Mutagenetix > Incidental Mutation

Incidental Mutation 'R5033:Ptpro'

389362

Institutional Source

Beutler Lab

Gene Symbol

Ptpro

Ensembl Gene

ENSMUSG00000030223

Gene Name

protein tyrosine phosphatase, receptor type, O

Synonyms

Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi, D28, PTPROt

MMRRC Submission

042624-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5033 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

137252319-137463233 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 137443594 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 1007 (V1007D)

Ref Sequence

ENSEMBL: ENSMUSP00000127112 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077115] [ENSMUST00000167002] [ENSMUST00000167679] [ENSMUST00000203914]

AlphaFold

E9Q612

Predicted Effect

probably damaging
Transcript: ENSMUST00000077115
AA Change: V1035D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000076364
Gene: ENSMUSG00000030223
AA Change: V1035D

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
transmembrane domain	890	912	N/A	INTRINSIC
PTPc	947	1207	1.43e-127	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000167002
AA Change: V214D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131764
Gene: ENSMUSG00000030223
AA Change: V214D

Domain	Start	End	E-Value	Type
transmembrane domain	10	32	N/A	INTRINSIC
transmembrane domain	69	91	N/A	INTRINSIC
PTPc	126	386	1.43e-127	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000167679
AA Change: V1007D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000127112
Gene: ENSMUSG00000030223
AA Change: V1007D

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
PTPc	919	1179	1.43e-127	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000203914
AA Change: V186D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000144870
Gene: ENSMUSG00000030223
AA Change: V186D

Domain	Start	End	E-Value	Type
signal peptide	1	33	N/A	INTRINSIC
PTPc	98	358	6.1e-130	SMART

Meta Mutation Damage Score

0.9197

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.4%
20x: 92.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
PHENOTYPE: Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 88 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1300017J02Rik	A	G	9: 103,279,414 (GRCm38)	V149A	probably benign	Het
1700012B07Rik	G	T	11: 109,794,154 (GRCm38)	C172*	probably null	Het
4931406P16Rik	C	T	7: 34,245,812 (GRCm38)	G336S	probably benign	Het
9930111J21Rik1	G	A	11: 48,947,706 (GRCm38)	R685W	probably damaging	Het
Arhgap10	A	T	8: 77,382,757 (GRCm38)	L399H	probably damaging	Het
Arih2	AGCCG	AG	9: 108,611,660 (GRCm38)		probably benign	Het
Atp13a2	A	G	4: 141,000,821 (GRCm38)	H575R	possibly damaging	Het
Bbof1	G	A	12: 84,411,270 (GRCm38)		probably null	Het
Catsperg2	A	C	7: 29,710,134 (GRCm38)	Y545D	possibly damaging	Het
Cdc42bpa	T	A	1: 180,065,015 (GRCm38)	I248N	probably damaging	Het
Cdk11b	A	T	4: 155,648,825 (GRCm38)		probably benign	Het
Cfap46	C	A	7: 139,603,860 (GRCm38)	L90F	probably benign	Het
Cndp2	A	G	18: 84,670,829 (GRCm38)	L276P	possibly damaging	Het
Col3a1	A	C	1: 45,346,110 (GRCm38)	D129A	probably damaging	Het
Daam1	C	A	12: 71,946,520 (GRCm38)	H354Q	unknown	Het
Dnah5	T	A	15: 28,421,678 (GRCm38)	F3892Y	probably damaging	Het
Dnajb3	A	G	1: 88,205,023 (GRCm38)	V219A	possibly damaging	Het
Drd5	A	G	5: 38,320,201 (GRCm38)	H179R	probably damaging	Het
Dym	A	G	18: 75,119,161 (GRCm38)	N333D	possibly damaging	Het
Eif2b3	A	G	4: 117,052,736 (GRCm38)	D156G	probably damaging	Het
Emc1	A	G	4: 139,371,696 (GRCm38)	D830G	probably damaging	Het
F13a1	A	C	13: 36,988,856 (GRCm38)	I183M	probably damaging	Het
Fam136b-ps	T	A	15: 31,276,897 (GRCm38)		probably benign	Het
Fdft1	C	A	14: 63,163,404 (GRCm38)	K93N	probably damaging	Het
Gcc2	A	G	10: 58,278,806 (GRCm38)	D959G	probably damaging	Het
Gm14085	T	A	2: 122,522,914 (GRCm38)		probably null	Het
Gm853	C	T	4: 130,221,615 (GRCm38)		probably null	Het
Gp2	A	G	7: 119,454,291 (GRCm38)	V149A	probably damaging	Het
Gpc1	G	A	1: 92,857,029 (GRCm38)	G308D	probably damaging	Het
Hdac9	A	T	12: 34,373,907 (GRCm38)	C587S	probably benign	Het
Hspg2	C	T	4: 137,518,940 (GRCm38)	R1010C	probably damaging	Het
Iars2	A	G	1: 185,317,928 (GRCm38)	V453A	possibly damaging	Het
Il1r1	T	G	1: 40,293,524 (GRCm38)	C121W	probably damaging	Het
Jazf1	A	G	6: 52,777,540 (GRCm38)	Y184H	probably damaging	Het
Kel	A	T	6: 41,699,055 (GRCm38)	Y234N	probably damaging	Het
Khk	G	A	5: 30,929,660 (GRCm38)	G186D	probably damaging	Het
Klf4	A	T	4: 55,530,301 (GRCm38)	M270K	probably benign	Het
Kmt2c	G	A	5: 25,314,708 (GRCm38)	L2135F	probably benign	Het
Krtap15	A	G	16: 88,829,156 (GRCm38)	Y37C	probably damaging	Het
Lars	A	G	18: 42,214,776 (GRCm38)	F994S	possibly damaging	Het
Lrp8	T	C	4: 107,834,755 (GRCm38)		probably null	Het
Lrrc2	A	T	9: 110,980,919 (GRCm38)	D341V	probably damaging	Het
Map4k4	A	G	1: 40,007,502 (GRCm38)	K646R	probably damaging	Het
Mrps9	T	A	1: 42,895,331 (GRCm38)		probably null	Het
Olfr1130	T	A	2: 87,607,711 (GRCm38)	C108S	probably damaging	Het
Olfr745	T	A	14: 50,643,162 (GRCm38)	Y288N	probably damaging	Het
Olfr898	C	T	9: 38,349,628 (GRCm38)	H176Y	probably damaging	Het
Pcnt	A	T	10: 76,399,945 (GRCm38)	C1401S	possibly damaging	Het
Pdgfrb	A	T	18: 61,077,668 (GRCm38)	K749M	probably damaging	Het
Pigo	A	T	4: 43,019,412 (GRCm38)	W969R	probably null	Het
Pigr	A	T	1: 130,844,699 (GRCm38)	Y218F	probably damaging	Het
Pih1d1	A	G	7: 45,154,854 (GRCm38)		probably benign	Het
Pik3cg	A	T	12: 32,199,196 (GRCm38)		probably null	Het
Pik3r6	A	T	11: 68,533,468 (GRCm38)	K300*	probably null	Het
Pip5k1c	A	G	10: 81,305,250 (GRCm38)	D64G	probably damaging	Het
Piwil2	A	T	14: 70,421,593 (GRCm38)	I161K	possibly damaging	Het
Pou3f1	A	G	4: 124,658,656 (GRCm38)	E317G	probably damaging	Het
Prdm8	C	T	5: 98,185,212 (GRCm38)	Q213*	probably null	Het
Prpf6	T	A	2: 181,650,106 (GRCm38)	C739S	possibly damaging	Het
Psmc3	T	A	2: 91,054,608 (GRCm38)	S40T	probably benign	Het
Psmd3	A	T	11: 98,682,824 (GRCm38)	D32V	probably damaging	Het
Rapgef6	A	T	11: 54,691,381 (GRCm38)	H1373L	possibly damaging	Het
Rnf207	A	C	4: 152,313,209 (GRCm38)	S328A	probably benign	Het
Ros1	C	T	10: 52,128,416 (GRCm38)		probably null	Het
Ryr2	T	A	13: 11,587,254 (GRCm38)	I4581F	possibly damaging	Het
Sacm1l	C	T	9: 123,586,399 (GRCm38)	R480W	probably damaging	Het
Sec16a	A	G	2: 26,419,649 (GRCm38)	V664A	probably benign	Het
Selenoo	T	A	15: 89,092,766 (GRCm38)	M207K	probably damaging	Het
Sh3tc2	G	A	18: 62,014,891 (GRCm38)		probably null	Het
Slco2b1	G	T	7: 99,660,049 (GRCm38)	Q692K	probably benign	Het
Slfn4	A	T	11: 83,186,797 (GRCm38)	D137V	probably damaging	Het
Srrm2	G	A	17: 23,820,618 (GRCm38)	A2175T	probably damaging	Het
Stard9	T	A	2: 120,693,399 (GRCm38)	C692S	probably benign	Het
Sulf2	T	A	2: 166,081,622 (GRCm38)	D559V	probably benign	Het
Tbpl2	T	C	2: 24,087,158 (GRCm38)	I283V	probably benign	Het
Tmem19	A	G	10: 115,359,761 (GRCm38)	F46S	probably benign	Het
Trp63	T	A	16: 25,763,306 (GRCm38)	Y35N	probably damaging	Het
Ttn	T	A	2: 76,886,442 (GRCm38)		probably benign	Het
Ube2z	A	T	11: 96,050,322 (GRCm38)	H331Q	probably benign	Het
Ubr1	C	T	2: 120,911,997 (GRCm38)		probably null	Het
Uhrf1bp1	A	G	17: 27,886,864 (GRCm38)	E788G	probably damaging	Het
Vmn1r235	A	T	17: 21,262,288 (GRCm38)	I292F	possibly damaging	Het
Vmn2r1	T	A	3: 64,105,080 (GRCm38)	D787E	probably damaging	Het
Vmn2r3	A	G	3: 64,259,799 (GRCm38)	V637A	probably benign	Het
Xpnpep1	C	A	19: 53,006,175 (GRCm38)	V341L	probably benign	Het
Yme1l1	A	G	2: 23,194,747 (GRCm38)	D619G	probably damaging	Het
Zfp597	G	A	16: 3,866,638 (GRCm38)	P85S	probably damaging	Het
Zscan20	A	G	4: 128,586,128 (GRCm38)	S857P	probably benign	Het

Other mutations in Ptpro

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Ptpro	APN	6	137,394,909 (GRCm38)	critical splice donor site	probably null
IGL00844:Ptpro	APN	6	137,414,239 (GRCm38)	missense	probably damaging	1.00
IGL00983:Ptpro	APN	6	137,418,248 (GRCm38)	missense	probably benign	0.01
IGL01073:Ptpro	APN	6	137,377,088 (GRCm38)	missense	probably damaging	1.00
IGL01832:Ptpro	APN	6	137,393,668 (GRCm38)	missense	possibly damaging	0.93
IGL02308:Ptpro	APN	6	137,454,700 (GRCm38)	missense	probably benign	0.37
IGL02387:Ptpro	APN	6	137,410,980 (GRCm38)	missense	probably damaging	0.96
IGL02605:Ptpro	APN	6	137,380,318 (GRCm38)	missense	probably benign	0.02
IGL02666:Ptpro	APN	6	137,378,059 (GRCm38)	missense	probably damaging	0.96
IGL03275:Ptpro	APN	6	137,450,006 (GRCm38)	missense	probably damaging	1.00
Brau	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
court	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
Hoff	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
Jester	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
mann	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0020:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0022:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0023:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0024:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0103:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0106:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0316:Ptpro	UTSW	6	137,376,989 (GRCm38)	missense	possibly damaging	0.81
R0427:Ptpro	UTSW	6	137,368,296 (GRCm38)	missense	possibly damaging	0.81
R0456:Ptpro	UTSW	6	137,414,230 (GRCm38)	missense	probably benign	0.04
R0536:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0537:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0552:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0555:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0664:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0708:Ptpro	UTSW	6	137,386,253 (GRCm38)	missense	probably benign	0.26
R0730:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0735:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0738:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0786:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0811:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0812:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0881:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0973:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1259:Ptpro	UTSW	6	137,392,741 (GRCm38)	missense	probably damaging	0.98
R1340:Ptpro	UTSW	6	137,441,081 (GRCm38)	missense	possibly damaging	0.95
R1381:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1382:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1385:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1396:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1401:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1416:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1422:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1448:Ptpro	UTSW	6	137,441,116 (GRCm38)	missense	probably damaging	1.00
R1513:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1518:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1526:Ptpro	UTSW	6	137,461,726 (GRCm38)	missense	probably damaging	1.00
R1540:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1571:Ptpro	UTSW	6	137,378,130 (GRCm38)	missense	probably benign
R1573:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1587:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1588:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1649:Ptpro	UTSW	6	137,444,017 (GRCm38)	nonsense	probably null
R1700:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1701:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1745:Ptpro	UTSW	6	137,400,645 (GRCm38)	missense	probably benign	0.03
R1772:Ptpro	UTSW	6	137,430,743 (GRCm38)	missense	probably damaging	1.00
R1911:Ptpro	UTSW	6	137,400,619 (GRCm38)	splice site	probably benign
R1958:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1967:Ptpro	UTSW	6	137,416,865 (GRCm38)	missense	probably benign	0.38
R2025:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2026:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2040:Ptpro	UTSW	6	137,386,164 (GRCm38)	splice site	probably benign
R2115:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2117:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2130:Ptpro	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R2161:Ptpro	UTSW	6	137,449,887 (GRCm38)	missense	probably benign	0.01
R2431:Ptpro	UTSW	6	137,443,585 (GRCm38)	nonsense	probably null
R2915:Ptpro	UTSW	6	137,414,241 (GRCm38)	start gained	probably benign
R2988:Ptpro	UTSW	6	137,443,599 (GRCm38)	nonsense	probably null
R3772:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3773:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3795:Ptpro	UTSW	6	137,380,309 (GRCm38)	missense	probably benign
R3885:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3886:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3887:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3888:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3893:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4032:Ptpro	UTSW	6	137,461,742 (GRCm38)	missense	probably damaging	1.00
R4133:Ptpro	UTSW	6	137,420,372 (GRCm38)	missense	probably damaging	1.00
R4377:Ptpro	UTSW	6	137,380,266 (GRCm38)	missense	probably benign	0.26
R4455:Ptpro	UTSW	6	137,393,659 (GRCm38)	missense	probably damaging	1.00
R4613:Ptpro	UTSW	6	137,416,836 (GRCm38)	nonsense	probably null
R4827:Ptpro	UTSW	6	137,442,710 (GRCm38)	missense	probably damaging	1.00
R4863:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4870:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R4910:Ptpro	UTSW	6	137,368,338 (GRCm38)	missense	probably damaging	0.99
R4932:Ptpro	UTSW	6	137,411,105 (GRCm38)	nonsense	probably null
R4941:Ptpro	UTSW	6	137,392,765 (GRCm38)	missense	probably damaging	1.00
R4989:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5009:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R5032:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5162:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5393:Ptpro	UTSW	6	137,380,224 (GRCm38)	missense	probably benign	0.04
R5423:Ptpro	UTSW	6	137,442,707 (GRCm38)	missense	probably damaging	1.00
R5782:Ptpro	UTSW	6	137,399,498 (GRCm38)	missense	possibly damaging	0.80
R6103:Ptpro	UTSW	6	137,400,706 (GRCm38)	missense	possibly damaging	0.76
R6239:Ptpro	UTSW	6	137,380,608 (GRCm38)	missense	probably benign	0.28
R6488:Ptpro	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
R6494:Ptpro	UTSW	6	137,382,642 (GRCm38)	missense	probably benign	0.20
R6746:Ptpro	UTSW	6	137,394,823 (GRCm38)	missense	probably damaging	1.00
R6763:Ptpro	UTSW	6	137,418,281 (GRCm38)	splice site	probably null
R6888:Ptpro	UTSW	6	137,380,200 (GRCm38)	missense	probably benign	0.30
R6983:Ptpro	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
R7019:Ptpro	UTSW	6	137,380,478 (GRCm38)	missense	probably benign
R7218:Ptpro	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
R7236:Ptpro	UTSW	6	137,368,337 (GRCm38)	missense	probably damaging	1.00
R7299:Ptpro	UTSW	6	137,441,144 (GRCm38)	critical splice donor site	probably null
R7381:Ptpro	UTSW	6	137,399,561 (GRCm38)	missense	possibly damaging	0.93
R7493:Ptpro	UTSW	6	137,382,649 (GRCm38)	missense	probably benign	0.01
R7733:Ptpro	UTSW	6	137,414,286 (GRCm38)	nonsense	probably null
R7793:Ptpro	UTSW	6	137,416,820 (GRCm38)	missense	probably damaging	0.99
R7804:Ptpro	UTSW	6	137,399,601 (GRCm38)	splice site	probably null
R7833:Ptpro	UTSW	6	137,416,863 (GRCm38)	nonsense	probably null
R7859:Ptpro	UTSW	6	137,392,807 (GRCm38)	critical splice donor site	probably null
R7873:Ptpro	UTSW	6	137,430,739 (GRCm38)	missense	probably benign	0.44
R8042:Ptpro	UTSW	6	137,416,883 (GRCm38)	missense	possibly damaging	0.71
R8859:Ptpro	UTSW	6	137,426,784 (GRCm38)	nonsense	probably null
R8979:Ptpro	UTSW	6	137,368,142 (GRCm38)	missense	probably benign
R9138:Ptpro	UTSW	6	137,411,115 (GRCm38)	critical splice donor site	probably null
R9309:Ptpro	UTSW	6	137,454,658 (GRCm38)	missense	probably damaging	1.00
R9420:Ptpro	UTSW	6	137,443,935 (GRCm38)	missense	probably benign	0.08
R9612:Ptpro	UTSW	6	137,414,320 (GRCm38)	missense	probably benign	0.31
R9625:Ptpro	UTSW	6	137,394,875 (GRCm38)	missense	probably damaging	1.00
R9697:Ptpro	UTSW	6	137,386,290 (GRCm38)	missense	probably damaging	1.00
R9715:Ptpro	UTSW	6	137,368,110 (GRCm38)	missense	probably damaging	0.96
Z1177:Ptpro	UTSW	6	137,378,140 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTGTGTGATCCTCTGCCAAC -3'
(R):5'- AAAAGAATGATGCAGCCCCATG -3'

Sequencing Primer
(F):5'- TTCGTCATCAGCAAAAACGG -3'
(R):5'- TGCAGCCCCATGAAGAAG -3'

Posted On

2016-06-06