Incidental Mutation 'R5007:Zfp616'
ID 390232
Institutional Source Beutler Lab
Gene Symbol Zfp616
Ensembl Gene ENSMUSG00000069476
Gene Name zinc finger protein 616
Synonyms Gm12330
MMRRC Submission 042598-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5007 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 73960781-73978118 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 73974643 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 395 (N395I)
Ref Sequence ENSEMBL: ENSMUSP00000104103 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074813] [ENSMUST00000108463] [ENSMUST00000116546] [ENSMUST00000178159]
AlphaFold J3QN14
Predicted Effect probably benign
Transcript: ENSMUST00000074813
SMART Domains Protein: ENSMUSP00000074365
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000108463
AA Change: N395I

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000104103
Gene: ENSMUSG00000069476
AA Change: N395I

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
low complexity region 249 258 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000116546
SMART Domains Protein: ENSMUSP00000112245
Gene: ENSMUSG00000069476

DomainStartEndE-ValueType
KRAB 8 68 1.79e-34 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137407
Predicted Effect unknown
Transcript: ENSMUST00000178159
AA Change: N304I
SMART Domains Protein: ENSMUSP00000136549
Gene: ENSMUSG00000069476
AA Change: N304I

DomainStartEndE-ValueType
internal_repeat_1 125 447 7.61e-6 PROSPERO
ZnF_C2H2 452 474 3.11e-2 SMART
ZnF_C2H2 509 531 2.61e-4 SMART
ZnF_C2H2 537 559 1.47e-3 SMART
ZnF_C2H2 565 587 5.21e-4 SMART
ZnF_C2H2 593 615 1.22e-4 SMART
ZnF_C2H2 621 643 2.57e-3 SMART
ZnF_C2H2 649 671 9.22e-5 SMART
ZnF_C2H2 677 699 5.9e-3 SMART
ZnF_C2H2 705 727 4.94e-5 SMART
ZnF_C2H2 733 755 8.34e-3 SMART
ZnF_C2H2 761 783 1.6e-4 SMART
ZnF_C2H2 789 811 6.88e-4 SMART
ZnF_C2H2 817 839 1.6e-4 SMART
ZnF_C2H2 845 867 1.3e-4 SMART
ZnF_C2H2 873 895 7.37e-4 SMART
ZnF_C2H2 901 923 1.6e-4 SMART
ZnF_C2H2 929 951 1.3e-4 SMART
ZnF_C2H2 957 979 3.95e-4 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 89.6%
Validation Efficiency 99% (89/90)
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022A10Rik C G 7: 27,278,192 (GRCm39) T242R probably damaging Het
Abca8b T C 11: 109,827,590 (GRCm39) T1473A probably damaging Het
Adam22 T C 5: 8,217,393 (GRCm39) Y134C probably damaging Het
Alg9 T A 9: 50,699,524 (GRCm39) M183K probably damaging Het
Ambra1 T C 2: 91,602,655 (GRCm39) I213T possibly damaging Het
Ankrd55 T A 13: 112,504,466 (GRCm39) V376D probably benign Het
Ano4 A C 10: 88,948,807 (GRCm39) V166G probably benign Het
Aox3 T A 1: 58,202,583 (GRCm39) C730S probably benign Het
Apc T A 18: 34,446,016 (GRCm39) Y953N probably damaging Het
Ass1 T C 2: 31,391,544 (GRCm39) F273S possibly damaging Het
Atg2b T C 12: 105,610,135 (GRCm39) probably null Het
B3gnt9 A G 8: 105,981,122 (GRCm39) Y89H probably damaging Het
Cd38 T G 5: 44,063,506 (GRCm39) F200V probably damaging Het
Cep170 G T 1: 176,597,380 (GRCm39) R388S probably benign Het
Col22a1 A T 15: 71,816,271 (GRCm39) D614E probably damaging Het
Crybg3 C A 16: 59,378,463 (GRCm39) probably benign Het
Ctdp1 A T 18: 80,463,695 (GRCm39) S114T probably damaging Het
Dctd C T 8: 48,590,449 (GRCm39) probably benign Het
Dmtf1 T C 5: 9,172,439 (GRCm39) probably benign Het
Dnhd1 G A 7: 105,362,283 (GRCm39) V3715M probably damaging Het
Dok1 A T 6: 83,009,297 (GRCm39) L185H probably damaging Het
Dpep1 T C 8: 123,926,117 (GRCm39) V152A probably damaging Het
Eif2ak1 G T 5: 143,810,698 (GRCm39) R136L probably benign Het
Eml5 A T 12: 98,797,224 (GRCm39) S1063T probably damaging Het
Fam171b T A 2: 83,685,853 (GRCm39) L179* probably null Het
Flot1 G T 17: 36,135,267 (GRCm39) probably benign Het
Fmn2 A T 1: 174,571,866 (GRCm39) H1491L probably damaging Het
Frem1 C T 4: 82,859,049 (GRCm39) probably benign Het
Gdf2 A G 14: 33,666,863 (GRCm39) D195G probably benign Het
Golga4 T G 9: 118,387,368 (GRCm39) C1497G probably benign Het
Gpaa1 T A 15: 76,215,868 (GRCm39) C33* probably null Het
Hectd1 A T 12: 51,849,443 (GRCm39) C254S possibly damaging Het
Hspa1b C T 17: 35,177,086 (GRCm39) A300T probably benign Het
Igf2bp2 A G 16: 21,898,246 (GRCm39) I233T probably damaging Het
Iqce C A 5: 140,661,003 (GRCm39) A491S possibly damaging Het
Irak3 A G 10: 119,982,334 (GRCm39) probably null Het
Kcnip1 T A 11: 33,592,495 (GRCm39) H124L probably benign Het
Klhdc10 G A 6: 30,450,640 (GRCm39) R393Q probably benign Het
Klhl28 C T 12: 65,004,001 (GRCm39) E171K probably damaging Het
Map2 T C 1: 66,452,448 (GRCm39) V288A possibly damaging Het
Mdp1 C T 14: 55,896,683 (GRCm39) R126Q probably damaging Het
Meltf A G 16: 31,706,380 (GRCm39) D288G possibly damaging Het
Mgat4e T A 1: 134,468,890 (GRCm39) I385F probably benign Het
Mical3 A C 6: 121,015,030 (GRCm39) V211G probably damaging Het
Mlh1 A G 9: 111,100,478 (GRCm39) *39R probably null Het
Mre11a A G 9: 14,721,116 (GRCm39) D345G probably benign Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Msh2 C A 17: 88,030,841 (GRCm39) A906E probably benign Het
Nat1 T G 8: 67,944,077 (GRCm39) L154R probably benign Het
Nlrp4a A G 7: 26,161,905 (GRCm39) D851G probably damaging Het
Npas4 A C 19: 5,039,684 (GRCm39) V54G possibly damaging Het
Or13n4 T C 7: 106,423,364 (GRCm39) Y123C probably damaging Het
Pcbp4 G A 9: 106,339,292 (GRCm39) G100R probably damaging Het
Pcdh17 A G 14: 84,770,737 (GRCm39) T1072A probably benign Het
Pcdh18 T C 3: 49,708,906 (GRCm39) N803S probably benign Het
Ppat C T 5: 77,076,525 (GRCm39) probably benign Het
Ppm1l T A 3: 69,224,931 (GRCm39) L11Q probably damaging Het
Pram1 T A 17: 33,864,411 (GRCm39) V658E probably damaging Het
Prr12 C T 7: 44,699,225 (GRCm39) probably benign Het
Prxl2b A G 4: 154,981,531 (GRCm39) probably null Het
Ptprq A G 10: 107,444,137 (GRCm39) V1489A probably benign Het
Ryr1 T A 7: 28,768,540 (GRCm39) I2817F probably damaging Het
Sall2 A G 14: 52,551,950 (GRCm39) L413P probably damaging Het
Slc7a9 T A 7: 35,153,554 (GRCm39) M185K probably benign Het
Stag2 C T X: 41,355,130 (GRCm39) H1149Y possibly damaging Het
Timm10b T A 7: 105,290,298 (GRCm39) Y64N probably damaging Het
Tmem30c T C 16: 57,086,868 (GRCm39) T312A probably benign Het
Tmem9b G T 7: 109,344,550 (GRCm39) C17* probably null Het
Vmn2r68 C A 7: 84,881,622 (GRCm39) R486L probably benign Het
Xkr9 T A 1: 13,771,387 (GRCm39) I301N probably damaging Het
Xpo7 T C 14: 70,925,704 (GRCm39) Q446R probably damaging Het
Ythdf3 T C 3: 16,259,362 (GRCm39) V503A possibly damaging Het
