Incidental Mutation 'R5033:Rapgef6'
| ID |
389386 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rapgef6
|
| Ensembl Gene |
ENSMUSG00000037533 |
| Gene Name |
Rap guanine nucleotide exchange factor (GEF) 6 |
| Synonyms |
PDZ-GEF2, Pdzgef2, C030018K18Rik, RA-GEF-2 |
| MMRRC Submission |
042624-MU
|
| Accession Numbers |
Genbank: NM_175258; MGI: 2384761 |
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5033 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
54522847-54699285 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 54691381 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 1373
(H1373L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099804
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094536]
[ENSMUST00000101206]
[ENSMUST00000102743]
[ENSMUST00000108894]
[ENSMUST00000207429]
|
| AlphaFold |
Q5NCJ1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094536
|
| SMART Domains |
Protein: ENSMUSP00000092114
Gene: ENSMUSG00000037533
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
853 |
3.88e-84 |
SMART |
|
low complexity region
|
944 |
957 |
N/A |
INTRINSIC |
|
low complexity region
|
972 |
989 |
N/A |
INTRINSIC |
|
low complexity region
|
1016 |
1061 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000101206
AA Change: H1381L
PolyPhen 2
Score 0.919 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000098766
Gene: ENSMUSG00000037533
AA Change: H1381L
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.45e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1095 |
5.35e-87 |
SMART |
|
low complexity region
|
1237 |
1250 |
N/A |
INTRINSIC |
|
low complexity region
|
1270 |
1293 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1364 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1452 |
N/A |
INTRINSIC |
|
low complexity region
|
1555 |
1568 |
N/A |
INTRINSIC |
|
low complexity region
|
1591 |
1604 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000102743
AA Change: H1373L
PolyPhen 2
Score 0.919 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000099804
Gene: ENSMUSG00000037533
AA Change: H1373L
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.42e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1138 |
3.88e-84 |
SMART |
|
low complexity region
|
1229 |
1242 |
N/A |
INTRINSIC |
|
low complexity region
|
1262 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1337 |
1356 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1372 |
N/A |
INTRINSIC |
|
low complexity region
|
1436 |
1444 |
N/A |
INTRINSIC |
|
low complexity region
|
1547 |
1560 |
N/A |
INTRINSIC |
|
low complexity region
|
1583 |
1596 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108894
|
| SMART Domains |
Protein: ENSMUSP00000104522
Gene: ENSMUSG00000037533
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
|
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
|
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
|
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
|
RA
|
464 |
550 |
1.47e-20 |
SMART |
|
RasGEF
|
571 |
810 |
5.35e-87 |
SMART |
|
low complexity region
|
952 |
965 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
997 |
N/A |
INTRINSIC |
|
low complexity region
|
1024 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136494
|
| SMART Domains |
Protein: ENSMUSP00000114574
Gene: ENSMUSG00000037533
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
47 |
55 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000207429
AA Change: H1378L
PolyPhen 2
Score 0.730 (Sensitivity: 0.86; Specificity: 0.92)
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(16) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(13) |
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1300017J02Rik |
A |
G |
9: 103,279,414 (GRCm38) |
V149A |
probably benign |
Het |
| 1700012B07Rik |
G |
T |
11: 109,794,154 (GRCm38) |
C172* |
probably null |
Het |
| 4931406P16Rik |
C |
T |
7: 34,245,812 (GRCm38) |
G336S |
probably benign |
Het |
| 9930111J21Rik1 |
G |
A |
11: 48,947,706 (GRCm38) |
R685W |
probably damaging |
Het |
| Arhgap10 |
A |
T |
8: 77,382,757 (GRCm38) |
L399H |
probably damaging |
Het |
| Arih2 |
AGCCG |
AG |
9: 108,611,660 (GRCm38) |
|
probably benign |
Het |
| Atp13a2 |
A |
G |
4: 141,000,821 (GRCm38) |
H575R |
possibly damaging |
Het |
| Bbof1 |
G |
A |
12: 84,411,270 (GRCm38) |
|
probably null |
Het |
| Catsperg2 |
A |
C |
7: 29,710,134 (GRCm38) |
Y545D |
possibly damaging |
Het |
| Cdc42bpa |
T |
A |
1: 180,065,015 (GRCm38) |
I248N |
probably damaging |
Het |
| Cdk11b |
A |
T |
4: 155,648,825 (GRCm38) |
|
probably benign |
Het |
| Cfap46 |
C |
A |
7: 139,603,860 (GRCm38) |
L90F |
probably benign |
Het |
| Cndp2 |
A |
G |
18: 84,670,829 (GRCm38) |
L276P |
possibly damaging |
Het |
| Col3a1 |
A |
C |
1: 45,346,110 (GRCm38) |
D129A |
probably damaging |
Het |
| Daam1 |
C |
A |
12: 71,946,520 (GRCm38) |
H354Q |
unknown |
Het |
| Dnah5 |
T |
A |
15: 28,421,678 (GRCm38) |
F3892Y |
probably damaging |
Het |
| Dnajb3 |
A |
G |
1: 88,205,023 (GRCm38) |
V219A |
possibly damaging |
Het |
| Drd5 |
A |
G |
5: 38,320,201 (GRCm38) |
H179R |
probably damaging |
Het |
| Dym |
A |
G |
18: 75,119,161 (GRCm38) |
N333D |
possibly damaging |
Het |
| Eif2b3 |
A |
G |
4: 117,052,736 (GRCm38) |
D156G |
probably damaging |
Het |
| Emc1 |
A |
G |
4: 139,371,696 (GRCm38) |
D830G |
probably damaging |
Het |
| F13a1 |
A |
C |
13: 36,988,856 (GRCm38) |
I183M |
probably damaging |
Het |
| Fam136b-ps |
T |
A |
15: 31,276,897 (GRCm38) |
|
probably benign |
Het |
| Fdft1 |
C |
A |
14: 63,163,404 (GRCm38) |
K93N |
probably damaging |
Het |
| Gcc2 |
A |
G |
10: 58,278,806 (GRCm38) |
D959G |
probably damaging |
Het |
| Gm14085 |
T |
A |
2: 122,522,914 (GRCm38) |
|
probably null |
Het |
| Gm853 |
C |
T |
4: 130,221,615 (GRCm38) |
|
probably null |
Het |
| Gp2 |
A |
G |
7: 119,454,291 (GRCm38) |
V149A |
probably damaging |
Het |
| Gpc1 |
G |
A |
1: 92,857,029 (GRCm38) |
G308D |
probably damaging |
Het |
| Hdac9 |
A |
T |
12: 34,373,907 (GRCm38) |
C587S |
probably benign |
Het |
| Hspg2 |
C |
T |
4: 137,518,940 (GRCm38) |
R1010C |
probably damaging |
Het |
| Iars2 |
A |
G |
1: 185,317,928 (GRCm38) |
V453A |
possibly damaging |
Het |
| Il1r1 |
T |
G |
1: 40,293,524 (GRCm38) |
C121W |
probably damaging |
Het |
| Jazf1 |
A |
G |
6: 52,777,540 (GRCm38) |
Y184H |
probably damaging |
Het |
| Kel |
A |
T |
6: 41,699,055 (GRCm38) |
Y234N |
probably damaging |
Het |
| Khk |
G |
A |
5: 30,929,660 (GRCm38) |
G186D |
probably damaging |
Het |
| Klf4 |
A |
T |
4: 55,530,301 (GRCm38) |
M270K |
probably benign |
Het |
| Kmt2c |
G |
A |
5: 25,314,708 (GRCm38) |
L2135F |
probably benign |
Het |
| Krtap15 |
A |
G |
16: 88,829,156 (GRCm38) |
Y37C |
probably damaging |
Het |
| Lars |
A |
