Incidental Mutation 'R5034:Hcar1'
ID 389436
Institutional Source Beutler Lab
Gene Symbol Hcar1
Ensembl Gene ENSMUSG00000049241
Gene Name hydrocarboxylic acid receptor 1
Synonyms Gpr81
MMRRC Submission 042625-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R5034 (G1)
Quality Score 158
Status Not validated
Chromosome 5
Chromosomal Location 124014802-124018066 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) T to C at 124017732 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000129280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164267]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000164267
SMART Domains Protein: ENSMUSP00000129280
Gene: ENSMUSG00000049241

DomainStartEndE-ValueType
Pfam:7tm_1 40 286 1.4e-33 PFAM
low complexity region 306 317 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.6%
Validation Efficiency 97% (67/69)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit resistance to lactate-induced suppression of lipolysis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T A 11: 84,136,090 (GRCm39) S482T probably benign Het
Adam6b G T 12: 113,454,547 (GRCm39) G455C probably damaging Het
Ahsg C A 16: 22,717,650 (GRCm39) P237Q probably damaging Het
Asxl2 A G 12: 3,552,193 (GRCm39) S1312G probably damaging Het
Brinp3 C T 1: 146,603,458 (GRCm39) probably benign Het
Col12a1 T C 9: 79,564,649 (GRCm39) H1677R probably damaging Het
Cops7a A G 6: 124,939,583 (GRCm39) probably null Het
Csmd2 G A 4: 127,952,901 (GRCm39) A117T probably damaging Het
Csmd3 T C 15: 47,492,683 (GRCm39) R3153G possibly damaging Het
Dctn4 A G 18: 60,685,956 (GRCm39) N342D probably benign Het
Dennd5a A T 7: 109,499,004 (GRCm39) I953N probably damaging Het
Dmwd T C 7: 18,814,219 (GRCm39) S290P probably damaging Het
Dsc1 T A 18: 20,228,084 (GRCm39) Y424F possibly damaging Het
Far2 C A 6: 148,074,939 (GRCm39) L391M probably benign Het
Foxd3 G A 4: 99,545,327 (GRCm39) G156S probably damaging Het
Galk2 A T 2: 125,771,495 (GRCm39) E173D probably benign Het
Hsd17b11 C T 5: 104,166,087 (GRCm39) V91M possibly damaging Het
Ighv1-77 C T 12: 115,825,494 (GRCm39) C115Y probably damaging Het
Ighv9-2 A G 12: 114,073,025 (GRCm39) F9S probably damaging Het
Kdm6b A G 11: 69,292,736 (GRCm39) probably benign Het
Kif21a T A 15: 90,852,561 (GRCm39) R890W probably null Het
Lin9 T A 1: 180,496,763 (GRCm39) L351I probably benign Het
Magel2 A T 7: 62,029,616 (GRCm39) H840L unknown Het
Mrgpra4 A G 7: 47,631,317 (GRCm39) F95L probably benign Het
Myo7b A G 18: 32,104,440 (GRCm39) L1436P probably damaging Het
Nf1 C T 11: 79,334,976 (GRCm39) P943S probably damaging Het
Obscn T A 11: 58,952,502 (GRCm39) R4153* probably null Het
Oosp2 T C 19: 11,628,899 (GRCm39) I67M probably damaging Het
Or5m13b C A 2: 85,753,891 (GRCm39) S93Y probably damaging Het
Pcdh9 T A 14: 93,564,285 (GRCm39) D1023V probably benign Het
Pcdhb14 T C 18: 37,581,859 (GRCm39) S322P probably damaging Het
Pde2a A G 7: 101,151,231 (GRCm39) D285G probably benign Het
Pde5a G C 3: 122,646,235 (GRCm39) G809R probably damaging Het
Pde5a G T 3: 122,646,236 (GRCm39) G809V probably damaging Het
Pphln1 T C 15: 93,350,010 (GRCm39) V120A probably benign Het
Rictor T C 15: 6,797,576 (GRCm39) S311P probably damaging Het
Rilpl1 T C 5: 124,631,887 (GRCm39) D153G probably damaging Het
Rmdn3 G T 2: 118,978,058 (GRCm39) A181E probably damaging Het
Rnf213 G A 11: 119,301,633 (GRCm39) V369M probably damaging Het
Scyl1 T A 19: 5,810,022 (GRCm39) R601S probably benign Het
Sdcbp G A 4: 6,393,118 (GRCm39) probably null Het
Septin8 A G 11: 53,425,265 (GRCm39) T53A probably damaging Het
Sfpq A G 4: 126,917,462 (GRCm39) probably benign Het
Slc35b3 A G 13: 39,127,134 (GRCm39) Y163H probably damaging Het
Sra1 A G 18: 36,812,048 (GRCm39) probably null Het
Sspo A T 6: 48,457,757 (GRCm39) N3231Y possibly damaging Het
Tcf3 A G 10: 80,253,377 (GRCm39) V218A possibly damaging Het
Tgm3 T C 2: 129,879,404 (GRCm39) V332A possibly damaging Het
Tmprss11f C T 5: 86,739,243 (GRCm39) probably benign Het
Trbv4 A G 6: 41,036,624 (GRCm39) T50A probably benign Het
Trdv2-2 C A 14: 54,198,882 (GRCm39) Y57* probably null Het
Trim50 T C 5: 135,396,147 (GRCm39) V365A possibly damaging Het
Ubash3b T C 9: 40,941,036 (GRCm39) Q245R probably benign Het
Ulk3 T A 9: 57,501,047 (GRCm39) V338E possibly damaging Het
Usf3 A C 16: 44,036,762 (GRCm39) K414T probably damaging Het
Usp48 C T 4: 137,334,068 (GRCm39) R161* probably null Het
Vps18 A T 2: 119,123,787 (GRCm39) D238V probably benign Het
Vps35l T C 7: 118,390,611 (GRCm39) V368A probably damaging Het
Zfp354c T C 11: 50,705,866 (GRCm39) E403G probably benign Het
Zscan18 A G 7: 12,508,072 (GRCm39) V476A probably damaging Het
Other mutations in Hcar1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02340:Hcar1 APN 5 124,017,135 (GRCm39) missense probably damaging 1.00
R1860:Hcar1 UTSW 5 124,017,092 (GRCm39) missense probably damaging 1.00
R1874:Hcar1 UTSW 5 124,017,328 (GRCm39) missense probably damaging 1.00
R2262:Hcar1 UTSW 5 124,016,649 (GRCm39) missense probably benign 0.00
R3981:Hcar1 UTSW 5 124,016,683 (GRCm39) missense probably benign 0.03
R4851:Hcar1 UTSW 5 124,016,731 (GRCm39) missense probably benign 0.00
R6805:Hcar1 UTSW 5 124,017,193 (GRCm39) missense probably benign 0.01
R7259:Hcar1 UTSW 5 124,017,275 (GRCm39) missense possibly damaging 0.92
R7346:Hcar1 UTSW 5 124,017,693 (GRCm39) start gained probably benign
R7410:Hcar1 UTSW 5 124,017,161 (GRCm39) missense possibly damaging 0.82
R8120:Hcar1 UTSW 5 124,017,068 (GRCm39) missense probably damaging 0.99
R8171:Hcar1 UTSW 5 124,017,152 (GRCm39) missense probably damaging 0.99
R8465:Hcar1 UTSW 5 124,017,109 (GRCm39) missense probably damaging 1.00
R8767:Hcar1 UTSW 5 124,017,113 (GRCm39) missense probably damaging 1.00
Z1176:Hcar1 UTSW 5 124,017,804 (GRCm39) start gained probably benign
Predicted Primers
Posted On 2016-06-06