Zfp280b T A 10: 75,875,048 (GRCm39) V309D probably damaging Het
Zfp53 T A 17: 21,729,772 (GRCm39) C602S probably benign Het
Zfp644 T C 5: 106,783,867 (GRCm39) I862M probably benign Het
Zfp715 T C 7: 42,949,019 (GRCm39) T314A possibly damaging Het
Other mutations in Zfp616
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00530:Zfp616 APN 11 73,974,439 (GRCm39) missense probably damaging 0.98
IGL00570:Zfp616 APN 11 73,976,631 (GRCm39) missense probably benign 0.03
IGL00594:Zfp616 APN 11 73,973,789 (GRCm39) missense possibly damaging 0.72
IGL01861:Zfp616 APN 11 73,973,742 (GRCm39) missense possibly damaging 0.53
IGL03022:Zfp616 APN 11 73,973,800 (GRCm39) missense possibly damaging 0.85
R0197:Zfp616 UTSW 11 73,976,500 (GRCm39) missense probably damaging 1.00
R0442:Zfp616 UTSW 11 73,975,321 (GRCm39) missense possibly damaging 0.92
R0497:Zfp616 UTSW 11 73,974,306 (GRCm39) missense probably benign 0.00
R0651:Zfp616 UTSW 11 73,974,555 (GRCm39) nonsense probably null
R0730:Zfp616 UTSW 11 73,975,648 (GRCm39) missense probably damaging 1.00
R0883:Zfp616 UTSW 11 73,976,500 (GRCm39) missense probably damaging 1.00
R0926:Zfp616 UTSW 11 73,976,644 (GRCm39) missense probably benign 0.04
R0940:Zfp616 UTSW 11 73,975,850 (GRCm39) missense probably damaging 1.00
R1068:Zfp616 UTSW 11 73,973,767 (GRCm39) makesense probably null
R1272:Zfp616 UTSW 11 73,976,062 (GRCm39) missense probably benign 0.08
R1446:Zfp616 UTSW 11 73,974,064 (GRCm39) splice site probably null
R1482:Zfp616 UTSW 11 73,974,803 (GRCm39) missense possibly damaging 0.72
R1553:Zfp616 UTSW 11 73,974,744 (GRCm39) missense possibly damaging 0.53
R1564:Zfp616 UTSW 11 73,975,548 (GRCm39) missense probably damaging 1.00
R1728:Zfp616 UTSW 11 73,976,597 (GRCm39) missense probably damaging 0.99
R1796:Zfp616 UTSW 11 73,976,671 (GRCm39) missense probably damaging 0.98
R1797:Zfp616 UTSW 11 73,976,105 (GRCm39) nonsense probably null
R1993:Zfp616 UTSW 11 73,975,795 (GRCm39) missense probably benign 0.08
R2026:Zfp616 UTSW 11 73,974,413 (GRCm39) missense possibly damaging 0.86
R2124:Zfp616 UTSW 11 73,973,869 (GRCm39) splice site probably null
R2126:Zfp616 UTSW 11 73,976,229 (GRCm39) missense probably benign 0.08
R2199:Zfp616 UTSW 11 73,975,456 (GRCm39) missense possibly damaging 0.58
R2265:Zfp616 UTSW 11 73,976,289 (GRCm39) missense possibly damaging 0.89
R2404:Zfp616 UTSW 11 73,975,682 (GRCm39) missense probably damaging 1.00
R2508:Zfp616 UTSW 11 73,974,121 (GRCm39) missense probably benign 0.01
R2519:Zfp616 UTSW 11 73,975,094 (GRCm39) nonsense probably null
R3103:Zfp616 UTSW 11 73,962,561 (GRCm39) missense probably benign 0.01
R3611:Zfp616 UTSW 11 73,974,268 (GRCm39) missense possibly damaging 0.53
R3703:Zfp616 UTSW 11 73,974,145 (GRCm39) nonsense probably null
R3744:Zfp616 UTSW 11 73,974,813 (GRCm39) missense probably benign 0.01
R4043:Zfp616 UTSW 11 73,976,108 (GRCm39) missense possibly damaging 0.50
R4273:Zfp616 UTSW 11 73,974,526 (GRCm39) missense probably benign 0.00
R4384:Zfp616 UTSW 11 73,974,005 (GRCm39) missense possibly damaging 0.94
R4469:Zfp616 UTSW 11 73,961,950 (GRCm39) missense probably damaging 0.98
R4560:Zfp616 UTSW 11 73,973,860 (GRCm39) missense probably benign 0.00
R4821:Zfp616 UTSW 11 73,975,033 (GRCm39) missense probably benign 0.41
R4844:Zfp616 UTSW 11 73,975,225 (GRCm39) missense probably benign 0.10
R4948:Zfp616 UTSW 11 73,974,830 (GRCm39) missense possibly damaging 0.72
R5198:Zfp616 UTSW 11 73,974,336 (GRCm39) missense probably benign 0.33
R5344:Zfp616 UTSW 11 73,975,321 (GRCm39) missense possibly damaging 0.92
R5918:Zfp616 UTSW 11 73,974,086 (GRCm39) missense possibly damaging 0.70
R5933:Zfp616 UTSW 11 73,973,952 (GRCm39) missense probably damaging 0.96
R6084:Zfp616 UTSW 11 73,974,672 (GRCm39) nonsense probably null
R6421:Zfp616 UTSW 11 73,974,696 (GRCm39) missense possibly damaging 0.53
R6494:Zfp616 UTSW 11 73,976,018 (GRCm39) missense probably damaging 1.00
R6523:Zfp616 UTSW 11 73,973,968 (GRCm39) missense possibly damaging 0.79
R6849:Zfp616 UTSW 11 73,976,276 (GRCm39) missense possibly damaging 0.70
R6910:Zfp616 UTSW 11 73,975,828 (GRCm39) missense probably damaging 1.00
R7146:Zfp616 UTSW 11 73,976,087 (GRCm39) missense possibly damaging 0.61
R7213:Zfp616 UTSW 11 73,976,689 (GRCm39) missense probably benign 0.05
R7302:Zfp616 UTSW 11 73,976,205 (GRCm39) missense probably benign 0.08
R7391:Zfp616 UTSW 11 73,976,155 (GRCm39) missense probably benign 0.08
R7654:Zfp616 UTSW 11 73,974,013 (GRCm39) missense possibly damaging 0.53
R7877:Zfp616 UTSW 11 73,975,188 (GRCm39) missense probably damaging 1.00
R7889:Zfp616 UTSW 11 73,976,271 (GRCm39) missense probably damaging 1.00
R8022:Zfp616 UTSW 11 73,974,894 (GRCm39) missense probably benign
R8061:Zfp616 UTSW 11 73,974,340 (GRCm39) missense possibly damaging 0.96
R8212:Zfp616 UTSW 11 73,976,569 (GRCm39) missense probably damaging 0.96
R8335:Zfp616 UTSW 11 73,974,726 (GRCm39) nonsense probably null
R8361:Zfp616 UTSW 11 73,975,476 (GRCm39) missense probably damaging 0.98
R8486:Zfp616 UTSW 11 73,974,909 (GRCm39) missense probably benign 0.18
R8695:Zfp616 UTSW 11 73,975,710 (GRCm39) missense probably benign 0.45
R8808:Zfp616 UTSW 11 73,976,523 (GRCm39) missense probably damaging 1.00
R9022:Zfp616 UTSW 11 73,976,539 (GRCm39) missense probably damaging 1.00
R9126:Zfp616 UTSW 11 73,976,280 (GRCm39) missense probably damaging 1.00
R9164:Zfp616 UTSW 11 73,975,825 (GRCm39) missense probably damaging 1.00
R9293:Zfp616 UTSW 11 73,974,744 (GRCm39) missense possibly damaging 0.53
R9421:Zfp616 UTSW 11 73,974,331 (GRCm39) missense possibly damaging 0.72
R9512:Zfp616 UTSW 11 73,975,936 (GRCm39) missense probably damaging 1.00
R9529:Zfp616 UTSW 11 73,976,596 (GRCm39) missense possibly damaging 0.90
R9529:Zfp616 UTSW 11 73,975,660 (GRCm39) missense probably damaging 1.00
R9606:Zfp616 UTSW 11 73,976,220 (GRCm39) missense probably damaging 1.00
R9708:Zfp616 UTSW 11 73,976,283 (GRCm39) missense probably damaging 1.00
R9788:Zfp616 UTSW 11 73,975,276 (GRCm39) missense probably damaging 0.99
Z1176:Zfp616 UTSW 11 73,976,467 (GRCm39) missense possibly damaging 0.90
Z1176:Zfp616 UTSW 11 73,974,045 (GRCm39) missense possibly damaging 0.72
Z1176:Zfp616 UTSW 11 73,973,859 (GRCm39) missense probably benign
Z1177:Zfp616 UTSW 11 73,975,878 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- GGAGAGATTTTATACCAAGGTGATG -3'
(R):5'- CCTTTCCATTATGGTTTGAATCGTG -3'

Sequencing Primer
(F):5'- CAGTCATCTTTGCAACAGC -3'
(R):5'- ATCGTGTTGAATGACATTGGAATTG -3'
Posted On 2016-06-06