Mutagenetix > Incidental Mutation

Incidental Mutation 'R5022:Tep1'

389292

Institutional Source

Beutler Lab

Gene Symbol

Tep1

Ensembl Gene

ENSMUSG00000006281

Gene Name

telomerase associated protein 1

Synonyms

Tp1

MMRRC Submission

042613-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5022 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

50824059-50870560 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 50828999 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 2335 (Y2335H)

Ref Sequence

ENSEMBL: ENSMUSP00000006444 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000006444] [ENSMUST00000227526]

AlphaFold

P97499

Predicted Effect

probably benign
Transcript: ENSMUST00000006444
AA Change: Y2335H

PolyPhen 2 Score 0.272 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000006444
Gene: ENSMUSG00000006281
AA Change: Y2335H

Domain	Start	End	E-Value	Type
Pfam:TEP1_N	1	29	2.8e-20	PFAM
Pfam:TEP1_N	31	59	1.4e-20	PFAM
Pfam:TEP1_N	61	89	3.1e-20	PFAM
Pfam:TEP1_N	91	119	3e-20	PFAM
low complexity region	195	207	N/A	INTRINSIC
low complexity region	211	229	N/A	INTRINSIC
Pfam:TROVE	230	685	3.2e-136	PFAM
Pfam:DUF4062	909	1020	2.4e-22	PFAM
Pfam:NACHT	1171	1346	9.2e-38	PFAM
low complexity region	1393	1405	N/A	INTRINSIC
low complexity region	1622	1641	N/A	INTRINSIC
WD40	1673	1711	2.98e-1	SMART
WD40	1714	1752	5.33e0	SMART
WD40	1755	1794	1.52e-4	SMART
WD40	1797	1835	3.27e-4	SMART
WD40	1838	1877	3.09e-1	SMART
WD40	1880	1919	2.24e-2	SMART
WD40	1925	1962	4.95e0	SMART
WD40	1968	2003	2.29e1	SMART
WD40	2008	2045	1.72e0	SMART
WD40	2058	2097	3.89e-11	SMART
WD40	2103	2142	3.93e-7	SMART
WD40	2145	2182	4.38e-5	SMART
WD40	2184	2232	1.24e0	SMART
WD40	2235	2273	1.14e-3	SMART
WD40	2275	2315	4.46e-1	SMART
Blast:WD40	2316	2353	4e-12	BLAST
WD40	2546	2583	6.79e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000226222

