|Institutional Source||Beutler Lab|
|Gene Name||phosphodiesterase 4B, cAMP specific|
|Essential gene?||Possibly essential (E-score: 0.575)|
|Stock #||R5055 (G1)|
|Chromosomal Location||102087543-102607259 bp(+) (GRCm38)|
|Type of Mutation||intron|
|DNA Base Change (assembly)||T to C at 102195114 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000133413 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000106911] [ENSMUST00000173119]|
|Coding Region Coverage||
|Validation Efficiency||98% (84/86)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for disruptions in this gene produce significantly less TNF-alpha in response to lipopolysaccharide stimulation. One mutation resulted in brain and spinal cord vacuoles. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Pde4b||
(F):5'- CAGTTACACCCTCGGGATTGAC -3'
(R):5'- ATGTAAGGCATACTCCTTCCCC -3'
(F):5'- CTGTTCAGGAAACTTACAGCTGC -3'
(R):5'- CCTCTTAAGAAGCAGATTTTCTTGC -3'