G |
18: 42,214,776 (GRCm38) |
F994S |
possibly damaging |
Het |
| Lrp8 |
T |
C |
4: 107,834,755 (GRCm38) |
|
probably null |
Het |
| Lrrc2 |
A |
T |
9: 110,980,919 (GRCm38) |
D341V |
probably damaging |
Het |
| Map4k4 |
A |
G |
1: 40,007,502 (GRCm38) |
K646R |
probably damaging |
Het |
| Mrps9 |
T |
A |
1: 42,895,331 (GRCm38) |
|
probably null |
Het |
| Olfr1130 |
T |
A |
2: 87,607,711 (GRCm38) |
C108S |
probably damaging |
Het |
| Olfr745 |
T |
A |
14: 50,643,162 (GRCm38) |
Y288N |
probably damaging |
Het |
| Olfr898 |
C |
T |
9: 38,349,628 (GRCm38) |
H176Y |
probably damaging |
Het |
| Pcnt |
A |
T |
10: 76,399,945 (GRCm38) |
C1401S |
possibly damaging |
Het |
| Pdgfrb |
A |
T |
18: 61,077,668 (GRCm38) |
K749M |
probably damaging |
Het |
| Pigo |
A |
T |
4: 43,019,412 (GRCm38) |
W969R |
probably null |
Het |
| Pigr |
A |
T |
1: 130,844,699 (GRCm38) |
Y218F |
probably damaging |
Het |
| Pih1d1 |
A |
G |
7: 45,154,854 (GRCm38) |
|
probably benign |
Het |
| Pik3cg |
A |
T |
12: 32,199,196 (GRCm38) |
|
probably null |
Het |
| Pik3r6 |
A |
T |
11: 68,533,468 (GRCm38) |
K300* |
probably null |
Het |
| Pip5k1c |
A |
G |
10: 81,305,250 (GRCm38) |
D64G |
probably damaging |
Het |
| Piwil2 |
A |
T |
14: 70,421,593 (GRCm38) |
I161K |
possibly damaging |
Het |
| Pou3f1 |
A |
G |
4: 124,658,656 (GRCm38) |
E317G |
probably damaging |
Het |
| Prdm8 |
C |
T |
5: 98,185,212 (GRCm38) |
Q213* |
probably null |
Het |
| Prpf6 |
T |
A |
2: 181,650,106 (GRCm38) |
C739S |
possibly damaging |
Het |
| Psmc3 |
T |
A |
2: 91,054,608 (GRCm38) |
S40T |
probably benign |
Het |
| Psmd3 |
A |
T |
11: 98,682,824 (GRCm38) |
D32V |
probably damaging |
Het |
| Ptpro |
T |
A |
6: 137,443,594 (GRCm38) |
V1007D |
probably damaging |
Het |
| Rnf207 |
A |
C |
4: 152,313,209 (GRCm38) |
S328A |
probably benign |
Het |
| Ros1 |
C |
T |
10: 52,128,416 (GRCm38) |
|
probably null |
Het |
| Ryr2 |
T |
A |
13: 11,587,254 (GRCm38) |
I4581F |
possibly damaging |
Het |
| Sacm1l |
C |
T |
9: 123,586,399 (GRCm38) |
R480W |
probably damaging |
Het |
| Sec16a |
A |
G |
2: 26,419,649 (GRCm38) |
V664A |
probably benign |
Het |
| Selenoo |
T |
A |
15: 89,092,766 (GRCm38) |
M207K |
probably damaging |
Het |
| Sh3tc2 |
G |
A |
18: 62,014,891 (GRCm38) |
|
probably null |
Het |
| Slco2b1 |
G |
T |
7: 99,660,049 (GRCm38) |
Q692K |
probably benign |
Het |
| Slfn4 |
A |
T |
11: 83,186,797 (GRCm38) |
D137V |
probably damaging |
Het |
| Srrm2 |
G |
A |
17: 23,820,618 (GRCm38) |
A2175T |
probably damaging |
Het |
| Stard9 |
T |
A |
2: 120,693,399 (GRCm38) |
C692S |
probably benign |
Het |
| Sulf2 |
T |
A |
2: 166,081,622 (GRCm38) |
D559V |
probably benign |
Het |
| Tbpl2 |
T |
C |
2: 24,087,158 (GRCm38) |
I283V |
probably benign |
Het |
| Tmem19 |
A |
G |
10: 115,359,761 (GRCm38) |
F46S |
probably benign |
Het |
| Trp63 |
T |
A |
16: 25,763,306 (GRCm38) |
Y35N |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,886,442 (GRCm38) |
|
probably benign |
Het |
| Ube2z |
A |
T |
11: 96,050,322 (GRCm38) |
H331Q |
probably benign |
Het |
| Ubr1 |
C |
T |
2: 120,911,997 (GRCm38) |
|
probably null |
Het |
| Uhrf1bp1 |
A |
G |
17: 27,886,864 (GRCm38) |
E788G |
probably damaging |
Het |
| Vmn1r235 |
A |
T |
17: 21,262,288 (GRCm38) |
I292F |
possibly damaging |
Het |
| Vmn2r1 |
T |
A |
3: 64,105,080 (GRCm38) |
D787E |
probably damaging |
Het |
| Vmn2r3 |
A |
G |
