Incidental Mutation 'R5004:Ptprk'
| ID |
390080 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ptprk
|
| Ensembl Gene |
ENSMUSG00000019889 |
| Gene Name |
protein tyrosine phosphatase receptor type K |
| Synonyms |
RPTPkappa, PTPk |
| MMRRC Submission |
042597-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5004 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
27950816-28473393 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 28462059 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 1181
(D1181E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151986
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166468]
[ENSMUST00000218276]
[ENSMUST00000218359]
[ENSMUST00000220357]
|
| AlphaFold |
P35822 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000166468
AA Change: D1193E
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000126279
Gene: ENSMUSG00000019889
AA Change: D1193E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
MAM
|
30 |
193 |
1.61e-73 |
SMART |
|
IG
|
200 |
288 |
2.16e-8 |
SMART |
|
FN3
|
290 |
373 |
1.48e-4 |
SMART |
|
FN3
|
389 |
475 |
4.24e1 |
SMART |
|
FN3
|
491 |
579 |
3.32e-7 |
SMART |
|
transmembrane domain
|
753 |
774 |
N/A |
INTRINSIC |
|
PTPc
|
898 |
1161 |
3.56e-132 |
SMART |
|
PTPc
|
1190 |
1455 |
2.68e-86 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000218276
AA Change: D1207E
PolyPhen 2
Score 0.050 (Sensitivity: 0.94; Specificity: 0.83)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000218359
AA Change: D1181E
PolyPhen 2
Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000220357
AA Change: D122E
PolyPhen 2
Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000220404
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700029H14Rik |
A |
C |
8: 13,605,927 (GRCm39) |
D189E |
possibly damaging |
Het |
| Abca5 |
C |
T |
11: 110,170,202 (GRCm39) |
E1298K |
probably damaging |
Het |
| Actg1 |
C |
A |
11: 120,238,986 (GRCm39) |
|
probably benign |
Het |
| Add2 |
A |
G |
6: 86,073,728 (GRCm39) |
T206A |
probably benign |
Het |
| Alox12e |
A |
G |
11: 70,212,330 (GRCm39) |
V116A |
probably benign |
Het |
| Ankrd27 |
T |
A |
7: 35,307,800 (GRCm39) |
D346E |
probably damaging |
Het |
| Arfgap3 |
T |
A |
15: 83,194,497 (GRCm39) |
S391C |
possibly damaging |
Het |
| Bcor |
C |
T |
X: 11,906,725 (GRCm39) |
R1551Q |
probably damaging |
Het |
| Cars2 |
C |
T |
8: 11,568,956 (GRCm39) |
|
probably null |
Het |
| Cav3 |
A |
G |
6: 112,436,885 (GRCm39) |
K38R |
probably damaging |
Het |
| Ccdc159 |
G |
A |
9: 21,844,241 (GRCm39) |
R101H |
probably damaging |
Het |
| Cops7b |
A |
G |
1: 86,515,132 (GRCm39) |
|
probably benign |
Het |
| Cyp4a12b |
C |
T |
4: 115,295,310 (GRCm39) |
T472I |
probably benign |
Het |
| Cyp4a32 |
T |
C |
4: 115,458,238 (GRCm39) |
S23P |
probably damaging |
Het |
| Cyp4f13 |
T |
G |
17: 33,144,760 (GRCm39) |
I275L |
probably benign |
Het |
| Dlgap1 |
T |
A |
17: 71,025,222 (GRCm39) |
|
probably null |
Het |
| Dnajc12 |
A |
T |
10: 63,222,486 (GRCm39) |
I4L |
probably benign |
Het |
| Ephb2 |
T |
A |
4: 136,387,010 (GRCm39) |
D739V |
possibly damaging |
Het |
| Fam169a |
A |
G |
13: 97,234,100 (GRCm39) |
Y124C |
probably damaging |
Het |
| Fbln5 |
T |
A |
12: 101,727,080 (GRCm39) |
N303I |
probably damaging |
Het |
| Fdxr |
T |
C |
11: 115,160,399 (GRCm39) |
E352G |
probably benign |
Het |
| Fhad1 |
T |
G |
4: 141,729,910 (GRCm39) |
|
probably null |
Het |
| Fhod1 |
C |
T |
8: 106,063,577 (GRCm39) |
|
probably benign |
Het |
| Fndc7 |
G |
A |
3: 108,790,789 (GRCm39) |
T79M |
probably damaging |
Het |
| Fry |
A |
G |
5: 150,357,069 (GRCm39) |
Q1872R |
probably benign |
Het |
| Gbx1 |
T |
C |
5: 24,709,837 (GRCm39) |
H336R |
probably damaging |
Het |
| Gkn3 |
C |
T |
6: 87,360,507 (GRCm39) |
A163T |
probably damaging |
Het |
| Gpr15lg |
A |
T |
14: 36,824,622 (GRCm39) |
C60S |
probably damaging |
Het |
| Hacl1 |
C |
A |
14: 31,340,996 (GRCm39) |
C346F |
probably benign |
Het |
| Hectd4 |
C |
A |
5: 121,466,262 (GRCm39) |
|
probably null |
Het |
| Hectd4 |
C |
T |
5: 121,467,628 (GRCm39) |
P2526S |
possibly damaging |
Het |
| Il3ra |
A |
T |
14: 14,355,381 (GRCm38) |
E289D |
probably benign |
Het |
| Itih4 |
T |
G |
14: 30,614,629 (GRCm39) |
L497R |
probably damaging |
Het |
| Kcnh3 |
A |
T |
15: 99,124,383 (GRCm39) |
K91* |
probably null |
Het |
| Kiz |
C |
G |
2: 146,811,899 (GRCm39) |
D669E |
possibly damaging |
Het |
| Klhl30 |
T |
A |
1: 91,287,046 (GRCm39) |
|
probably null |
Het |
| Kndc1 |
C |
A |
7: 139,512,792 (GRCm39) |
C1514* |
probably null |
Het |
| Lipo2 |
A |
G |
19: 33,699,076 (GRCm39) |
|
probably null |
Het |
| Macf1 |
T |
C |
4: 123,279,268 (GRCm39) |
D5921G |
probably damaging |
Het |
| Mau2 |
A |
G |
8: 70,478,537 (GRCm39) |
Y394H |
probably damaging |
Het |
| Mctp1 |
T |
A |
13: 76,789,923 (GRCm39) |
S50R |
possibly damaging |
Het |
| Mllt10 |
T |
C |
2: 18,175,079 (GRCm39) |
Y3H |
probably damaging |
Het |
| Mon1b |
T |
C |
8: 114,365,859 (GRCm39) |
S396P |
probably damaging |
Het |
| Mrgpra4 |
A |
C |
7: 47,631,535 (GRCm39) |
L22R |
probably benign |
Het |
| Msln |
T |
G |
17: 25,973,193 (GRCm39) |
M1L |
possibly damaging |
Het |
| Myh15 |
T |
A |
16: 48,952,411 (GRCm39) |
I827N |
probably damaging |
Het |
| Myh7 |
T |
C |
14: 55,209,140 (GRCm39) |
D1866G |
probably damaging |
Het |
| Myo5b |
T |
G |
18: 74,877,844 (GRCm39) |
|
probably null |
Het |
| Nlrc5 |
T |
G |
8: 95,247,844 (GRCm39) |
|
probably benign |
Het |
| Nup210l |
A |
T |
3: 90,087,472 (GRCm39) |
R1082* |
probably null |
Het |
| Or12k7 |
A |
G |
2: 36,958,422 (GRCm39) |
Y35C |
probably damaging |
Het |
| Or4f4b |
G |
A |
2: 111,314,005 (GRCm39) |
V105I |
possibly damaging |
Het |
| Or5p63 |
T |
A |
7: 107,811,323 (GRCm39) |
K138* |
probably null |
Het |
| Or7e169 |
T |
C |
9: 19,757,398 (GRCm39) |
I172M |
probably benign |
Het |
| Pi4ka |
A |
T |
16: 17,195,033 (GRCm39) |
C122S |
probably damaging |
Het |
| Pkd2l1 |
G |
T |
19: 44,138,016 (GRCm39) |
A690E |
probably benign |
Het |
| Pramel22 |
T |
C |
4: 143,380,706 (GRCm39) |
Q439R |
probably benign |
Het |
| Prickle2 |
A |
T |
6: 92,393,736 (GRCm39) |
D312E |
probably benign |
Het |
| Prrc2a |
T |
A |
17: 35,368,974 (GRCm39) |
N2021Y |
probably benign |
Het |
| Prss3 |
T |
C |
6: 41,350,836 (GRCm39) |
Y218C |
probably damaging |
Het |
| Psg20 |
T |
C |
7: 18,414,837 (GRCm39) |
T350A |
probably damaging |
Het |
| Ptprg |
A |
T |
14: 12,220,667 (GRCm38) |
I1235F |
probably damaging |
Het |
| Rcc2 |
T |
A |
4: 140,444,977 (GRCm39) |
S415T |
possibly damaging |
Het |
| Ripor1 |
CAA |
CA |
8: 106,345,452 (GRCm39) |
|
probably null |
Het |
| Rnf31 |
T |
C |
14: 55,829,639 (GRCm39) |
L68P |
probably damaging |
Het |
| Rsph6a |
A |
T |
7: 18,791,665 (GRCm39) |
E278V |
possibly damaging |
Het |
| Rubcnl |
C |
T |
14: 75,269,617 (GRCm39) |
Q92* |
probably null |
Het |
| Scfd1 |
A |
G |
12: 51,491,777 (GRCm39) |
R580G |
probably benign |
Het |
| Sec31a |
A |
T |
5: 100,516,192 (GRCm39) |
N967K |
probably damaging |
Het |
| Sema4b |
C |
A |
7: 79,866,093 (GRCm39) |
T154N |
probably benign |
Het |
| Septin14 |
T |
A |
5: 129,770,040 (GRCm39) |
I219F |
possibly damaging |
Het |
| Serpinb9c |
A |
T |
13: 33,334,338 (GRCm39) |
S235T |
probably benign |
Het |
| Setd4 |
G |
T |
16: 93,388,133 (GRCm39) |
H118N |
probably benign |
Het |
| Siglec1 |
C |
T |
2: 130,911,789 (GRCm39) |
V1697M |
probably benign |
Het |
| Siglec1 |
A |
T |
2: 130,915,331 (GRCm39) |
L1420Q |
possibly damaging |
Het |
| Soat2 |
T |
A |
15: 102,069,546 (GRCm39) |
H402Q |
probably damaging |
Het |
| Sp3 |
A |
T |
2: 72,768,633 (GRCm39) |
V666D |
probably benign |
Het |
| Spef2 |
T |
G |
15: 9,578,413 (GRCm39) |
S1704R |
probably benign |
Het |
| Spidr |
A |
T |
16: 15,936,806 (GRCm39) |
W100R |
possibly damaging |
Het |
| Steap1 |
G |
T |
5: 5,792,829 (GRCm39) |
Y27* |
probably null |
Het |
| Svep1 |
G |
T |
4: 58,087,751 (GRCm39) |
T1776K |
probably benign |
Het |
| Tdpoz1 |
T |
A |
3: 93,578,440 (GRCm39) |
T115S |
probably benign |
Het |
| Tet2 |
A |
T |
3: 133,193,140 (GRCm39) |
H431Q |
possibly damaging |
Het |
| Tnrc6c |
T |
G |
11: 117,611,872 (GRCm39) |
V170G |
probably benign |
Het |
| Tom1 |
T |
C |
8: 75,778,630 (GRCm39) |
L99P |
probably damaging |
Het |
| Trim11 |
C |
A |
11: 58,872,164 (GRCm39) |
|
probably benign |
Het |
| Trio |
T |
C |
15: 27,755,264 (GRCm39) |
K955R |
probably damaging |
Het |
| Tubd1 |
C |
T |
11: 86,452,146 (GRCm39) |
T371I |
probably damaging |
Het |
| Usp17lb |
C |
T |
7: 104,490,884 (GRCm39) |
M13I |
probably benign |
Het |
| Usp29 |
A |
G |
7: 6,965,158 (GRCm39) |
M334V |
probably benign |
Het |
| Usp34 |
A |
G |
11: 23,414,586 (GRCm39) |
Y2843C |
probably damaging |
Het |
| Utp20 |
A |
T |
10: 88,584,135 (GRCm39) |
I2674N |
probably damaging |
Het |
| Vmn2r14 |
T |
G |
5: 109,368,246 (GRCm39) |
T249P |
probably benign |
Het |
| Vmn2r43 |
A |
T |
7: 8,247,848 (GRCm39) |
F772I |
probably damaging |
Het |
| Vmn2r51 |
T |
A |
7: 9,821,932 (GRCm39) |
E584D |
probably benign |
Het |
| Zbtb22 |
G |
T |
17: 34,136,217 (GRCm39) |
A121S |
probably benign |
Het |
| Zfp273 |
A |
T |
13: 67,973,673 (GRCm39) |
H267L |
probably damaging |
Het |
| Zkscan2 |
C |
T |
7: 123,089,267 (GRCm39) |
V335M |
probably damaging |
Het |
|
| Other mutations in Ptprk |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00310:Ptprk
|
APN |
10 |
28,212,506 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL00533:Ptprk
|
APN |
10 |
28,461,971 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01062:Ptprk
|
APN |
10 |
28,456,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01295:Ptprk
|
APN |
10 |
28,351,174 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01372:Ptprk
|
APN |
10 |
28,445,923 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01452:Ptprk
|
APN |
10 |
28,450,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01829:Ptprk
|
APN |
10 |
28,449,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01861:Ptprk
|
APN |
10 |
28,259,441 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01955:Ptprk
|
APN |
10 |
28,471,861 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02263:Ptprk
|
APN |
10 |
27,951,110 (GRCm39) |
missense |
unknown |
|
|
IGL02489:Ptprk
|
APN |
10 |
28,259,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Ptprk
|
APN |
10 |
28,451,614 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02713:Ptprk
|
APN |
10 |
28,468,807 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02943:Ptprk
|
APN |
10 |
28,351,172 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03240:Ptprk
|
APN |
10 |
28,368,957 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03373:Ptprk
|
APN |
10 |
28,442,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
LCD18:Ptprk
|
UTSW |
10 |
28,450,983 (GRCm39) |
intron |
probably benign |
|
|
PIT4366001:Ptprk
|
UTSW |
10 |
28,462,015 (GRCm39) |
missense |
probably benign |
|
|
R0010:Ptprk
|
UTSW |
10 |
28,461,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0021:Ptprk
|
UTSW |
10 |
28,468,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0021:Ptprk
|
UTSW |
10 |
28,468,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0035:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R0035:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R0053:Ptprk
|
UTSW |
10 |
28,351,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0063:Ptprk
|
UTSW |
10 |
28,139,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0063:Ptprk
|
UTSW |
10 |
28,139,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0244:Ptprk
|
UTSW |
10 |
28,082,221 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0281:Ptprk
|
UTSW |
10 |
28,449,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0387:Ptprk
|
UTSW |
10 |
28,230,625 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0480:Ptprk
|
UTSW |
10 |
28,461,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0480:Ptprk
|
UTSW |
10 |
28,461,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0585:Ptprk
|
UTSW |
10 |
28,451,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Ptprk
|
UTSW |
10 |
27,951,132 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0684:Ptprk
|
UTSW |
10 |
28,359,294 (GRCm39) |
splice site |
probably benign |
|
|
R1073:Ptprk
|
UTSW |
10 |
28,372,943 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1377:Ptprk
|
UTSW |
10 |
28,462,022 (GRCm39) |
missense |
probably benign |
0.42 |
|
R1422:Ptprk
|
UTSW |
10 |
28,351,276 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1482:Ptprk
|
UTSW |
10 |
28,139,512 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Ptprk
|
UTSW |
10 |
28,461,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1576:Ptprk
|
UTSW |
10 |
28,427,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1618:Ptprk
|
UTSW |
10 |
28,369,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1654:Ptprk
|
UTSW |
10 |
28,259,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1701:Ptprk
|
UTSW |
10 |
28,342,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Ptprk
|
UTSW |
10 |
28,230,688 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2033:Ptprk
|
UTSW |
10 |
28,468,763 (GRCm39) |
unclassified |
probably benign |
|
|
R2059:Ptprk
|
UTSW |
10 |
28,442,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2076:Ptprk
|
UTSW |
10 |
28,465,364 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2164:Ptprk
|
UTSW |
10 |
28,436,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2260:Ptprk
|
UTSW |
10 |
28,082,145 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2394:Ptprk
|
UTSW |
10 |
28,427,713 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2432:Ptprk
|
UTSW |
10 |
28,468,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2437:Ptprk
|
UTSW |
10 |
28,230,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2495:Ptprk
|
UTSW |
10 |
28,351,074 (GRCm39) |
splice site |
probably benign |
|
|
R3037:Ptprk
|
UTSW |
10 |
28,456,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3162:Ptprk
|
UTSW |
10 |
28,468,822 (GRCm39) |
missense |
probably benign |
|
|
R3162:Ptprk
|
UTSW |
10 |
28,468,822 (GRCm39) |
missense |
probably benign |
|
|
R3687:Ptprk
|
UTSW |
10 |
28,349,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3722:Ptprk
|
UTSW |
10 |
28,259,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3892:Ptprk
|
UTSW |
10 |
28,139,617 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3963:Ptprk
|
UTSW |
10 |
28,427,661 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4077:Ptprk
|
UTSW |
10 |
28,139,508 (GRCm39) |
missense |
probably benign |
|
|
R4079:Ptprk
|
UTSW |
10 |
28,139,508 (GRCm39) |
missense |
probably benign |
|
|
R4112:Ptprk
|
UTSW |
10 |
28,351,284 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4255:Ptprk
|
UTSW |
10 |
28,082,241 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4523:Ptprk
|
UTSW |
10 |
28,342,048 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4651:Ptprk
|
UTSW |
10 |
28,139,686 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4652:Ptprk
|
UTSW |
10 |
28,139,686 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4828:Ptprk
|
UTSW |
10 |
28,436,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4829:Ptprk
|
UTSW |
10 |
28,456,480 (GRCm39) |
nonsense |
probably null |
|
|
R4883:Ptprk
|
UTSW |
10 |
28,464,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5013:Ptprk
|
UTSW |
10 |
28,427,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5092:Ptprk
|
UTSW |
10 |
28,468,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5126:Ptprk
|
UTSW |
10 |
28,451,640 (GRCm39) |
splice site |
probably null |
|
|
R5183:Ptprk
|
UTSW |
10 |
28,351,232 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5264:Ptprk
|
UTSW |
10 |
28,461,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Ptprk
|
UTSW |
10 |
28,468,050 (GRCm39) |
splice site |
probably null |
|
|
R5330:Ptprk
|
UTSW |
10 |
28,463,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5474:Ptprk
|
UTSW |
10 |
28,372,926 (GRCm39) |
nonsense |
probably null |
|
|
R5516:Ptprk
|
UTSW |
10 |
28,372,926 (GRCm39) |
nonsense |
probably null |
|
|
R5796:Ptprk
|
UTSW |
10 |
28,259,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5843:Ptprk
|
UTSW |
10 |
28,369,060 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5952:Ptprk
|
UTSW |
10 |
28,461,671 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6065:Ptprk
|
UTSW |
10 |
28,351,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6226:Ptprk
|
UTSW |
10 |
28,440,099 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6264:Ptprk
|
UTSW |
10 |
28,442,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6638:Ptprk
|
UTSW |
10 |
28,471,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6843:Ptprk
|
UTSW |
10 |
28,467,978 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6860:Ptprk
|
UTSW |
10 |
28,210,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6869:Ptprk
|
UTSW |
10 |
28,349,055 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7214:Ptprk
|
UTSW |
10 |
28,450,905 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7307:Ptprk
|
UTSW |
10 |
28,465,004 (GRCm39) |
nonsense |
probably null |
|
|
R7349:Ptprk
|
UTSW |
10 |
28,468,834 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7442:Ptprk
|
UTSW |
10 |
28,450,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7585:Ptprk
|
UTSW |
10 |
28,436,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7661:Ptprk
|
UTSW |
10 |
28,342,036 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7694:Ptprk
|
UTSW |
10 |
28,465,366 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7740:Ptprk
|
UTSW |
10 |
28,372,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7810:Ptprk
|
UTSW |
10 |
28,468,853 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7831:Ptprk
|
UTSW |
10 |
28,444,404 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7836:Ptprk
|
UTSW |
10 |
28,449,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8049:Ptprk
|
UTSW |
10 |
28,259,565 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8235:Ptprk
|
UTSW |
10 |
28,465,037 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8274:Ptprk
|
UTSW |
10 |
28,456,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8286:Ptprk
|
UTSW |
10 |
28,444,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8372:Ptprk
|
UTSW |
10 |
28,230,688 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8727:Ptprk
|
UTSW |
10 |
28,442,541 (GRCm39) |
unclassified |
probably benign |
|
|
R8794:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R8842:Ptprk
|
UTSW |
10 |
28,442,497 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8861:Ptprk
|
UTSW |
10 |
28,446,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8897:Ptprk
|
UTSW |
10 |
28,467,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8910:Ptprk
|
UTSW |
10 |
28,368,993 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8919:Ptprk
|
UTSW |
10 |
28,359,203 (GRCm39) |
nonsense |
probably null |
|
|
R8976:Ptprk
|
UTSW |
10 |
28,461,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8982:Ptprk
|
UTSW |
10 |
28,436,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9036:Ptprk
|
UTSW |
10 |
28,461,928 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9135:Ptprk
|
UTSW |
10 |
28,456,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9308:Ptprk
|
UTSW |
10 |
28,450,850 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9317:Ptprk
|
UTSW |
10 |
28,230,731 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9475:Ptprk
|
UTSW |
10 |
28,210,476 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9585:Ptprk
|
UTSW |
10 |
28,369,147 (GRCm39) |
nonsense |
probably null |
|
|
R9625:Ptprk
|
UTSW |
10 |
28,462,006 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9700:Ptprk
|
UTSW |
10 |
28,456,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9745:Ptprk
|
UTSW |
10 |
28,139,608 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
Z1177:Ptprk
|
UTSW |
10 |
28,369,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTCGGCGCATTAATATGGTAC -3'
(R):5'- TTTTGCCTGTCAGGATATAGCAG -3'
Sequencing Primer
(F):5'- GTGTCTACCATATACCAAATGGGAC -3'
(R):5'- GCCTGTCAGGATATAGCAGATATC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation