181,613 (GRCm38) probably null Het
Ankrd27 A T 7: 35,628,435 (GRCm38) K793N probably damaging Het
Arhgef28 T C 13: 98,075,206 (GRCm38) T90A probably damaging Het
Armc9 A T 1: 86,257,237 (GRCm38) H670L probably benign Het
Arvcf A G 16: 18,398,986 (GRCm38) Y412C probably damaging Het
Ass1 C T 2: 31,510,173 (GRCm38) T301M probably damaging Het
Baiap3 A T 17: 25,249,108 (GRCm38) C283S probably damaging Het
BC055324 T C 1: 163,987,674 (GRCm38) T93A possibly damaging Het
Birc6 C T 17: 74,565,972 (GRCm38) R409C probably damaging Het
Calcoco1 A G 15: 102,711,092 (GRCm38) L354P probably damaging Het
Cdh3 A G 8: 106,536,826 (GRCm38) N126S probably benign Het
Cfap54 A C 10: 92,937,774 (GRCm38) F135L probably benign Het
Dlg1 G T 16: 31,684,295 (GRCm38) probably null Het
Dnah3 T C 7: 120,032,790 (GRCm38) H1314R probably benign Het
Dsp A C 13: 38,197,123 (GRCm38) T2615P possibly damaging Het
Enpp2 T C 15: 54,864,054 (GRCm38) Y513C probably damaging Het
Ercc6 T C 14: 32,570,063 (GRCm38) V1128A probably benign Het
Gipc2 A G 3: 152,094,248 (GRCm38) F282L probably benign Het
Gm1043 T G 5: 37,187,236 (GRCm38) L231R probably damaging Het
Gm13178 T A 4: 144,703,867 (GRCm38) D184V probably damaging Het
Gm14085 A T 2: 122,494,373 (GRCm38) N142I possibly damaging Het
Gm14685 T C X: 73,127,971 (GRCm38) I323T probably damaging Het
Gpr153 T A 4: 152,279,883 (GRCm38) M132K probably damaging Het
Hbs1l T A 10: 21,354,647 (GRCm38) S496T probably damaging Het
Inpp5f A G 7: 128,676,727 (GRCm38) probably null Het
Kat6a G A 8: 22,903,133 (GRCm38) C209Y probably damaging Het
Kcna2 T A 3: 107,104,637 (GRCm38) V178D probably damaging Het
Krt75 A G 15: 101,566,238 (GRCm38) probably null Het
Letm2 G A 8: 25,593,964 (GRCm38) Q84* probably null Het
Mib1 A G 18: 10,793,002 (GRCm38) E646G probably damaging Het
Mmp14 T A 14: 54,439,113 (GRCm38) Y372N probably damaging Het
Muc6 A G 7: 141,651,299 (GRCm38) C218R probably damaging Het
Myof A T 19: 37,905,325 (GRCm38) I1130N possibly damaging Het
Neil3 A G 8: 53,601,041 (GRCm38) S318P possibly damaging Het
Nhlh1 A G 1: 172,053,900 (GRCm38) V133A probably benign Het
Nup153 A C 13: 46,709,792 (GRCm38) S331A probably benign Het
Nup98 T C 7: 102,145,655 (GRCm38) T882A probably benign Het
Olfr1413 T A 1: 92,573,413 (GRCm38) S81T probably damaging Het
Olfr599 A T 7: 103,338,022 (GRCm38) probably null Het
Olfr744 T A 14: 50,618,740 (GRCm38) C173S probably damaging Het
Olfr749 C A 14: 50,737,074 (GRCm38) L29F probably benign Het
Otx1 C A 11: 21,997,037 (GRCm38) A91S probably damaging Het
Pald1 A T 10: 61,341,246 (GRCm38) M675K possibly damaging Het
Pex5 A G 6: 124,413,596 (GRCm38) S97P probably benign Het
Pitpnm1 C T 19: 4,111,140 (GRCm38) A897V probably benign Het
Plxnd1 A T 6: 115,965,901 (GRCm38) V1274E probably damaging Het
Polr2a T C 11: 69,736,735 (GRCm38) probably null Het
Ppfia1 G A 7: 144,514,473 (GRCm38) Q446* probably null Het
Psma2 G A 13: 14,616,028 (GRCm38) V20I probably benign Het
Rhbdl2 T A 4: 123,817,917 (GRCm38) L149* probably null Het
Rnf17 T C 14: 56,505,928 (GRCm38) V1317A probably damaging Het
Rtel1 G A 2: 181,355,492 (GRCm38) V1042M probably benign Het
Sidt2 A T 9: 45,939,461 (GRCm38) probably null Het
Slc11a1 G A 1: 74,385,184 (GRCm38) A434T probably damaging Het
Slc4a10 G A 2: 62,267,571 (GRCm38) R508H probably benign Het
Slc5a8 A T 10: 88,886,598 (GRCm38) I98F possibly damaging Het
Slf2 T A 19: 44,935,253 (GRCm38) S169T possibly damaging Het
Snx33 A T 9: 56,926,191 (GRCm38) I198N probably damaging Het
Spock3 A G 8: 63,355,265 (GRCm38) T396A probably benign Het
Sva A T 6: 42,038,417 (GRCm38) probably benign Het
Syt7 A G 19: 10,439,237 (GRCm38) N261S probably benign Het
Taar7b T G 10: 24,000,461 (GRCm38) S175A probably benign Het
Thoc2 C T X: 41,806,693 (GRCm38) E1491K probably damaging Het
Tlr1 T C 5: 64,926,400 (GRCm38) Y278C probably benign Het
Tph2 T A 10: 115,151,174 (GRCm38) Y237F probably benign Het
Trim35 C T 14: 66,308,972 (GRCm38) probably benign Het
Trpm4 T G 7: 45,310,469 (GRCm38) Y667S probably damaging Het
Ttc27 T A 17: 74,799,342 (GRCm38) H541Q probably damaging Het
Ube4a T C 9: 44,940,089 (GRCm38) H709R probably damaging Het
Vwa7 G A 17: 35,024,190 (GRCm38) V615I probably benign Het
Wars2 A G 3: 99,187,533 (GRCm38) H48R probably damaging Het
Xlr4c T A X: 73,238,684 (GRCm38) K121M probably damaging Het
Zfc3h1 T A 10: 115,418,783 (GRCm38) C1427* probably null Het
Other mutations in Ankar
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00338:Ankar APN 1 72,690,131 (GRCm38) missense probably damaging 1.00
IGL01013:Ankar APN 1 72,650,989 (GRCm38) missense possibly damaging 0.90
IGL01135:Ankar APN 1 72,665,219 (GRCm38) missense probably benign 0.28
IGL01824:Ankar APN 1 72,651,727 (GRCm38) missense probably benign 0.40
IGL01885:Ankar APN 1 72,658,703 (GRCm38) missense probably damaging 1.00
IGL01932:Ankar APN 1 72,698,987 (GRCm38) missense probably benign 0.25
IGL02143:Ankar APN 1 72,658,649 (GRCm38) critical splice donor site probably null
IGL02326:Ankar APN 1 72,666,355 (GRCm38) missense probably damaging 1.00
IGL02445:Ankar APN 1 72,666,365 (GRCm38) missense probably benign 0.05
IGL02606:Ankar APN 1 72,690,285 (GRCm38) missense possibly damaging 0.61
IGL02635:Ankar APN 1 72,652,431 (GRCm38) missense possibly damaging 0.93
IGL02680:Ankar APN 1 72,670,116 (GRCm38) missense probably damaging 1.00
IGL02704:Ankar APN 1 72,652,343 (GRCm38) missense possibly damaging 0.88
IGL03086:Ankar APN 1 72,643,278 (GRCm38) missense possibly damaging 0.84
IGL03269:Ankar APN 1 72,665,201 (GRCm38) missense probably damaging 0.99
IGL03368:Ankar APN 1 72,675,813 (GRCm38) missense probably damaging 1.00
R0050:Ankar UTSW 1 72,656,164 (GRCm38) missense probably damaging 1.00
R0050:Ankar UTSW 1 72,656,164 (GRCm38) missense probably damaging 1.00
R0488:Ankar UTSW 1 72,658,732 (GRCm38) missense probably damaging 1.00
R0650:Ankar UTSW 1 72,656,221 (GRCm38) splice site probably benign
R1121:Ankar UTSW 1 72,651,663 (GRCm38) splice site probably null
R1163:Ankar UTSW 1 72,688,705 (GRCm38) missense possibly damaging 0.82
R1300:Ankar UTSW 1 72,643,164 (GRCm38) missense probably benign 0.00
R1309:Ankar UTSW 1 72,674,004 (GRCm38) missense possibly damaging 0.59
R1366:Ankar UTSW 1 72,698,649 (GRCm38) missense probably damaging 1.00
R1456:Ankar UTSW 1 72,665,118 (GRCm38) missense probably benign 0.34
R1495:Ankar UTSW 1 72,643,291 (GRCm38) missense probably benign
R1583:Ankar UTSW 1 72,679,555 (GRCm38) splice site probably benign
R1635:Ankar UTSW 1 72,650,138 (GRCm38) missense probably damaging 0.99
R1975:Ankar UTSW 1 72,658,441 (GRCm38) missense possibly damaging 0.95
R2036:Ankar UTSW 1 72,666,530 (GRCm38) nonsense probably null
R2511:Ankar UTSW 1 72,658,694 (GRCm38) missense probably damaging 1.00
R2965:Ankar UTSW 1 72,675,820 (GRCm38) missense probably benign 0.00
R3404:Ankar UTSW 1 72,643,093 (GRCm38) nonsense probably null
R3417:Ankar UTSW 1 72,658,976 (GRCm38) critical splice donor site probably null
R4072:Ankar UTSW 1 72,688,592 (GRCm38) missense probably damaging 1.00
R4231:Ankar UTSW 1 72,658,542 (GRCm38) missense probably benign 0.23
