Incidental Mutation 'R5033:Vmn2r1'
ID 389337
Institutional Source Beutler Lab
Gene Symbol Vmn2r1
Ensembl Gene ENSMUSG00000027824
Gene Name vomeronasal 2, receptor 1
Synonyms V2r83, EG56544
MMRRC Submission 042624-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R5033 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 63988968-64016905 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 64012501 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 787 (D787E)
Ref Sequence ENSEMBL: ENSMUSP00000029406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029406]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000029406
AA Change: D787E

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000029406
Gene: ENSMUSG00000027824
AA Change: D787E

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 86 504 6e-92 PFAM
Pfam:NCD3G 546 599 2.4e-17 PFAM
Pfam:7tm_3 632 866 4.1e-48 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158414
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 88 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
9930111J21Rik1 G A 11: 48,838,533 (GRCm39) R685W probably damaging Het
Arhgap10 A T 8: 78,109,386 (GRCm39) L399H probably damaging Het
Arih2 AGCCG AG 9: 108,488,859 (GRCm39) probably benign Het
Atp13a2 A G 4: 140,728,132 (GRCm39) H575R possibly damaging Het
Bbof1 G A 12: 84,458,044 (GRCm39) probably null Het
Bltp3a A G 17: 28,105,838 (GRCm39) E788G probably damaging Het
Catsperg2 A C 7: 29,409,559 (GRCm39) Y545D possibly damaging Het
Cdc42bpa T A 1: 179,892,580 (GRCm39) I248N probably damaging Het
Cdk11b A T 4: 155,733,282 (GRCm39) probably benign Het
Cfap46 C A 7: 139,183,776 (GRCm39) L90F probably benign Het
Cndp2 A G 18: 84,688,954 (GRCm39) L276P possibly damaging Het
Col3a1 A C 1: 45,385,270 (GRCm39) D129A probably damaging Het
Daam1 C A 12: 71,993,294 (GRCm39) H354Q unknown Het
Dnah5 T A 15: 28,421,824 (GRCm39) F3892Y probably damaging Het
Dnajb3 A G 1: 88,132,745 (GRCm39) V219A possibly damaging Het
Drd5 A G 5: 38,477,544 (GRCm39) H179R probably damaging Het
Dym A G 18: 75,252,232 (GRCm39) N333D possibly damaging Het
Eif2b3 A G 4: 116,909,933 (GRCm39) D156G probably damaging Het
Emc1 A G 4: 139,099,007 (GRCm39) D830G probably damaging Het
F13a1 A C 13: 37,172,830 (GRCm39) I183M probably damaging Het
Fam136b-ps T A 15: 31,277,043 (GRCm39) probably benign Het
Fdft1 C A 14: 63,400,853 (GRCm39) K93N probably damaging Het
Garre1 C T 7: 33,945,237 (GRCm39) G336S probably benign Het
Gcc2 A G 10: 58,114,628 (GRCm39) D959G probably damaging Het
Gp2 A G 7: 119,053,514 (GRCm39) V149A probably damaging Het
Gpc1 G A 1: 92,784,751 (GRCm39) G308D probably damaging Het
Hdac9 A T 12: 34,423,906 (GRCm39) C587S probably benign Het
Hspg2 C T 4: 137,246,251 (GRCm39) R1010C probably damaging Het
Iars2 A G 1: 185,050,125 (GRCm39) V453A possibly damaging Het
Il1r1 T G 1: 40,332,684 (GRCm39) C121W probably damaging Het
Inhca A G 9: 103,156,613 (GRCm39) V149A probably benign Het
Jazf1 A G 6: 52,754,525 (GRCm39) Y184H probably damaging Het
Kel A T 6: 41,675,989 (GRCm39) Y234N probably damaging Het
Khk G A 5: 31,087,004 (GRCm39) G186D probably damaging Het
Klf4 A T 4: 55,530,301 (GRCm39) M270K probably benign Het
Kmt2c G A 5: 25,519,706 (GRCm39) L2135F probably benign Het
Krtap15-1 A G 16: 88,626,044 (GRCm39) Y37C probably damaging Het
Lars1 A G 18: 42,347,841 (GRCm39) F994S possibly damaging Het
Ldc1 C T 4: 130,115,408 (GRCm39) probably null Het
Lrp8 T C 4: 107,691,952 (GRCm39) probably null Het
Lrrc2 A T 9: 110,809,987 (GRCm39) D341V probably damaging Het
Map4k4 A G 1: 40,046,662 (GRCm39) K646R probably damaging Het
Mrps9 T A 1: 42,934,491 (GRCm39) probably null Het
Or10ag60 T A 2: 87,438,055 (GRCm39) C108S probably damaging Het
Or11h6 T A 14: 50,880,619 (GRCm39) Y288N probably damaging Het
Or8c20 C T 9: 38,260,924 (GRCm39) H176Y probably damaging Het
Pcnt A T 10: 76,235,779 (GRCm39) C1401S possibly damaging Het
Pdgfrb A T 18: 61,210,740 (GRCm39) K749M probably damaging Het
Pigo A T 4: 43,019,412 (GRCm39) W969R probably null Het
Pigr A T 1: 130,772,436 (GRCm39) Y218F probably damaging Het
Pih1d1 A G 7: 44,804,278 (GRCm39) probably benign Het
Pik3cg A T 12: 32,249,195 (GRCm39) probably null Het
Pik3r6 A T 11: 68,424,294 (GRCm39) K300* probably null Het
Pip5k1c A G 10: 81,141,084 (GRCm39) D64G probably damaging Het
Piwil2 A T 14: 70,659,042 (GRCm39) I161K possibly damaging Het
Pou3f1 A G 4: 124,552,449 (GRCm39) E317G probably damaging Het
Prdm8 C T 5: 98,333,071 (GRCm39) Q213* probably null Het
Prpf6 T A 2: 181,291,899 (GRCm39) C739S possibly damaging Het
Psmc3 T A 2: 90,884,953 (GRCm39) S40T probably benign Het
Psmd3 A T 11: 98,573,650 (GRCm39) D32V probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rapgef6 A T 11: 54,582,207 (GRCm39) H1373L possibly damaging Het
Rnf207 A C 4: 152,397,666 (GRCm39) S328A probably benign Het
Ros1 C T 10: 52,004,512 (GRCm39) probably null Het
Ryr2 T A 13: 11,602,140 (GRCm39) I4581F possibly damaging Het
Sacm1l C T 9: 123,415,464 (GRCm39) R480W probably damaging Het
Sec16a A G 2: 26,309,661 (GRCm39) V664A probably benign Het
Selenoo T A 15: 88,976,969 (GRCm39) M207K probably damaging Het
Sh3tc2 G A 18: 62,147,962 (GRCm39) probably null Het
Slc28a2b T A 2: 122,353,395 (GRCm39) probably null Het
Slco2b1 G T 7: 99,309,256 (GRCm39) Q692K probably benign Het
Slfn4 A T 11: 83,077,623 (GRCm39) D137V probably damaging Het
Srrm2 G A 17: 24,039,592 (GRCm39) A2175T probably damaging Het
Stard9 T A 2: 120,523,880 (GRCm39) C692S probably benign Het
Sulf2 T A 2: 165,923,542 (GRCm39) D559V probably benign Het
Tbpl2 T C 2: 23,977,170 (GRCm39) I283V probably benign Het
Tmem19 A G 10: 115,195,666 (GRCm39) F46S probably benign Het
Trp63 T A 16: 25,582,056 (GRCm39) Y35N probably damaging Het
Ttn T A 2: 76,716,786 (GRCm39) probably benign Het
Ube2z A T 11: 95,941,148 (GRCm39) H331Q probably benign Het
Ubr1 C T 2: 120,742,478 (GRCm39) probably null Het
Vmn1r235 A T 17: 21,482,550 (GRCm39) I292F possibly damaging Het
Vmn2r3 A G 3: 64,167,220 (GRCm39) V637A probably benign Het
Xpnpep1 C A 19: 52,994,606 (GRCm39) V341L probably benign Het
Yme1l1 A G 2: 23,084,759 (GRCm39) D619G probably damaging Het
Zfp597 G A 16: 3,684,502 (GRCm39) P85S probably damaging Het
Zscan20 A G 4: 128,479,921 (GRCm39) S857P probably benign Het
Other mutations in Vmn2r1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Vmn2r1 APN 3 64,012,389 (GRCm39) nonsense probably null
IGL00335:Vmn2r1 APN 3 64,012,809 (GRCm39) missense probably damaging 0.96
IGL01509:Vmn2r1 APN 3 64,010,466 (GRCm39) missense probably benign 0.03
IGL01641:Vmn2r1 APN 3 64,011,924 (GRCm39) missense probably benign 0.19
IGL01656:Vmn2r1 APN 3 63,989,274 (GRCm39) missense probably damaging 0.96
IGL01927:Vmn2r1 APN 3 63,989,105 (GRCm39) missense probably benign 0.01
IGL02093:Vmn2r1 APN 3 64,012,130 (GRCm39) missense probably benign
IGL02146:Vmn2r1 APN 3 64,012,104 (GRCm39) missense probably benign 0.39
IGL02186:Vmn2r1 APN 3 63,989,138 (GRCm39) missense probably benign 0.01
IGL02320:Vmn2r1 APN 3 63,989,180 (GRCm39) missense possibly damaging 0.61
IGL02423:Vmn2r1 APN 3 63,997,665 (GRCm39) missense probably benign 0.00
IGL02709:Vmn2r1 APN 3 64,012,355 (GRCm39) missense probably benign 0.24
R0034:Vmn2r1 UTSW 3 63,997,435 (GRCm39) missense probably damaging 1.00
R0064:Vmn2r1 UTSW 3 64,012,209 (GRCm39) missense possibly damaging 0.76
R0152:Vmn2r1 UTSW 3 63,989,240 (GRCm39) missense possibly damaging 0.92
R0305:Vmn2r1 UTSW 3 63,997,087 (GRCm39) missense probably damaging 1.00
R0314:Vmn2r1 UTSW 3 63,993,980 (GRCm39) missense probably damaging 1.00
R0317:Vmn2r1 UTSW 3 63,989,240 (GRCm39) missense possibly damaging 0.92
R0465:Vmn2r1 UTSW 3 63,989,180 (GRCm39) missense possibly damaging 0.61
R1144:Vmn2r1 UTSW 3 63,997,541 (GRCm39) missense probably damaging 1.00
R1163:Vmn2r1 UTSW 3 63,994,046 (GRCm39) missense probably benign 0.03
R1448:Vmn2r1 UTSW 3 64,008,734 (GRCm39) missense probably damaging 1.00
R1491:Vmn2r1 UTSW 3 63,997,034 (GRCm39) missense probably damaging 1.00
R1543:Vmn2r1 UTSW 3 63,996,994 (GRCm39) missense probably damaging 1.00
R1611:Vmn2r1 UTSW 3 64,011,958 (GRCm39) nonsense probably null
R1676:Vmn2r1 UTSW 3 63,997,603 (GRCm39) nonsense probably null
R1727:Vmn2r1 UTSW 3 63,989,163 (GRCm39) missense probably benign
R1851:Vmn2r1 UTSW 3 64,008,926 (GRCm39) missense probably benign 0.32
R3080:Vmn2r1 UTSW 3 63,997,205 (GRCm39) missense probably damaging 1.00
R3790:Vmn2r1 UTSW 3 63,994,185 (GRCm39) critical splice donor site probably null
R4111:Vmn2r1 UTSW 3 63,997,176 (GRCm39) missense probably benign 0.23
R4689:Vmn2r1 UTSW 3 64,012,074 (GRCm39) missense possibly damaging 0.94
R4747:Vmn2r1 UTSW 3 63,989,267 (GRCm39) missense probably benign 0.00
R4970:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5086:Vmn2r1 UTSW 3 63,997,418 (GRCm39) missense probably benign 0.00
R5112:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5385:Vmn2r1 UTSW 3 64,008,819 (GRCm39) missense possibly damaging 0.89
R5629:Vmn2r1 UTSW 3 64,012,538 (GRCm39) missense possibly damaging 0.87
R5762:Vmn2r1 UTSW 3 63,997,474 (GRCm39) missense probably benign 0.24
R5867:Vmn2r1 UTSW 3 64,011,990 (GRCm39) missense probably benign
R5893:Vmn2r1 UTSW 3 63,993,974 (GRCm39) missense probably damaging 1.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6290:Vmn2r1 UTSW 3 64,012,873 (GRCm39) missense probably benign 0.02
R6443:Vmn2r1 UTSW 3 64,012,374 (GRCm39) missense possibly damaging 0.78
R6464:Vmn2r1 UTSW 3 64,008,766 (GRCm39) missense probably benign
R6826:Vmn2r1 UTSW 3 64,012,567 (GRCm39) nonsense probably null
R6874:Vmn2r1 UTSW 3 64,012,376 (GRCm39) missense probably damaging 1.00
R6882:Vmn2r1 UTSW 3 63,997,529 (GRCm39) missense possibly damaging 0.64
R6983:Vmn2r1 UTSW 3 63,989,118 (GRCm39) missense probably benign
R7010:Vmn2r1 UTSW 3 64,012,146 (GRCm39) missense probably benign 0.19
R7144:Vmn2r1 UTSW 3 63,997,362 (GRCm39) missense probably damaging 1.00
R7341:Vmn2r1 UTSW 3 64,012,877 (GRCm39) makesense probably null
R7510:Vmn2r1 UTSW 3 63,993,922 (GRCm39) missense probably damaging 1.00
R7557:Vmn2r1 UTSW 3 63,997,475 (GRCm39) missense probably damaging 0.99
R7895:Vmn2r1 UTSW 3 63,997,130 (GRCm39) missense possibly damaging 0.90
R8108:Vmn2r1 UTSW 3 64,010,471 (GRCm39) missense probably damaging 0.98
R8209:Vmn2r1 UTSW 3 63,997,199 (GRCm39) missense possibly damaging 0.64
R8365:Vmn2r1 UTSW 3 63,994,034 (GRCm39) missense possibly damaging 0.80
R8514:Vmn2r1 UTSW 3 63,993,942 (GRCm39) missense probably benign 0.11
R8554:Vmn2r1 UTSW 3 63,997,334 (GRCm39) missense probably damaging 0.98
R8980:Vmn2r1 UTSW 3 64,010,501 (GRCm39) missense
R9140:Vmn2r1 UTSW 3 63,997,465 (GRCm39) missense probably benign 0.05
R9239:Vmn2r1 UTSW 3 64,011,959 (GRCm39) missense probably damaging 0.99
R9441:Vmn2r1 UTSW 3 64,012,674 (GRCm39) missense probably damaging 1.00
R9549:Vmn2r1 UTSW 3 63,997,493 (GRCm39) missense probably benign 0.17
R9771:Vmn2r1 UTSW 3 63,997,559 (GRCm39) missense possibly damaging 0.79
X0065:Vmn2r1 UTSW 3 63,997,678 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AACCCGTCTTATATCCATGCAC -3'
(R):5'- GCCATAGCTAGATGCCAAAATG -3'

Sequencing Primer
(F):5'- GCACCCCATTTTTCGAAAATTAATTG -3'
(R):5'- GGCAAATATTTCCACAGCCACTTTG -3'
Posted On 2016-06-06