Incidental Mutation 'R5009:Vmn2r77'
ID |
390348 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r77
|
Ensembl Gene |
ENSMUSG00000090949 |
Gene Name |
vomeronasal 2, receptor 77 |
Synonyms |
EG546983 |
MMRRC Submission |
042600-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.079)
|
Stock # |
R5009 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
86444349-86461240 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to G
at 86451015 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 300
(D300E)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129540
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164996]
|
AlphaFold |
L7N2B7 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000164996
AA Change: D300E
PolyPhen 2
Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000129540 Gene: ENSMUSG00000090949 AA Change: D300E
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
78 |
467 |
1.4e-30 |
PFAM |
Pfam:NCD3G
|
510 |
562 |
1e-20 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
2.6e-52 |
PFAM |
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.5%
|
Validation Efficiency |
100% (91/91) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 80 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Afg2a |
T |
A |
3: 37,487,426 (GRCm39) |
|
probably benign |
Het |
Aim2 |
T |
C |
1: 173,282,932 (GRCm39) |
Y5H |
probably damaging |
Het |
Atosa |
G |
A |
9: 74,916,171 (GRCm39) |
E257K |
probably damaging |
Het |
Atp7b |
A |
G |
8: 22,517,714 (GRCm39) |
S375P |
possibly damaging |
Het |
BC106179 |
C |
A |
16: 23,043,192 (GRCm39) |
|
probably benign |
Het |
Brinp3 |
T |
A |
1: 146,776,787 (GRCm39) |
N411K |
probably benign |
Het |
Cacna1d |
A |
G |
14: 29,801,289 (GRCm39) |
V1386A |
probably damaging |
Het |
Cuzd1 |
T |
A |
7: 130,913,252 (GRCm39) |
Y455F |
probably damaging |
Het |
Dctd |
C |
T |
8: 48,590,449 (GRCm39) |
|
probably benign |
Het |
Dip2b |
T |
A |
15: 100,093,665 (GRCm39) |
|
probably null |
Het |
Dot1l |
G |
T |
10: 80,607,030 (GRCm39) |
R108L |
probably benign |
Het |
Dysf |
T |
C |
6: 84,128,968 (GRCm39) |
S1413P |
probably damaging |
Het |
Eea1 |
C |
A |
10: 95,846,883 (GRCm39) |
R388S |
probably benign |
Het |
Elavl1 |
C |
T |
8: 4,351,723 (GRCm39) |
R131Q |
probably benign |
Het |
Erich6b |
A |
G |
14: 75,902,596 (GRCm39) |
T138A |
possibly damaging |
Het |
Esr1 |
C |
T |
10: 4,662,394 (GRCm39) |
T4I |
probably damaging |
Het |
Ets1 |
T |
C |
9: 32,644,295 (GRCm39) |
S152P |
possibly damaging |
Het |
Fcsk |
C |
T |
8: 111,614,462 (GRCm39) |
C609Y |
probably damaging |
Het |
Flrt2 |
T |
C |
12: 95,746,547 (GRCm39) |
V295A |
probably damaging |
Het |
Gm13196 |
A |
G |
2: 4,705,149 (GRCm39) |
|
noncoding transcript |
Het |
Gm5965 |
T |
A |
16: 88,575,312 (GRCm39) |
Y162N |
probably benign |
Het |
Gm7853 |
A |
T |
14: 35,811,466 (GRCm39) |
|
noncoding transcript |
Het |
Gm8126 |
C |
T |
14: 43,119,065 (GRCm39) |
A178V |
probably benign |
Het |
Gpihbp1 |
A |
T |
15: 75,469,570 (GRCm39) |
|
probably benign |
Het |
Greb1 |
T |
C |
12: 16,774,858 (GRCm39) |
T180A |
possibly damaging |
Het |
Gsdme |
C |
T |
6: 50,222,992 (GRCm39) |
V108M |
possibly damaging |
Het |
Gtpbp4 |
T |
C |
13: 9,039,102 (GRCm39) |
Y157C |
probably benign |
Het |
Gvin3 |
A |
G |
7: 106,200,767 (GRCm39) |
|
noncoding transcript |
Het |
Hivep1 |
T |
A |
13: 42,312,229 (GRCm39) |
F1490I |
probably benign |
Het |
Il17ra |
T |
C |
6: 120,459,168 (GRCm39) |
V773A |
probably benign |
Het |
Kctd8 |
T |
A |
5: 69,268,076 (GRCm39) |
T345S |
probably benign |
Het |
Kdm3b |
T |
C |
18: 34,957,763 (GRCm39) |
S1243P |
probably benign |
Het |
Klhdc1 |
T |
C |
12: 69,298,712 (GRCm39) |
V99A |
possibly damaging |
Het |
Lars1 |
T |
G |
18: 42,354,612 (GRCm39) |
E778D |
probably benign |
Het |
Map7 |
C |
T |
10: 20,137,664 (GRCm39) |
R279* |
probably null |
Het |
Mdp1 |
C |
T |
14: 55,896,683 (GRCm39) |
R126Q |
probably damaging |
Het |
Mtbp |
A |
G |
15: 55,466,583 (GRCm39) |
D532G |
probably benign |
Het |
Mylk |
G |
A |
16: 34,719,877 (GRCm39) |
V597I |
probably benign |
Het |
Necab1 |
A |
G |
4: 14,947,503 (GRCm39) |
|
probably benign |
Het |
Nisch |
C |
T |
14: 30,909,186 (GRCm39) |
|
probably benign |
Het |
Nlrp1a |
T |
C |
11: 71,013,531 (GRCm39) |
D573G |
probably benign |
Het |
Noct |
C |
A |
3: 51,155,482 (GRCm39) |
N83K |
probably damaging |
Het |
Or10am5 |
A |
G |
7: 6,517,546 (GRCm39) |
L294P |
probably damaging |
Het |
Or1b1 |
C |
T |
2: 36,995,467 (GRCm39) |
R65H |
possibly damaging |
Het |
Or2a12 |
C |
A |
6: 42,904,367 (GRCm39) |
D67E |
probably damaging |
Het |
Or2ad1 |
T |
C |
13: 21,326,435 (GRCm39) |
N264S |
probably benign |
Het |
Or52n4b |
A |
G |
7: 108,144,055 (GRCm39) |
I106V |
probably benign |
Het |
Or6b13 |
C |
T |
7: 139,781,751 (GRCm39) |
A311T |
probably benign |
Het |
Or6c201 |
T |
C |
10: 128,969,484 (GRCm39) |
H51R |
probably benign |
Het |
Osgepl1 |
T |
A |
1: 53,357,339 (GRCm39) |
V167D |
probably damaging |
Het |
Pabpc6 |
T |
C |
17: 9,887,489 (GRCm39) |
E354G |
probably damaging |
Het |
Pgghg |
A |
C |
7: 140,523,303 (GRCm39) |
D194A |
probably benign |
Het |
Podnl1 |
A |
T |
8: 84,852,887 (GRCm39) |
H19L |
probably benign |
Het |
Pold1 |
G |
T |
7: 44,183,326 (GRCm39) |
A977E |
probably benign |
Het |
Poldip3 |
T |
C |
15: 83,017,395 (GRCm39) |
T227A |
probably damaging |
Het |
Prss43 |
A |
G |
9: 110,656,489 (GRCm39) |
S59G |
possibly damaging |
Het |
Ptpn14 |
T |
A |
1: 189,582,731 (GRCm39) |
I526N |
probably benign |
Het |
Ptprb |
T |
C |
10: 116,184,032 (GRCm39) |
S1615P |
possibly damaging |
Het |
Ptpro |
A |
G |
6: 137,354,130 (GRCm39) |
K169E |
probably damaging |
Het |
Rab15 |
T |
C |
12: 76,847,341 (GRCm39) |
E114G |
probably damaging |
Het |
Rcvrn |
A |
G |
11: 67,586,550 (GRCm39) |
E103G |
probably benign |
Het |
Repin1 |
T |
A |
6: 48,571,779 (GRCm39) |
|
probably benign |
Het |
Rita1 |
T |
A |
5: 120,749,448 (GRCm39) |
K88N |
probably damaging |
Het |
Rtkn2 |
T |
C |
10: 67,877,239 (GRCm39) |
V433A |
probably benign |
Het |
Runx1t1 |
T |
C |
4: 13,865,231 (GRCm39) |
I314T |
possibly damaging |
Het |
Serpinb9c |
A |
C |
13: 33,338,414 (GRCm39) |
S190A |
probably benign |
Het |
Shank2 |
C |
A |
7: 143,623,916 (GRCm39) |
H300Q |
probably benign |
Het |
Slc4a4 |
A |
G |
5: 89,297,157 (GRCm39) |
|
probably null |
Het |
Slc5a8 |
T |
C |
10: 88,745,516 (GRCm39) |
S375P |
probably benign |
Het |
Spns3 |
C |
A |
11: 72,428,027 (GRCm39) |
W251L |
probably damaging |
Het |
Spta1 |
A |
G |
1: 174,067,789 (GRCm39) |
N2072S |
possibly damaging |
Het |
Sptbn1 |
A |
G |
11: 30,074,016 (GRCm39) |
V1351A |
probably benign |
Het |
Sytl2 |
A |
T |
7: 90,030,523 (GRCm39) |
|
probably benign |
Het |
Tax1bp1 |
A |
G |
6: 52,706,478 (GRCm39) |
|
probably benign |
Het |
Tg |
A |
G |
15: 66,568,435 (GRCm39) |
D1374G |
probably benign |
Het |
Tlr1 |
A |
G |
5: 65,083,567 (GRCm39) |
S337P |
probably damaging |
Het |
Trp63 |
A |
T |
16: 25,686,977 (GRCm39) |
D303V |
probably damaging |
Het |
Ttn |
G |
A |
2: 76,683,250 (GRCm39) |
|
probably benign |
Het |
Txndc5 |
T |
C |
13: 38,712,160 (GRCm39) |
|
probably null |
Het |
Zfp729a |
A |
T |
13: 67,768,365 (GRCm39) |
N621K |
probably benign |
Het |
|
Other mutations in Vmn2r77 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00954:Vmn2r77
|
APN |
7 |
86,449,975 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01105:Vmn2r77
|
APN |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01367:Vmn2r77
|
APN |
7 |
86,461,124 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01634:Vmn2r77
|
APN |
7 |
86,460,857 (GRCm39) |
missense |
probably benign |
|
IGL01805:Vmn2r77
|
APN |
7 |
86,460,395 (GRCm39) |
missense |
probably benign |
0.18 |
IGL01868:Vmn2r77
|
APN |
7 |
86,452,224 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01980:Vmn2r77
|
APN |
7 |
86,450,678 (GRCm39) |
missense |
probably benign |
0.14 |
IGL02055:Vmn2r77
|
APN |
7 |
86,450,763 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02066:Vmn2r77
|
APN |
7 |
86,452,836 (GRCm39) |
nonsense |
probably null |
|
IGL02185:Vmn2r77
|
APN |
7 |
86,444,360 (GRCm39) |
missense |
unknown |
|
IGL02200:Vmn2r77
|
APN |
7 |
86,451,187 (GRCm39) |
missense |
probably benign |
0.04 |
IGL02336:Vmn2r77
|
APN |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02445:Vmn2r77
|
APN |
7 |
86,452,848 (GRCm39) |
nonsense |
probably null |
|
IGL02557:Vmn2r77
|
APN |
7 |
86,444,342 (GRCm39) |
unclassified |
probably benign |
|
IGL02659:Vmn2r77
|
APN |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.32 |
IGL02978:Vmn2r77
|
APN |
7 |
86,460,555 (GRCm39) |
missense |
probably benign |
|
IGL03180:Vmn2r77
|
APN |
7 |
86,450,843 (GRCm39) |
missense |
possibly damaging |
0.85 |
IGL03255:Vmn2r77
|
APN |
7 |
86,461,131 (GRCm39) |
missense |
probably benign |
0.04 |
IGL03273:Vmn2r77
|
APN |
7 |
86,460,494 (GRCm39) |
missense |
probably damaging |
0.99 |
R0046:Vmn2r77
|
UTSW |
7 |
86,451,146 (GRCm39) |
missense |
possibly damaging |
0.73 |
R0047:Vmn2r77
|
UTSW |
7 |
86,460,858 (GRCm39) |
missense |
probably benign |
0.01 |
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R0389:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
R0635:Vmn2r77
|
UTSW |
7 |
86,460,383 (GRCm39) |
missense |
probably benign |
|
R0689:Vmn2r77
|
UTSW |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
R0827:Vmn2r77
|
UTSW |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
1.00 |
R1167:Vmn2r77
|
UTSW |
7 |
86,450,954 (GRCm39) |
missense |
probably benign |
0.02 |
R1228:Vmn2r77
|
UTSW |
7 |
86,450,242 (GRCm39) |
critical splice donor site |
probably null |
|
R1353:Vmn2r77
|
UTSW |
7 |
86,451,394 (GRCm39) |
missense |
probably benign |
0.29 |
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
R1613:Vmn2r77
|
UTSW |
7 |
86,460,356 (GRCm39) |
missense |
probably damaging |
1.00 |
R1654:Vmn2r77
|
UTSW |
7 |
86,461,123 (GRCm39) |
missense |
probably damaging |
1.00 |
R1742:Vmn2r77
|
UTSW |
7 |
86,444,543 (GRCm39) |
missense |
probably benign |
0.35 |
R1827:Vmn2r77
|
UTSW |
7 |
86,450,821 (GRCm39) |
missense |
probably damaging |
0.99 |
R1911:Vmn2r77
|
UTSW |
7 |
86,461,001 (GRCm39) |
missense |
probably damaging |
1.00 |
R1974:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R2008:Vmn2r77
|
UTSW |
7 |
86,450,921 (GRCm39) |
missense |
probably benign |
0.31 |
R2093:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
R2143:Vmn2r77
|
UTSW |
7 |
86,461,152 (GRCm39) |
missense |
probably damaging |
1.00 |
R2269:Vmn2r77
|
UTSW |
7 |
86,460,897 (GRCm39) |
missense |
probably benign |
0.03 |
R2972:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
R2974:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
R3037:Vmn2r77
|
UTSW |
7 |
86,450,191 (GRCm39) |
missense |
probably benign |
|
R3694:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R3695:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R3805:Vmn2r77
|
UTSW |
7 |
86,444,368 (GRCm39) |
nonsense |
probably null |
|
R3870:Vmn2r77
|
UTSW |
7 |
86,461,050 (GRCm39) |
missense |
probably damaging |
1.00 |
R4732:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
R4733:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
R5201:Vmn2r77
|
UTSW |
7 |
86,460,846 (GRCm39) |
missense |
probably damaging |
0.98 |
R5218:Vmn2r77
|
UTSW |
7 |
86,451,341 (GRCm39) |
missense |
probably damaging |
0.98 |
R5469:Vmn2r77
|
UTSW |
7 |
86,451,271 (GRCm39) |
missense |
probably benign |
0.01 |
R5673:Vmn2r77
|
UTSW |
7 |
86,461,214 (GRCm39) |
missense |
probably benign |
0.05 |
R5771:Vmn2r77
|
UTSW |
7 |
86,461,235 (GRCm39) |
missense |
probably benign |
0.06 |
R5832:Vmn2r77
|
UTSW |
7 |
86,460,670 (GRCm39) |
nonsense |
probably null |
|
R5899:Vmn2r77
|
UTSW |
7 |
86,460,924 (GRCm39) |
missense |
probably damaging |
1.00 |
R6151:Vmn2r77
|
UTSW |
7 |
86,450,878 (GRCm39) |
missense |
probably benign |
0.00 |
R6182:Vmn2r77
|
UTSW |
7 |
86,460,957 (GRCm39) |
missense |
probably damaging |
1.00 |
R6326:Vmn2r77
|
UTSW |
7 |
86,451,031 (GRCm39) |
missense |
probably benign |
|
R6419:Vmn2r77
|
UTSW |
7 |
86,460,767 (GRCm39) |
missense |
probably damaging |
0.99 |
R6549:Vmn2r77
|
UTSW |
7 |
86,450,065 (GRCm39) |
missense |
probably benign |
0.06 |
R6874:Vmn2r77
|
UTSW |
7 |
86,451,286 (GRCm39) |
missense |
probably benign |
0.00 |
R6972:Vmn2r77
|
UTSW |
7 |
86,452,202 (GRCm39) |
missense |
probably damaging |
1.00 |
R7056:Vmn2r77
|
UTSW |
7 |
86,451,023 (GRCm39) |
missense |
probably benign |
0.06 |
R7185:Vmn2r77
|
UTSW |
7 |
86,451,035 (GRCm39) |
missense |
probably benign |
0.00 |
R7261:Vmn2r77
|
UTSW |
7 |
86,460,518 (GRCm39) |
nonsense |
probably null |
|
R7298:Vmn2r77
|
UTSW |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.00 |
R7662:Vmn2r77
|
UTSW |
7 |
86,460,492 (GRCm39) |
nonsense |
probably null |
|
R8182:Vmn2r77
|
UTSW |
7 |
86,460,801 (GRCm39) |
missense |
probably damaging |
1.00 |
R8327:Vmn2r77
|
UTSW |
7 |
86,450,680 (GRCm39) |
missense |
probably benign |
0.08 |
R8387:Vmn2r77
|
UTSW |
7 |
86,450,947 (GRCm39) |
missense |
probably benign |
0.00 |
R8825:Vmn2r77
|
UTSW |
7 |
86,452,855 (GRCm39) |
missense |
probably benign |
|
R8898:Vmn2r77
|
UTSW |
7 |
86,444,430 (GRCm39) |
missense |
probably damaging |
1.00 |
R8973:Vmn2r77
|
UTSW |
7 |
86,452,150 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9258:Vmn2r77
|
UTSW |
7 |
86,452,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9338:Vmn2r77
|
UTSW |
7 |
86,460,994 (GRCm39) |
missense |
probably damaging |
1.00 |
R9358:Vmn2r77
|
UTSW |
7 |
86,452,236 (GRCm39) |
missense |
probably benign |
0.00 |
R9377:Vmn2r77
|
UTSW |
7 |
86,444,442 (GRCm39) |
missense |
probably benign |
0.05 |
R9404:Vmn2r77
|
UTSW |
7 |
86,451,247 (GRCm39) |
missense |
probably benign |
|
R9673:Vmn2r77
|
UTSW |
7 |
86,450,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
R9679:Vmn2r77
|
UTSW |
7 |
86,460,741 (GRCm39) |
missense |
probably benign |
0.07 |
|
Predicted Primers |
PCR Primer
(F):5'- GAAACACTGTCTGCTTAGCATTTG -3'
(R):5'- TCAGGTGGTGGCAATGAAC -3'
Sequencing Primer
(F):5'- AGCATTTGTCACTTCTATCACTTATG -3'
(R):5'- GGCAATGAACACTTAAAGTAAGTCC -3'
|
Posted On |
2016-06-06 |