3: 64,259,799 (GRCm38) |
V637A |
probably benign |
Het |
| Xpnpep1 |
C |
A |
19: 53,006,175 (GRCm38) |
V341L |
probably benign |
Het |
| Yme1l1 |
A |
G |
2: 23,194,747 (GRCm38) |
D619G |
probably damaging |
Het |
| Zfp597 |
G |
A |
16: 3,866,638 (GRCm38) |
P85S |
probably damaging |
Het |
| Zscan20 |
A |
G |
4: 128,586,128 (GRCm38) |
S857P |
probably benign |
Het |
|
| Other mutations in Rapgef6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00436:Rapgef6
|
APN |
11 |
54,679,265 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL00507:Rapgef6
|
APN |
11 |
54,664,109 (GRCm38) |
nonsense |
probably null |
|
|
IGL00809:Rapgef6
|
APN |
11 |
54,649,300 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00843:Rapgef6
|
APN |
11 |
54,691,273 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL00899:Rapgef6
|
APN |
11 |
54,620,018 (GRCm38) |
nonsense |
probably null |
|
|
IGL01372:Rapgef6
|
APN |
11 |
54,668,611 (GRCm38) |
splice site |
probably benign |
|
|
IGL01604:Rapgef6
|
APN |
11 |
54,694,563 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01935:Rapgef6
|
APN |
11 |
54,610,842 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL01991:Rapgef6
|
APN |
11 |
54,552,869 (GRCm38) |
missense |
probably benign |
0.37 |
|
IGL02243:Rapgef6
|
APN |
11 |
54,676,400 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02407:Rapgef6
|
APN |
11 |
54,676,355 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
IGL02676:Rapgef6
|
APN |
11 |
54,649,346 (GRCm38) |
unclassified |
probably benign |
|
|
IGL02934:Rapgef6
|
APN |
11 |
54,625,864 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03076:Rapgef6
|
APN |
11 |
54,625,967 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03110:Rapgef6
|
APN |
11 |
54,696,089 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL03256:Rapgef6
|
APN |
11 |
54,657,429 (GRCm38) |
missense |
probably damaging |
1.00 |
|
shocker
|
UTSW |
11 |
54,620,016 (GRCm38) |
missense |
probably damaging |
1.00 |
|
D4216:Rapgef6
|
UTSW |
11 |
54,668,746 (GRCm38) |
splice site |
probably benign |
|
|
PIT4305001:Rapgef6
|
UTSW |
11 |
54,679,377 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4366001:Rapgef6
|
UTSW |
11 |
54,691,620 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,546,378 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,546,378 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R0125:Rapgef6
|
UTSW |
11 |
54,625,875 (GRCm38) |
nonsense |
probably null |
|
|
R0189:Rapgef6
|
UTSW |
11 |
54,691,249 (GRCm38) |
missense |
probably benign |
|
|
R0201:Rapgef6
|
UTSW |
11 |
54,619,941 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0505:Rapgef6
|
UTSW |
11 |
54,625,963 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0524:Rapgef6
|
UTSW |
11 |
54,690,284 (GRCm38) |
missense |
probably benign |
0.32 |
|
R0853:Rapgef6
|
UTSW |
11 |
54,668,677 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1203:Rapgef6
|
UTSW |
11 |
54,691,699 (GRCm38) |
missense |
probably benign |
0.09 |
|
R1440:Rapgef6
|
UTSW |
11 |
54,626,708 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1453:Rapgef6
|
UTSW |
11 |
54,639,727 (GRCm38) |
splice site |
probably null |
|
|
R1530:Rapgef6
|
UTSW |
11 |
54,661,183 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1593:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1620:Rapgef6
|
UTSW |
11 |
