Mutagenetix > Incidental Mutation

Incidental Mutation 'R0437:Fat2'

39091

Institutional Source

Beutler Lab

Gene Symbol

Fat2

Ensembl Gene

ENSMUSG00000055333

Gene Name

FAT atypical cadherin 2

Synonyms

mKIAA0811, LOC245827, Fath2, EMI2

MMRRC Submission

038638-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0437 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

55250609-55336564 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 55282799 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 2363 (T2363A)

Ref Sequence

ENSEMBL: ENSMUSP00000104492 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068853] [ENSMUST00000108864]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000068853
AA Change: T2363A

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000067556
Gene: ENSMUSG00000055333
AA Change: T2363A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108864
AA Change: T2363A

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000104492
Gene: ENSMUSG00000055333
AA Change: T2363A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Meta Mutation Damage Score

0.0899

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.0%
20x: 94.8%

Validation Efficiency

100% (104/104)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are healthy, fertile and overtly normal, with no apparent defects in the development of red blood cells or platelets. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 99 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110051M20Rik	A	G	2: 91,421,953	L21P	probably damaging	Het
4833420G17Rik	G	A	13: 119,470,095	R291K	probably benign	Het
4932438A13Rik	A	T	3: 36,989,804	H2820L	possibly damaging	Het
Abca2	T	C	2: 25,442,845	S1519P	probably damaging	Het
Abcb11	G	A	2: 69,257,295	A1042V	probably damaging	Het
Abcc10	A	T	17: 46,312,919		probably null	Het
Abcc10	G	T	17: 46,312,920		probably benign	Het
Alkbh3	A	C	2: 93,981,569	L240V	probably damaging	Het
Apol10b	T	C	15: 77,585,408	S190G	probably benign	Het
Atp1a3	C	A	7: 24,998,967	C135F	probably benign	Het
Atp4a	C	G	7: 30,720,101	R659G	probably benign	Het
BC030499	T	C	11: 78,291,536	L57P	probably benign	Het
Bicra	A	G	7: 15,988,762	S277P	possibly damaging	Het
Bmp8a	T	C	4: 123,316,897	E275G	probably benign	Het
Ccdc102a	T	C	8: 94,913,426	E80G	probably damaging	Het
Cdh23	T	C	10: 60,410,797	D954G	probably damaging	Het
Chrm4	A	G	2: 91,928,443	T399A	possibly damaging	Het
Clcn3	A	G	8: 60,934,537	V199A	possibly damaging	Het
Crlf1	T	C	8: 70,499,514		probably null	Het
Crx	G	T	7: 15,871,146	S57*	probably null	Het
Cyp4f16	A	G	17: 32,537,098	I34V	possibly damaging	Het
Daxx	T	C	17: 33,913,624	V576A	probably benign	Het
Ddx17	C	T	15: 79,537,471	R351H	probably damaging	Het
Dhx38	T	C	8: 109,558,629		probably benign	Het
Dnd1	T	C	18: 36,764,499		probably benign	Het
Dync1i2	A	T	2: 71,227,825		probably null	Het
E2f6	T	C	12: 16,816,445	S52P	probably benign	Het
Epb41l4a	A	G	18: 33,880,273	F116S	probably damaging	Het
Ext1	T	C	15: 53,106,106	N362S	probably damaging	Het
Fam227a	C	A	15: 79,643,988	K79N	possibly damaging	Het
Fam228a	T	A	12: 4,732,759	L111F	probably damaging	Het
Fat3	A	T	9: 15,996,932	N2591K	probably damaging	Het
Frem2	A	G	3: 53,653,015	M1357T	possibly damaging	Het
Frmd4b	A	T	6: 97,423,463	V29D	probably damaging	Het
G930045G22Rik	A	G	6: 50,846,938		noncoding transcript	Het
Galnt3	A	G	2: 66,107,229	S46P	possibly damaging	Het
Gmeb2	A	G	2: 181,253,973	V468A	possibly damaging	Het
Herc2	C	T	7: 56,219,815	R4271*	probably null	Het
Il5	C	A	11: 53,723,906		probably benign	Het
Ints9	G	A	14: 64,986,369		probably benign	Het
Itga10	T	C	3: 96,649,137	F196S	probably damaging	Het
Itgb3bp	T	C	4: 99,781,889	T138A	probably damaging	Het
Kcnd1	G	A	X: 7,824,683	V281M	probably benign	Het
Lcp2	T	C	11: 34,087,229	L391P	probably benign	Het
Lrrc66	T	C	5: 73,607,687	Y671C	probably benign	Het
Mettl23	T	C	11: 116,849,294	V197A	possibly damaging	Het
Mmp15	C	A	8: 95,370,772	D456E	probably benign	Het
Mospd4	T	C	18: 46,465,781		noncoding transcript	Het
Mov10l1	C	A	15: 89,005,312	H484N	probably damaging	Het
Mphosph9	T	C	5: 124,315,568	Q197R	probably benign	Het
Ms4a1	T	A	19: 11,256,569		probably null	Het
Mybbp1a	T	C	11: 72,448,848	V919A	possibly damaging	Het
Mycbpap	A	T	11: 94,513,512		probably benign	Het
Naip6	G	A	13: 100,296,924	S1135F	possibly damaging	Het
Ndufc2	T	A	7: 97,400,337	M50K	probably benign	Het
Npr2	T	C	4: 43,648,082	V842A	probably damaging	Het
Ntsr2	G	T	12: 16,653,695	G66W	probably damaging	Het
Obscn	T	C	11: 58,995,088		probably benign	Het
Olfr1206	T	A	2: 88,864,885	N93K	probably benign	Het
Olfr1219	T	A	2: 89,074,612	I160F	probably benign	Het
Olfr427	G	A	1: 174,100,399	G314R	probably benign	Het
Olfr820	T	C	10: 130,018,096	V245A	probably damaging	Het
Optn	C	T	2: 5,024,115	G526R	probably damaging	Het
Otud4	T	A	8: 79,669,997	H628Q	probably benign	Het
Padi6	T	C	4: 140,728,929	T585A	probably benign	Het
Pex16	G	T	2: 92,375,592	R10L	probably damaging	Het
Pitpnm2	A	G	5: 124,131,089		probably benign	Het
Pom121l2	A	G	13: 21,983,205	T549A	possibly damaging	Het
Prdm15	A	T	16: 97,812,559	M470K	probably benign	Het
Prkag2	T	A	5: 25,028,505	D49V	possibly damaging	Het
Prl3c1	A	G	13: 27,199,464	M38V	probably benign	Het
Prpf18	T	A	2: 4,643,761	I85F	possibly damaging	Het
Psg27	A	G	7: 18,560,711		probably benign	Het
Relt	A	G	7: 100,848,784		probably benign	Het
Serpina3b	A	T	12: 104,130,670	N70I	probably damaging	Het
Slc19a3	T	C	1: 83,022,565	S244G	probably benign	Het
Slc39a5	T	C	10: 128,399,847	T81A	possibly damaging	Het
Slc7a2	G	A	8: 40,904,526	G277D	probably damaging	Het
Slc9c1	C	T	16: 45,599,887		probably benign	Het
Slx1b	A	G	7: 126,692,581	F104L	probably benign	Het
Smg6	G	A	11: 74,929,701	S266N	probably damaging	Het
Spata9	T	C	13: 75,998,495	V162A	possibly damaging	Het
Szrd1	T	C	4: 141,118,744	I47V	probably benign	Het
Tha1	G	T	11: 117,868,575	L363M	probably benign	Het
Tmc6	G	A	11: 117,778,261	T89I	possibly damaging	Het
Tmem132d	C	T	5: 127,789,785	G684R	probably damaging	Het
Trim55	G	A	3: 19,670,978	G220S	probably benign	Het
Ttn	A	G	2: 76,770,530	L18836P	probably damaging	Het
Ubn1	G	T	16: 5,072,184		probably benign	Het
Ush2a	T	G	1: 188,911,031	W4197G	probably benign	Het
Vmn1r189	A	T	13: 22,102,061	V202E	probably damaging	Het
Vmn1r209	T	C	13: 22,806,356	I55V	probably benign	Het
Vmn2r86	A	T	10: 130,446,543	C735S	probably damaging	Het
Vwf	A	T	6: 125,566,318	D174V	probably damaging	Het
Zfp438	T	C	18: 5,214,910	N16S	probably damaging	Het
Zfp444	C	T	7: 6,189,409	T142I	probably benign	Het
Zfp804a	A	G	2: 82,053,791	M1V	probably null	Het
Zfp936	T	G	7: 43,189,310	I67S	probably benign	Het
Zfp948	A	T	17: 21,586,998	N151Y	unknown	Het

