Incidental Mutation 'R0433:Usp25'
ID 38973
Institutional Source Beutler Lab
Gene Symbol Usp25
Ensembl Gene ENSMUSG00000022867
Gene Name ubiquitin specific peptidase 25
Synonyms
MMRRC Submission 038635-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0433 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 76810594-76913668 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 76906105 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 854 (I854V)
Ref Sequence ENSEMBL: ENSMUSP00000023580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023580]
AlphaFold P57080
PDB Structure Solution Structure of RSGI RUH-013, a UBA domain in Mouse cDNA [SOLUTION NMR]
Predicted Effect probably benign
Transcript: ENSMUST00000023580
AA Change: I854V

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000023580
Gene: ENSMUSG00000022867
AA Change: I854V

DomainStartEndE-ValueType
PDB:1VDL|A 1 67 2e-35 PDB
Blast:UBA 17 56 9e-16 BLAST
UIM 97 116 5.27e-3 SMART
Pfam:UIM 124 140 6.7e-3 PFAM
Pfam:UCH 168 655 9.3e-55 PFAM
Pfam:UCH_1 169 632 3.1e-14 PFAM
coiled coil region 685 714 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232351
Meta Mutation Damage Score 0.0669 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 94.3%
Validation Efficiency 99% (108/109)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased severity of IL17-induced pulmonary inflammation and MOG-induced experimental autoimmune encephalomyelitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 102 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110032F04Rik T C 3: 68,777,636 (GRCm39) V199A possibly damaging Het
Abcb5 T C 12: 118,841,545 (GRCm39) M967V probably benign Het
Adcy10 T A 1: 165,379,591 (GRCm39) L951Q probably damaging Het
Amer2 A T 14: 60,616,032 (GRCm39) S76C probably damaging Het
Atad1 T C 19: 32,675,877 (GRCm39) I182M probably benign Het
Bpi A G 2: 158,100,339 (GRCm39) D42G probably damaging Het
C7 G T 15: 5,018,398 (GRCm39) T815K probably damaging Het
Cacna1g T A 11: 94,350,033 (GRCm39) D604V probably benign Het
Camk1g A G 1: 193,036,366 (GRCm39) F165L probably damaging Het
Ccdc69 C T 11: 54,943,716 (GRCm39) probably null Het
Ccser2 A C 14: 36,640,486 (GRCm39) F37L probably damaging Het
Cfap43 A G 19: 47,814,210 (GRCm39) F208S probably benign Het
Cfap54 G A 10: 92,814,942 (GRCm39) probably benign Het
Cfap69 A C 5: 5,699,853 (GRCm39) D62E probably damaging Het
Cnksr2 A T X: 156,671,554 (GRCm39) M483K probably benign Het
Cnksr2 C A X: 156,671,553 (GRCm39) M483I probably benign Het
Cog8 T C 8: 107,783,110 (GRCm39) S60G possibly damaging Het
Col4a3 C T 1: 82,647,940 (GRCm39) P484S unknown Het
Col6a4 C T 9: 105,945,193 (GRCm39) G974R probably damaging Het
Cplane1 T C 15: 8,246,046 (GRCm39) S1473P probably benign Het
Dbnl T G 11: 5,746,825 (GRCm39) probably null Het
Dhcr7 T C 7: 143,394,200 (GRCm39) C114R possibly damaging Het
Dnah2 C A 11: 69,350,114 (GRCm39) D2340Y probably damaging Het
Dnai4 T C 4: 102,960,450 (GRCm39) N67D probably benign Het
Dusp10 T A 1: 183,801,393 (GRCm39) Y387N probably damaging Het
Eipr1 C T 12: 28,909,330 (GRCm39) T199I possibly damaging Het
Emc2 T G 15: 43,360,520 (GRCm39) probably null Het
Enpp3 A G 10: 24,696,495 (GRCm39) S147P probably benign Het
