Incidental Mutation 'R5000:Robo4'
| ID |
389835 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo4
|
| Ensembl Gene |
ENSMUSG00000032125 |
| Gene Name |
roundabout guidance receptor 4 |
| Synonyms |
Magic roundabout, 1200012D01Rik |
| MMRRC Submission |
042594-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.224)
|
| Stock # |
R5000 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
37313198-37325319 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 37319664 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Leucine
at position 527
(R527L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000110700
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102895]
[ENSMUST00000115046]
[ENSMUST00000115048]
[ENSMUST00000156972]
[ENSMUST00000214185]
|
| AlphaFold |
Q8C310 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102895
AA Change: R638L
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000099959
Gene: ENSMUSG00000032125
AA Change: R638L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
748 |
762 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
799 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
866 |
N/A |
INTRINSIC |
|
low complexity region
|
871 |
880 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115046
AA Change: R690L
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000110698
Gene: ENSMUSG00000032125
AA Change: R690L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
484 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
540 |
546 |
N/A |
INTRINSIC |
|
low complexity region
|
596 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
756 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
821 |
N/A |
INTRINSIC |
|
low complexity region
|
834 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
914 |
925 |
N/A |
INTRINSIC |
|
low complexity region
|
930 |
939 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115048
AA Change: R527L
PolyPhen 2
Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000110700
Gene: ENSMUSG00000032125
AA Change: R527L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
695 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
740 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
769 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
806 |
N/A |
INTRINSIC |
|
low complexity region
|
862 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
887 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156972
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000214185
AA Change: R638L
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215777
|
| Meta Mutation Damage Score |
0.0674 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.4%
|
| Validation Efficiency |
98% (97/99) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a reporter/null allele display enhanced VEGF-induced endothelial migration, tube formation and vascular permeability, and show increased pathologic angiogenesis and vascular leak in models of oxygen-induced retinopathy and choroidal neovascularization. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022A10Rik |
T |
A |
7: 27,255,946 (GRCm39) |
F11Y |
probably benign |
Het |
| Abca5 |
A |
G |
11: 110,201,050 (GRCm39) |
L450P |
probably damaging |
Het |
| Abi1 |
T |
A |
2: 22,840,211 (GRCm39) |
R357W |
probably damaging |
Het |
| Acot7 |
G |
A |
4: 152,270,820 (GRCm39) |
G55R |
probably benign |
Het |
| Aicda |
G |
A |
6: 122,538,826 (GRCm39) |
V14I |
probably damaging |
Het |
| Anxa4 |
G |
T |
6: 86,742,766 (GRCm39) |
|
probably benign |
Het |
| Apobr |
T |
A |
7: 126,185,729 (GRCm39) |
D413E |
possibly damaging |
Het |
| Ash1l |
T |
C |
3: 88,965,941 (GRCm39) |
Y2448H |
probably damaging |
Het |
| Atf7ip |
A |
G |
6: 136,559,426 (GRCm39) |
E749G |
probably damaging |
Het |
| Atp8b3 |
A |
T |
10: 80,357,676 (GRCm39) |
N1114K |
possibly damaging |
Het |
| Bdnf |
C |
A |
2: 109,553,993 (GRCm39) |
N122K |
probably benign |
Het |
| Boc |
A |
T |
16: 44,310,517 (GRCm39) |
I801N |
probably damaging |
Het |
| Brap |
A |
T |
5: 121,800,089 (GRCm39) |
K37* |
probably null |
Het |
| Ccar1 |
C |
T |
10: 62,586,784 (GRCm39) |
E885K |
unknown |
Het |
| Ccdc103 |
A |
G |
11: 102,774,932 (GRCm39) |
N177S |
probably benign |
Het |
| Ccdc116 |
G |
A |
16: 16,959,657 (GRCm39) |
P344L |
possibly damaging |
Het |
| Cdca5 |
T |
C |
19: 6,135,463 (GRCm39) |
S28P |
possibly damaging |
Het |
| Ceacam20 |
T |
C |
7: 19,699,453 (GRCm39) |
I14T |
probably damaging |
Het |
| Chrnb1 |
A |
T |
11: 69,677,858 (GRCm39) |
V298E |
probably damaging |
Het |
| Cnksr3 |
G |
A |
10: 7,076,746 (GRCm39) |
Q149* |
probably null |
Het |
| Csnk1a1 |
T |
C |
18: 61,711,840 (GRCm39) |
F97L |
probably damaging |
Het |
| Dag1 |
A |
T |
9: 108,085,216 (GRCm39) |
S642T |
probably benign |
Het |
| Dedd2 |
A |
G |
7: 24,903,068 (GRCm39) |
V297A |
possibly damaging |
Het |
| Dhcr7 |
C |
T |
7: 143,395,060 (GRCm39) |
T189M |
possibly damaging |
Het |
| Dlgap1 |
T |
C |
17: 71,073,053 (GRCm39) |
S691P |
probably damaging |
Het |
| Dmgdh |
A |
C |
13: 93,825,046 (GRCm39) |
H123P |
probably damaging |
Het |
| Dnah6 |
C |
T |
6: 73,121,798 (GRCm39) |
V1395I |
probably benign |
Het |
| Dnah7a |
T |
C |
1: 53,606,201 (GRCm39) |
Y1273C |
probably damaging |
Het |
| Dnah7b |
T |
A |
1: 46,138,663 (GRCm39) |
L235* |
probably null |
Het |
| Elac2 |
T |
C |
11: 64,876,379 (GRCm39) |
F3L |
probably benign |
Het |
| Elovl7 |
A |
T |
13: 108,410,915 (GRCm39) |
K163N |
probably benign |
Het |
| Epg5 |
T |
C |
18: 77,997,376 (GRCm39) |
V413A |
probably benign |
Het |
| Espl1 |
T |
A |
15: 102,206,986 (GRCm39) |
L150Q |
probably damaging |
Het |
| F2rl3 |
T |
A |
8: 73,489,307 (GRCm39) |
L178Q |
probably damaging |
Het |
| Fam120a |
T |
C |
13: 49,051,143 (GRCm39) |
E754G |
probably damaging |
Het |
| Fam53b |
T |
C |
7: 132,317,730 (GRCm39) |
N304S |
probably benign |
Het |
| Fbxo41 |
T |
C |
6: 85,460,901 (GRCm39) |
E269G |
probably damaging |
Het |
| Fcrla |
T |
C |
1: 170,749,959 (GRCm39) |
T4A |
probably benign |
Het |
| Frmpd1 |
A |
T |
4: 45,261,931 (GRCm39) |
|
probably null |
Het |
| Gm9376 |
A |
G |
14: 118,504,702 (GRCm39) |
M45V |
probably benign |
Het |
| Gpr68 |
G |
A |
12: 100,844,596 (GRCm39) |
A316V |
probably benign |
Het |
| Hmgcl |
G |
A |
4: 135,689,511 (GRCm39) |
C323Y |
probably benign |
Het |
| Hnrnpu |
T |
C |
1: 178,156,941 (GRCm39) |
|
probably benign |
Het |
| Ier2 |
T |
A |
8: 85,389,353 (GRCm39) |
I10F |
probably damaging |
Het |
| Ip6k1 |
C |
T |
9: 107,922,798 (GRCm39) |
Q234* |
probably null |
Het |
| Llgl2 |
T |
C |
11: 115,735,728 (GRCm39) |
V108A |
probably benign |
Het |
| Lrfn3 |
T |
C |
7: 30,059,805 (GRCm39) |
N140S |
possibly damaging |
Het |
| Lrig1 |
T |
A |
6: 94,588,430 (GRCm39) |
H573L |
probably damaging |
Het |
| Lrrk2 |
T |
A |
15: 91,634,081 (GRCm39) |
W1393R |
probably damaging |
Het |
| Mrc1 |
T |
A |
2: 14,249,000 (GRCm39) |
Y179N |
probably damaging |
Het |
| Mtfr1 |
C |
T |
3: 19,265,743 (GRCm39) |
L93F |
probably damaging |
Het |
| Muc19 |
T |
C |
15: 91,757,429 (GRCm39) |
|
noncoding transcript |
Het |
| Ndst2 |
C |
T |
14: 20,774,975 (GRCm39) |
|
probably null |
Het |
| Nmd3 |
A |
T |
3: 69,624,735 (GRCm39) |
|
probably benign |
Het |
| Nsd3 |
A |
G |
8: 26,172,593 (GRCm39) |
Y784C |
probably damaging |
Het |
| Or4a27 |
A |
T |
2: 88,559,910 (GRCm39) |
I11N |
probably damaging |
Het |
| Or7a36 |
G |
A |
10: 78,820,514 (GRCm39) |
V297I |
probably benign |
Het |
| Papln |
A |
G |
12: 83,821,663 (GRCm39) |
Y297C |
probably damaging |
Het |
| Pdhx |
T |
C |
2: 102,871,385 (GRCm39) |
|
probably null |
Het |
| Pdpk1 |
T |
C |
17: 24,330,019 (GRCm39) |
T6A |
possibly damaging |
Het |
| Prcp |
T |
C |
7: 92,568,368 (GRCm39) |
W267R |
probably damaging |
Het |
| Prg2 |
T |
C |
2: 84,812,367 (GRCm39) |
S26P |
probably benign |
Het |
| Psg26 |
A |
T |
7: 18,214,057 (GRCm39) |
Y202N |
possibly damaging |
Het |
| Psrc1 |
T |
C |
3: 108,287,839 (GRCm39) |
|
probably benign |
Het |
| Rap1gds1 |
A |
T |
3: 138,662,011 (GRCm39) |
M366K |
probably damaging |
Het |
| Sel1l3 |
G |
A |
5: 53,357,776 (GRCm39) |
T72M |
probably damaging |
Het |
| Selenoo |
G |
A |
15: 88,978,387 (GRCm39) |
R270H |
probably damaging |
Het |
| Sema3d |
A |
G |
5: 12,498,005 (GRCm39) |
T4A |
probably benign |
Het |
| Shroom1 |
A |
T |
11: 53,357,944 (GRCm39) |
|
probably benign |
Het |
| Slc25a19 |
T |
C |
11: 115,507,497 (GRCm39) |
|
probably null |
Het |
| Snx29 |
A |
C |
16: 11,221,371 (GRCm39) |
I266L |
probably damaging |
Het |
| Spo11 |
T |
C |
2: 172,831,193 (GRCm39) |
S255P |
probably damaging |
Het |
| Spock3 |
T |
C |
8: 63,698,158 (GRCm39) |
V167A |
possibly damaging |
Het |
| Tmc7 |
A |
G |
7: 118,158,077 (GRCm39) |
|
probably null |
Het |
| Tmtc4 |
A |
G |
14: 123,170,743 (GRCm39) |
V509A |
possibly damaging |
Het |
| Trim24 |
A |
G |
6: 37,935,547 (GRCm39) |
D880G |
probably benign |
Het |
| Ube2j2 |
G |
A |
4: 156,030,841 (GRCm39) |
M1I |
probably null |
Het |
| Ubr4 |
T |
A |
4: 139,163,480 (GRCm39) |
C2627S |
probably damaging |
Het |
| Unc5d |
A |
T |
8: 29,205,775 (GRCm39) |
M512K |
possibly damaging |
Het |
| Usp18 |
A |
G |
6: 121,229,479 (GRCm39) |
R33G |
possibly damaging |
Het |
| Utp23 |
T |
A |
15: 51,745,569 (GRCm39) |
V23D |
probably damaging |
Het |
| Wdr17 |
T |
A |
8: 55,118,161 (GRCm39) |
M512L |
possibly damaging |
Het |
| Wdr64 |
T |
A |
1: 175,553,941 (GRCm39) |
|
probably null |
Het |
| Zbtb6 |
T |
C |
2: 37,319,251 (GRCm39) |
T226A |
probably benign |
Het |
| Zc3hc1 |
T |
A |
6: 30,375,987 (GRCm39) |
H191L |
possibly damaging |
Het |
| Zdhhc4 |
C |
A |
5: 143,310,688 (GRCm39) |
C48F |
probably damaging |
Het |
| Zfp335 |
T |
A |
2: 164,736,588 (GRCm39) |
T1016S |
probably benign |
Het |
| Zfp583 |
A |
G |
7: 6,328,473 (GRCm39) |
Y39H |
probably damaging |
Het |
|
| Other mutations in Robo4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Robo4
|
APN |
9 |
37,322,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Robo4
|
APN |
9 |
37,319,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00491:Robo4
|
APN |
9 |
37,317,231 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL00792:Robo4
|
APN |
9 |
37,319,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01062:Robo4
|
APN |
9 |
37,317,296 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01287:Robo4
|
APN |
9 |
37,324,336 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02289:Robo4
|
APN |
9 |
37,319,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02486:Robo4
|
APN |
9 |
37,319,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02851:Robo4
|
APN |
9 |
37,324,678 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02898:Robo4
|
APN |
9 |
37,319,472 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02965:Robo4
|
APN |
9 |
37,321,765 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03071:Robo4
|
APN |
9 |
37,315,580 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Robo4
|
APN |
9 |
37,315,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8562:Robo4
|
UTSW |
9 |
37,317,106 (GRCm39) |
intron |
probably benign |
|
|
PIT4305001:Robo4
|
UTSW |
9 |
37,322,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0068:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0416:Robo4
|
UTSW |
9 |
37,316,062 (GRCm39) |
splice site |
probably benign |
|
|
R1005:Robo4
|
UTSW |
9 |
37,319,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1174:Robo4
|
UTSW |
9 |
37,324,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1183:Robo4
|
UTSW |
9 |
37,319,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1254:Robo4
|
UTSW |
9 |
37,322,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1398:Robo4
|
UTSW |
9 |
37,319,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1505:Robo4
|
UTSW |
9 |
37,314,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Robo4
|
UTSW |
9 |
37,314,739 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1834:Robo4
|
UTSW |
9 |
37,324,355 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1899:Robo4
|
UTSW |
9 |
37,315,366 (GRCm39) |
splice site |
probably benign |
|
|
R2203:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2204:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2351:Robo4
|
UTSW |
9 |
37,322,956 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2448:Robo4
|
UTSW |
9 |
37,313,958 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2847:Robo4
|
UTSW |
9 |
37,315,772 (GRCm39) |
nonsense |
probably null |
|
|
R2851:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2852:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2877:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3123:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3124:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3125:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3805:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3806:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3892:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3905:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R3938:Robo4
|
UTSW |
9 |
37,313,313 (GRCm39) |
start gained |
probably benign |
|
|
R4261:Robo4
|
UTSW |
9 |
37,316,877 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4434:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4435:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4561:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4562:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4568:Robo4
|
UTSW |
9 |
37,316,118 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4695:Robo4
|
UTSW |
9 |
37,314,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4921:Robo4
|
UTSW |
9 |
37,313,856 (GRCm39) |
missense |
probably benign |
|
|
R5056:Robo4
|
UTSW |
9 |
37,316,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5125:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5279:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5285:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5347:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5348:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5361:Robo4
|
UTSW |
9 |
37,324,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5403:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5404:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5488:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5489:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5490:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5494:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5629:Robo4
|
UTSW |
9 |
37,319,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5736:Robo4
|
UTSW |
9 |
37,316,093 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5796:Robo4
|
UTSW |
9 |
37,322,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5987:Robo4
|
UTSW |
9 |
37,322,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6178:Robo4
|
UTSW |
9 |
37,316,926 (GRCm39) |
nonsense |
probably null |
|
|
R6189:Robo4
|
UTSW |
9 |
37,314,829 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6365:Robo4
|
UTSW |
9 |
37,322,008 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6528:Robo4
|
UTSW |
9 |
37,315,664 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6887:Robo4
|
UTSW |
9 |
37,313,363 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7196:Robo4
|
UTSW |
9 |
37,314,001 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7408:Robo4
|
UTSW |
9 |
37,322,277 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7419:Robo4
|
UTSW |
9 |
37,314,105 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7486:Robo4
|
UTSW |
9 |
37,316,870 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7707:Robo4
|
UTSW |
9 |
37,324,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7839:Robo4
|
UTSW |
9 |
37,322,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8079:Robo4
|
UTSW |
9 |
37,313,931 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8081:Robo4
|
UTSW |
9 |
37,316,936 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8280:Robo4
|
UTSW |
9 |
37,315,372 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8526:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R8547:Robo4
|
UTSW |
9 |
37,315,674 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8735:Robo4
|
UTSW |
9 |
37,319,577 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8836:Robo4
|
UTSW |
9 |
37,317,130 (GRCm39) |
missense |
unknown |
|
|
R8889:Robo4
|
UTSW |
9 |
37,314,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9018:Robo4
|
UTSW |
9 |
37,315,520 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Robo4
|
UTSW |
9 |
37,313,206 (GRCm39) |
start gained |
probably benign |
|
|
R9375:Robo4
|
UTSW |
9 |
37,316,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9621:Robo4
|
UTSW |
9 |
37,317,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTAGTGATCTCCTGGGACC -3'
(R):5'- CACTATTGTAAAGAGGAGCTGAGC -3'
Sequencing Primer
(F):5'- ATCTCCTGGGACCCTCGGAG -3'
(R):5'- GAGGAGCTGAGCAATCATCCC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation