Mutagenetix > Incidental Mutation

Incidental Mutation 'R5024:Hmcn1'

391193

Institutional Source

Beutler Lab

Gene Symbol

Hmcn1

Ensembl Gene

ENSMUSG00000066842

Gene Name

hemicentin 1

Synonyms

LOC240793, EG545370

MMRRC Submission

042615-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5024 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

150562524-150993435 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 150680688 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Valine at position 2449 (E2449V)

Ref Sequence

ENSEMBL: ENSMUSP00000121500 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074783] [ENSMUST00000137197]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000074783
AA Change: E2449V

PolyPhen 2 Score 0.655 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000074340
Gene: ENSMUSG00000066842
AA Change: E2449V

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
VWA	39	213	3e-1	SMART
IG_like	445	506	1.13e0	SMART
IGc2	532	598	2.32e-8	SMART
IGc2	624	688	1.24e-8	SMART
IGc2	714	779	7.52e-8	SMART
IGc2	805	874	2.19e-9	SMART
IGc2	902	967	5.15e-15	SMART
IGc2	993	1058	1.28e-10	SMART
IGc2	1092	1157	1.69e-10	SMART
IGc2	1183	1247	1.09e-13	SMART
IGc2	1278	1344	6.49e-12	SMART
IGc2	1372	1437	5.2e-11	SMART
IGc2	1465	1531	1.34e-13	SMART
IGc2	1559	1624	6.25e-14	SMART
IGc2	1653	1718	4.06e-13	SMART
IGc2	1746	1811	4.12e-14	SMART
IGc2	1838	1904	5.92e-15	SMART
IGc2	1932	1997	7.69e-14	SMART
IGc2	2023	2089	3.3e-13	SMART
IGc2	2115	2180	5e-13	SMART
IGc2	2208	2275	1.32e-12	SMART
IGc2	2304	2369	2.91e-14	SMART
IGc2	2398	2463	4e-12	SMART
IGc2	2491	2556	1.94e-19	SMART
IGc2	2587	2652	2.54e-14	SMART
IGc2	2686	2751	7.57e-13	SMART
IGc2	2789	2854	4.88e-16	SMART
IGc2	2884	2949	2.7e-9	SMART
IGc2	2976	3041	1.47e-10	SMART
IGc2	3071	3136	2.24e-15	SMART
IGc2	3163	3230	8.83e-14	SMART
IGc2	3258	3325	9.76e-16	SMART
IGc2	3354	3419	1.54e-13	SMART
IGc2	3447	3512	4.35e-13	SMART
IGc2	3540	3605	2e-12	SMART
IGc2	3633	3698	7.69e-14	SMART
IGc2	3724	3789	1.92e-14	SMART
IGc2	3815	3882	2.58e-6	SMART
IGc2	3908	3973	6.4e-11	SMART
IGc2	3999	4064	2.78e-11	SMART
IGc2	4090	4154	1.74e-12	SMART
low complexity region	4155	4160	N/A	INTRINSIC
IGc2	4180	4245	3.35e-14	SMART
IGc2	4271	4334	8.12e-13	SMART
IGc2	4361	4425	1.79e-14	SMART
IGc2	4451	4515	1.06e-11	SMART
TSP1	4531	4583	4.72e-15	SMART
TSP1	4588	4640	2.39e-16	SMART
TSP1	4645	4697	1.67e-15	SMART
TSP1	4702	4754	2.2e-15	SMART
TSP1	4759	4811	2.77e-12	SMART
TSP1	4816	4868	2.67e-14	SMART
Pfam:G2F	4869	5051	1.5e-57	PFAM
EGF_CA	5106	5145	4.38e-11	SMART
EGF_CA	5146	5190	4.49e-8	SMART
EGF_CA	5191	5228	2.38e-12	SMART
EGF_CA	5229	5270	6.8e-8	SMART
EGF_CA	5271	5313	3.51e-10	SMART
EGF_CA	5314	5354	4.32e-10	SMART
low complexity region	5384	5400	N/A	INTRINSIC
low complexity region	5401	5412	N/A	INTRINSIC
EGF_CA	5431	5470	2.78e-13	SMART
EGF	5474	5516	1.44e1	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000137197
AA Change: E2449V

PolyPhen 2 Score 0.655 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000121500
Gene: ENSMUSG00000066842
AA Change: E2449V

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
VWA	39	213	3e-1	SMART
IG_like	445	506	1.13e0	SMART
IGc2	532	598	2.32e-8	SMART
IGc2	624	688	1.24e-8	SMART
IGc2	714	779	7.52e-8	SMART
IGc2	805	874	2.19e-9	SMART
IGc2	902	967	5.15e-15	SMART
IGc2	993	1058	1.28e-10	SMART
IGc2	1092	1157	1.69e-10	SMART
IGc2	1183	1247	1.09e-13	SMART
IGc2	1278	1344	6.49e-12	SMART
IGc2	1372	1437	5.2e-11	SMART
IGc2	1465	1531	1.34e-13	SMART
IGc2	1559	1624	6.25e-14	SMART
IGc2	1653	1718	4.06e-13	SMART
IGc2	1746	1811	4.12e-14	SMART
IGc2	1838	1904	5.92e-15	SMART
IGc2	1932	1997	7.69e-14	SMART
IGc2	2023	2089	3.3e-13	SMART
IGc2	2115	2180	5e-13	SMART
IGc2	2208	2275	1.32e-12	SMART
IGc2	2304	2369	2.91e-14	SMART
IGc2	2398	2463	4e-12	SMART
IGc2	2491	2556	1.94e-19	SMART
IGc2	2587	2652	2.54e-14	SMART
IGc2	2686	2751	7.57e-13	SMART
IGc2	2789	2854	4.88e-16	SMART
IGc2	2884	2949	2.7e-9	SMART
IGc2	2976	3041	1.47e-10	SMART
IGc2	3071	3136	2.24e-15	SMART
IGc2	3163	3230	8.83e-14	SMART
IGc2	3258	3325	9.76e-16	SMART
IGc2	3354	3419	1.54e-13	SMART
IGc2	3447	3512	4.35e-13	SMART
IGc2	3540	3605	2e-12	SMART
IGc2	3633	3698	7.69e-14	SMART
IGc2	3724	3789	1.92e-14	SMART
IGc2	3815	3882	2.58e-6	SMART
IGc2	3908	3973	6.4e-11	SMART
IGc2	3999	4064	2.78e-11	SMART
IGc2	4090	4154	1.74e-12	SMART
low complexity region	4155	4160	N/A	INTRINSIC
IGc2	4180	4245	3.35e-14	SMART
IGc2	4271	4334	8.12e-13	SMART
IGc2	4361	4425	1.79e-14	SMART
IGc2	4451	4515	1.06e-11	SMART
TSP1	4531	4583	4.72e-15	SMART
TSP1	4588	4640	2.39e-16	SMART
TSP1	4645	4697	1.67e-15	SMART
TSP1	4702	4754	2.2e-15	SMART
TSP1	4759	4811	2.77e-12	SMART
TSP1	4816	4868	2.67e-14	SMART
PDB:1GL4\|A	4869	5082	3e-6	PDB
SCOP:d1gl4a1	4869	5082	3e-79	SMART
EGF_CA	5106	5145	4.38e-11	SMART
EGF_CA	5146	5190	4.49e-8	SMART
EGF_CA	5191	5228	2.38e-12	SMART
EGF_CA	5229	5270	6.8e-8	SMART
EGF_CA	5271	5313	3.51e-10	SMART
EGF_CA	5314	5353	2.78e-13	SMART
EGF	5357	5399	1.44e1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177268

Meta Mutation Damage Score

0.1887

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.6%
20x: 93.4%

Validation Efficiency

99% (95/96)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration. [provided by RefSeq, Jul 2008]

Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock

Total: 85 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrd1	A	G	5: 129,171,895 (GRCm38)	N575S	probably damaging	Het
Akap6	C	T	12: 53,142,562 (GRCm38)	T2253M	probably benign	Het
Arhgef37	A	C	18: 61,506,440 (GRCm38)	N289K	probably damaging	Het
Armc4	T	C	18: 7,088,555 (GRCm38)	M1005V	probably benign	Het
Atad2b	A	C	12: 4,937,534 (GRCm38)	T121P	probably benign	Het
Atp4a	A	C	7: 30,715,864 (GRCm38)	D303A	possibly damaging	Het
BC005561	A	G	5: 104,522,258 (GRCm38)	K1549E	possibly damaging	Het
Calu	A	T	6: 29,374,519 (GRCm38)		probably benign	Het
Ccdc141	A	C	2: 77,054,703 (GRCm38)	N531K	probably benign	Het
Ccdc146	T	C	5: 21,399,614 (GRCm38)		probably null	Het
Cd207	G	A	6: 83,674,319 (GRCm38)	T218I	probably damaging	Het
Cd2ap	A	C	17: 42,805,345 (GRCm38)		probably null	Het
Clip3	G	A	7: 30,292,219 (GRCm38)		probably benign	Het
Clstn1	G	A	4: 149,635,294 (GRCm38)	R432H	possibly damaging	Het
Csmd2	A	G	4: 128,321,348 (GRCm38)	Y521C	possibly damaging	Het
Dnah8	A	T	17: 30,736,096 (GRCm38)	E2033V	probably damaging	Het
Eng	T	G	2: 32,673,392 (GRCm38)	V319G	probably benign	Het
Erp44	C	T	4: 48,241,296 (GRCm38)	W57*	probably null	Het
Etv1	T	A	12: 38,854,234 (GRCm38)		probably null	Het
Eva1c	T	C	16: 90,876,193 (GRCm38)		probably null	Het
Fam196a	A	G	7: 134,918,478 (GRCm38)	S108P	probably damaging	Het
Fam221b	T	A	4: 43,659,674 (GRCm38)	N482I	probably damaging	Het
Fam83h	T	C	15: 76,005,142 (GRCm38)	H202R	probably damaging	Het
Fbxw13	T	C	9: 109,179,335 (GRCm38)	T449A	probably benign	Het
Fbxw25	A	T	9: 109,663,374 (GRCm38)		probably null	Het
Frmd3	T	A	4: 74,098,144 (GRCm38)	S99T	probably benign	Het
Gm5155	A	G	7: 17,910,682 (GRCm38)	I575V	probably benign	Het
Gm5174	G	T	10: 86,656,587 (GRCm38)		noncoding transcript	Het
Gm6904	T	C	14: 59,258,483 (GRCm38)		probably null	Het
Gm815	C	T	19: 26,887,775 (GRCm38)	Q49*	probably null	Het
H2-DMa	A	T	17: 34,138,487 (GRCm38)	I245F	possibly damaging	Het
Herc1	A	T	9: 66,470,326 (GRCm38)	K3458M	possibly damaging	Het
Hirip3	A	G	7: 126,864,489 (GRCm38)		probably null	Het
Hjurp	A	T	1: 88,275,050 (GRCm38)	Y71N	possibly damaging	Het
Igll1	G	T	16: 16,863,793 (GRCm38)	H33N	probably benign	Het
Il6	T	C	5: 30,019,514 (GRCm38)	L184P	probably damaging	Het
Impg2	T	A	16: 56,260,100 (GRCm38)	S756T	probably damaging	Het
Kank4	T	G	4: 98,785,661 (GRCm38)	D5A	probably damaging	Het
Kcna7	G	A	7: 45,406,591 (GRCm38)	R77H	probably damaging	Het
Kcns2	A	T	15: 34,839,537 (GRCm38)	T349S	probably benign	Het
Keap1	A	G	9: 21,237,226 (GRCm38)	Y162H	probably damaging	Het
Kif9	T	C	9: 110,483,093 (GRCm38)	F10L	possibly damaging	Het
Klhdc8b	ACACGCACGCACGCACGCACGCACGCACGCACGCACGCAC	ACACGCACGCACGCACGCACGCACGCACGCACGCACGCACGCAC	9: 108,448,985 (GRCm38)		probably benign	Het
Klk14	G	A	7: 43,692,077 (GRCm38)	C51Y	probably damaging	Het
Lpar6	A	G	14: 73,239,369 (GRCm38)	T257A	probably damaging	Het
Lpin1	A	T	12: 16,554,006 (GRCm38)	L608Q	probably benign	Het
Lyst	T	C	13: 13,634,404 (GRCm38)	S220P	probably benign	Het
M1ap	A	G	6: 83,028,358 (GRCm38)		probably benign	Het
Mbd6	C	T	10: 127,286,441 (GRCm38)	V173I	probably benign	Het
Myo5b	A	T	18: 74,716,034 (GRCm38)	T1115S	possibly damaging	Het
Mysm1	C	A	4: 94,951,016 (GRCm38)	V683F	possibly damaging	Het
Nlrp4g	T	A	9: 124,350,155 (GRCm38)		noncoding transcript	Het
Olfr1040	G	T	2: 86,146,533 (GRCm38)	A67E	probably damaging	Het
Olfr1062	C	T	2: 86,423,461 (GRCm38)	G72S	possibly damaging	Het
Olfr292	A	T	7: 86,694,881 (GRCm38)	M142L	probably benign	Het
Olfr318	T	A	11: 58,720,950 (GRCm38)	I33F	probably benign	Het
Otud6b	T	A	4: 14,826,293 (GRCm38)	Q34L	probably damaging	Het
Parp11	C	T	6: 127,471,636 (GRCm38)	T72I	probably damaging	Het
Pbx1	T	A	1: 168,183,589 (GRCm38)	D343V	possibly damaging	Het
Ppp1r12b	G	T	1: 134,955,733 (GRCm38)	A17E	probably benign	Het
Pramef20	C	A	4: 144,373,308 (GRCm38)	E296*	probably null	Het
Ranbp9	A	T	13: 43,434,855 (GRCm38)	I67N	probably damaging	Het
Rasgrp4	A	G	7: 29,148,407 (GRCm38)	E414G	probably damaging	Het
Rbbp5	A	G	1: 132,490,488 (GRCm38)	H15R	possibly damaging	Het
Scd2	A	G	19: 44,301,271 (GRCm38)	Y235C	probably benign	Het
Sdr16c5	C	T	4: 4,010,365 (GRCm38)	G170S	probably damaging	Het
Sh3bp4	G	T	1: 89,145,595 (GRCm38)	G722C	probably damaging	Het
Shmt1	A	T	11: 60,797,479 (GRCm38)		probably benign	Het
Slc12a1	A	G	2: 125,166,137 (GRCm38)	I206V	probably benign	Het
Slc26a3	A	G	12: 31,453,908 (GRCm38)	D304G	probably benign	Het
Slc26a7	T	A	4: 14,532,572 (GRCm38)	D434V	possibly damaging	Het
Slc6a16	G	T	7: 45,259,966 (GRCm38)	M185I	probably benign	Het
Stat4	A	G	1: 52,082,570 (GRCm38)	I363V	possibly damaging	Het
Tgfb1i1	G	T	7: 128,248,217 (GRCm38)	M1I	probably null	Het
Tmem225	T	C	9: 40,149,343 (GRCm38)	V66A	probably benign	Het
Tmtc4	T	C	14: 122,941,302 (GRCm38)		probably null	Het
Trpc4	T	A	3: 54,194,796 (GRCm38)	N38K	probably benign	Het
Ttll12	A	T	15: 83,587,113 (GRCm38)	Y218N	probably damaging	Het
Ttn	A	T	2: 76,948,425 (GRCm38)		probably null	Het
Tulp1	A	C	17: 28,351,995 (GRCm38)	Y178*	probably null	Het
Vmn2r58	A	G	7: 41,864,322 (GRCm38)	V299A	probably damaging	Het
Washc4	C	A	10: 83,583,336 (GRCm38)	Q911K	possibly damaging	Het
Wdr3	T	C	3: 100,154,936 (GRCm38)	D221G	probably benign	Het
Zan	A	T	5: 137,461,893 (GRCm38)	C1245*	probably null	Het
Zfyve9	A	C	4: 108,691,669 (GRCm38)	S773A	probably benign	Het

Other mutations in Hmcn1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00417:Hmcn1	APN	1	150,677,278 (GRCm38)	missense	probably benign
IGL00571:Hmcn1	APN	1	150,638,999 (GRCm38)	missense	probably benign	0.05
IGL00726:Hmcn1	APN	1	150,806,366 (GRCm38)	critical splice donor site	probably null
IGL00802:Hmcn1	APN	1	150,664,936 (GRCm38)	missense	probably benign	0.19
IGL00824:Hmcn1	APN	1	150,656,734 (GRCm38)	missense	probably damaging	1.00
IGL00834:Hmcn1	APN	1	150,630,340 (GRCm38)	missense	probably benign	0.00
IGL00843:Hmcn1	APN	1	150,610,713 (GRCm38)	missense	possibly damaging	0.95
IGL00845:Hmcn1	APN	1	150,605,006 (GRCm38)	missense	probably damaging	0.98
IGL00851:Hmcn1	APN	1	150,582,301 (GRCm38)	missense	probably benign	0.02
IGL00909:Hmcn1	APN	1	150,638,869 (GRCm38)	missense	probably benign	0.12
IGL01074:Hmcn1	APN	1	150,627,033 (GRCm38)	missense	possibly damaging	0.82
IGL01112:Hmcn1	APN	1	150,632,552 (GRCm38)	splice site	probably benign
IGL01304:Hmcn1	APN	1	150,622,924 (GRCm38)	missense	probably damaging	0.99
IGL01307:Hmcn1	APN	1	150,745,001 (GRCm38)	missense	possibly damaging	0.84
IGL01318:Hmcn1	APN	1	150,719,240 (GRCm38)	missense	probably damaging	1.00
IGL01403:Hmcn1	APN	1	150,593,097 (GRCm38)	missense	probably damaging	1.00
IGL01417:Hmcn1	APN	1	150,859,239 (GRCm38)	missense	probably damaging	1.00
IGL01503:Hmcn1	APN	1	150,605,072 (GRCm38)	missense	probably benign	0.38
IGL01509:Hmcn1	APN	1	150,609,631 (GRCm38)	missense	probably damaging	1.00
IGL01550:Hmcn1	APN	1	150,598,397 (GRCm38)	missense	probably damaging	1.00
IGL01601:Hmcn1	APN	1	150,627,413 (GRCm38)	missense	probably benign	0.01
IGL01617:Hmcn1	APN	1	150,672,032 (GRCm38)	missense	probably benign	0.05
IGL01636:Hmcn1	APN	1	150,580,233 (GRCm38)	missense	probably damaging	1.00
IGL01662:Hmcn1	APN	1	150,737,299 (GRCm38)	missense	possibly damaging	0.46
IGL01693:Hmcn1	APN	1	150,583,280 (GRCm38)	missense	probably damaging	1.00
IGL01723:Hmcn1	APN	1	150,744,960 (GRCm38)	missense	probably benign	0.01
IGL01776:Hmcn1	APN	1	150,672,038 (GRCm38)	missense	possibly damaging	0.70
IGL01783:Hmcn1	APN	1	150,615,300 (GRCm38)	missense	possibly damaging	0.60
IGL01789:Hmcn1	APN	1	150,690,601 (GRCm38)	missense	probably damaging	1.00
IGL01900:Hmcn1	APN	1	150,742,260 (GRCm38)	splice site	probably benign
IGL01906:Hmcn1	APN	1	150,667,887 (GRCm38)	missense	probably benign	0.01
IGL01947:Hmcn1	APN	1	150,732,892 (GRCm38)	missense	possibly damaging	0.93
IGL01958:Hmcn1	APN	1	150,603,871 (GRCm38)	missense	probably benign	0.01
IGL02002:Hmcn1	APN	1	150,615,298 (GRCm38)	missense	probably damaging	1.00
IGL02058:Hmcn1	APN	1	150,704,181 (GRCm38)	missense	probably benign	0.02
IGL02115:Hmcn1	APN	1	150,630,728 (GRCm38)	missense	probably damaging	1.00
IGL02127:Hmcn1	APN	1	150,722,607 (GRCm38)	missense	probably benign
IGL02155:Hmcn1	APN	1	150,563,598 (GRCm38)	missense	probably damaging	1.00
IGL02222:Hmcn1	APN	1	150,806,401 (GRCm38)	missense	probably benign	0.05
IGL02293:Hmcn1	APN	1	150,664,915 (GRCm38)	missense	probably damaging	0.97
IGL02398:Hmcn1	APN	1	150,802,897 (GRCm38)	missense	possibly damaging	0.78
IGL02420:Hmcn1	APN	1	150,722,424 (GRCm38)	missense	probably damaging	1.00
IGL02553:Hmcn1	APN	1	150,993,023 (GRCm38)	missense	probably benign	0.12
IGL02561:Hmcn1	APN	1	150,809,726 (GRCm38)	missense	probably benign	0.32
IGL02569:Hmcn1	APN	1	150,697,493 (GRCm38)	missense	probably benign	0.01
IGL02607:Hmcn1	APN	1	150,744,995 (GRCm38)	missense	possibly damaging	0.88
IGL02676:Hmcn1	APN	1	150,619,009 (GRCm38)	missense	probably benign	0.01
IGL02725:Hmcn1	APN	1	150,604,903 (GRCm38)	missense	possibly damaging	0.92
IGL02726:Hmcn1	APN	1	150,656,694 (GRCm38)	nonsense	probably null
IGL02735:Hmcn1	APN	1	150,646,832 (GRCm38)	missense	probably benign	0.02
IGL02737:Hmcn1	APN	1	150,563,828 (GRCm38)	missense	probably damaging	1.00
IGL02892:Hmcn1	APN	1	150,675,974 (GRCm38)	critical splice donor site	probably null
IGL02927:Hmcn1	APN	1	150,577,278 (GRCm38)	missense	probably damaging	1.00
IGL02931:Hmcn1	APN	1	150,657,207 (GRCm38)	missense	probably benign	0.37
IGL02936:Hmcn1	APN	1	150,697,522 (GRCm38)	missense	probably damaging	0.98
IGL02985:Hmcn1	APN	1	150,671,917 (GRCm38)	missense	probably damaging	1.00
IGL03027:Hmcn1	APN	1	150,808,539 (GRCm38)	missense	probably benign
IGL03195:Hmcn1	APN	1	150,802,909 (GRCm38)	missense	probably benign	0.06
IGL03217:Hmcn1	APN	1	150,743,667 (GRCm38)	missense	possibly damaging	0.58
IGL03232:Hmcn1	APN	1	150,770,352 (GRCm38)	splice site	probably benign
IGL03268:Hmcn1	APN	1	150,772,510 (GRCm38)	missense	probably damaging	1.00
IGL03271:Hmcn1	APN	1	150,598,424 (GRCm38)	missense	possibly damaging	0.92
IGL03304:Hmcn1	APN	1	150,630,231 (GRCm38)	missense	probably damaging	0.97
IGL03329:Hmcn1	APN	1	150,732,910 (GRCm38)	missense	probably damaging	1.00
IGL03339:Hmcn1	APN	1	150,701,969 (GRCm38)	missense	probably benign	0.04
IGL03368:Hmcn1	APN	1	150,663,872 (GRCm38)	missense	probably damaging	1.00
Backbone	UTSW	1	150,622,994 (GRCm38)	missense	probably benign	0.09
Cambrian	UTSW	1	150,732,846 (GRCm38)	missense	probably damaging	1.00
chordate	UTSW	1	150,587,015 (GRCm38)	missense	probably benign	0.00
Justamere	UTSW	1	150,588,257 (GRCm38)	missense	probably damaging	1.00
Lancelet	UTSW	1	150,675,540 (GRCm38)	missense	probably benign	0.00
notochord	UTSW	1	150,770,293 (GRCm38)	missense	probably benign	0.00
wippoorwill	UTSW	1	150,732,946 (GRCm38)	missense	probably damaging	1.00
BB004:Hmcn1	UTSW	1	150,609,775 (GRCm38)	missense	probably damaging	1.00
BB014:Hmcn1	UTSW	1	150,609,775 (GRCm38)	missense	probably damaging	1.00
IGL02991:Hmcn1	UTSW	1	150,738,658 (GRCm38)	missense	possibly damaging	0.56
P0017:Hmcn1	UTSW	1	150,720,689 (GRCm38)	missense	possibly damaging	0.49
PIT1430001:Hmcn1	UTSW	1	150,808,737 (GRCm38)	missense	probably benign	0.00
PIT4514001:Hmcn1	UTSW	1	150,669,487 (GRCm38)	missense	possibly damaging	0.93
R0006:Hmcn1	UTSW	1	150,808,676 (GRCm38)	missense	probably damaging	0.99
R0018:Hmcn1	UTSW	1	150,652,551 (GRCm38)	missense	probably benign	0.16
R0052:Hmcn1	UTSW	1	150,677,406 (GRCm38)	missense	probably damaging	1.00
R0107:Hmcn1	UTSW	1	150,587,015 (GRCm38)	missense	probably benign	0.00
R0115:Hmcn1	UTSW	1	150,808,647 (GRCm38)	missense	possibly damaging	0.88
R0149:Hmcn1	UTSW	1	150,677,324 (GRCm38)	missense	probably benign	0.00
R0152:Hmcn1	UTSW	1	150,663,879 (GRCm38)	missense	probably benign	0.01
R0381:Hmcn1	UTSW	1	150,603,811 (GRCm38)	missense	probably damaging	1.00
R0398:Hmcn1	UTSW	1	150,798,814 (GRCm38)	missense	possibly damaging	0.83
R0414:Hmcn1	UTSW	1	150,715,822 (GRCm38)	missense	possibly damaging	0.72
R0494:Hmcn1	UTSW	1	150,732,792 (GRCm38)	splice site	probably benign
R0503:Hmcn1	UTSW	1	150,859,252 (GRCm38)	missense	probably damaging	1.00
R0504:Hmcn1	UTSW	1	150,876,419 (GRCm38)	splice site	probably benign
R0506:Hmcn1	UTSW	1	150,742,341 (GRCm38)	missense	possibly damaging	0.69
R0554:Hmcn1	UTSW	1	150,719,117 (GRCm38)	missense	probably benign	0.34
R0576:Hmcn1	UTSW	1	150,650,017 (GRCm38)	nonsense	probably null
R0599:Hmcn1	UTSW	1	150,609,801 (GRCm38)	missense	possibly damaging	0.91
R0605:Hmcn1	UTSW	1	150,657,376 (GRCm38)	critical splice donor site	probably null
R0607:Hmcn1	UTSW	1	150,638,900 (GRCm38)	missense	probably benign	0.01
R0620:Hmcn1	UTSW	1	150,594,016 (GRCm38)	missense	probably benign	0.04
R0626:Hmcn1	UTSW	1	150,798,719 (GRCm38)	splice site	probably null
R0699:Hmcn1	UTSW	1	150,819,410 (GRCm38)	missense	probably damaging	1.00
R0765:Hmcn1	UTSW	1	150,808,787 (GRCm38)	missense	probably damaging	1.00
R0782:Hmcn1	UTSW	1	150,753,665 (GRCm38)	missense	possibly damaging	0.82
R0783:Hmcn1	UTSW	1	150,650,073 (GRCm38)	missense	probably damaging	1.00
R0841:Hmcn1	UTSW	1	150,679,607 (GRCm38)	splice site	probably null
R0975:Hmcn1	UTSW	1	150,577,377 (GRCm38)	missense	probably benign	0.00
R1070:Hmcn1	UTSW	1	150,689,590 (GRCm38)	missense	probably damaging	0.98
R1118:Hmcn1	UTSW	1	150,618,928 (GRCm38)	missense	possibly damaging	0.56
R1119:Hmcn1	UTSW	1	150,618,928 (GRCm38)	missense	possibly damaging	0.56
R1145:Hmcn1	UTSW	1	150,679,607 (GRCm38)	splice site	probably null
R1145:Hmcn1	UTSW	1	150,679,607 (GRCm38)	splice site	probably null
R1233:Hmcn1	UTSW	1	150,749,026 (GRCm38)	missense	probably benign
R1234:Hmcn1	UTSW	1	150,753,654 (GRCm38)	nonsense	probably null
R1291:Hmcn1	UTSW	1	150,748,191 (GRCm38)	missense	probably damaging	1.00
R1334:Hmcn1	UTSW	1	150,586,468 (GRCm38)	missense	possibly damaging	0.73
R1372:Hmcn1	UTSW	1	150,680,715 (GRCm38)	missense	probably benign	0.22
R1424:Hmcn1	UTSW	1	150,646,794 (GRCm38)	missense	probably benign	0.00
R1450:Hmcn1	UTSW	1	150,652,506 (GRCm38)	splice site	probably benign
R1458:Hmcn1	UTSW	1	150,609,700 (GRCm38)	missense	probably damaging	1.00
R1467:Hmcn1	UTSW	1	150,689,590 (GRCm38)	missense	probably damaging	0.98
R1467:Hmcn1	UTSW	1	150,689,590 (GRCm38)	missense	probably damaging	0.98
R1473:Hmcn1	UTSW	1	150,772,552 (GRCm38)	missense	probably benign	0.03
R1517:Hmcn1	UTSW	1	150,669,421 (GRCm38)	missense	probably damaging	1.00
R1527:Hmcn1	UTSW	1	150,773,803 (GRCm38)	missense	probably benign	0.00
R1557:Hmcn1	UTSW	1	150,734,532 (GRCm38)	missense	possibly damaging	0.86
R1576:Hmcn1	UTSW	1	150,657,241 (GRCm38)	missense	possibly damaging	0.77
R1617:Hmcn1	UTSW	1	150,745,027 (GRCm38)	missense	probably damaging	0.98
R1635:Hmcn1	UTSW	1	150,669,558 (GRCm38)	missense	probably benign	0.00
R1655:Hmcn1	UTSW	1	150,630,333 (GRCm38)	missense	probably benign	0.03
R1698:Hmcn1	UTSW	1	150,565,369 (GRCm38)	nonsense	probably null
R1710:Hmcn1	UTSW	1	150,675,984 (GRCm38)	missense	probably damaging	1.00
R1717:Hmcn1	UTSW	1	150,859,186 (GRCm38)	missense	probably damaging	1.00
R1753:Hmcn1	UTSW	1	150,586,468 (GRCm38)	missense	possibly damaging	0.73
R1756:Hmcn1	UTSW	1	150,599,030 (GRCm38)	missense	probably damaging	1.00
R1772:Hmcn1	UTSW	1	150,563,568 (GRCm38)	missense	probably damaging	0.99
R1793:Hmcn1	UTSW	1	150,749,083 (GRCm38)	missense	probably benign	0.01
R1794:Hmcn1	UTSW	1	150,627,152 (GRCm38)	missense	probably damaging	0.98
R1794:Hmcn1	UTSW	1	150,598,285 (GRCm38)	missense	probably benign	0.00
R1856:Hmcn1	UTSW	1	150,721,664 (GRCm38)	missense	probably benign	0.02
R1859:Hmcn1	UTSW	1	150,657,193 (GRCm38)	missense	probably damaging	1.00
R1862:Hmcn1	UTSW	1	150,638,900 (GRCm38)	missense	probably benign	0.01
R1865:Hmcn1	UTSW	1	150,603,812 (GRCm38)	missense	probably damaging	1.00
R1874:Hmcn1	UTSW	1	150,720,695 (GRCm38)	missense	probably damaging	1.00
R1880:Hmcn1	UTSW	1	150,638,900 (GRCm38)	missense	probably benign	0.01
R1881:Hmcn1	UTSW	1	150,638,900 (GRCm38)	missense	probably benign	0.01
R1886:Hmcn1	UTSW	1	150,577,295 (GRCm38)	missense	probably benign	0.02
R1888:Hmcn1	UTSW	1	150,819,500 (GRCm38)	missense	possibly damaging	0.82
R1888:Hmcn1	UTSW	1	150,819,500 (GRCm38)	missense	possibly damaging	0.82
R1899:Hmcn1	UTSW	1	150,657,451 (GRCm38)	missense	probably damaging	1.00
R1905:Hmcn1	UTSW	1	150,992,855 (GRCm38)	missense	probably damaging	1.00
R1912:Hmcn1	UTSW	1	150,604,882 (GRCm38)	missense	probably benign	0.28
R1959:Hmcn1	UTSW	1	150,649,676 (GRCm38)	missense	probably benign	0.00
R1960:Hmcn1	UTSW	1	150,677,376 (GRCm38)	missense	possibly damaging	0.72
R1960:Hmcn1	UTSW	1	150,675,991 (GRCm38)	missense	probably benign	0.00
R2001:Hmcn1	UTSW	1	150,738,613 (GRCm38)	missense	possibly damaging	0.81
R2011:Hmcn1	UTSW	1	150,677,334 (GRCm38)	missense	probably benign	0.01
R2075:Hmcn1	UTSW	1	150,577,323 (GRCm38)	missense	possibly damaging	0.86
R2136:Hmcn1	UTSW	1	150,633,659 (GRCm38)	missense	probably damaging	1.00
R2192:Hmcn1	UTSW	1	150,715,815 (GRCm38)	missense	probably damaging	0.97
R2267:Hmcn1	UTSW	1	150,599,010 (GRCm38)	missense	probably benign	0.00
R2268:Hmcn1	UTSW	1	150,624,598 (GRCm38)	splice site	probably benign
R2303:Hmcn1	UTSW	1	150,704,226 (GRCm38)	missense	probably damaging	1.00
R2330:Hmcn1	UTSW	1	150,652,678 (GRCm38)	splice site	probably benign
R2338:Hmcn1	UTSW	1	150,622,934 (GRCm38)	missense	possibly damaging	0.89
R2380:Hmcn1	UTSW	1	150,565,384 (GRCm38)	missense	probably benign	0.01
R2405:Hmcn1	UTSW	1	150,860,341 (GRCm38)	missense	probably damaging	1.00
R2443:Hmcn1	UTSW	1	150,599,032 (GRCm38)	missense	probably benign	0.01
R2496:Hmcn1	UTSW	1	150,615,221 (GRCm38)	missense	probably benign	0.01
R2504:Hmcn1	UTSW	1	150,686,867 (GRCm38)	nonsense	probably null
R2519:Hmcn1	UTSW	1	150,773,820 (GRCm38)	nonsense	probably null
R2520:Hmcn1	UTSW	1	150,743,647 (GRCm38)	missense	possibly damaging	0.72
R2679:Hmcn1	UTSW	1	150,652,575 (GRCm38)	missense	possibly damaging	0.67
R2831:Hmcn1	UTSW	1	150,630,652 (GRCm38)	critical splice donor site	probably null
R2847:Hmcn1	UTSW	1	150,563,599 (GRCm38)	nonsense	probably null
R2849:Hmcn1	UTSW	1	150,563,599 (GRCm38)	nonsense	probably null
R2869:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2869:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2871:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2871:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2872:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2872:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2873:Hmcn1	UTSW	1	150,738,716 (GRCm38)	missense	possibly damaging	0.95
R2897:Hmcn1	UTSW	1	150,802,873 (GRCm38)	missense	probably damaging	1.00
R2905:Hmcn1	UTSW	1	150,749,035 (GRCm38)	missense	probably damaging	1.00
R3498:Hmcn1	UTSW	1	150,605,102 (GRCm38)	missense	probably damaging	0.98
R3499:Hmcn1	UTSW	1	150,605,102 (GRCm38)	missense	probably damaging	0.98
R3724:Hmcn1	UTSW	1	150,689,518 (GRCm38)	missense	possibly damaging	0.82
R3765:Hmcn1	UTSW	1	150,745,025 (GRCm38)	missense	possibly damaging	0.72
R3778:Hmcn1	UTSW	1	150,802,824 (GRCm38)	missense	possibly damaging	0.95
R3790:Hmcn1	UTSW	1	150,622,994 (GRCm38)	missense	probably benign	0.09
R3796:Hmcn1	UTSW	1	150,586,418 (GRCm38)	missense	probably damaging	1.00
R3811:Hmcn1	UTSW	1	150,649,577 (GRCm38)	critical splice donor site	probably null
R3825:Hmcn1	UTSW	1	150,586,965 (GRCm38)	missense	probably benign	0.28
R3890:Hmcn1	UTSW	1	150,635,195 (GRCm38)	missense	probably damaging	1.00
R3891:Hmcn1	UTSW	1	150,635,195 (GRCm38)	missense	probably damaging	1.00
R3892:Hmcn1	UTSW	1	150,635,195 (GRCm38)	missense	probably damaging	1.00
R3918:Hmcn1	UTSW	1	150,690,610 (GRCm38)	missense	probably benign	0.00
R3964:Hmcn1	UTSW	1	150,573,569 (GRCm38)	missense	probably benign	0.00
R4005:Hmcn1	UTSW	1	150,722,453 (GRCm38)	missense	possibly damaging	0.88
R4026:Hmcn1	UTSW	1	150,722,369 (GRCm38)	missense	probably benign	0.03
R4037:Hmcn1	UTSW	1	150,772,502 (GRCm38)	missense	probably benign	0.00
R4088:Hmcn1	UTSW	1	150,703,216 (GRCm38)	missense	possibly damaging	0.58
R4096:Hmcn1	UTSW	1	150,658,508 (GRCm38)	missense	probably benign	0.20
R4169:Hmcn1	UTSW	1	150,595,999 (GRCm38)	splice site	probably null
R4441:Hmcn1	UTSW	1	150,657,459 (GRCm38)	missense	probably null
R4493:Hmcn1	UTSW	1	150,701,899 (GRCm38)	missense	probably damaging	1.00
R4501:Hmcn1	UTSW	1	150,633,666 (GRCm38)	missense	probably damaging	1.00
R4535:Hmcn1	UTSW	1	150,563,780 (GRCm38)	missense	probably damaging	0.99
R4576:Hmcn1	UTSW	1	150,734,487 (GRCm38)	missense	probably benign
R4601:Hmcn1	UTSW	1	150,738,645 (GRCm38)	missense	probably damaging	0.99
R4627:Hmcn1	UTSW	1	150,595,894 (GRCm38)	missense	probably benign	0.11
R4647:Hmcn1	UTSW	1	150,675,511 (GRCm38)	critical splice donor site	probably null
R4657:Hmcn1	UTSW	1	150,624,550 (GRCm38)	missense	probably damaging	1.00
R4717:Hmcn1	UTSW	1	150,619,065 (GRCm38)	missense	probably benign	0.00
R4721:Hmcn1	UTSW	1	150,772,571 (GRCm38)	splice site	probably null
R4724:Hmcn1	UTSW	1	150,694,833 (GRCm38)	splice site	probably null
R4737:Hmcn1	UTSW	1	150,689,595 (GRCm38)	missense	possibly damaging	0.90
R4744:Hmcn1	UTSW	1	150,577,612 (GRCm38)	missense	probably damaging	1.00
R4795:Hmcn1	UTSW	1	150,753,611 (GRCm38)	missense	probably benign	0.00
R4796:Hmcn1	UTSW	1	150,753,611 (GRCm38)	missense	probably benign	0.00
R4871:Hmcn1	UTSW	1	150,593,085 (GRCm38)	missense	probably benign	0.02
R4895:Hmcn1	UTSW	1	150,677,379 (GRCm38)	missense	probably benign	0.00
R4934:Hmcn1	UTSW	1	150,722,535 (GRCm38)	missense	probably damaging	1.00
R4953:Hmcn1	UTSW	1	150,876,360 (GRCm38)	intron	probably benign
R4968:Hmcn1	UTSW	1	150,657,470 (GRCm38)	missense	possibly damaging	0.67
R4974:Hmcn1	UTSW	1	150,819,449 (GRCm38)	missense	probably benign	0.01
R5031:Hmcn1	UTSW	1	150,588,257 (GRCm38)	missense	probably damaging	1.00
R5093:Hmcn1	UTSW	1	150,737,256 (GRCm38)	missense	probably benign	0.14
R5096:Hmcn1	UTSW	1	150,610,669 (GRCm38)	missense	probably damaging	1.00
R5185:Hmcn1	UTSW	1	150,656,741 (GRCm38)	missense	probably benign	0.03
R5228:Hmcn1	UTSW	1	150,646,701 (GRCm38)	missense	probably benign	0.00
R5260:Hmcn1	UTSW	1	150,595,861 (GRCm38)	missense	possibly damaging	0.65
R5264:Hmcn1	UTSW	1	150,679,514 (GRCm38)	missense	probably benign	0.01
R5282:Hmcn1	UTSW	1	150,582,296 (GRCm38)	missense	probably damaging	1.00
R5334:Hmcn1	UTSW	1	150,755,372 (GRCm38)	missense	probably damaging	0.99
R5346:Hmcn1	UTSW	1	150,623,244 (GRCm38)	missense	probably damaging	1.00
R5423:Hmcn1	UTSW	1	150,701,972 (GRCm38)	missense	probably damaging	1.00
R5484:Hmcn1	UTSW	1	150,675,540 (GRCm38)	missense	probably benign	0.00
R5491:Hmcn1	UTSW	1	150,609,825 (GRCm38)	splice site	probably null
R5531:Hmcn1	UTSW	1	150,743,788 (GRCm38)	missense	probably damaging	1.00
R5536:Hmcn1	UTSW	1	150,755,291 (GRCm38)	missense	probably benign	0.01
R5547:Hmcn1	UTSW	1	150,737,506 (GRCm38)	missense	possibly damaging	0.64
R5580:Hmcn1	UTSW	1	150,577,539 (GRCm38)	missense	probably benign	0.43
R5626:Hmcn1	UTSW	1	150,656,567 (GRCm38)	missense	probably damaging	1.00
R5657:Hmcn1	UTSW	1	150,658,562 (GRCm38)	missense	probably benign	0.02
R5677:Hmcn1	UTSW	1	150,609,778 (GRCm38)	missense	probably benign	0.00
R5718:Hmcn1	UTSW	1	150,690,600 (GRCm38)	nonsense	probably null
R5718:Hmcn1	UTSW	1	150,609,666 (GRCm38)	missense	probably damaging	1.00
R5723:Hmcn1	UTSW	1	150,694,849 (GRCm38)	missense	possibly damaging	0.95
R5739:Hmcn1	UTSW	1	150,758,474 (GRCm38)	splice site	probably null
R5739:Hmcn1	UTSW	1	150,808,697 (GRCm38)	missense	probably benign	0.45
R5751:Hmcn1	UTSW	1	150,573,554 (GRCm38)	missense	probably damaging	1.00
R5772:Hmcn1	UTSW	1	150,694,878 (GRCm38)	missense	possibly damaging	0.47
R5804:Hmcn1	UTSW	1	150,674,347 (GRCm38)	nonsense	probably null
R5809:Hmcn1	UTSW	1	150,649,607 (GRCm38)	missense	probably damaging	1.00
R5817:Hmcn1	UTSW	1	150,737,524 (GRCm38)	missense	possibly damaging	0.77
R5824:Hmcn1	UTSW	1	150,993,023 (GRCm38)	missense	probably benign	0.12
R5881:Hmcn1	UTSW	1	150,630,327 (GRCm38)	missense	probably damaging	0.99
R5928:Hmcn1	UTSW	1	150,598,897 (GRCm38)	missense	possibly damaging	0.64
R5929:Hmcn1	UTSW	1	150,577,296 (GRCm38)	nonsense	probably null
R5940:Hmcn1	UTSW	1	150,657,222 (GRCm38)	missense	probably benign	0.41
R5973:Hmcn1	UTSW	1	150,563,817 (GRCm38)	missense	probably damaging	1.00
R5997:Hmcn1	UTSW	1	150,704,173 (GRCm38)	missense	possibly damaging	0.74
R6027:Hmcn1	UTSW	1	150,802,895 (GRCm38)	missense	possibly damaging	0.79
R6029:Hmcn1	UTSW	1	150,632,437 (GRCm38)	missense	probably benign	0.13
R6056:Hmcn1	UTSW	1	150,663,909 (GRCm38)	missense	probably damaging	1.00
R6065:Hmcn1	UTSW	1	150,770,330 (GRCm38)	missense	probably benign	0.06
R6083:Hmcn1	UTSW	1	150,755,294 (GRCm38)	missense	probably damaging	1.00
R6083:Hmcn1	UTSW	1	150,755,293 (GRCm38)	missense	probably damaging	1.00
R6108:Hmcn1	UTSW	1	150,631,227 (GRCm38)	missense	possibly damaging	0.95
R6112:Hmcn1	UTSW	1	150,618,936 (GRCm38)	missense	probably damaging	1.00
R6140:Hmcn1	UTSW	1	150,732,846 (GRCm38)	missense	probably damaging	1.00
R6144:Hmcn1	UTSW	1	150,722,424 (GRCm38)	missense	probably damaging	1.00
R6152:Hmcn1	UTSW	1	150,565,425 (GRCm38)	missense	probably damaging	1.00
R6174:Hmcn1	UTSW	1	150,646,784 (GRCm38)	missense	probably benign	0.06
R6185:Hmcn1	UTSW	1	150,615,438 (GRCm38)	splice site	probably null
R6187:Hmcn1	UTSW	1	150,630,728 (GRCm38)	missense	probably damaging	1.00
R6276:Hmcn1	UTSW	1	150,738,681 (GRCm38)	missense	possibly damaging	0.69
R6278:Hmcn1	UTSW	1	150,697,419 (GRCm38)	critical splice donor site	probably null
R6427:Hmcn1	UTSW	1	150,697,476 (GRCm38)	missense	possibly damaging	0.85
R6431:Hmcn1	UTSW	1	150,744,960 (GRCm38)	missense	probably benign	0.01
R6441:Hmcn1	UTSW	1	150,703,216 (GRCm38)	missense	possibly damaging	0.58
R6451:Hmcn1	UTSW	1	150,992,919 (GRCm38)	missense	probably damaging	1.00
R6478:Hmcn1	UTSW	1	150,664,784 (GRCm38)	missense	probably damaging	1.00
R6479:Hmcn1	UTSW	1	150,677,302 (GRCm38)	nonsense	probably null
R6490:Hmcn1	UTSW	1	150,583,278 (GRCm38)	missense	probably benign	0.00
R6525:Hmcn1	UTSW	1	150,697,566 (GRCm38)	missense	probably damaging	1.00
R6571:Hmcn1	UTSW	1	150,615,438 (GRCm38)	splice site	probably null
R6612:Hmcn1	UTSW	1	150,595,118 (GRCm38)	critical splice donor site	probably null
R6616:Hmcn1	UTSW	1	150,723,257 (GRCm38)	critical splice donor site	probably null
R6617:Hmcn1	UTSW	1	150,743,796 (GRCm38)	missense	probably benign	0.01
R6623:Hmcn1	UTSW	1	150,758,306 (GRCm38)	missense	probably benign
R6687:Hmcn1	UTSW	1	150,745,033 (GRCm38)	missense	probably benign	0.30
R6714:Hmcn1	UTSW	1	150,704,175 (GRCm38)	missense	probably damaging	0.97
R6751:Hmcn1	UTSW	1	150,734,518 (GRCm38)	missense	probably damaging	0.98
R6831:Hmcn1	UTSW	1	150,770,293 (GRCm38)	missense	probably benign	0.00
R6971:Hmcn1	UTSW	1	150,993,051 (GRCm38)	start codon destroyed	probably benign	0.00
R7048:Hmcn1	UTSW	1	150,599,653 (GRCm38)	critical splice acceptor site	probably null
R7058:Hmcn1	UTSW	1	150,773,890 (GRCm38)	missense	probably benign	0.43
R7071:Hmcn1	UTSW	1	150,604,102 (GRCm38)	missense	probably damaging	1.00
R7078:Hmcn1	UTSW	1	150,860,367 (GRCm38)	missense	probably damaging	1.00
R7092:Hmcn1	UTSW	1	150,604,246 (GRCm38)	missense	probably damaging	1.00
R7120:Hmcn1	UTSW	1	150,700,541 (GRCm38)	missense	probably damaging	0.98
R7129:Hmcn1	UTSW	1	150,577,210 (GRCm38)	splice site	probably null
R7144:Hmcn1	UTSW	1	150,663,873 (GRCm38)	missense	probably damaging	1.00
R7148:Hmcn1	UTSW	1	150,686,854 (GRCm38)	missense	probably benign	0.00
R7162:Hmcn1	UTSW	1	150,748,993 (GRCm38)	missense	probably benign	0.18
R7172:Hmcn1	UTSW	1	150,753,699 (GRCm38)	missense	possibly damaging	0.92
R7193:Hmcn1	UTSW	1	150,649,580 (GRCm38)	missense	probably null	1.00
R7231:Hmcn1	UTSW	1	150,638,876 (GRCm38)	missense	probably benign	0.00
R7237:Hmcn1	UTSW	1	150,722,643 (GRCm38)	missense	probably damaging	0.98
R7258:Hmcn1	UTSW	1	150,715,823 (GRCm38)	missense	probably benign	0.12
R7286:Hmcn1	UTSW	1	150,582,337 (GRCm38)	missense	probably damaging	0.98
R7289:Hmcn1	UTSW	1	150,683,715 (GRCm38)	missense	possibly damaging	0.52
R7292:Hmcn1	UTSW	1	150,733,129 (GRCm38)	splice site	probably null
R7316:Hmcn1	UTSW	1	150,732,946 (GRCm38)	missense	probably damaging	1.00
R7327:Hmcn1	UTSW	1	150,603,814 (GRCm38)	missense	probably benign	0.01
R7328:Hmcn1	UTSW	1	150,638,866 (GRCm38)	missense	possibly damaging	0.95
R7346:Hmcn1	UTSW	1	150,683,745 (GRCm38)	missense	probably damaging	1.00
R7351:Hmcn1	UTSW	1	150,667,889 (GRCm38)	missense	probably damaging	0.98
R7354:Hmcn1	UTSW	1	150,806,445 (GRCm38)	nonsense	probably null
R7360:Hmcn1	UTSW	1	150,618,846 (GRCm38)	missense	probably damaging	1.00
R7396:Hmcn1	UTSW	1	150,563,631 (GRCm38)	missense	possibly damaging	0.83
R7398:Hmcn1	UTSW	1	150,646,670 (GRCm38)	missense	probably benign	0.00
R7400:Hmcn1	UTSW	1	150,674,430 (GRCm38)	missense	probably damaging	1.00
R7404:Hmcn1	UTSW	1	150,720,759 (GRCm38)	missense	probably benign	0.00
R7424:Hmcn1	UTSW	1	150,630,266 (GRCm38)	nonsense	probably null
R7454:Hmcn1	UTSW	1	150,563,604 (GRCm38)	missense	probably damaging	1.00
R7476:Hmcn1	UTSW	1	150,580,267 (GRCm38)	missense	probably damaging	0.99
R7480:Hmcn1	UTSW	1	150,677,234 (GRCm38)	critical splice donor site	probably null
R7516:Hmcn1	UTSW	1	150,622,967 (GRCm38)	missense	probably benign	0.35
R7526:Hmcn1	UTSW	1	150,656,573 (GRCm38)	missense	probably damaging	1.00
R7531:Hmcn1	UTSW	1	150,686,780 (GRCm38)	missense	probably benign	0.06
R7555:Hmcn1	UTSW	1	150,604,874 (GRCm38)	missense	probably benign	0.40
R7564:Hmcn1	UTSW	1	150,655,835 (GRCm38)	missense	probably benign
R7588:Hmcn1	UTSW	1	150,657,134 (GRCm38)	missense	possibly damaging	0.90
R7719:Hmcn1	UTSW	1	150,565,329 (GRCm38)	missense	possibly damaging	0.95
R7720:Hmcn1	UTSW	1	150,646,709 (GRCm38)	missense	probably benign	0.00
R7722:Hmcn1	UTSW	1	150,667,880 (GRCm38)	missense	probably damaging	0.98
R7761:Hmcn1	UTSW	1	150,722,445 (GRCm38)	missense	possibly damaging	0.70
R7787:Hmcn1	UTSW	1	150,756,592 (GRCm38)	missense	probably damaging	1.00
R7803:Hmcn1	UTSW	1	150,770,279 (GRCm38)	missense	probably benign	0.32
R7862:Hmcn1	UTSW	1	150,806,421 (GRCm38)	missense	probably damaging	0.96
R7876:Hmcn1	UTSW	1	150,744,971 (GRCm38)	missense	probably benign	0.03
R7886:Hmcn1	UTSW	1	150,657,470 (GRCm38)	missense	possibly damaging	0.94
R7891:Hmcn1	UTSW	1	150,593,189 (GRCm38)	missense	probably damaging	1.00
R7892:Hmcn1	UTSW	1	150,664,892 (GRCm38)	missense	probably benign	0.00
R7927:Hmcn1	UTSW	1	150,609,775 (GRCm38)	missense	probably damaging	1.00
R7941:Hmcn1	UTSW	1	150,650,084 (GRCm38)	missense	possibly damaging	0.95
R7960:Hmcn1	UTSW	1	150,655,855 (GRCm38)	missense	probably damaging	1.00
R8001:Hmcn1	UTSW	1	150,664,878 (GRCm38)	nonsense	probably null
R8015:Hmcn1	UTSW	1	150,598,311 (GRCm38)	missense	possibly damaging	0.83
R8070:Hmcn1	UTSW	1	150,649,992 (GRCm38)	nonsense	probably null
R8072:Hmcn1	UTSW	1	150,656,505 (GRCm38)	missense	possibly damaging	0.62
R8113:Hmcn1	UTSW	1	150,749,090 (GRCm38)	missense	possibly damaging	0.50
R8143:Hmcn1	UTSW	1	150,859,206 (GRCm38)	missense	probably benign	0.03
R8145:Hmcn1	UTSW	1	150,753,660 (GRCm38)	missense	probably benign	0.33
R8155:Hmcn1	UTSW	1	150,604,954 (GRCm38)	missense	probably damaging	1.00
R8165:Hmcn1	UTSW	1	150,646,658 (GRCm38)	missense	probably benign	0.09
R8179:Hmcn1	UTSW	1	150,722,514 (GRCm38)	missense	probably benign	0.19
R8193:Hmcn1	UTSW	1	150,577,477 (GRCm38)	nonsense	probably null
R8234:Hmcn1	UTSW	1	150,594,010 (GRCm38)	missense	possibly damaging	0.83
R8249:Hmcn1	UTSW	1	150,819,366 (GRCm38)	missense	probably benign	0.24
R8267:Hmcn1	UTSW	1	150,859,254 (GRCm38)	missense	probably damaging	1.00
R8312:Hmcn1	UTSW	1	150,738,764 (GRCm38)	missense	probably damaging	0.99
R8338:Hmcn1	UTSW	1	150,738,734 (GRCm38)	missense	probably benign	0.35
R8354:Hmcn1	UTSW	1	150,758,391 (GRCm38)	missense	possibly damaging	0.79
R8440:Hmcn1	UTSW	1	150,694,920 (GRCm38)	missense	probably damaging	1.00
R8473:Hmcn1	UTSW	1	150,603,800 (GRCm38)	missense	possibly damaging	0.64
R8497:Hmcn1	UTSW	1	150,580,239 (GRCm38)	missense	probably benign	0.01
R8509:Hmcn1	UTSW	1	150,573,551 (GRCm38)	nonsense	probably null
R8559:Hmcn1	UTSW	1	150,676,038 (GRCm38)	missense	probably benign	0.25
R8701:Hmcn1	UTSW	1	150,755,257 (GRCm38)	missense	probably benign	0.00
R8755:Hmcn1	UTSW	1	150,633,620 (GRCm38)	missense	probably benign	0.19
R8765:Hmcn1	UTSW	1	150,680,662 (GRCm38)	missense	probably damaging	0.98
R8782:Hmcn1	UTSW	1	150,664,885 (GRCm38)	missense	probably benign	0.08
R8794:Hmcn1	UTSW	1	150,715,718 (GRCm38)	missense	probably benign	0.00
R8803:Hmcn1	UTSW	1	150,734,497 (GRCm38)	missense	probably damaging	1.00
R8808:Hmcn1	UTSW	1	150,655,819 (GRCm38)	missense	possibly damaging	0.64
R8853:Hmcn1	UTSW	1	150,671,975 (GRCm38)	missense	probably damaging	1.00
R8877:Hmcn1	UTSW	1	150,638,908 (GRCm38)	missense	probably benign	0.00
R8881:Hmcn1	UTSW	1	150,649,972 (GRCm38)	missense	probably damaging	1.00
R8916:Hmcn1	UTSW	1	150,773,779 (GRCm38)	missense	probably damaging	1.00
R9008:Hmcn1	UTSW	1	150,755,044 (GRCm38)	intron	probably benign
R9030:Hmcn1	UTSW	1	150,817,119 (GRCm38)	missense	probably benign	0.00
R9072:Hmcn1	UTSW	1	150,689,569 (GRCm38)	missense	probably benign	0.04
R9090:Hmcn1	UTSW	1	150,756,558 (GRCm38)	missense	probably damaging	1.00
R9096:Hmcn1	UTSW	1	150,657,118 (GRCm38)	missense	probably benign	0.04
R9102:Hmcn1	UTSW	1	150,697,580 (GRCm38)	missense	probably benign	0.01
R9146:Hmcn1	UTSW	1	150,598,390 (GRCm38)	missense	probably benign	0.02
R9157:Hmcn1	UTSW	1	150,646,592 (GRCm38)	missense	probably benign	0.06
R9169:Hmcn1	UTSW	1	150,630,341 (GRCm38)	missense	probably damaging	0.99
R9182:Hmcn1	UTSW	1	150,612,654 (GRCm38)	missense	probably damaging	1.00
R9182:Hmcn1	UTSW	1	150,624,586 (GRCm38)	nonsense	probably null
R9204:Hmcn1	UTSW	1	150,734,511 (GRCm38)	missense	probably benign	0.40
R9219:Hmcn1	UTSW	1	150,719,093 (GRCm38)	critical splice donor site	probably null
R9267:Hmcn1	UTSW	1	150,597,989 (GRCm38)	missense	probably benign	0.26
R9271:Hmcn1	UTSW	1	150,756,558 (GRCm38)	missense	probably damaging	1.00
R9274:Hmcn1	UTSW	1	150,630,295 (GRCm38)	missense	probably benign	0.01
R9313:Hmcn1	UTSW	1	150,646,592 (GRCm38)	missense	probably benign	0.06
R9414:Hmcn1	UTSW	1	150,669,436 (GRCm38)	missense	probably damaging	1.00
R9456:Hmcn1	UTSW	1	150,630,302 (GRCm38)	nonsense	probably null
R9464:Hmcn1	UTSW	1	150,723,497 (GRCm38)	missense	possibly damaging	0.80
R9474:Hmcn1	UTSW	1	150,630,720 (GRCm38)	missense	probably damaging	1.00
R9476:Hmcn1	UTSW	1	150,586,376 (GRCm38)	missense	probably benign	0.00
R9482:Hmcn1	UTSW	1	150,734,530 (GRCm38)	missense	probably benign	0.06
R9496:Hmcn1	UTSW	1	150,704,220 (GRCm38)	missense	probably benign	0.00
R9501:Hmcn1	UTSW	1	150,595,239 (GRCm38)	missense	possibly damaging	0.67
R9510:Hmcn1	UTSW	1	150,586,376 (GRCm38)	missense	probably benign	0.00
R9529:Hmcn1	UTSW	1	150,669,424 (GRCm38)	missense	probably damaging	1.00
R9566:Hmcn1	UTSW	1	150,622,909 (GRCm38)	missense	probably benign	0.00
R9608:Hmcn1	UTSW	1	150,599,552 (GRCm38)	missense	probably damaging	1.00
R9609:Hmcn1	UTSW	1	150,679,595 (GRCm38)	missense	probably damaging	0.96
R9616:Hmcn1	UTSW	1	150,808,722 (GRCm38)	missense	probably benign	0.16
R9627:Hmcn1	UTSW	1	150,630,303 (GRCm38)	missense	probably damaging	1.00
R9668:Hmcn1	UTSW	1	150,743,741 (GRCm38)	missense	probably benign	0.02
R9686:Hmcn1	UTSW	1	150,737,605 (GRCm38)	missense	probably damaging	0.99
R9717:Hmcn1	UTSW	1	150,609,627 (GRCm38)	missense	probably damaging	1.00
R9727:Hmcn1	UTSW	1	150,798,815 (GRCm38)	missense	probably benign	0.06
R9744:Hmcn1	UTSW	1	150,748,190 (GRCm38)	missense	probably damaging	1.00
R9749:Hmcn1	UTSW	1	150,756,588 (GRCm38)	missense	possibly damaging	0.94
R9761:Hmcn1	UTSW	1	150,992,874 (GRCm38)	missense	probably damaging	0.98
R9783:Hmcn1	UTSW	1	150,722,629 (GRCm38)	missense	probably benign	0.16
R9788:Hmcn1	UTSW	1	150,652,582 (GRCm38)	missense	probably benign	0.00
R9792:Hmcn1	UTSW	1	150,732,938 (GRCm38)	missense	possibly damaging	0.94
R9793:Hmcn1	UTSW	1	150,732,938 (GRCm38)	missense	possibly damaging	0.94
R9795:Hmcn1	UTSW	1	150,732,938 (GRCm38)	missense	possibly damaging	0.94
R9802:Hmcn1	UTSW	1	150,808,640 (GRCm38)	missense	probably benign	0.07
RF003:Hmcn1	UTSW	1	150,624,561 (GRCm38)	missense	probably damaging	1.00
RF005:Hmcn1	UTSW	1	150,635,146 (GRCm38)	nonsense	probably null
X0022:Hmcn1	UTSW	1	150,700,530 (GRCm38)	missense	probably benign	0.04
X0027:Hmcn1	UTSW	1	150,860,376 (GRCm38)	missense	probably damaging	1.00
X0028:Hmcn1	UTSW	1	150,663,901 (GRCm38)	missense	probably damaging	1.00
Z1088:Hmcn1	UTSW	1	150,648,937 (GRCm38)	missense	probably damaging	1.00
Z1176:Hmcn1	UTSW	1	150,663,917 (GRCm38)	missense	probably benign	0.12
Z1176:Hmcn1	UTSW	1	150,655,921 (GRCm38)	missense	possibly damaging	0.65
Z1176:Hmcn1	UTSW	1	150,586,445 (GRCm38)	missense	probably null	0.92

Predicted Primers

PCR Primer
(F):5'- TGCTGAAACCTTGCCAAGAATC -3'
(R):5'- GACAGTACTATCATCCCTGCC -3'

Sequencing Primer
(F):5'- CCTTGCCAAGAATCATAGTCTGAAGG -3'
(R):5'- GCCTTATAACTCAGTCGCTTCATAC -3'

Posted On

2016-06-06