54,626,594 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R1628:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1629:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1630:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1634:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1640:Rapgef6
|
UTSW |
11 |
54,657,405 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1686:Rapgef6
|
UTSW |
11 |
54,691,632 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R1722:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1743:Rapgef6
|
UTSW |
11 |
54,676,284 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1816:Rapgef6
|
UTSW |
11 |
54,694,488 (GRCm38) |
missense |
probably benign |
|
|
R1851:Rapgef6
|
UTSW |
11 |
54,642,811 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1852:Rapgef6
|
UTSW |
11 |
54,642,811 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1868:Rapgef6
|
UTSW |
11 |
54,546,397 (GRCm38) |
frame shift |
probably null |
|
|
R1888:Rapgef6
|
UTSW |
11 |
54,660,828 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1888:Rapgef6
|
UTSW |
11 |
54,660,828 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1942:Rapgef6
|
UTSW |
11 |
54,657,263 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1943:Rapgef6
|
UTSW |
11 |
54,657,263 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R2031:Rapgef6
|
UTSW |
11 |
54,552,858 (GRCm38) |
missense |
probably benign |
0.30 |
|
R2087:Rapgef6
|
UTSW |
11 |
54,631,249 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2106:Rapgef6
|
UTSW |
11 |
54,668,686 (GRCm38) |
missense |
probably benign |
0.17 |
|
R2362:Rapgef6
|
UTSW |
11 |
54,694,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2484:Rapgef6
|
UTSW |
11 |
54,642,756 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R2566:Rapgef6
|
UTSW |
11 |
54,687,711 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,661,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,661,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3744:Rapgef6
|
UTSW |
11 |
54,625,934 (GRCm38) |
missense |
probably benign |
0.40 |
|
R3848:Rapgef6
|
UTSW |
11 |
54,691,308 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4823:Rapgef6
|
UTSW |
11 |
54,694,500 (GRCm38) |
missense |
probably benign |
0.08 |
|
R4859:Rapgef6
|
UTSW |
11 |
54,636,163 (GRCm38) |
missense |
probably benign |
|
|
R4906:Rapgef6
|
UTSW |
11 |
54,552,836 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4911:Rapgef6
|
UTSW |
11 |
54,622,317 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4937:Rapgef6
|
UTSW |
11 |
54,657,317 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5249:Rapgef6
|
UTSW |
11 |
54,523,117 (GRCm38) |
missense |
probably benign |
0.19 |
|
R5304:Rapgef6
|
UTSW |
11 |
54,657,374 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5656:Rapgef6
|
UTSW |
11 |
54,636,136 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5701:Rapgef6
|
UTSW |
11 |
54,676,394 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R5758:Rapgef6
|
UTSW |
11 |
54,668,644 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5973:Rapgef6
|
UTSW |
11 |
54,639,783 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6177:Rapgef6
|
UTSW |
11 |
54,620,016 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6268:Rapgef6
|
UTSW |
11 |
54,649,247 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6287:Rapgef6
|
UTSW |
11 |
54,626,338 (GRCm38) |
splice site |
probably null |
|
|
R6293:Rapgef6
|
UTSW |
11 |
54,634,781 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6471:Rapgef6
|
UTSW |
11 |
54,691,737 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6863:Rapgef6
|
UTSW |
11 |
54,546,380 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6950:Rapgef6
|
UTSW |
11 |
54,676,380 (GRCm38) |
missense |
probably benign |
0.09 |
|
R7144:Rapgef6
|
UTSW |
11 |
54,657,365 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R7171:Rapgef6
|
UTSW |
11 |
54,676,363 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7199:Rapgef6
|
UTSW |
11 |
54,546,426 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7291:Rapgef6
|
UTSW |
11 |
54,691,239 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7436:Rapgef6
|
UTSW |
11 |
54,610,921 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7498:Rapgef6
|
UTSW |
11 |
54,620,004 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7506:Rapgef6
|
UTSW |
11 |
54,636,171 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7527:Rapgef6
|
UTSW |
11 |
54,634,961 (GRCm38) |
missense |
unknown |
|
|
R7646:Rapgef6
|
UTSW |
11 |
54,625,954 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7655:Rapgef6
|
UTSW |
11 |
54,694,453 (GRCm38) |
missense |
probably benign |
0.10 |
|
R7656:Rapgef6
|
UTSW |
11 |
54,694,453 (GRCm38) |
missense |
probably benign |
0.10 |
|
R7687:Rapgef6
|
UTSW |
11 |
54,661,075 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7768:Rapgef6
|
UTSW |
11 |
54,626,588 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7788:Rapgef6
|
UTSW |
11 |
54,694,399 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7890:Rapgef6
|
UTSW |
11 |
54,626,723 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8113:Rapgef6
|
UTSW |
11 |
54,625,958 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8337:Rapgef6
|
UTSW |
11 |
54,631,301 (GRCm38) |
nonsense |
probably null |
|
|
R8393:Rapgef6
|
UTSW |
11 |
54,687,661 (GRCm38) |
missense |
probably benign |
|
|
R8465:Rapgef6
|
UTSW |
11 |
54,691,482 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8492:Rapgef6
|
UTSW |
11 |
54,690,237 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8791:Rapgef6
|
UTSW |
11 |
54,568,469 (GRCm38) |
missense |
probably benign |
0.15 |
|
R8866:Rapgef6
|
UTSW |
11 |
54,552,874 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8917:Rapgef6
|
UTSW |
11 |
54,691,566 (GRCm38) |
nonsense |
probably null |
|
|
R8921:Rapgef6
|
UTSW |
11 |
54,679,239 (GRCm38) |
missense |
probably benign |
0.09 |
|
R9031:Rapgef6
|
UTSW |
11 |
54,687,841 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9093:Rapgef6
|
UTSW |
11 |
54,597,086 (GRCm38) |
nonsense |
probably null |
|
|
R9354:Rapgef6
|
UTSW |
11 |
54,619,923 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R9514:Rapgef6
|
UTSW |
11 |
54,552,858 (GRCm38) |
missense |
probably benign |
0.14 |
|
R9516:Rapgef6
|
UTSW |
11 |
54,691,343 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9739:Rapgef6
|
UTSW |
11 |
54,622,363 (GRCm38) |
missense |
probably benign |
0.03 |
|
R9789:Rapgef6
|
UTSW |
11 |
54,649,271 (GRCm38) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCAGATTACTCATTGCTCATCTG -3'
(R):5'- ACATGTGTCCGAGAGTGAGC -3'
Sequencing Primer
(F):5'- GTTTGTCCCCACTTTCAGGTG -3'
(R):5'- CAGCTGGTTCGTCTCTAGGC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation