Incidental Mutation 'R5073:Tpp2'
| ID |
388934 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tpp2
|
| Ensembl Gene |
ENSMUSG00000041763 |
| Gene Name |
tripeptidyl peptidase II |
| Synonyms |
TppII |
| MMRRC Submission |
042662-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.589)
|
| Stock # |
R5073 (G1)
|
| Quality Score |
160 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
43973130-44042160 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 43993896 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Arginine
at position 260
(S260R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139918
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087933]
[ENSMUST00000188302]
[ENSMUST00000188313]
[ENSMUST00000189388]
|
| AlphaFold |
Q64514 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000087933
AA Change: S260R
PolyPhen 2
Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
AA Change: S260R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000186028
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000188302
AA Change: S260R
PolyPhen 2
Score 0.788 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000140474
Gene: ENSMUSG00000041763
AA Change: S260R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
4.3e-84 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000188313
AA Change: S260R
PolyPhen 2
Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
AA Change: S260R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000189388
AA Change: S260R
PolyPhen 2
Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000140562
Gene: ENSMUSG00000041763
AA Change: S260R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
2.3e-81 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
880 |
7.8e-49 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190401
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 92.6%
|
| Validation Efficiency |
100% (113/113) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
PHENOTYPE: Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca3 |
C |
T |
17: 24,593,274 (GRCm39) |
R224C |
probably damaging |
Het |
| Adcy8 |
A |
T |
15: 64,659,207 (GRCm39) |
W528R |
probably damaging |
Het |
| Agbl5 |
G |
A |
5: 31,060,403 (GRCm39) |
R141Q |
probably damaging |
Het |
| Ahnak |
T |
A |
19: 8,980,595 (GRCm39) |
H626Q |
probably benign |
Het |
| Ampd2 |
A |
T |
3: 107,986,549 (GRCm39) |
M245K |
probably damaging |
Het |
| Apob |
G |
A |
12: 8,055,219 (GRCm39) |
|
probably null |
Het |
| Apool |
C |
T |
X: 111,259,540 (GRCm39) |
Q60* |
probably null |
Het |
| Aqp1 |
A |
T |
6: 55,322,520 (GRCm39) |
I172F |
probably damaging |
Het |
| Atp7a |
A |
G |
X: 105,153,374 (GRCm39) |
D1092G |
probably benign |
Het |
| Bcas3 |
A |
G |
11: 85,261,958 (GRCm39) |
Y110C |
probably damaging |
Het |
| Brpf1 |
T |
C |
6: 113,287,215 (GRCm39) |
S148P |
probably damaging |
Het |
| Capn3 |
A |
G |
2: 120,322,301 (GRCm39) |
H339R |
probably damaging |
Het |
| Ccdc141 |
A |
T |
2: 76,954,722 (GRCm39) |
|
probably null |
Het |
| Ccl2 |
A |
G |
11: 81,927,984 (GRCm39) |
|
probably benign |
Het |
| Cct8l1 |
G |
A |
5: 25,721,881 (GRCm39) |
V199I |
probably benign |
Het |
| Cdc23 |
C |
A |
18: 34,784,742 (GRCm39) |
V7L |
unknown |
Het |
| Cit |
T |
A |
5: 116,084,902 (GRCm39) |
M811K |
probably benign |
Het |
| Crim1 |
T |
C |
17: 78,588,776 (GRCm39) |
C284R |
possibly damaging |
Het |
| Cyp2d10 |
C |
T |
15: 82,287,954 (GRCm39) |
R383H |
probably benign |
Het |
| Cyp4a29 |
A |
G |
4: 115,104,860 (GRCm39) |
T123A |
probably benign |
Het |
| Dbndd2 |
A |
G |
2: 164,332,224 (GRCm39) |
|
probably benign |
Het |
| Dnaja3 |
A |
T |
16: 4,514,289 (GRCm39) |
T274S |
probably damaging |
Het |
| Dot1l |
A |
G |
10: 80,620,480 (GRCm39) |
D514G |
possibly damaging |
Het |
| Dysf |
A |
T |
6: 84,114,254 (GRCm39) |
K1226M |
probably damaging |
Het |
| Eef1akmt1 |
A |
G |
14: 57,803,464 (GRCm39) |
L30P |
probably damaging |
Het |
| Elavl1 |
A |
G |
8: 4,351,741 (GRCm39) |
M125T |
possibly damaging |
Het |
| Eml4 |
C |
A |
17: 83,771,006 (GRCm39) |
S723R |
probably damaging |
Het |
| Fgf15 |
A |
C |
7: 144,450,576 (GRCm39) |
Y54S |
possibly damaging |
Het |
| Fign |
A |
T |
2: 63,810,037 (GRCm39) |
L411* |
probably null |
Het |
| Flt1 |
C |
A |
5: 147,620,749 (GRCm39) |
A132S |
probably benign |
Het |
| Fryl |
G |
A |
5: 73,232,110 (GRCm39) |
P1550L |
probably damaging |
Het |
| Gas2l3 |
CACTCGTCATACT |
CACT |
10: 89,266,820 (GRCm39) |
|
probably benign |
Het |
| Gprasp2 |
C |
T |
X: 134,743,346 (GRCm39) |
T235I |
possibly damaging |
Het |
| H2ab3 |
T |
C |
X: 119,222,543 (GRCm39) |
T84A |
probably damaging |
Het |
| Hal |
A |
T |
10: 93,349,904 (GRCm39) |
I555F |
probably damaging |
Het |
| Hdac6 |
A |
G |
X: 7,811,036 (GRCm39) |
F104L |
probably damaging |
Het |
| Hibadh |
C |
T |
6: 52,597,079 (GRCm39) |
V122M |
possibly damaging |
Het |
| Hmga1b |
C |
T |
11: 120,654,012 (GRCm39) |
Q100* |
probably null |
Het |
| Hydin |
A |
G |
8: 111,265,105 (GRCm39) |
N2763D |
probably benign |
Het |
| Ifi47 |
A |
G |
11: 48,986,361 (GRCm39) |
T43A |
probably benign |
Het |
| Ifnlr1 |
A |
G |
4: 135,432,457 (GRCm39) |
T298A |
probably benign |
Het |
| Impdh2 |
G |
A |
9: 108,440,535 (GRCm39) |
|
probably null |
Het |
| Insr |
A |
G |
8: 3,209,475 (GRCm39) |
F1203L |
probably damaging |
Het |
| Kcnq4 |
A |
G |
4: 120,574,714 (GRCm39) |
S117P |
probably damaging |
Het |
| Kif19a |
G |
A |
11: 114,658,053 (GRCm39) |
M37I |
probably benign |
Het |
| Kif1a |
T |
C |
1: 92,950,227 (GRCm39) |
H1400R |
probably damaging |
Het |
| Kiss1r |
C |
A |
10: 79,754,596 (GRCm39) |
S30* |
probably null |
Het |
| Krt222 |
T |
A |
11: 99,134,796 (GRCm39) |
|
probably benign |
Het |
| Lekr1 |
A |
T |
3: 65,727,215 (GRCm39) |
|
noncoding transcript |
Het |
| Ltn1 |
A |
G |
16: 87,224,628 (GRCm39) |
V32A |
probably damaging |
Het |
| Marchf1 |
T |
A |
8: 66,839,020 (GRCm39) |
W21R |
probably benign |
Het |
| Marchf5 |
A |
G |
19: 37,188,207 (GRCm39) |
N58S |
possibly damaging |
Het |
| Mast4 |
G |
A |
13: 102,875,391 (GRCm39) |
Q1158* |
probably null |
Het |
| Mib2 |
C |
G |
4: 155,741,233 (GRCm39) |
A535P |
probably damaging |
Het |
| Mrtfa |
A |
G |
15: 80,906,627 (GRCm39) |
V91A |
probably damaging |
Het |
| Msc |
C |
T |
1: 14,824,537 (GRCm39) |
V178M |
probably benign |
Het |
| Muc4 |
C |
A |
16: 32,754,529 (GRCm38) |
H1468N |
probably benign |
Het |
| Muc5b |
A |
T |
7: 141,412,999 (GRCm39) |
T1982S |
unknown |
Het |
| Mvk |
A |
T |
5: 114,591,013 (GRCm39) |
|
probably benign |
Het |
| Myo1a |
T |
C |
10: 127,543,288 (GRCm39) |
|
probably null |
Het |
| Myo6 |
T |
G |
9: 80,195,290 (GRCm39) |
S887A |
probably benign |
Het |
| Myo7a |
G |
A |
7: 97,722,425 (GRCm39) |
Q1167* |
probably null |
Het |
| Ncald |
A |
T |
15: 37,397,478 (GRCm39) |
H67Q |
probably damaging |
Het |
| Nmnat1 |
C |
A |
4: 149,553,595 (GRCm39) |
M172I |
probably benign |
Het |
| Nudt1 |
G |
T |
5: 140,317,662 (GRCm39) |
|
probably null |
Het |
| Nudt5 |
T |
A |
2: 5,869,198 (GRCm39) |
H141Q |
probably benign |
Het |
| Or1m1 |
T |
C |
9: 18,666,118 (GRCm39) |
E271G |
possibly damaging |
Het |
| Or4e1 |
T |
A |
14: 52,701,032 (GRCm39) |
M118L |
probably damaging |
Het |
| Or8h10 |
A |
T |
2: 86,808,666 (GRCm39) |
V158D |
possibly damaging |
Het |
| Parp14 |
A |
T |
16: 35,655,077 (GRCm39) |
I1798K |
probably damaging |
Het |
| Pcdhga7 |
A |
G |
18: 37,849,025 (GRCm39) |
D344G |
probably damaging |
Het |
| Pck1 |
A |
G |
2: 172,998,770 (GRCm39) |
T343A |
probably benign |
Het |
| Pik3c2g |
T |
A |
6: 139,665,873 (GRCm39) |
C65S |
probably null |
Het |
| Pilra |
A |
G |
5: 137,833,674 (GRCm39) |
F131L |
probably damaging |
Het |
| Ppl |
A |
T |
16: 4,906,742 (GRCm39) |
S1184R |
probably benign |
Het |
| Prmt2 |
C |
T |
10: 76,058,390 (GRCm39) |
V140I |
probably damaging |
Het |
| Prpf38b |
A |
G |
3: 108,818,484 (GRCm39) |
F92S |
probably damaging |
Het |
| Psmc3 |
A |
G |
2: 90,884,915 (GRCm39) |
|
probably benign |
Het |
| Ptgs1 |
A |
T |
2: 36,141,272 (GRCm39) |
N573I |
probably damaging |
Het |
| Rgs9 |
C |
A |
11: 109,118,157 (GRCm39) |
A332S |
probably benign |
Het |
| Rptor |
T |
C |
11: 119,787,305 (GRCm39) |
I1290T |
possibly damaging |
Het |
| Slc38a7 |
C |
A |
8: 96,568,278 (GRCm39) |
R369L |
probably damaging |
Het |
| Slc4a2 |
G |
A |
5: 24,643,760 (GRCm39) |
S855N |
probably benign |
Het |
| Slco2a1 |
G |
T |
9: 102,923,925 (GRCm39) |
L46F |
probably damaging |
Het |
| Snrpd3 |
G |
T |
10: 75,355,227 (GRCm39) |
C20F |
possibly damaging |
Het |
| Stab2 |
A |
T |
10: 86,699,422 (GRCm39) |
I481N |
probably benign |
Het |
| Tbc1d9 |
A |
G |
8: 83,960,176 (GRCm39) |
E143G |
probably damaging |
Het |
| Tenm2 |
T |
A |
11: 35,959,208 (GRCm39) |
T1114S |
probably damaging |
Het |
| Tg |
A |
C |
15: 66,607,101 (GRCm39) |
M213L |
probably benign |
Het |
| Tnc |
A |
G |
4: 63,938,648 (GRCm39) |
C64R |
probably damaging |
Het |
| Tpd52l1 |
A |
G |
10: 31,233,916 (GRCm39) |
L79S |
probably damaging |
Het |
| Tppp2 |
G |
A |
14: 52,157,912 (GRCm39) |
R119Q |
probably benign |
Het |
| Tshz2 |
A |
T |
2: 169,804,493 (GRCm39) |
|
probably benign |
Het |
| Tuba8 |
T |
C |
6: 121,199,862 (GRCm39) |
V182A |
probably damaging |
Het |
| Ufl1 |
A |
G |
4: 25,254,780 (GRCm39) |
Y559H |
probably benign |
Het |
| Usp53 |
A |
T |
3: 122,727,595 (GRCm39) |
S996T |
probably benign |
Het |
| Vcam1 |
A |
G |
3: 115,918,037 (GRCm39) |
V308A |
probably damaging |
Het |
| Wdr17 |
T |
A |
8: 55,143,271 (GRCm39) |
|
probably null |
Het |
| Wdr6 |
G |
A |
9: 108,451,565 (GRCm39) |
H773Y |
probably damaging |
Het |
| Wnk4 |
T |
G |
11: 101,152,014 (GRCm39) |
F173V |
probably damaging |
Het |
| Xrcc5 |
T |
C |
1: 72,378,188 (GRCm39) |
Y395H |
probably damaging |
Het |
| Zcwpw1 |
T |
A |
5: 137,793,781 (GRCm39) |
M1K |
probably null |
Het |
| Zfp263 |
A |
G |
16: 3,564,704 (GRCm39) |
R240G |
possibly damaging |
Het |
| Zfp652 |
A |
G |
11: 95,640,890 (GRCm39) |
I272V |
possibly damaging |
Het |
|
| Other mutations in Tpp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00977:Tpp2
|
APN |
1 |
44,022,451 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01021:Tpp2
|
APN |
1 |
43,973,347 (GRCm39) |
nonsense |
probably null |
|
|
IGL01096:Tpp2
|
APN |
1 |
44,000,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01344:Tpp2
|
APN |
1 |
44,022,422 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01642:Tpp2
|
APN |
1 |
43,993,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02719:Tpp2
|
APN |
1 |
43,979,391 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02890:Tpp2
|
APN |
1 |
44,038,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Tpp2
|
APN |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03175:Tpp2
|
APN |
1 |
44,012,671 (GRCm39) |
missense |
probably benign |
0.35 |
|
beaver
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
billingsly
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
cleaver
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
dow
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
Eddie
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
jerry
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
June
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
landers
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
mathers
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
recurrentis
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
state
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
wally
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
Ward
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
wilson
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
BB010:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB020:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0001:Tpp2
|
UTSW |
1 |
44,010,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0003:Tpp2
|
UTSW |
1 |
43,999,299 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Tpp2
|
UTSW |
1 |
44,020,908 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0110:Tpp2
|
UTSW |
1 |
44,017,664 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0110:Tpp2
|
UTSW |
1 |
44,038,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0167:Tpp2
|
UTSW |
1 |
44,009,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0441:Tpp2
|
UTSW |
1 |
44,029,722 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0520:Tpp2
|
UTSW |
1 |
44,029,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Tpp2
|
UTSW |
1 |
44,014,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1118:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1119:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1593:Tpp2
|
UTSW |
1 |
44,014,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1702:Tpp2
|
UTSW |
1 |
44,029,708 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1756:Tpp2
|
UTSW |
1 |
44,017,885 (GRCm39) |
splice site |
probably null |
|
|
R2066:Tpp2
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2171:Tpp2
|
UTSW |
1 |
43,996,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Tpp2
|
UTSW |
1 |
44,038,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2394:Tpp2
|
UTSW |
1 |
44,022,346 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2507:Tpp2
|
UTSW |
1 |
44,040,609 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2879:Tpp2
|
UTSW |
1 |
44,010,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3436:Tpp2
|
UTSW |
1 |
43,979,304 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4106:Tpp2
|
UTSW |
1 |
44,040,617 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4658:Tpp2
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4760:Tpp2
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4963:Tpp2
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Tpp2
|
UTSW |
1 |
44,040,633 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6010:Tpp2
|
UTSW |
1 |
43,990,373 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6118:Tpp2
|
UTSW |
1 |
43,979,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6155:Tpp2
|
UTSW |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Tpp2
|
UTSW |
1 |
44,022,739 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6236:Tpp2
|
UTSW |
1 |
44,016,477 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6695:Tpp2
|
UTSW |
1 |
44,022,436 (GRCm39) |
missense |
probably benign |
|
|
R6845:Tpp2
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Tpp2
|
UTSW |
1 |
44,022,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7094:Tpp2
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7223:Tpp2
|
UTSW |
1 |
44,008,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7316:Tpp2
|
UTSW |
1 |
44,009,591 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7324:Tpp2
|
UTSW |
1 |
44,017,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7363:Tpp2
|
UTSW |
1 |
44,024,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7454:Tpp2
|
UTSW |
1 |
43,993,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7496:Tpp2
|
UTSW |
1 |
44,022,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7699:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7700:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7804:Tpp2
|
UTSW |
1 |
44,022,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7933:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7979:Tpp2
|
UTSW |
1 |
43,979,297 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8032:Tpp2
|
UTSW |
1 |
44,014,628 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8101:Tpp2
|
UTSW |
1 |
44,009,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tpp2
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Tpp2
|
UTSW |
1 |
43,973,387 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8518:Tpp2
|
UTSW |
1 |
44,019,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Tpp2
|
UTSW |
1 |
44,016,365 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8529:Tpp2
|
UTSW |
1 |
44,022,300 (GRCm39) |
missense |
probably benign |
|
|
R8756:Tpp2
|
UTSW |
1 |
43,999,295 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Tpp2
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8773:Tpp2
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
R8915:Tpp2
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9049:Tpp2
|
UTSW |
1 |
43,992,502 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9090:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Tpp2
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
R9214:Tpp2
|
UTSW |
1 |
44,031,514 (GRCm39) |
missense |
probably benign |
|
|
R9271:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9316:Tpp2
|
UTSW |
1 |
44,017,604 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9371:Tpp2
|
UTSW |
1 |
43,999,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Tpp2
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9488:Tpp2
|
UTSW |
1 |
44,041,272 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9513:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9514:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9516:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGTGGGAGGATAAATTTTAATGCC -3'
(R):5'- CCACAGTTAGGGTTGAATTTCTC -3'
Sequencing Primer
(F):5'- ATGCCTATTTCTCCTTCCCAACAGAG -3'
(R):5'- CAGTTAGGGTTGAATTTCTCAAAGG -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation