Incidental Mutation 'R5001:Trip11'
| ID |
389952 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip11
|
| Ensembl Gene |
ENSMUSG00000021188 |
| Gene Name |
thyroid hormone receptor interactor 11 |
| Synonyms |
3110031G15Rik, TRIP230, 2610511G22Rik, GMAP-210, 6030460N08Rik |
| MMRRC Submission |
042595-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5001 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
101800304-101879463 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 101851169 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 680
(L680*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134976
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021605]
[ENSMUST00000176728]
[ENSMUST00000177183]
[ENSMUST00000177536]
|
| AlphaFold |
E9Q512 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000021605
AA Change: L965*
|
| SMART Domains |
Protein: ENSMUSP00000021605
Gene: ENSMUSG00000021188
AA Change: L965*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
54 |
130 |
N/A |
INTRINSIC |
|
coiled coil region
|
167 |
194 |
N/A |
INTRINSIC |
|
coiled coil region
|
218 |
702 |
N/A |
INTRINSIC |
|
coiled coil region
|
754 |
990 |
N/A |
INTRINSIC |
|
coiled coil region
|
1022 |
1051 |
N/A |
INTRINSIC |
|
coiled coil region
|
1196 |
1261 |
N/A |
INTRINSIC |
|
low complexity region
|
1310 |
1322 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1481 |
N/A |
INTRINSIC |
|
coiled coil region
|
1547 |
1657 |
N/A |
INTRINSIC |
|
coiled coil region
|
1681 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1934 |
1945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176728
|
| SMART Domains |
Protein: ENSMUSP00000134992
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
Pfam:Orthopox_A5L
|
48 |
282 |
6.5e-9 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000177183
AA Change: L680*
|
| SMART Domains |
Protein: ENSMUSP00000134976
Gene: ENSMUSG00000021188
AA Change: L680*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
33 |
158 |
N/A |
INTRINSIC |
|
coiled coil region
|
179 |
417 |
N/A |
INTRINSIC |
|
coiled coil region
|
469 |
705 |
N/A |
INTRINSIC |
|
coiled coil region
|
737 |
766 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
1025 |
1037 |
N/A |
INTRINSIC |
|
coiled coil region
|
1051 |
1196 |
N/A |
INTRINSIC |
|
coiled coil region
|
1262 |
1372 |
N/A |
INTRINSIC |
|
coiled coil region
|
1396 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1660 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177480
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177536
|
| SMART Domains |
Protein: ENSMUSP00000135669
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
53 |
129 |
N/A |
INTRINSIC |
|
coiled coil region
|
166 |
193 |
N/A |
INTRINSIC |
|
coiled coil region
|
217 |
517 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(12) : Gene trapped(11) Chemically induced(1)
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy3 |
G |
A |
12: 4,248,434 (GRCm39) |
V499M |
possibly damaging |
Het |
| Aff4 |
T |
C |
11: 53,295,184 (GRCm39) |
S795P |
probably damaging |
Het |
| Ank |
G |
A |
15: 27,562,819 (GRCm39) |
V176I |
probably damaging |
Het |
| Ankfn1 |
A |
G |
11: 89,332,268 (GRCm39) |
I446T |
possibly damaging |
Het |
| Arhgap33 |
C |
A |
7: 30,232,441 (GRCm39) |
S32I |
possibly damaging |
Het |
| Ascc3 |
T |
A |
10: 50,699,744 (GRCm39) |
Y1856N |
probably damaging |
Het |
| Atf3 |
T |
C |
1: 190,909,472 (GRCm39) |
T66A |
probably benign |
Het |
| Atf7ip |
T |
C |
6: 136,538,386 (GRCm39) |
C548R |
probably damaging |
Het |
| Bag6 |
A |
G |
17: 35,364,152 (GRCm39) |
T841A |
probably damaging |
Het |
| Bbof1 |
A |
T |
12: 84,473,630 (GRCm39) |
Q320L |
possibly damaging |
Het |
| Bmp2k |
A |
T |
5: 97,201,001 (GRCm39) |
Q307L |
probably damaging |
Het |
| Btaf1 |
T |
A |
19: 36,964,052 (GRCm39) |
N874K |
possibly damaging |
Het |
| Calr4 |
G |
A |
4: 109,096,179 (GRCm39) |
|
probably null |
Het |
| Camk1d |
T |
C |
2: 5,317,912 (GRCm39) |
I248V |
possibly damaging |
Het |
| Ccdc177 |
G |
A |
12: 80,804,160 (GRCm39) |
R705C |
unknown |
Het |
| Cdk18 |
C |
T |
1: 132,046,587 (GRCm39) |
|
probably null |
Het |
| Cers4 |
A |
G |
8: 4,565,565 (GRCm39) |
S4G |
probably benign |
Het |
| Cfap54 |
A |
G |
10: 92,800,396 (GRCm39) |
V1604A |
probably benign |
Het |
| Chd8 |
C |
T |
14: 52,441,372 (GRCm39) |
G907S |
probably benign |
Het |
| Cilk1 |
T |
C |
9: 78,038,801 (GRCm39) |
S17P |
probably damaging |
Het |
| Cnksr3 |
G |
A |
10: 7,076,746 (GRCm39) |
Q149* |
probably null |
Het |
| Cntd1 |
T |
C |
11: 101,176,557 (GRCm39) |
V218A |
possibly damaging |
Het |
| Cog7 |
A |
T |
7: 121,549,109 (GRCm39) |
V384E |
probably damaging |
Het |
| Col5a2 |
A |
G |
1: 45,542,058 (GRCm39) |
V6A |
unknown |
Het |
| Col7a1 |
T |
C |
9: 108,794,146 (GRCm39) |
|
probably null |
Het |
| Cpsf6 |
T |
A |
10: 117,203,866 (GRCm39) |
I29L |
possibly damaging |
Het |
| Cyp3a13 |
T |
C |
5: 137,897,178 (GRCm39) |
T379A |
probably benign |
Het |
| Ddx46 |
T |
C |
13: 55,800,732 (GRCm39) |
S296P |
probably damaging |
Het |
| Dmbt1 |
A |
G |
7: 130,651,742 (GRCm39) |
D328G |
probably damaging |
Het |
| Dnah8 |
T |
G |
17: 31,006,159 (GRCm39) |
L3692W |
probably damaging |
Het |
| Dnmt3l |
A |
C |
10: 77,895,565 (GRCm39) |
S368R |
probably null |
Het |
| Egfr |
A |
G |
11: 16,854,434 (GRCm39) |
K869E |
probably damaging |
Het |
| Ehd1 |
G |
A |
19: 6,347,724 (GRCm39) |
M359I |
probably benign |
Het |
| F5 |
A |
T |
1: 164,023,139 (GRCm39) |
T1566S |
probably benign |
Het |
| Flrt2 |
T |
C |
12: 95,745,725 (GRCm39) |
I21T |
probably benign |
Het |
| Galnt1 |
T |
A |
18: 24,404,812 (GRCm39) |
I383K |
probably benign |
Het |
| Ghdc |
G |
T |
11: 100,657,660 (GRCm39) |
A523D |
probably damaging |
Het |
| Gm24022 |
A |
G |
12: 113,393,399 (GRCm39) |
|
probably benign |
Het |
| Golga3 |
T |
C |
5: 110,353,643 (GRCm39) |
S934P |
probably damaging |
Het |
| Gpr135 |
T |
A |
12: 72,117,282 (GRCm39) |
T162S |
probably benign |
Het |
| Gucd1 |
G |
A |
10: 75,353,036 (GRCm39) |
|
probably null |
Het |
| Hcrtr2 |
T |
A |
9: 76,137,886 (GRCm39) |
I410F |
probably benign |
Het |
| Igkv6-15 |
T |
C |
6: 70,383,633 (GRCm39) |
Y56C |
probably damaging |
Het |
| Il22ra1 |
A |
T |
4: 135,460,415 (GRCm39) |
Y57F |
probably damaging |
Het |
| Irak4 |
A |
G |
15: 94,456,154 (GRCm39) |
E247G |
possibly damaging |
Het |
| Kank3 |
T |
C |
17: 34,040,746 (GRCm39) |
V13A |
possibly damaging |
Het |
| Klhl1 |
A |
T |
14: 96,374,046 (GRCm39) |
S667T |
probably damaging |
Het |
| Klhl6 |
T |
G |
16: 19,765,741 (GRCm39) |
*620C |
probably null |
Het |
| Lct |
A |
G |
1: 128,235,978 (GRCm39) |
L343P |
probably damaging |
Het |
| Lgr6 |
G |
T |
1: 134,918,370 (GRCm39) |
P264T |
probably benign |
Het |
| Lilrb4a |
T |
A |
10: 51,367,516 (GRCm39) |
|
probably null |
Het |
| Lin7a |
G |
T |
10: 107,218,530 (GRCm39) |
G25* |
probably null |
Het |
| Lmnb2 |
G |
A |
10: 80,753,946 (GRCm39) |
T36M |
probably damaging |
Het |
| Manba |
T |
C |
3: 135,273,391 (GRCm39) |
F775S |
probably benign |
Het |
| Marchf6 |
A |
G |
15: 31,465,468 (GRCm39) |
V812A |
probably damaging |
Het |
| Megf6 |
T |
A |
4: 154,352,517 (GRCm39) |
L1292H |
probably damaging |
Het |
| Myo18b |
T |
G |
5: 112,909,206 (GRCm39) |
Q1979P |
probably damaging |
Het |
| Myoz1 |
T |
C |
14: 20,703,769 (GRCm39) |
M59V |
probably damaging |
Het |
| Naa35 |
T |
C |
13: 59,773,345 (GRCm39) |
I100T |
possibly damaging |
Het |
| Nox4 |
A |
T |
7: 87,010,011 (GRCm39) |
Y404F |
probably damaging |
Het |
| Ntn1 |
T |
C |
11: 68,151,358 (GRCm39) |
Y441C |
probably damaging |
Het |
| Onecut3 |
A |
G |
10: 80,331,154 (GRCm39) |
T105A |
unknown |
Het |
| Or10ak8 |
C |
A |
4: 118,774,440 (GRCm39) |
V75F |
probably damaging |
Het |
| Or1n1 |
T |
C |
2: 36,750,082 (GRCm39) |
T93A |
probably benign |
Het |
| Or4d5 |
G |
A |
9: 40,012,523 (GRCm39) |
H88Y |
probably benign |
Het |
| Pabpc1l |
A |
G |
2: 163,884,438 (GRCm39) |
S392G |
probably benign |
Het |
| Pan3 |
T |
A |
5: 147,463,492 (GRCm39) |
|
probably null |
Het |
| Pcdha4 |
G |
A |
18: 37,088,001 (GRCm39) |
S728N |
probably benign |
Het |
| Pds5a |
T |
C |
5: 65,854,128 (GRCm39) |
D38G |
probably damaging |
Het |
| Pgm2l1 |
A |
G |
7: 99,921,583 (GRCm39) |
I605V |
probably benign |
Het |
| Phip |
T |
C |
9: 82,778,072 (GRCm39) |
|
probably null |
Het |
| Pilra |
T |
C |
5: 137,833,777 (GRCm39) |
I96M |
probably damaging |
Het |
| Ppig |
T |
A |
2: 69,571,830 (GRCm39) |
V183D |
unknown |
Het |
| Ppp2r2a |
A |
T |
14: 67,259,757 (GRCm39) |
L313* |
probably null |
Het |
| Ppp4c |
A |
G |
7: 126,386,709 (GRCm39) |
F126S |
probably damaging |
Het |
| Ptger2 |
C |
A |
14: 45,226,824 (GRCm39) |
R135S |
probably damaging |
Het |
| Rab11fip5 |
T |
A |
6: 85,324,788 (GRCm39) |
E506D |
probably damaging |
Het |
| Rdh12 |
G |
A |
12: 79,259,516 (GRCm39) |
G133R |
probably damaging |
Het |
| Rims2 |
A |
T |
15: 39,315,824 (GRCm39) |
D610V |
probably benign |
Het |
| Saa1 |
T |
A |
7: 46,390,132 (GRCm39) |
Y122F |
probably damaging |
Het |
| Septin10 |
A |
T |
10: 59,012,811 (GRCm39) |
V269E |
probably damaging |
Het |
| Serpina3n |
T |
A |
12: 104,374,998 (GRCm39) |
D23E |
probably benign |
Het |
| Serpinb11 |
A |
G |
1: 107,304,598 (GRCm39) |
K188E |
possibly damaging |
Het |
| Slc18a3 |
C |
T |
14: 32,185,736 (GRCm39) |
V216M |
possibly damaging |
Het |
| Slc19a3 |
G |
T |
1: 83,000,341 (GRCm39) |
N225K |
probably benign |
Het |
| Slc4a1 |
T |
A |
11: 102,242,329 (GRCm39) |
I797F |
probably benign |
Het |
| Slx9 |
A |
G |
10: 77,325,850 (GRCm39) |
V154A |
probably benign |
Het |
| Spic |
A |
G |
10: 88,511,761 (GRCm39) |
M165T |
possibly damaging |
Het |
| Timm44 |
A |
T |
8: 4,325,886 (GRCm39) |
M1K |
probably null |
Het |
| Tmc6 |
A |
G |
11: 117,661,610 (GRCm39) |
L572P |
probably benign |
Het |
| Tnc |
G |
A |
4: 63,918,299 (GRCm39) |
T1204M |
probably benign |
Het |
| Tnc |
G |
A |
4: 63,902,726 (GRCm39) |
T1517I |
probably damaging |
Het |
| Trps1 |
T |
A |
15: 50,524,703 (GRCm39) |
M887L |
possibly damaging |
Het |
| Tulp3 |
A |
C |
6: 128,302,031 (GRCm39) |
V330G |
probably damaging |
Het |
| Upf1 |
A |
G |
8: 70,787,350 (GRCm39) |
S835P |
probably damaging |
Het |
| Wdr64 |
A |
G |
1: 175,620,525 (GRCm39) |
|
probably null |
Het |
| Yju2b |
G |
A |
8: 84,985,304 (GRCm39) |
P322S |
probably benign |
Het |
| Zbtb40 |
A |
G |
4: 136,723,461 (GRCm39) |
L643P |
probably damaging |
Het |
| Zc3h18 |
A |
T |
8: 123,110,259 (GRCm39) |
D36V |
probably damaging |
Het |
|
| Other mutations in Trip11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00430:Trip11
|
APN |
12 |
101,852,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00484:Trip11
|
APN |
12 |
101,851,570 (GRCm39) |
nonsense |
probably null |
|
|
IGL00972:Trip11
|
APN |
12 |
101,860,596 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01476:Trip11
|
APN |
12 |
101,865,170 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01591:Trip11
|
APN |
12 |
101,849,604 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01667:Trip11
|
APN |
12 |
101,845,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Trip11
|
APN |
12 |
101,850,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01789:Trip11
|
APN |
12 |
101,838,090 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01814:Trip11
|
APN |
12 |
101,850,747 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01898:Trip11
|
APN |
12 |
101,851,935 (GRCm39) |
missense |
probably benign |
|
|
IGL01924:Trip11
|
APN |
12 |
101,853,143 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02020:Trip11
|
APN |
12 |
101,850,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02475:Trip11
|
APN |
12 |
101,861,942 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02544:Trip11
|
APN |
12 |
101,859,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Trip11
|
APN |
12 |
101,849,649 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02714:Trip11
|
APN |
12 |
101,850,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02718:Trip11
|
APN |
12 |
101,852,284 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02904:Trip11
|
APN |
12 |
101,853,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Trip11
|
APN |
12 |
101,850,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03191:Trip11
|
APN |
12 |
101,865,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Trip11
|
APN |
12 |
101,849,677 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03337:Trip11
|
APN |
12 |
101,851,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
NA:Trip11
|
UTSW |
12 |
101,860,580 (GRCm39) |
splice site |
probably null |
|
|
R0027:Trip11
|
UTSW |
12 |
101,851,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0028:Trip11
|
UTSW |
12 |
101,851,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trip11
|
UTSW |
12 |
101,851,931 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0556:Trip11
|
UTSW |
12 |
101,850,777 (GRCm39) |
nonsense |
probably null |
|
|
R0573:Trip11
|
UTSW |
12 |
101,853,119 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0626:Trip11
|
UTSW |
12 |
101,852,235 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1519:Trip11
|
UTSW |
12 |
101,852,419 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1530:Trip11
|
UTSW |
12 |
101,879,026 (GRCm39) |
missense |
unknown |
|
|
R1647:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1648:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1856:Trip11
|
UTSW |
12 |
101,849,592 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Trip11
|
UTSW |
12 |
101,803,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Trip11
|
UTSW |
12 |
101,851,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2206:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2207:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2304:Trip11
|
UTSW |
12 |
101,865,236 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R2328:Trip11
|
UTSW |
12 |
101,845,086 (GRCm39) |
makesense |
probably null |
|
|
R2513:Trip11
|
UTSW |
12 |
101,803,986 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3499:Trip11
|
UTSW |
12 |
101,859,953 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4105:Trip11
|
UTSW |
12 |
101,860,581 (GRCm39) |
nonsense |
probably null |
|
|
R4124:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4126:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4128:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4175:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4176:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4181:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4296:Trip11
|
UTSW |
12 |
101,852,127 (GRCm39) |
nonsense |
probably null |
|
|
R4302:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Trip11
|
UTSW |
12 |
101,853,198 (GRCm39) |
missense |
probably benign |
|
|
R4342:Trip11
|
UTSW |
12 |
101,850,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Trip11
|
UTSW |
12 |
101,852,499 (GRCm39) |
nonsense |
probably null |
|
|
R4586:Trip11
|
UTSW |
12 |
101,849,600 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4634:Trip11
|
UTSW |
12 |
101,803,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4696:Trip11
|
UTSW |
12 |
101,851,549 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4792:Trip11
|
UTSW |
12 |
101,851,705 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4903:Trip11
|
UTSW |
12 |
101,853,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5017:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5227:Trip11
|
UTSW |
12 |
101,851,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5231:Trip11
|
UTSW |
12 |
101,851,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5539:Trip11
|
UTSW |
12 |
101,851,386 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5755:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5890:Trip11
|
UTSW |
12 |
101,852,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5910:Trip11
|
UTSW |
12 |
101,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6083:Trip11
|
UTSW |
12 |
101,856,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6208:Trip11
|
UTSW |
12 |
101,865,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6216:Trip11
|
UTSW |
12 |
101,856,859 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6315:Trip11
|
UTSW |
12 |
101,851,837 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6413:Trip11
|
UTSW |
12 |
101,851,790 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6590:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6690:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6914:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6938:Trip11
|
UTSW |
12 |
101,803,886 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Trip11
|
UTSW |
12 |
101,859,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Trip11
|
UTSW |
12 |
101,852,126 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7133:Trip11
|
UTSW |
12 |
101,850,329 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7271:Trip11
|
UTSW |
12 |
101,850,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Trip11
|
UTSW |
12 |
101,851,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Trip11
|
UTSW |
12 |
101,850,278 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7472:Trip11
|
UTSW |
12 |
101,851,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7491:Trip11
|
UTSW |
12 |
101,851,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7752:Trip11
|
UTSW |
12 |
101,853,233 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7763:Trip11
|
UTSW |
12 |
101,811,114 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7779:Trip11
|
UTSW |
12 |
101,849,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7844:Trip11
|
UTSW |
12 |
101,844,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8055:Trip11
|
UTSW |
12 |
101,803,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8076:Trip11
|
UTSW |
12 |
101,849,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Trip11
|
UTSW |
12 |
101,860,643 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8294:Trip11
|
UTSW |
12 |
101,811,160 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8318:Trip11
|
UTSW |
12 |
101,879,063 (GRCm39) |
missense |
unknown |
|
|
R8690:Trip11
|
UTSW |
12 |
101,839,656 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8879:Trip11
|
UTSW |
12 |
101,828,857 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8964:Trip11
|
UTSW |
12 |
101,811,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9005:Trip11
|
UTSW |
12 |
101,845,131 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9013:Trip11
|
UTSW |
12 |
101,851,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9020:Trip11
|
UTSW |
12 |
101,850,770 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9041:Trip11
|
UTSW |
12 |
101,845,127 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9234:Trip11
|
UTSW |
12 |
101,811,990 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9447:Trip11
|
UTSW |
12 |
101,850,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Trip11
|
UTSW |
12 |
101,859,807 (GRCm39) |
missense |
probably benign |
|
|
R9641:Trip11
|
UTSW |
12 |
101,859,957 (GRCm39) |
nonsense |
probably null |
|
|
R9691:Trip11
|
UTSW |
12 |
101,850,123 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Trip11
|
UTSW |
12 |
101,850,765 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
X0020:Trip11
|
UTSW |
12 |
101,852,172 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AAGCTTGATCTCCAGCTCCC -3'
(R):5'- TGCACAGAATCAAGGGTCATC -3'
Sequencing Primer
(F):5'- GATCTCCAGCTCCCTCTCC -3'
(R):5'- TCTGGAAGAAGAGATTAAACATCACC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation