Mutagenetix > Incidental Mutation

Incidental Mutation 'R5028:Or11g7'

391531

Institutional Source

Beutler Lab

Gene Symbol

Or11g7

Ensembl Gene

ENSMUSG00000095917

Gene Name

olfactory receptor family 11 subfamily G member 7

Synonyms

MOR106-4, Olfr740, GA_x6K02T2PMLR-6167145-6168080

MMRRC Submission

042619-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R5028 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

50690511-50693135 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 50691196 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 229 (V229A)

Ref Sequence

ENSEMBL: ENSMUSP00000148916 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089838] [ENSMUST00000214792]

AlphaFold

E9PV79

Predicted Effect

probably damaging
Transcript: ENSMUST00000089838
AA Change: V229A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000087276
Gene: ENSMUSG00000095917
AA Change: V229A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	2.3e-56	PFAM
Pfam:7tm_1	45	294	1.6e-21	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000214792
AA Change: V229A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

Meta Mutation Damage Score

0.5181

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.5%
20x: 93.1%

Validation Efficiency

97% (62/64)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb11	T	A	2: 69,104,356 (GRCm39)	S777C	probably damaging	Het
Ano5	T	A	7: 51,187,458 (GRCm39)		probably null	Het
Arhgap17	T	A	7: 122,893,896 (GRCm39)	H508L	probably benign	Het
Arhgap29	T	A	3: 121,803,709 (GRCm39)		probably null	Het
Atp12a	T	C	14: 56,624,435 (GRCm39)	F961S	probably damaging	Het
B4galnt4	C	A	7: 140,647,975 (GRCm39)	P497Q	probably benign	Het
Camsap1	A	G	2: 25,834,568 (GRCm39)	S364P	probably damaging	Het
Ccdc150	C	A	1: 54,302,636 (GRCm39)	D85E	probably benign	Het
Cdc45	A	G	16: 18,613,930 (GRCm39)	Y291H	probably benign	Het
Comp	A	C	8: 70,829,290 (GRCm39)	N289T	probably damaging	Het
Cops3	T	A	11: 59,708,856 (GRCm39)		probably benign	Het
Crybg1	G	A	10: 43,874,208 (GRCm39)	H967Y	possibly damaging	Het
Csmd1	A	T	8: 16,039,090 (GRCm39)	F2423I	probably damaging	Het
Dact1	C	A	12: 71,365,347 (GRCm39)	C709*	probably null	Het
Dcxr	T	G	11: 120,617,273 (GRCm39)	Q90P	probably damaging	Het
Ell	A	G	8: 71,043,349 (GRCm39)	Y494C	probably damaging	Het
Emilin2	T	C	17: 71,581,727 (GRCm39)	E333G	possibly damaging	Het
Eml2	T	C	7: 18,913,372 (GRCm39)		probably null	Het
Fam186b	T	A	15: 99,178,682 (GRCm39)	M215L	probably damaging	Het
Gm17078	T	A	14: 51,848,699 (GRCm39)	R13W	probably null	Het
Gm4787	G	C	12: 81,424,604 (GRCm39)	T518S	probably benign	Het
Hspa14	A	G	2: 3,499,206 (GRCm39)	F196S	possibly damaging	Het
Ier5	A	G	1: 154,974,849 (GRCm39)	S110P	possibly damaging	Het
Kif1a	T	A	1: 92,982,049 (GRCm39)	I793F	possibly damaging	Het
Lrrc43	T	C	5: 123,646,176 (GRCm39)	I643T	probably damaging	Het
Map3k19	A	T	1: 127,750,969 (GRCm39)	L794Q	probably benign	Het
Meox2	A	T	12: 37,158,935 (GRCm39)	M36L	probably benign	Het
Mgat5b	T	A	11: 116,875,855 (GRCm39)	L693Q	probably damaging	Het
Mup4	T	A	4: 59,958,124 (GRCm39)	E148V	possibly damaging	Het
Napb	T	C	2: 148,545,057 (GRCm39)	N162S	possibly damaging	Het
Nlgn2	T	C	11: 69,718,563 (GRCm39)	D339G	probably benign	Het
Nucks1	C	T	1: 131,855,840 (GRCm39)	R90C	possibly damaging	Het
Or5an9	T	A	19: 12,187,518 (GRCm39)	V196E	possibly damaging	Het
Plekhd1	A	T	12: 80,739,723 (GRCm39)	D24V	probably damaging	Het
Prpf4b	C	T	13: 35,083,958 (GRCm39)	P909L	probably damaging	Het
Rasgrp1	T	A	2: 117,132,485 (GRCm39)	K116*	probably null	Het
Ror1	A	G	4: 100,269,133 (GRCm39)	T324A	possibly damaging	Het
Slc24a4	G	A	12: 102,230,629 (GRCm39)	G505R	probably damaging	Het
Slc8a1	A	G	17: 81,956,702 (GRCm39)	I112T	possibly damaging	Het
Smarcc2	A	G	10: 128,297,314 (GRCm39)	S69G	probably damaging	Het
Smc2	A	T	4: 52,458,447 (GRCm39)	E429D	probably damaging	Het
Sry	T	C	Y: 2,663,312 (GRCm39)	D116G	probably damaging	Het
Tcea3	T	A	4: 135,985,246 (GRCm39)	V154E	possibly damaging	Het
Tigd2	G	A	6: 59,188,205 (GRCm39)	W357*	probably null	Het
Tmem177	T	A	1: 119,838,419 (GRCm39)	T87S	probably benign	Het
Treh	A	T	9: 44,594,186 (GRCm39)	E144V	probably null	Het
Trpm6	T	A	19: 18,764,124 (GRCm39)	D243E	probably damaging	Het
Ttn	T	C	2: 76,608,394 (GRCm39)	D17843G	probably damaging	Het
Vars2	A	C	17: 35,970,365 (GRCm39)		probably null	Het
Vmn1r201	G	A	13: 22,659,530 (GRCm39)	W248*	probably null	Het
Yap1	T	C	9: 8,001,690 (GRCm39)	T99A	probably benign	Het
Zbtb8b	C	A	4: 129,326,793 (GRCm39)	C91F	probably damaging	Het
Zfp882	A	G	8: 72,668,498 (GRCm39)	T442A	possibly damaging	Het
Zxdc	G	T	6: 90,359,320 (GRCm39)	G651C	probably benign	Het

Other mutations in Or11g7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01663:Or11g7	APN	14	50,690,607 (GRCm39)	missense	probably benign	0.04
IGL02117:Or11g7	APN	14	50,691,399 (GRCm39)	missense	possibly damaging	0.91
IGL02663:Or11g7	APN	14	50,691,309 (GRCm39)	missense	probably benign	0.02
IGL02858:Or11g7	APN	14	50,690,507 (GRCm39)	utr 5 prime	probably benign
IGL02955:Or11g7	APN	14	50,691,442 (GRCm39)	missense	probably damaging	0.99
IGL03210:Or11g7	APN	14	50,691,440 (GRCm39)	missense	probably benign	0.10
IGL03249:Or11g7	APN	14	50,690,668 (GRCm39)	missense	probably damaging	0.98
G1Funyon:Or11g7	UTSW	14	50,691,021 (GRCm39)	missense	probably benign	0.08
R0946:Or11g7	UTSW	14	50,691,130 (GRCm39)	missense	probably benign	0.13
R1449:Or11g7	UTSW	14	50,691,378 (GRCm39)	missense	probably damaging	1.00
R1465:Or11g7	UTSW	14	50,690,634 (GRCm39)	missense	possibly damaging	0.91
R1465:Or11g7	UTSW	14	50,690,634 (GRCm39)	missense	possibly damaging	0.91
R1513:Or11g7	UTSW	14	50,691,138 (GRCm39)	missense	probably benign	0.00
R1908:Or11g7	UTSW	14	50,691,295 (GRCm39)	missense	probably damaging	0.99
R2422:Or11g7	UTSW	14	50,690,893 (GRCm39)	missense	probably damaging	1.00
R3406:Or11g7	UTSW	14	50,690,653 (GRCm39)	missense	probably benign	0.14
R4184:Or11g7	UTSW	14	50,690,827 (GRCm39)	missense	probably damaging	1.00
R4795:Or11g7	UTSW	14	50,690,874 (GRCm39)	missense	probably damaging	0.96
R5436:Or11g7	UTSW	14	50,691,184 (GRCm39)	missense	probably damaging	1.00
R6057:Or11g7	UTSW	14	50,691,201 (GRCm39)	nonsense	probably null
R6455:Or11g7	UTSW	14	50,691,042 (GRCm39)	missense	possibly damaging	0.92
R6903:Or11g7	UTSW	14	50,691,412 (GRCm39)	missense	possibly damaging	0.93
R6998:Or11g7	UTSW	14	50,690,890 (GRCm39)	missense	probably benign	0.29
R7671:Or11g7	UTSW	14	50,691,342 (GRCm39)	missense	probably benign	0.04
R8048:Or11g7	UTSW	14	50,691,373 (GRCm39)	missense	possibly damaging	0.52
R8301:Or11g7	UTSW	14	50,691,021 (GRCm39)	missense	probably benign	0.08
X0066:Or11g7	UTSW	14	50,691,115 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CTGTGGGTCCAGAATTATAGACC -3'
(R):5'- CTGCAGGGCATGTTTCATATCC -3'

Sequencing Primer
(F):5'- GGTCCAGAATTATAGACCACTTCCTG -3'
(R):5'- TCACAGGATTAATGAGTGGAGTAACC -3'

Posted On

2016-06-06