Incidental Mutation 'R5035:Olfr970'
ID389504
Institutional Source Beutler Lab
Gene Symbol Olfr970
Ensembl Gene ENSMUSG00000095774
Gene Nameolfactory receptor 970
SynonymsMOR171-16, GA_x6K02T2PVTD-33517322-33518257
MMRRC Submission 042626-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.409) question?
Stock #R5035 (G1)
Quality Score225
Status Validated
Chromosome9
Chromosomal Location39808860-39820997 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 39820094 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 152 (A152T)
Ref Sequence ENSEMBL: ENSMUSP00000150325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071132] [ENSMUST00000213975] [ENSMUST00000215922]
Predicted Effect possibly damaging
Transcript: ENSMUST00000071132
AA Change: A152T

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000071132
Gene: ENSMUSG00000095774
AA Change: A152T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.2e-53 PFAM
Pfam:7tm_1 41 290 1.6e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213975
AA Change: A152T

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215265
Predicted Effect possibly damaging
Transcript: ENSMUST00000215922
AA Change: A152T

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency 98% (46/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat1 T C 9: 53,583,510 I361V probably benign Het
Afp A G 5: 90,507,905 D583G probably benign Het
Bcas3 C T 11: 85,543,945 A552V probably damaging Het
Bfsp2 T G 9: 103,479,866 T121P probably benign Het
Bicra C T 7: 15,979,424 R951Q possibly damaging Het
Cdc40 G A 10: 40,849,813 T220I probably benign Het
Cdk5rap3 T C 11: 96,916,085 probably benign Het
Clcnka A T 4: 141,395,158 Y179* probably null Het
Creb3l1 T A 2: 91,987,086 I361F probably benign Het
Csmd3 T C 15: 47,590,779 Y3557C probably damaging Het
Dab2ip A G 2: 35,709,941 S190G probably benign Het
Dbx1 T C 7: 49,632,536 H307R unknown Het
Dock8 C A 19: 25,086,207 P258T probably damaging Het
Eml6 T C 11: 29,854,187 I305V probably benign Het
Frem3 T A 8: 80,615,914 F1612Y probably damaging Het
Fubp1 A G 3: 152,214,851 T76A probably benign Het
Glmp G C 3: 88,326,644 probably benign Het
Gm20918 A G Y: 5,045,992 Q183R probably benign Het
Krt28 T C 11: 99,366,824 N397S probably benign Het
Lin9 T A 1: 180,669,198 L351I probably benign Het
Map3k13 T C 16: 21,921,671 Y583H probably benign Het
Mcm3 A T 1: 20,803,418 probably benign Het
Misp T C 10: 79,827,956 V588A probably benign Het
Olfr1202 A T 2: 88,818,099 K309N probably benign Het
Olfr348 A G 2: 36,786,891 D122G probably damaging Het
Olfr373 T A 8: 72,100,078 L106H probably damaging Het
Olfr644 G A 7: 104,068,407 T208I possibly damaging Het
Osbpl9 A G 4: 109,066,167 F449L probably damaging Het
Pkhd1l1 A G 15: 44,568,324 D3358G probably damaging Het
Prodh2 A T 7: 30,506,479 S247C possibly damaging Het
Prr23a3 G A 9: 98,865,130 E46K possibly damaging Het
Ptprz1 A G 6: 23,016,215 I837V probably benign Het
Rabgap1l A C 1: 160,724,036 F263V probably damaging Het
Rnf4 A G 5: 34,351,339 K182E probably damaging Het
Slc24a2 G T 4: 87,011,706 R469S possibly damaging Het
Speer2 A G 16: 69,857,941 probably null Het
Tcrg-C4 G T 13: 19,352,336 R188L unknown Het
Tg C A 15: 66,681,813 probably null Het
Tns1 G A 1: 73,953,820 probably benign Het
Top2b G T 14: 16,409,966 A878S probably benign Het
Ugt3a2 G A 15: 9,361,618 R160Q probably benign Het
Ush2a G T 1: 188,910,808 L4122F probably damaging Het
Other mutations in Olfr970
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01388:Olfr970 APN 9 39820002 missense probably damaging 1.00
IGL02674:Olfr970 APN 9 39819638 splice site probably null
R0659:Olfr970 UTSW 9 39819816 missense possibly damaging 0.78
R0686:Olfr970 UTSW 9 39819668 missense probably damaging 0.98
R1952:Olfr970 UTSW 9 39820067 missense probably benign 0.09
R2068:Olfr970 UTSW 9 39820550 missense probably benign 0.00
R4472:Olfr970 UTSW 9 39820574 makesense probably null
R4798:Olfr970 UTSW 9 39819897 missense probably benign 0.13
R5339:Olfr970 UTSW 9 39819933 missense probably damaging 0.97
R6751:Olfr970 UTSW 9 39819897 missense probably benign 0.13
R7211:Olfr970 UTSW 9 39819858 missense possibly damaging 0.76
R7471:Olfr970 UTSW 9 39820127 missense probably benign 0.00
R7609:Olfr970 UTSW 9 39820287 missense probably benign
R7638:Olfr970 UTSW 9 39819893 missense probably damaging 1.00
R7890:Olfr970 UTSW 9 39820014 missense probably damaging 0.99
R7918:Olfr970 UTSW 9 39820110 missense probably damaging 0.98
R8548:Olfr970 UTSW 9 39820241 missense probably benign 0.00
R8817:Olfr970 UTSW 9 39819643 start codon destroyed probably null 0.40
R8868:Olfr970 UTSW 9 39819956 missense probably benign
Z1176:Olfr970 UTSW 9 39820355 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCTGAATGTATGACTCAGCTCTAC -3'
(R):5'- TTTGGACCTGCCTTCAGTGG -3'

Sequencing Primer
(F):5'- GCAATCTGTAACCCCTTG -3'
(R):5'- GGACCTGCCTTCAGTGGATTTAATC -3'
Posted On2016-06-06