Predicted Effect

probably benign
Transcript: ENSMUST00000226430

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000227193

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000227228

Predicted Effect

probably benign
Transcript: ENSMUST00000227526

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228562

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.4%
20x: 92.6%

Validation Efficiency

99% (110/111)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for a disruption in this gene show no obvious phenotype. No changes are seen in telomerase activity or telomere length. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 105 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca1	TCGACTGC	T	4: 53,041,570 (GRCm38)		probably null	Het
Abca15	T	C	7: 120,346,096 (GRCm38)	I465T	probably damaging	Het
Abca3	C	T	17: 24,374,300 (GRCm38)	R224C	probably damaging	Het
Abcb4	T	A	5: 8,909,054 (GRCm38)		probably null	Het
Acan	T	C	7: 79,092,808 (GRCm38)		probably null	Het
Aebp2	G	A	6: 140,637,730 (GRCm38)	R109Q	possibly damaging	Het
Agfg2	A	T	5: 137,660,160 (GRCm38)		probably null	Het
Ankib1	T	A	5: 3,734,011 (GRCm38)	I322F	possibly damaging	Het
AW551984	A	T	9: 39,597,965 (GRCm38)	N293K	probably benign	Het
BC028528	T	A	3: 95,888,823 (GRCm38)		probably benign	Het
Bicc1	A	G	10: 70,947,883 (GRCm38)	S393P	possibly damaging	Het
Birc6	A	G	17: 74,692,332 (GRCm38)	Y4656C	probably damaging	Het
Bmp3	A	G	5: 98,872,824 (GRCm38)	R369G	probably damaging	Het
C1d	T	A	11: 17,266,674 (GRCm38)	N135K	probably benign	Het
Ccdc148	G	A	2: 58,827,632 (GRCm38)	A453V	probably damaging	Het
Cd163	C	T	6: 124,325,288 (GRCm38)	T937I	probably damaging	Het
Celf2	C	T	2: 6,607,847 (GRCm38)		probably benign	Het
Chga	T	C	12: 102,562,837 (GRCm38)	W358R	probably damaging	Het
Clec4b2	A	T	6: 123,200,956 (GRCm38)	S77C	probably null	Het
Crim1	T	C	17: 78,280,129 (GRCm38)	V221A	possibly damaging	Het
D630003M21Rik	A	T	2: 158,217,633 (GRCm38)	S116T	probably damaging	Het
Dlg5	T	C	14: 24,136,622 (GRCm38)	E1847G	probably damaging	Het
Dmxl1	T	A	18: 49,895,127 (GRCm38)	I2206K	probably damaging	Het
Dusp7	T	A	9: 106,373,741 (GRCm38)	L355Q	probably damaging	Het
Exd2	T	A	12: 80,496,790 (GRCm38)	N582K	probably damaging	Het
Fbln1	G	A	15: 85,237,626 (GRCm38)	S316N	probably damaging	Het
Fchsd1	A	G	18: 37,964,810 (GRCm38)	I340T	possibly damaging	Het
Fn1	T	C	1: 71,624,179 (GRCm38)	Y1050C	probably damaging	Het
Fsip2	A	G	2: 82,979,429 (GRCm38)	I2031V	probably benign	Het
Gm10803	A	C	2: 93,564,172 (GRCm38)	L96F	probably damaging	Het
Gm12169	T	A	11: 46,528,532 (GRCm38)	D58E	probably damaging	Het
Gm14569	T	C	X: 36,430,817 (GRCm38)	D1413G	probably benign	Het
Gm15455	T	C	1: 33,837,351 (GRCm38)		noncoding transcript	Het
Gm1818	G	C	12: 48,555,535 (GRCm38)		noncoding transcript	Het
Gm4907	G	A	X: 23,907,241 (GRCm38)	G327E	probably damaging	Het
Gm5039	T	C	12: 88,321,301 (GRCm38)	I61V	probably benign	Het
Gm5420	A	T	10: 21,691,727 (GRCm38)		noncoding transcript	Het
Gm6803	A	T	12: 88,018,711 (GRCm38)	S21T	unknown	Het
Gm7104	A	T	12: 88,285,759 (GRCm38)		noncoding transcript	Het
Gp2	A	G	7: 119,449,114 (GRCm38)	I427T	probably damaging	Het
Gpc4	G	A	X: 52,074,563 (GRCm38)	R148C	probably damaging	Het
Gpr142	A	C	11: 114,804,388 (GRCm38)	S60R	probably benign	Het
Helz2	T	C	2: 181,240,569 (GRCm38)	R144G	probably benign	Het
Herc1	A	T	9: 66,470,326 (GRCm38)	K3458M	possibly damaging	Het
Hnf4g	G	T	3: 3,644,587 (GRCm38)	A144S	probably damaging	Het
Irs2	A	C	8: 10,987,012 (GRCm38)	*1322G	probably null	Het
Keg1	A	G	19: 12,719,157 (GRCm38)	N288S	probably damaging	Het
Kif19a	G	A	11: 114,767,227 (GRCm38)	M37I	probably benign	Het
Klhl1	G	A	14: 96,136,706 (GRCm38)	P635S	probably benign	Het
Klk14	G	A	7: 43,692,077 (GRCm38)	C51Y	probably damaging	Het
Lsm11	T	C	11: 45,944,839 (GRCm38)	D25G	probably damaging	Het
Manea	A	T	4: 26,336,630 (GRCm38)	Y215*	probably null	Het
Mdga2	C	T	12: 66,470,760 (GRCm38)	C100Y	possibly damaging	Het
Mthfd1	T	A	12: 76,301,328 (GRCm38)	M582K	probably damaging	Het
Mthfd1	T	G	12: 76,294,374 (GRCm38)	V480G	probably damaging	Het
Myh7b	G	C	2: 155,632,373 (GRCm38)	R1669S	possibly damaging	Het
Nanos1	T	C	19: 60,756,980 (GRCm38)	Y239H	probably damaging	Het
Nat8	G	A	6: 85,830,857 (GRCm38)	T98I	possibly damaging	Het
Ndufs3	C	A	2: 90,898,660 (GRCm38)	A161S	probably benign	Het
Nexmif	A	T	X: 104,087,350 (GRCm38)	N320K	probably damaging	Het
Olfr1216	A	G	2: 89,014,043 (GRCm38)	V7A	probably damaging	Het
Olfr1228	C	T	2: 89,249,417 (GRCm38)	M92I	probably benign	Het
Olfr164	A	T	16: 19,286,059 (GRCm38)	V228D	probably damaging	Het
Olfr239	T	C	17: 33,199,777 (GRCm38)	F239S	probably damaging	Het
Olfr457	A	T	6: 42,471,287 (GRCm38)	V297E	possibly damaging	Het
Olfr589	G	A	7: 103,155,735 (GRCm38)	P4L	probably benign	Het
Olfr727	T	C	14: 50,127,012 (GRCm38)	V145A	possibly damaging	Het
Olfr822	T	C	10: 130,074,593 (GRCm38)	L61P	probably damaging	Het
Pcdhb14	T	A	18: 37,450,170 (GRCm38)	N776K	probably benign	Het
Pip5k1c	G	A	10: 81,310,889 (GRCm38)		probably null	Het
Plk4	G	A	3: 40,802,077 (GRCm38)		probably null	Het
Prmt8	A	G	6: 127,711,163 (GRCm38)	Y231H	possibly damaging	Het
Prpf4b	T	C	13: 34,883,599 (GRCm38)		probably benign	Het
Ptpn21	G	A	12: 98,679,407 (GRCm38)	R1091C	probably damaging	Het
Pwwp2b	C	T	7: 139,255,578 (GRCm38)	P312S	possibly damaging	Het
Rad21	A	T	15: 51,966,706 (GRCm38)	I503K	probably benign	Het
Rai14	A	G	15: 10,574,506 (GRCm38)	S789P	probably damaging	Het
Rbm26	C	T	14: 105,144,252 (GRCm38)	D486N	probably damaging	Het
Rnf20	A	G	4: 49,642,016 (GRCm38)		probably benign	Het
Ros1	A	G	10: 52,124,075 (GRCm38)	V1118A	possibly damaging	Het
Sema3d	A	C	5: 12,584,956 (GRCm38)	Y663S	probably damaging	Het
Serpina6	A	G	12: 103,651,712 (GRCm38)	W281R	probably damaging	Het
Slc8a3	A	G	12: 81,199,558 (GRCm38)	V900A	probably damaging	Het
Spats2l	G	T	1: 57,879,556 (GRCm38)	V30L	probably damaging	Het
Spg21	A	G	9: 65,475,949 (GRCm38)	D139G	probably damaging	Het
Sun3	T	C	11: 9,038,314 (GRCm38)	T3A	probably damaging	Het
Tcrg-V1	T	A	13: 19,340,231 (GRCm38)	S42T	probably benign	Het
Timm21	C	A	18: 84,949,414 (GRCm38)	V112L	possibly damaging	Het
Tlk1	A	T	2: 70,742,065 (GRCm38)	N386K	probably benign	Het
Trappc10	G	T	10: 78,217,160 (GRCm38)	F260L	possibly damaging	Het
Trmt112	T	C	19: 6,910,753 (GRCm38)	V91A	probably benign	Het
Ucp2	A	T	7: 100,498,372 (GRCm38)	N186I	possibly damaging	Het
Vmn1r119	A	G	7: 21,012,320 (GRCm38)	S46P	probably benign	Het
Vmn2r101	A	T	17: 19,611,387 (GRCm38)		probably null	Het
Vmn2r105	T	A	17: 20,208,414 (GRCm38)	H800L	probably damaging	Het
Vmn2r69	T	C	7: 85,411,159 (GRCm38)	M406V	possibly damaging	Het
Vmn2r84	A	G	10: 130,386,548 (GRCm38)	L601P	probably damaging	Het
Vps16	A	G	2: 130,439,452 (GRCm38)	S235G	probably benign	Het
Wap	T	C	11: 6,637,339 (GRCm38)		probably benign	Het
Wdr11	A	G	7: 129,624,711 (GRCm38)	I744M	probably benign	Het
Xiap	T	C	X: 42,094,465 (GRCm38)	F23L	probably benign	Het
Xkr7	A	G	2: 153,054,380 (GRCm38)	T385A	probably benign	Het
Zfp524	A	T	7: 5,018,417 (GRCm38)	I315F	probably benign	Het
Zfp62	T	A	11: 49,215,729 (GRCm38)	S216T	probably damaging	Het
Znfx1	T	C	2: 167,039,826 (GRCm38)	Y217C	probably damaging	Het

Other mutations in Tep1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00482:Tep1	APN	14	50,843,184 (GRCm38)	missense	probably damaging	1.00
IGL00490:Tep1	APN	14	50,833,473 (GRCm38)	missense	probably damaging	0.97
IGL01114:Tep1	APN	14	50,850,639 (GRCm38)	missense	probably damaging	0.98
IGL01294:Tep1	APN	14	50,829,657 (GRCm38)	splice site	probably benign
IGL01902:Tep1	APN	14	50,866,091 (GRCm38)	splice site	probably benign
IGL01910:Tep1	APN	14	50,844,112 (GRCm38)	missense	probably benign	0.06
IGL01925:Tep1	APN	14	50,824,498 (GRCm38)	unclassified	probably benign
IGL01965:Tep1	APN	14	50,863,495 (GRCm38)	splice site	probably benign
IGL02071:Tep1	APN	14	50,834,049 (GRCm38)	missense	possibly damaging	0.93
IGL02124:Tep1	APN	14	50,854,124 (GRCm38)	unclassified	probably benign
IGL02189:Tep1	APN	14	50,826,826 (GRCm38)	missense	probably benign
IGL02252:Tep1	APN	14	50,830,255 (GRCm38)	missense	possibly damaging	0.93
IGL02299:Tep1	APN	14	50,840,671 (GRCm38)	missense	probably damaging	0.99
IGL02343:Tep1	APN	14	50,829,247 (GRCm38)	missense	probably damaging	0.99
IGL02423:Tep1	APN	14	50,844,620 (GRCm38)	missense	possibly damaging	0.53
IGL02537:Tep1	APN	14	50,836,113 (GRCm38)	missense	probably damaging	0.96
IGL02601:Tep1	APN	14	50,833,478 (GRCm38)	nonsense	probably null
IGL02941:Tep1	APN	14	50,866,037 (GRCm38)	missense	probably damaging	0.98
IGL02990:Tep1	APN	14	50,868,246 (GRCm38)	missense	possibly damaging	0.86
IGL03144:Tep1	APN	14	50,844,017 (GRCm38)	splice site	probably benign
IGL03209:Tep1	APN	14	50,840,703 (GRCm38)	splice site	probably benign
R0240_Tep1_347	UTSW	14	50,863,029 (GRCm38)	splice site	probably benign
R0972_Tep1_893	UTSW	14	50,824,296 (GRCm38)	unclassified	probably benign
R1686_Tep1_375	UTSW	14	50,836,788 (GRCm38)	missense	probably benign	0.12
R7232_Tep1_671	UTSW	14	50,844,332 (GRCm38)	missense	unknown
R8009_Tep1_822	UTSW	14	50,824,230 (GRCm38)	missense	possibly damaging	0.93
PIT4305001:Tep1	UTSW	14	50,829,227 (GRCm38)	missense	possibly damaging	0.90
PIT4362001:Tep1	UTSW	14	50,866,053 (GRCm38)	missense	probably benign	0.23
R0058:Tep1	UTSW	14	50,834,065 (GRCm38)	missense	possibly damaging	0.85
R0060:Tep1	UTSW	14	50,866,029 (GRCm38)	missense	probably damaging	1.00
R0109:Tep1	UTSW	14	50,851,916 (GRCm38)	splice site	probably null
R0123:Tep1	UTSW	14	50,829,693 (GRCm38)	missense	possibly damaging	0.84
R0134:Tep1	UTSW	14	50,829,693 (GRCm38)	missense	possibly damaging	0.84
R0148:Tep1	UTSW	14	50,824,789 (GRCm38)	missense	possibly damaging	0.70
R0240:Tep1	UTSW	14	50,863,029 (GRCm38)	splice site	probably benign
R0243:Tep1	UTSW	14	50,846,987 (GRCm38)	missense	probably damaging	1.00
R0373:Tep1	UTSW	14	50,836,768 (GRCm38)	missense	possibly damaging	0.85
R0432:Tep1	UTSW	14	50,866,823 (GRCm38)	small deletion	probably benign
R0464:Tep1	UTSW	14	50,847,684 (GRCm38)	missense	probably benign	0.00
R0566:Tep1	UTSW	14	50,845,414 (GRCm38)	critical splice donor site	probably null
R0691:Tep1	UTSW	14	50,866,844 (GRCm38)	nonsense	probably null
R0787:Tep1	UTSW	14	50,829,230 (GRCm38)	missense	possibly damaging	0.85
R0972:Tep1	UTSW	14	50,824,296 (GRCm38)	unclassified	probably benign
R1263:Tep1	UTSW	14	50,845,513 (GRCm38)	missense	possibly damaging	0.84
R1300:Tep1	UTSW	14	50,827,055 (GRCm38)	critical splice donor site	probably null
R1327:Tep1	UTSW	14	50,853,099 (GRCm38)	missense	probably benign	0.18
R1556:Tep1	UTSW	14	50,853,042 (GRCm38)	missense	probably benign	0.06
R1584:Tep1	UTSW	14	50,866,037 (GRCm38)	missense	probably damaging	0.98
R1607:Tep1	UTSW	14	50,824,563 (GRCm38)	missense	probably null	0.99
R1686:Tep1	UTSW	14	50,836,788 (GRCm38)	missense	probably benign	0.12
R1715:Tep1	UTSW	14	50,854,567 (GRCm38)	missense	possibly damaging	0.92
R1778:Tep1	UTSW	14	50,829,622 (GRCm38)	intron	probably benign
R1993:Tep1	UTSW	14	50,824,184 (GRCm38)	missense	possibly damaging	0.93
R2071:Tep1	UTSW	14	50,854,282 (GRCm38)	missense	probably benign	0.23
R2104:Tep1	UTSW	14	50,850,580 (GRCm38)	splice site	probably benign
R2118:Tep1	UTSW	14	50,855,572 (GRCm38)	splice site	probably null
R2119:Tep1	UTSW	14	50,838,986 (GRCm38)	missense	probably benign	0.13
R2208:Tep1	UTSW	14	50,866,864 (GRCm38)	missense	probably benign	0.01
R2241:Tep1	UTSW	14	50,854,210 (GRCm38)	missense	probably benign	0.01
R2243:Tep1	UTSW	14	50,854,210 (GRCm38)	missense	probably benign	0.01
R2311:Tep1	UTSW	14	50,833,567 (GRCm38)	missense	possibly damaging	0.95
R2420:Tep1	UTSW	14	50,834,023 (GRCm38)	missense	probably benign
R2874:Tep1	UTSW	14	50,850,650 (GRCm38)	missense	possibly damaging	0.71
R3084:Tep1	UTSW	14	50,827,054 (GRCm38)	critical splice donor site	probably null
R3086:Tep1	UTSW	14	50,827,054 (GRCm38)	critical splice donor site	probably null
R3621:Tep1	UTSW	14	50,829,020 (GRCm38)	missense	probably damaging	0.99
R3815:Tep1	UTSW	14	50,868,315 (GRCm38)	missense	possibly damaging	0.71
R4124:Tep1	UTSW	14	50,843,734 (GRCm38)	missense	possibly damaging	0.93
R4125:Tep1	UTSW	14	50,843,734 (GRCm38)	missense	possibly damaging	0.93
R4127:Tep1	UTSW	14	50,843,734 (GRCm38)	missense	possibly damaging	0.93
R4134:Tep1	UTSW	14	50,844,860 (GRCm38)	missense	probably benign
R4152:Tep1	UTSW	14	50,837,594 (GRCm38)	missense	possibly damaging	0.72
R4153:Tep1	UTSW	14	50,837,594 (GRCm38)	missense	possibly damaging	0.72
R4191:Tep1	UTSW	14	50,836,806 (GRCm38)	missense	probably damaging	0.96
R4248:Tep1	UTSW	14	50,862,894 (GRCm38)	missense	possibly damaging	0.93
R4293:Tep1	UTSW	14	50,846,861 (GRCm38)	missense	probably benign
R4569:Tep1	UTSW	14	50,824,740 (GRCm38)	missense	probably benign	0.01
R4704:Tep1	UTSW	14	50,837,073 (GRCm38)	missense	probably benign	0.06
R4815:Tep1	UTSW	14	50,841,302 (GRCm38)	missense	probably damaging	0.99
R4978:Tep1	UTSW	14	50,845,434 (GRCm38)	missense	possibly damaging	0.93
R4989:Tep1	UTSW	14	50,839,000 (GRCm38)	missense	probably benign
R5057:Tep1	UTSW	14	50,828,999 (GRCm38)	missense	probably benign	0.27
R5063:Tep1	UTSW	14	50,850,627 (GRCm38)	missense	possibly damaging	0.86
R5118:Tep1	UTSW	14	50,855,587 (GRCm38)	splice site	probably null
R5128:Tep1	UTSW	14	50,844,279 (GRCm38)	makesense	probably null
R5149:Tep1	UTSW	14	50,837,398 (GRCm38)	nonsense	probably null
R5171:Tep1	UTSW	14	50,824,802 (GRCm38)	missense	probably benign	0.01
R5201:Tep1	UTSW	14	50,868,110 (GRCm38)	missense	probably benign	0.01
R5260:Tep1	UTSW	14	50,838,631 (GRCm38)	missense	probably benign
R5339:Tep1	UTSW	14	50,844,574 (GRCm38)	missense	probably damaging	0.99
R5384:Tep1	UTSW	14	50,868,317 (GRCm38)	missense	probably damaging	0.98
R5385:Tep1	UTSW	14	50,868,317 (GRCm38)	missense	probably damaging	0.98
R5386:Tep1	UTSW	14	50,868,317 (GRCm38)	missense	probably damaging	0.98
R5594:Tep1	UTSW	14	50,829,882 (GRCm38)	missense	possibly damaging	0.86
R5639:Tep1	UTSW	14	50,853,605 (GRCm38)	missense	possibly damaging	0.85
R5749:Tep1	UTSW	14	50,844,072 (GRCm38)	missense	possibly damaging	0.59
R5756:Tep1	UTSW	14	50,837,379 (GRCm38)	critical splice donor site	probably null
R6013:Tep1	UTSW	14	50,861,048 (GRCm38)	missense	probably damaging	0.97
R6014:Tep1	UTSW	14	50,847,000 (GRCm38)	missense	probably benign	0.12
R6248:Tep1	UTSW	14	50,830,258 (GRCm38)	missense	probably damaging	0.98
R6264:Tep1	UTSW	14	50,845,513 (GRCm38)	missense	probably damaging	0.99
R6363:Tep1	UTSW	14	50,824,548 (GRCm38)	missense	probably benign	0.04
R6381:Tep1	UTSW	14	50,845,431 (GRCm38)	missense	probably damaging	0.99
R6462:Tep1	UTSW	14	50,844,379 (GRCm38)	missense	probably benign
R6942:Tep1	UTSW	14	50,836,737 (GRCm38)	missense	possibly damaging	0.85
R6951:Tep1	UTSW	14	50,833,913 (GRCm38)	critical splice donor site	probably null
R6979:Tep1	UTSW	14	50,838,637 (GRCm38)	missense	possibly damaging	0.93
R6999:Tep1	UTSW	14	50,850,705 (GRCm38)	missense	possibly damaging	0.86
R7099:Tep1	UTSW	14	50,844,487 (GRCm38)	splice site	probably null
R7208:Tep1	UTSW	14	50,824,556 (GRCm38)	critical splice acceptor site	probably null
R7232:Tep1	UTSW	14	50,844,332 (GRCm38)	missense	unknown
R7249:Tep1	UTSW	14	50,824,275 (GRCm38)	missense	possibly damaging	0.86
R7325:Tep1	UTSW	14	50,866,038 (GRCm38)	missense	probably damaging	0.99
R7409:Tep1	UTSW	14	50,866,855 (GRCm38)	missense	possibly damaging	0.67
R7499:Tep1	UTSW	14	50,853,590 (GRCm38)	missense	probably damaging	0.99
R7542:Tep1	UTSW	14	50,862,491 (GRCm38)	nonsense	probably null
R7806:Tep1	UTSW	14	50,836,809 (GRCm38)	missense	possibly damaging	0.85
R7825:Tep1	UTSW	14	50,843,887 (GRCm38)	critical splice acceptor site	probably null
R7901:Tep1	UTSW	14	50,826,851 (GRCm38)	missense	possibly damaging	0.88
R7961:Tep1	UTSW	14	50,824,230 (GRCm38)	missense	possibly damaging	0.93
R7993:Tep1	UTSW	14	50,830,253 (GRCm38)	missense	probably benign	0.41
R8009:Tep1	UTSW	14	50,824,230 (GRCm38)	missense	possibly damaging	0.93
R8085:Tep1	UTSW	14	50,829,296 (GRCm38)	missense	probably benign	0.11
R8299:Tep1	UTSW	14	50,868,045 (GRCm38)	missense	probably benign	0.06
R8330:Tep1	UTSW	14	50,847,705 (GRCm38)	missense	possibly damaging	0.86
R8396:Tep1	UTSW	14	50,837,072 (GRCm38)	missense	probably benign	0.23
R8475:Tep1	UTSW	14	50,841,255 (GRCm38)	missense	probably damaging	1.00
R8695:Tep1	UTSW	14	50,845,437 (GRCm38)	missense	possibly damaging	0.85
R8726:Tep1	UTSW	14	50,847,623 (GRCm38)	missense	probably damaging	0.98
R8812:Tep1	UTSW	14	50,837,132 (GRCm38)	missense	probably damaging	0.98
R9152:Tep1	UTSW	14	50,866,705 (GRCm38)	missense	probably benign	0.14
R9269:Tep1	UTSW	14	50,844,309 (GRCm38)	missense	probably damaging	0.98
R9299:Tep1	UTSW	14	50,844,531 (GRCm38)	splice site	probably benign
R9365:Tep1	UTSW	14	50,827,140 (GRCm38)	missense	probably damaging	1.00
R9398:Tep1	UTSW	14	50,828,972 (GRCm38)	missense	possibly damaging	0.85
R9408:Tep1	UTSW	14	50,837,180 (GRCm38)	missense	possibly damaging	0.85
R9445:Tep1	UTSW	14	50,845,510 (GRCm38)	missense	possibly damaging	0.95
R9487:Tep1	UTSW	14	50,829,230 (GRCm38)	missense	possibly damaging	0.93
R9555:Tep1	UTSW	14	50,868,431 (GRCm38)	missense	possibly damaging	0.52
R9597:Tep1	UTSW	14	50,863,008 (GRCm38)	missense	probably damaging	0.99
R9715:Tep1	UTSW	14	50,844,302 (GRCm38)	missense
R9732:Tep1	UTSW	14	50,850,705 (GRCm38)	missense	probably benign	0.33
R9777:Tep1	UTSW	14	50,838,986 (GRCm38)	nonsense	probably null
RF007:Tep1	UTSW	14	50,860,945 (GRCm38)	missense	possibly damaging	0.92
X0024:Tep1	UTSW	14	50,827,119 (GRCm38)	missense	possibly damaging	0.86
X0060:Tep1	UTSW	14	50,836,764 (GRCm38)	missense	probably benign	0.25
Z1177:Tep1	UTSW	14	50,847,765 (GRCm38)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TTGCCCGAAAGCAGACACAG -3'
(R):5'- TGGTGTCCGGAAATGAAGC -3'

Sequencing Primer
(F):5'- GACAGATCCTAACAAAATGCTAGGCG -3'
(R):5'- TGACACTGTGGCAGCAAGC -3'

Posted On

2016-06-06