R4447:Ankar UTSW 1 72,687,789 (GRCm38) missense possibly damaging 0.60
R4632:Ankar UTSW 1 72,647,184 (GRCm38) missense probably benign 0.01
R4720:Ankar UTSW 1 72,699,011 (GRCm38) missense possibly damaging 0.55
R4754:Ankar UTSW 1 72,698,694 (GRCm38) missense probably damaging 1.00
R4884:Ankar UTSW 1 72,698,807 (GRCm38) missense probably damaging 0.97
R5068:Ankar UTSW 1 72,680,210 (GRCm38) splice site probably null
R5070:Ankar UTSW 1 72,680,210 (GRCm38) splice site probably null
R5189:Ankar UTSW 1 72,658,414 (GRCm38) missense probably benign 0.01
R5247:Ankar UTSW 1 72,680,184 (GRCm38) missense probably benign 0.08
R5322:Ankar UTSW 1 72,690,386 (GRCm38) splice site probably null
R5345:Ankar UTSW 1 72,670,151 (GRCm38) missense possibly damaging 0.94
R5864:Ankar UTSW 1 72,659,165 (GRCm38) missense probably benign 0.00
R5976:Ankar UTSW 1 72,643,291 (GRCm38) missense probably benign
R6003:Ankar UTSW 1 72,698,887 (GRCm38) missense probably damaging 1.00
R6042:Ankar UTSW 1 72,674,054 (GRCm38) nonsense probably null
R6296:Ankar UTSW 1 72,643,258 (GRCm38) missense probably damaging 1.00
R6488:Ankar UTSW 1 72,681,808 (GRCm38) critical splice donor site probably null
R6885:Ankar UTSW 1 72,643,036 (GRCm38) missense unknown
R6985:Ankar UTSW 1 72,658,482 (GRCm38) missense probably damaging 1.00
R7060:Ankar UTSW 1 72,656,113 (GRCm38) missense probably benign 0.18
R7099:Ankar UTSW 1 72,643,293 (GRCm38) missense probably damaging 0.99
R7194:Ankar UTSW 1 72,659,033 (GRCm38) missense probably benign 0.32
R7221:Ankar UTSW 1 72,650,231 (GRCm38) missense probably damaging 1.00
R7222:Ankar UTSW 1 72,666,355 (GRCm38) missense probably damaging 0.99
R7258:Ankar UTSW 1 72,651,727 (GRCm38) missense probably benign 0.40
R7303:Ankar UTSW 1 72,659,033 (GRCm38) missense probably benign 0.32
R7308:Ankar UTSW 1 72,651,794 (GRCm38) nonsense probably null
R7384:Ankar UTSW 1 72,658,465 (GRCm38) missense probably benign 0.00
R7424:Ankar UTSW 1 72,680,058 (GRCm38) missense probably damaging 1.00
R7464:Ankar UTSW 1 72,698,894 (GRCm38) missense possibly damaging 0.94
R7525:Ankar UTSW 1 72,688,641 (GRCm38) missense probably benign 0.18
R7618:Ankar UTSW 1 72,675,766 (GRCm38) missense probably benign 0.22
R7659:Ankar UTSW 1 72,690,135 (GRCm38) missense possibly damaging 0.95
R7974:Ankar UTSW 1 72,698,979 (GRCm38) nonsense probably null
R8008:Ankar UTSW 1 72,666,484 (GRCm38) missense possibly damaging 0.47
R8119:Ankar UTSW 1 72,647,001 (GRCm38) missense probably damaging 0.98
R8244:Ankar UTSW 1 72,651,024 (GRCm38) missense probably benign
R8342:Ankar UTSW 1 72,652,460 (GRCm38) missense probably damaging 1.00
R8494:Ankar UTSW 1 72,658,794 (GRCm38) missense probably benign 0.16
R8851:Ankar UTSW 1 72,652,376 (GRCm38) missense probably damaging 1.00
R8970:Ankar UTSW 1 72,652,337 (GRCm38) critical splice donor site probably null
R9228:Ankar UTSW 1 72,674,051 (GRCm38) missense probably benign 0.27
R9511:Ankar UTSW 1 72,680,002 (GRCm38) missense probably benign 0.23
R9577:Ankar UTSW 1 72,681,908 (GRCm38) missense probably benign 0.02
R9612:Ankar UTSW 1 72,665,135 (GRCm38) missense possibly damaging 0.65
R9647:Ankar UTSW 1 72,650,148 (GRCm38) missense probably damaging 1.00
R9803:Ankar UTSW 1 72,659,181 (GRCm38) missense possibly damaging 0.47
Z1176:Ankar UTSW 1 72,689,961 (GRCm38) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- GATGAAGCGTCTCTGGTTGAC -3'
(R):5'- ACTATGACTTTAGCGTTGTTCAGG -3'

Sequencing Primer
(F):5'- TTGAAGTTGGCGCTCCACAG -3'
(R):5'- TTCAGGGGGAAGCTCTTCAC -3'
Posted On 2016-06-06