Other mutations in Fat2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00720:Fat2	APN	11	55311244	missense	probably benign
IGL00897:Fat2	APN	11	55289252	missense	probably damaging	0.99
IGL01161:Fat2	APN	11	55284191	missense	probably benign
IGL01306:Fat2	APN	11	55310872	missense	probably benign	0.28
IGL01393:Fat2	APN	11	55269309	missense	probably benign	0.00
IGL01529:Fat2	APN	11	55282156	missense	probably damaging	1.00
IGL01530:Fat2	APN	11	55283387	missense	probably benign	0.42
IGL01555:Fat2	APN	11	55278930	missense	probably damaging	0.99
IGL01758:Fat2	APN	11	55296209	missense	probably damaging	1.00
IGL01768:Fat2	APN	11	55262568	missense	probably damaging	1.00
IGL01939:Fat2	APN	11	55283980	missense	probably benign	0.01
IGL01941:Fat2	APN	11	55312005	missense	probably benign	0.01
IGL01967:Fat2	APN	11	55311823	missense	probably damaging	1.00
IGL01978:Fat2	APN	11	55270146	missense	probably benign	0.34
IGL01998:Fat2	APN	11	55296195	missense	probably benign	0.00
IGL02001:Fat2	APN	11	55312245	start codon destroyed	probably null	0.89
IGL02004:Fat2	APN	11	55282840	missense	probably damaging	1.00
IGL02103:Fat2	APN	11	55289296	missense	probably damaging	0.96
IGL02131:Fat2	APN	11	55309042	missense	probably damaging	1.00
IGL02155:Fat2	APN	11	55262419	missense	probably benign	0.00
IGL02223:Fat2	APN	11	55273129	missense	probably benign	0.01
IGL02231:Fat2	APN	11	55281092	missense	probably damaging	0.98
IGL02312:Fat2	APN	11	55270259	missense	probably damaging	1.00
IGL02476:Fat2	APN	11	55311124	missense	probably damaging	1.00
IGL02539:Fat2	APN	11	55281793	missense	probably damaging	1.00
IGL02553:Fat2	APN	11	55311283	missense	probably damaging	1.00
IGL02645:Fat2	APN	11	55282828	missense	probably damaging	1.00
IGL02664:Fat2	APN	11	55311096	missense	probably damaging	1.00
IGL02708:Fat2	APN	11	55282385	missense	probably damaging	0.99
IGL02883:Fat2	APN	11	55256618	missense	probably benign	0.16
IGL02894:Fat2	APN	11	55256653	missense	probably damaging	1.00
IGL02975:Fat2	APN	11	55270194	missense	probably benign	0.00
IGL03085:Fat2	APN	11	55283246	missense	probably benign	0.09
IGL03106:Fat2	APN	11	55311901	missense	probably benign	0.45
IGL03132:Fat2	APN	11	55253920	missense	probably benign	0.25
IGL03133:Fat2	APN	11	55286043	missense	probably benign	0.01
IGL03194:Fat2	APN	11	55310995	missense	probably benign	0.02
IGL03266:Fat2	APN	11	55284029	missense	possibly damaging	0.62
IGL03290:Fat2	APN	11	55256219	missense	probably benign	0.33
IGL03291:Fat2	APN	11	55262595	missense	probably benign
IGL03325:Fat2	APN	11	55282342	missense	probably damaging	1.00
IGL03345:Fat2	APN	11	55282361	missense	probably damaging	1.00
IGL03371:Fat2	APN	11	55311164	missense	probably benign	0.10
ANU23:Fat2	UTSW	11	55310872	missense	probably benign	0.28
BB001:Fat2	UTSW	11	55262787	missense	probably benign	0.03
BB011:Fat2	UTSW	11	55262787	missense	probably benign	0.03
P0040:Fat2	UTSW	11	55282213	missense	possibly damaging	0.89
PIT4504001:Fat2	UTSW	11	55256110	missense	possibly damaging	0.68
R0008:Fat2	UTSW	11	55311249	missense	probably damaging	1.00
R0008:Fat2	UTSW	11	55311249	missense	probably damaging	1.00
R0012:Fat2	UTSW	11	55262871	missense	probably benign	0.16
R0012:Fat2	UTSW	11	55262871	missense	probably benign	0.16
R0048:Fat2	UTSW	11	55310039	missense	probably benign	0.00
R0048:Fat2	UTSW	11	55310039	missense	probably benign	0.00
R0098:Fat2	UTSW	11	55298605	missense	probably damaging	0.98
R0124:Fat2	UTSW	11	55283678	missense	probably damaging	0.98
R0127:Fat2	UTSW	11	55289286	missense	probably benign	0.01
R0130:Fat2	UTSW	11	55252118	missense	probably benign	0.26
R0131:Fat2	UTSW	11	55273211	missense	probably benign
R0158:Fat2	UTSW	11	55296185	missense	probably benign	0.00
R0184:Fat2	UTSW	11	55296288	missense	probably damaging	1.00
R0367:Fat2	UTSW	11	55292093	splice site	probably benign
R0384:Fat2	UTSW	11	55269465	missense	possibly damaging	0.81
R0390:Fat2	UTSW	11	55310777	missense	probably damaging	0.99
R0403:Fat2	UTSW	11	55270349	missense	probably benign	0.42
R0416:Fat2	UTSW	11	55284134	missense	possibly damaging	0.94
R0463:Fat2	UTSW	11	55262829	missense	probably damaging	1.00
R0497:Fat2	UTSW	11	55283402	missense	probably benign	0.03
R0617:Fat2	UTSW	11	55311843	missense	possibly damaging	0.60
R0622:Fat2	UTSW	11	55283128	missense	probably damaging	1.00
R0675:Fat2	UTSW	11	55309209	missense	probably damaging	0.97
R0811:Fat2	UTSW	11	55253633	missense	possibly damaging	0.75
R0812:Fat2	UTSW	11	55253633	missense	possibly damaging	0.75
R0869:Fat2	UTSW	11	55311775	missense	probably benign	0.08
R0870:Fat2	UTSW	11	55311775	missense	probably benign	0.08
R0899:Fat2	UTSW	11	55256225	missense	probably damaging	1.00
R1278:Fat2	UTSW	11	55268179	missense	probably damaging	1.00
R1383:Fat2	UTSW	11	55310773	missense	probably benign
R1428:Fat2	UTSW	11	55296087	missense	probably damaging	1.00
R1438:Fat2	UTSW	11	55287811	missense	probably damaging	1.00
R1495:Fat2	UTSW	11	55262673	missense	probably benign
R1506:Fat2	UTSW	11	55284264	missense	probably benign
R1547:Fat2	UTSW	11	55252255	missense	probably benign	0.01
R1554:Fat2	UTSW	11	55253664	missense	probably benign	0.01
R1562:Fat2	UTSW	11	55309974	missense	probably damaging	1.00
R1588:Fat2	UTSW	11	55283404	missense	probably damaging	1.00
R1592:Fat2	UTSW	11	55291870	splice site	probably null
R1601:Fat2	UTSW	11	55282010	missense	probably benign	0.01
R1610:Fat2	UTSW	11	55278924	missense	probably damaging	1.00
R1634:Fat2	UTSW	11	55267684	missense	probably damaging	1.00
R1634:Fat2	UTSW	11	55284719	missense	probably benign
R1644:Fat2	UTSW	11	55287783	missense	possibly damaging	0.91
R1644:Fat2	UTSW	11	55296181	missense	possibly damaging	0.94
R1691:Fat2	UTSW	11	55311852	missense	probably damaging	0.99
R1734:Fat2	UTSW	11	55281371	missense	probably benign	0.00
R1748:Fat2	UTSW	11	55256647	missense	probably damaging	0.97
R1771:Fat2	UTSW	11	55310865	missense	probably benign	0.01
R1800:Fat2	UTSW	11	55283892	missense	probably damaging	1.00
R1807:Fat2	UTSW	11	55289259	missense	probably damaging	1.00
R1823:Fat2	UTSW	11	55256780	missense	probably benign	0.29
R1848:Fat2	UTSW	11	55311558	missense	probably damaging	1.00
R1866:Fat2	UTSW	11	55292014	missense	probably benign	0.00
R1899:Fat2	UTSW	11	55262178	missense	probably benign
R1954:Fat2	UTSW	11	55311084	missense	probably benign	0.06
R2010:Fat2	UTSW	11	55253827	missense	probably damaging	0.99
R2011:Fat2	UTSW	11	55282757	missense	probably damaging	1.00
R2057:Fat2	UTSW	11	55281860	missense	possibly damaging	0.60
R2081:Fat2	UTSW	11	55309677	missense	possibly damaging	0.94
R2106:Fat2	UTSW	11	55256564	missense	probably benign	0.00
R2165:Fat2	UTSW	11	55303716	missense	probably benign	0.00
R2176:Fat2	UTSW	11	55267575	critical splice donor site	probably null
R2284:Fat2	UTSW	11	55282360	missense	probably damaging	1.00
R2338:Fat2	UTSW	11	55311901	missense	possibly damaging	0.93
R2340:Fat2	UTSW	11	55270096	missense	possibly damaging	0.90
R2427:Fat2	UTSW	11	55310812	missense	probably benign	0.15
R2444:Fat2	UTSW	11	55281973	missense	probably damaging	1.00
R2858:Fat2	UTSW	11	55283773	missense	possibly damaging	0.94
R2882:Fat2	UTSW	11	55311305	missense	probably damaging	0.96
R3029:Fat2	UTSW	11	55284709	missense	probably damaging	1.00
R3085:Fat2	UTSW	11	55252171	missense	possibly damaging	0.79
R3121:Fat2	UTSW	11	55311796	missense	probably damaging	1.00
R3418:Fat2	UTSW	11	55278998	missense	probably benign	0.01
R3500:Fat2	UTSW	11	55260516	missense	probably damaging	0.99
R3607:Fat2	UTSW	11	55281685	missense	probably damaging	1.00
R3611:Fat2	UTSW	11	55312069	missense	probably benign
R3620:Fat2	UTSW	11	55256695	missense	probably damaging	0.97
R3688:Fat2	UTSW	11	55281101	missense	probably damaging	0.99
R3704:Fat2	UTSW	11	55309650	missense	probably damaging	1.00
R3784:Fat2	UTSW	11	55256186	missense	probably benign
R3889:Fat2	UTSW	11	55281763	missense	probably damaging	1.00
R3951:Fat2	UTSW	11	55296382	missense	probably benign	0.00
R4211:Fat2	UTSW	11	55283984	missense	probably damaging	1.00
R4249:Fat2	UTSW	11	55284301	missense	probably damaging	0.98
R4406:Fat2	UTSW	11	55262268	missense	probably benign	0.00
R4433:Fat2	UTSW	11	55309640	missense	possibly damaging	0.91
R4436:Fat2	UTSW	11	55296198	missense	probably damaging	1.00
R4498:Fat2	UTSW	11	55270097	missense	possibly damaging	0.90
R4560:Fat2	UTSW	11	55265951	missense	possibly damaging	0.89
R4594:Fat2	UTSW	11	55284752	missense	possibly damaging	0.78
R4663:Fat2	UTSW	11	55296213	nonsense	probably null
R4669:Fat2	UTSW	11	55311615	missense	probably benign	0.01
R4696:Fat2	UTSW	11	55285015	missense	probably benign	0.00
R4734:Fat2	UTSW	11	55311468	missense	probably benign	0.01
R4749:Fat2	UTSW	11	55311468	missense	probably benign	0.01
R4765:Fat2	UTSW	11	55281187	missense	probably damaging	1.00
R4803:Fat2	UTSW	11	55285060	missense	probably benign	0.03
R4805:Fat2	UTSW	11	55283979	missense	probably benign	0.01
R4822:Fat2	UTSW	11	55311318	missense	probably benign	0.02
R4840:Fat2	UTSW	11	55279018	missense	probably benign	0.21
R4849:Fat2	UTSW	11	55310637	missense	probably damaging	1.00
R4943:Fat2	UTSW	11	55279033	missense	probably benign	0.00
R4993:Fat2	UTSW	11	55283092	missense	probably damaging	0.99
R5097:Fat2	UTSW	11	55310704	missense	probably damaging	1.00
R5104:Fat2	UTSW	11	55278988	missense	possibly damaging	0.93
R5115:Fat2	UTSW	11	55296333	missense	probably damaging	1.00
R5213:Fat2	UTSW	11	55253832	missense	probably benign	0.00
R5254:Fat2	UTSW	11	55281175	missense	probably damaging	1.00
R5269:Fat2	UTSW	11	55287878	missense	probably benign	0.00
R5288:Fat2	UTSW	11	55267656	missense	probably benign	0.00
R5355:Fat2	UTSW	11	55282166	missense	probably damaging	1.00
R5375:Fat2	UTSW	11	55262820	missense	probably benign	0.00
R5379:Fat2	UTSW	11	55303941	missense	probably damaging	0.99
R5411:Fat2	UTSW	11	55252226	missense	probably benign	0.23
R5416:Fat2	UTSW	11	55303688	missense	possibly damaging	0.77
R5480:Fat2	UTSW	11	55310086	missense	probably damaging	0.99
R5486:Fat2	UTSW	11	55253681	missense	probably benign	0.00
R5526:Fat2	UTSW	11	55269361	missense	possibly damaging	0.90
R5532:Fat2	UTSW	11	55262337	missense	probably damaging	1.00
R5583:Fat2	UTSW	11	55253889	missense	probably benign	0.00
R5588:Fat2	UTSW	11	55282277	missense	probably damaging	1.00
R5598:Fat2	UTSW	11	55281130	missense	probably damaging	1.00
R5636:Fat2	UTSW	11	55282481	missense	probably damaging	1.00
R5653:Fat2	UTSW	11	55310316	missense	probably damaging	1.00
R5657:Fat2	UTSW	11	55310681	nonsense	probably null
R5660:Fat2	UTSW	11	55284176	missense	probably benign	0.00
R5752:Fat2	UTSW	11	55289237	missense	possibly damaging	0.48
R5757:Fat2	UTSW	11	55252346	missense	probably damaging	1.00
R5792:Fat2	UTSW	11	55262325	missense	possibly damaging	0.77
R5872:Fat2	UTSW	11	55270382	missense	probably damaging	1.00
R5933:Fat2	UTSW	11	55284051	missense	probably damaging	1.00
R6030:Fat2	UTSW	11	55310303	nonsense	probably null
R6030:Fat2	UTSW	11	55310303	nonsense	probably null
R6032:Fat2	UTSW	11	55253934	missense	probably damaging	1.00
R6032:Fat2	UTSW	11	55253934	missense	probably damaging	1.00
R6221:Fat2	UTSW	11	55296072	critical splice donor site	probably null
R6253:Fat2	UTSW	11	55296271	missense	probably damaging	1.00
R6257:Fat2	UTSW	11	55262581	missense	probably benign
R6307:Fat2	UTSW	11	55281280	missense	possibly damaging	0.63
R6450:Fat2	UTSW	11	55289310	missense	probably damaging	0.97
R6453:Fat2	UTSW	11	55282216	missense	probably benign	0.29
R6455:Fat2	UTSW	11	55270457	missense	probably damaging	0.96
R6483:Fat2	UTSW	11	55296345	missense	probably damaging	1.00
R6504:Fat2	UTSW	11	55262397	missense	probably benign	0.00
R6520:Fat2	UTSW	11	55284988	missense	probably damaging	0.99
R6525:Fat2	UTSW	11	55283800	missense	probably damaging	1.00
R6617:Fat2	UTSW	11	55296105	missense	probably benign	0.01
R6652:Fat2	UTSW	11	55252262	missense	probably benign
R6679:Fat2	UTSW	11	55309305	missense	probably damaging	1.00
R6680:Fat2	UTSW	11	55310858	nonsense	probably null
R6762:Fat2	UTSW	11	55253482	splice site	probably null
R6810:Fat2	UTSW	11	55282241	missense	possibly damaging	0.88
R6818:Fat2	UTSW	11	55309341	missense	probably benign	0.31
R6919:Fat2	UTSW	11	55282771	missense	possibly damaging	0.68
R6939:Fat2	UTSW	11	55252474	nonsense	probably null
R6941:Fat2	UTSW	11	55262088	missense	probably benign
R7023:Fat2	UTSW	11	55310502	missense	probably benign	0.00
R7027:Fat2	UTSW	11	55269433	missense	probably benign	0.03
R7027:Fat2	UTSW	11	55281851	nonsense	probably null
R7095:Fat2	UTSW	11	55311331	missense	probably damaging	1.00
R7102:Fat2	UTSW	11	55283434	missense	probably damaging	1.00
R7116:Fat2	UTSW	11	55282336	missense	probably damaging	1.00
R7117:Fat2	UTSW	11	55281262	missense	probably damaging	1.00
R7167:Fat2	UTSW	11	55285001	missense	possibly damaging	0.48
R7213:Fat2	UTSW	11	55281045	nonsense	probably null
R7246:Fat2	UTSW	11	55296382	missense	probably benign	0.00
R7252:Fat2	UTSW	11	55311262	missense	probably damaging	0.98
R7266:Fat2	UTSW	11	55285030	missense	probably damaging	0.99
R7316:Fat2	UTSW	11	55286067	missense	probably damaging	1.00
R7326:Fat2	UTSW	11	55282304	missense	probably damaging	0.99
R7355:Fat2	UTSW	11	55256551	missense	probably benign	0.00
R7431:Fat2	UTSW	11	55309101	missense	probably damaging	1.00
R7459:Fat2	UTSW	11	55303919	missense	probably damaging	1.00
R7460:Fat2	UTSW	11	55278963	missense	probably damaging	1.00
R7466:Fat2	UTSW	11	55310432	missense	probably damaging	1.00
R7475:Fat2	UTSW	11	55303653	missense	probably benign	0.31
R7678:Fat2	UTSW	11	55282330	missense	probably damaging	0.99
R7689:Fat2	UTSW	11	55309840	missense	probably damaging	1.00
R7704:Fat2	UTSW	11	55284347	missense	probably benign	0.03
R7710:Fat2	UTSW	11	55310763	missense	probably benign	0.35
R7724:Fat2	UTSW	11	55284796	missense	probably damaging	1.00
R7731:Fat2	UTSW	11	55310706	missense	probably damaging	1.00
R7739:Fat2	UTSW	11	55281131	nonsense	probably null
R7757:Fat2	UTSW	11	55311421	missense	probably benign	0.00
R7876:Fat2	UTSW	11	55311220	missense	probably benign	0.01
R7883:Fat2	UTSW	11	55253364	splice site	probably null
R7924:Fat2	UTSW	11	55262787	missense	probably benign	0.03
R7936:Fat2	UTSW	11	55310167	missense	probably benign
R7936:Fat2	UTSW	11	55311160	nonsense	probably null
R7938:Fat2	UTSW	11	55273096	missense	probably damaging	1.00
R7947:Fat2	UTSW	11	55287734	missense	probably damaging	1.00
R8049:Fat2	UTSW	11	55312066	missense	probably benign	0.13
R8094:Fat2	UTSW	11	55296139	missense	probably benign	0.06
R8157:Fat2	UTSW	11	55252084	missense	possibly damaging	0.90
R8170:Fat2	UTSW	11	55270455	missense	probably damaging	1.00
R8172:Fat2	UTSW	11	55287812	missense	probably damaging	1.00
R8182:Fat2	UTSW	11	55284397	missense	possibly damaging	0.51
R8188:Fat2	UTSW	11	55273171	missense	probably damaging	0.98
R8204:Fat2	UTSW	11	55284610	missense	probably benign	0.02
R8211:Fat2	UTSW	11	55312209	missense	possibly damaging	0.92
R8255:Fat2	UTSW	11	55270275	missense	probably benign	0.19
R8263:Fat2	UTSW	11	55284136	missense	probably benign
R8269:Fat2	UTSW	11	55282709	missense	possibly damaging	0.48
R8443:Fat2	UTSW	11	55311709	missense	probably damaging	1.00
R8465:Fat2	UTSW	11	55256704	missense	possibly damaging	0.61
R8480:Fat2	UTSW	11	55282968	missense	possibly damaging	0.61
R8511:Fat2	UTSW	11	55309237	missense	probably damaging	0.99
R8680:Fat2	UTSW	11	55253866	missense	probably benign
R8704:Fat2	UTSW	11	55281311	missense	probably damaging	1.00
R8711:Fat2	UTSW	11	55268303	missense	probably benign	0.22
R8724:Fat2	UTSW	11	55282960	missense	probably damaging	1.00
R8788:Fat2	UTSW	11	55281103	missense	possibly damaging	0.90
R8802:Fat2	UTSW	11	55282924	missense	possibly damaging	0.95
R8902:Fat2	UTSW	11	55310070	missense	probably damaging	1.00
R8940:Fat2	UTSW	11	55256810	missense	possibly damaging	0.48
R8956:Fat2	UTSW	11	55282903	missense	probably damaging	1.00
R9035:Fat2	UTSW	11	55303721	missense	probably damaging	0.99
R9100:Fat2	UTSW	11	55262521	missense	probably damaging	1.00
R9132:Fat2	UTSW	11	55298610	missense	possibly damaging	0.88
R9173:Fat2	UTSW	11	55278937	missense	probably damaging	1.00
R9241:Fat2	UTSW	11	55256740	missense	probably benign	0.00
R9253:Fat2	UTSW	11	55310571	missense	probably damaging	1.00
R9280:Fat2	UTSW	11	55310697	missense	probably benign	0.36
R9351:Fat2	UTSW	11	55281301	missense	probably damaging	1.00
R9369:Fat2	UTSW	11	55310688	missense	possibly damaging	0.67
R9404:Fat2	UTSW	11	55253522	critical splice donor site	probably null
R9431:Fat2	UTSW	11	55252012	missense	probably damaging	1.00
R9484:Fat2	UTSW	11	55309926	missense	probably damaging	0.99
R9509:Fat2	UTSW	11	55309887	missense	possibly damaging	0.51
R9514:Fat2	UTSW	11	55284982	missense	probably damaging	0.98
R9606:Fat2	UTSW	11	55289267	missense	probably damaging	1.00
R9630:Fat2	UTSW	11	55256779	missense	probably benign	0.29
R9727:Fat2	UTSW	11	55268311	missense	probably damaging	1.00
R9736:Fat2	UTSW	11	55303925	missense	probably damaging	1.00
X0010:Fat2	UTSW	11	55252260	missense	probably benign	0.00
X0011:Fat2	UTSW	11	55310431	missense	probably damaging	0.98
X0018:Fat2	UTSW	11	55296210	missense	probably damaging	1.00
X0028:Fat2	UTSW	11	55309414	missense	possibly damaging	0.84
X0067:Fat2	UTSW	11	55283234	missense	possibly damaging	0.48
Z1176:Fat2	UTSW	11	55282795	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55284991	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55303700	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55310121	missense	probably damaging	0.96
Z1177:Fat2	UTSW	11	55278966	nonsense	probably null
Z1186:Fat2	UTSW	11	55308970	frame shift	probably null
Z1186:Fat2	UTSW	11	55309799	missense	probably benign
Z1187:Fat2	UTSW	11	55308970	frame shift	probably null
Z1187:Fat2	UTSW	11	55309799	missense	probably benign
Z1188:Fat2	UTSW	11	55308970	frame shift	probably null
Z1188:Fat2	UTSW	11	55309799	missense	probably benign
Z1189:Fat2	UTSW	11	55308970	frame shift	probably null
Z1189:Fat2	UTSW	11	55309799	missense	probably benign
Z1190:Fat2	UTSW	11	55308970	frame shift	probably null
Z1190:Fat2	UTSW	11	55309799	missense	probably benign
Z1191:Fat2	UTSW	11	55308970	frame shift	probably null
Z1191:Fat2	UTSW	11	55309799	missense	probably benign
Z1192:Fat2	UTSW	11	55308970	frame shift	probably null
Z1192:Fat2	UTSW	11	55309799	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TGTTGATATACACTGGCACCGTTGC -3'
(R):5'- TGGCTTCTGACCAAGACTCAGGAC -3'

Sequencing Primer
(F):5'- CCCTCAAGTTGTAAGATGAGTCCAG -3'
(R):5'- ACTCAGGACAGAACCAAGATG -3'

Posted On

2013-05-23