Fam133b T A 5: 3,608,560 (GRCm39) probably benign Het
Fat1 C A 8: 45,477,686 (GRCm39) T2244K possibly damaging Het
Fbn1 A G 2: 125,190,135 (GRCm39) S1453P possibly damaging Het
Fez2 A T 17: 78,725,476 (GRCm39) F13I probably damaging Het
Ggnbp2 T C 11: 84,727,246 (GRCm39) K530R probably damaging Het
Gpa33 T C 1: 165,991,330 (GRCm39) probably benign Het
Gpr142 T C 11: 114,696,823 (GRCm39) I123T probably damaging Het
Il21 T G 3: 37,286,684 (GRCm39) I11L possibly damaging Het
Klhl7 A G 5: 24,332,700 (GRCm39) E86G probably damaging Het
Klk10 G T 7: 43,430,989 (GRCm39) A11S possibly damaging Het
Knl1 A T 2: 118,934,542 (GRCm39) D2115V probably damaging Het
Lonp2 A G 8: 87,360,582 (GRCm39) D185G probably damaging Het
Lrrc47 T C 4: 154,102,822 (GRCm39) probably benign Het
Lrrcc1 A G 3: 14,624,434 (GRCm39) I698V probably damaging Het
Lzts2 T C 19: 45,010,115 (GRCm39) V83A possibly damaging Het
Melk C A 4: 44,340,614 (GRCm39) probably benign Het
Mical1 G A 10: 41,355,486 (GRCm39) V150I probably benign Het
Morn3 C A 5: 123,177,396 (GRCm39) M129I probably benign Het
Mroh2b T A 15: 4,971,116 (GRCm39) D1040E probably benign Het
Mroh5 T C 15: 73,661,877 (GRCm39) N438S probably benign Het
Mroh5 T A 15: 73,662,657 (GRCm39) Q387L probably damaging Het
Myh15 A G 16: 48,965,599 (GRCm39) D1168G probably damaging Het
Nek10 A G 14: 14,860,927 (GRCm38) E493G probably benign Het
Nipsnap3a A G 4: 53,000,316 (GRCm39) Y227C probably damaging Het
Nlrp9c T A 7: 26,085,244 (GRCm39) T112S probably benign Het
Nphp4 T C 4: 152,602,629 (GRCm39) V401A probably benign Het
Nr1h2 A G 7: 44,199,411 (GRCm39) *365Q probably null Het
Or13p5 T C 4: 118,592,287 (GRCm39) V187A probably benign Het
Or5p54 T C 7: 107,554,469 (GRCm39) I207T probably damaging Het
Pacs2 T A 12: 113,020,464 (GRCm39) V279D possibly damaging Het
Pdcd2 C T 17: 15,746,646 (GRCm39) C171Y probably benign Het
Pde11a T A 2: 76,168,050 (GRCm39) D301V possibly damaging Het
Pfpl T G 19: 12,406,839 (GRCm39) N363K probably damaging Het
Phf14 T A 6: 11,933,742 (GRCm39) S201R probably damaging Het
Pip4k2c G A 10: 127,044,815 (GRCm39) P66S probably benign Het
Pou2f3 G T 9: 43,038,693 (GRCm39) H392N probably benign Het
Pou3f1 G T 4: 124,552,697 (GRCm39) G400C probably damaging Het
Ptprg T C 14: 12,220,620 (GRCm38) I1219T probably damaging Het
Rfx6 A G 10: 51,596,124 (GRCm39) D435G probably damaging Het
Rhpn2 T A 7: 35,084,899 (GRCm39) S598T probably benign Het
Sdccag8 C A 1: 176,672,387 (GRCm39) probably null Het
Sec16b C A 1: 157,362,279 (GRCm39) Y43* probably null Het
Sele T C 1: 163,876,813 (GRCm39) Y30H possibly damaging Het
Sgsm2 C T 11: 74,749,016 (GRCm39) probably null Het
Slc45a2 T C 15: 11,025,831 (GRCm39) Y394H probably benign Het
Slc4a10 T G 2: 62,120,327 (GRCm39) I788S probably benign Het
Slmap A T 14: 26,174,749 (GRCm39) L161* probably null Het
Slx4 A T 16: 3,803,882 (GRCm39) D977E probably benign Het
Spata31e5 A T 1: 28,816,423 (GRCm39) Y536* probably null Het
Spata31f3 A G 4: 42,874,013 (GRCm39) probably benign Het
Spen A T 4: 141,211,069 (GRCm39) M608K unknown Het
St8sia4 G C 1: 95,519,429 (GRCm39) T353R probably damaging Het
Stab2 G T 10: 86,679,355 (GRCm39) probably benign Het
Stx12 C T 4: 132,585,741 (GRCm39) G213D probably damaging Het
Synj2 A T 17: 6,084,123 (GRCm39) N270Y probably damaging Het
Tdrd9 C T 12: 111,992,015 (GRCm39) R438* probably null Het
Tert T C 13: 73,775,200 (GRCm39) Y18H probably damaging Het
Tph1 A T 7: 46,303,245 (GRCm39) F244L probably damaging Het
Triobp T C 15: 78,852,401 (GRCm39) F852L possibly damaging Het
Trpv1 T C 11: 73,143,834 (GRCm39) probably benign Het
Uggt2 A T 14: 119,312,741 (GRCm39) probably null Het
Ulk4 A G 9: 120,873,885 (GRCm39) I1182T probably benign Het
Uqcc1 A G 2: 155,752,288 (GRCm39) Y98H probably damaging Het
Usp50 T C 2: 126,603,464 (GRCm39) S361G probably damaging Het
Uspl1 C A 5: 149,151,625 (GRCm39) Q743K probably damaging Het
Vmn2r3 A G 3: 64,183,054 (GRCm39) V215A possibly damaging Het
Vmn2r61 A T 7: 41,915,335 (GRCm39) H94L probably benign Het
Vps37c T C 19: 10,690,393 (GRCm39) V285A probably benign Het
Vwa8 T C 14: 79,300,116 (GRCm39) V983A probably damaging Het
Zcchc9 C T 13: 91,954,081 (GRCm39) R58H probably benign Het
Zdbf2 T C 1: 63,345,302 (GRCm39) V1227A possibly damaging Het
Zfp292 T C 4: 34,839,959 (GRCm39) K64E probably damaging Het
Zfp948 A G 17: 21,807,764 (GRCm39) T319A probably benign Het
Zp3r T G 1: 130,504,870 (GRCm39) probably benign Het
Other mutations in Usp25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00846:Usp25 APN 16 76,859,293 (GRCm39) missense probably damaging 1.00
IGL01359:Usp25 APN 16 76,856,141 (GRCm39) missense probably damaging 1.00
IGL01380:Usp25 APN 16 76,890,566 (GRCm39) missense probably benign 0.06
IGL01614:Usp25 APN 16 76,874,005 (GRCm39) missense probably damaging 1.00
IGL02065:Usp25 APN 16 76,880,670 (GRCm39) missense probably benign 0.06
IGL02271:Usp25 APN 16 76,912,335 (GRCm39) missense probably damaging 1.00
IGL03184:Usp25 APN 16 76,878,541 (GRCm39) missense probably damaging 1.00
IGL03046:Usp25 UTSW 16 76,871,754 (GRCm39) missense probably damaging 1.00
R0741:Usp25 UTSW 16 76,868,596 (GRCm39) missense possibly damaging 0.80
R0944:Usp25 UTSW 16 76,878,335 (GRCm39) splice site probably benign
R1324:Usp25 UTSW 16 76,877,275 (GRCm39) missense probably damaging 0.98
R1341:Usp25 UTSW 16 76,912,331 (GRCm39) missense probably benign
R1373:Usp25 UTSW 16 76,859,273 (GRCm39) splice site probably benign
R1641:Usp25 UTSW 16 76,868,559 (GRCm39) missense possibly damaging 0.89
R1777:Usp25 UTSW 16 76,878,442 (GRCm39) missense probably damaging 1.00
R1813:Usp25 UTSW 16 76,911,838 (GRCm39) missense probably benign 0.00
R1960:Usp25 UTSW 16 76,873,259 (GRCm39) missense probably damaging 1.00
R2256:Usp25 UTSW 16 76,910,682 (GRCm39) missense probably benign
R2271:Usp25 UTSW 16 76,873,317 (GRCm39) missense probably damaging 0.97
R4404:Usp25 UTSW 16 76,912,341 (GRCm39) missense probably damaging 1.00
R4408:Usp25 UTSW 16 76,912,341 (GRCm39) missense probably damaging 1.00
R4502:Usp25 UTSW 16 76,912,284 (GRCm39) missense probably damaging 1.00
R4604:Usp25 UTSW 16 76,912,303 (GRCm39) missense probably damaging 1.00
R4612:Usp25 UTSW 16 76,830,833 (GRCm39) missense possibly damaging 0.92
R4744:Usp25 UTSW 16 76,911,877 (GRCm39) missense probably damaging 1.00
R4867:Usp25 UTSW 16 76,847,355 (GRCm39) missense probably damaging 1.00
R4932:Usp25 UTSW 16 76,830,870 (GRCm39) critical splice donor site probably null
R5087:Usp25 UTSW 16 76,874,007 (GRCm39) missense probably benign 0.00
R5165:Usp25 UTSW 16 76,873,293 (GRCm39) missense possibly damaging 0.85
R5184:Usp25 UTSW 16 76,906,115 (GRCm39) missense probably benign 0.00
R5307:Usp25 UTSW 16 76,890,594 (GRCm39) missense probably benign
R5331:Usp25 UTSW 16 76,847,446 (GRCm39) missense probably damaging 1.00
R5355:Usp25 UTSW 16 76,847,342 (GRCm39) missense probably damaging 1.00
R5479:Usp25 UTSW 16 76,904,801 (GRCm39) missense possibly damaging 0.51
R5619:Usp25 UTSW 16 76,830,833 (GRCm39) missense probably benign 0.22
R5646:Usp25 UTSW 16 76,847,360 (GRCm39) missense probably benign 0.34
R5946:Usp25 UTSW 16 76,911,942 (GRCm39) nonsense probably null
R6013:Usp25 UTSW 16 76,873,909 (GRCm39) missense probably benign 0.00
R6418:Usp25 UTSW 16 76,859,330 (GRCm39) missense probably damaging 1.00
R6653:Usp25 UTSW 16 76,856,176 (GRCm39) missense probably benign 0.29
R6709:Usp25 UTSW 16 76,880,820 (GRCm39) missense probably benign
R6987:Usp25 UTSW 16 76,874,068 (GRCm39) missense probably damaging 1.00
R7418:Usp25 UTSW 16 76,910,730 (GRCm39) nonsense probably null
R7500:Usp25 UTSW 16 76,874,089 (GRCm39) missense probably damaging 1.00
R7886:Usp25 UTSW 16 76,910,659 (GRCm39) missense probably damaging 0.99
R7961:Usp25 UTSW 16 76,856,150 (GRCm39) missense probably damaging 1.00
R8005:Usp25 UTSW 16 76,873,956 (GRCm39) missense probably benign
R8046:Usp25 UTSW 16 76,906,063 (GRCm39) missense probably damaging 1.00
R8069:Usp25 UTSW 16 76,865,943 (GRCm39) missense possibly damaging 0.58
R8140:Usp25 UTSW 16 76,868,569 (GRCm39) nonsense probably null
R8167:Usp25 UTSW 16 76,904,819 (GRCm39) missense probably damaging 1.00
R8437:Usp25 UTSW 16 76,830,800 (GRCm39) missense probably damaging 1.00
R8704:Usp25 UTSW 16 76,856,178 (GRCm39) missense probably benign 0.00
R8903:Usp25 UTSW 16 76,878,421 (GRCm39) missense probably damaging 1.00
R9123:Usp25 UTSW 16 76,911,969 (GRCm39) critical splice donor site probably null
R9276:Usp25 UTSW 16 76,910,721 (GRCm39) missense probably benign 0.09
R9286:Usp25 UTSW 16 76,904,864 (GRCm39) missense probably damaging 1.00
R9368:Usp25 UTSW 16 76,904,843 (GRCm39) missense probably damaging 1.00
R9489:Usp25 UTSW 16 76,874,046 (GRCm39) missense probably damaging 1.00
R9515:Usp25 UTSW 16 76,852,076 (GRCm39) missense probably damaging 1.00
R9516:Usp25 UTSW 16 76,852,076 (GRCm39) missense probably damaging 1.00
R9580:Usp25 UTSW 16 76,880,682 (GRCm39) missense probably benign 0.00
R9605:Usp25 UTSW 16 76,874,046 (GRCm39) missense probably damaging 1.00
R9667:Usp25 UTSW 16 76,874,123 (GRCm39) critical splice donor site probably null
X0065:Usp25 UTSW 16 76,878,444 (GRCm39) missense probably damaging 1.00
Z1176:Usp25 UTSW 16 76,878,409 (GRCm39) missense probably damaging 1.00
Z1176:Usp25 UTSW 16 76,868,680 (GRCm39) missense possibly damaging 0.93
Z1176:Usp25 UTSW 16 76,868,679 (GRCm39) missense probably damaging 0.98
Z1176:Usp25 UTSW 16 76,910,718 (GRCm39) missense probably benign
Z1176:Usp25 UTSW 16 76,880,801 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GCCACCAAACCTTTGCGTCATC -3'
(R):5'- ACCCGCAGTGCTTAGAAGAACATTC -3'

Sequencing Primer
(F):5'- TTGCGTCATCCCACTGG -3'
(R):5'- TTAGAAGAACATTCAGCAGGCTC -3'
Posted On 2013-05-23