Incidental Mutation 'R5029:Tnik'
| ID |
391548 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnik
|
| Ensembl Gene |
ENSMUSG00000027692 |
| Gene Name |
TRAF2 and NCK interacting kinase |
| Synonyms |
C530008O15Rik, 4831440I19Rik, 1500031A17Rik, C630040K21Rik |
| MMRRC Submission |
042620-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5029 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
28317362-28724734 bp(+) (GRCm39) |
| Type of Mutation |
splice site (5 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 28719993 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124726
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000160518]
[ENSMUST00000160934]
[ENSMUST00000161964]
[ENSMUST00000161964]
[ENSMUST00000162485]
[ENSMUST00000162485]
[ENSMUST00000162777]
[ENSMUST00000162777]
|
| AlphaFold |
P83510 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000159236
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000159236
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000159308
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000159308
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000159680
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000159680
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159733
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000160307
|
| SMART Domains |
Protein: ENSMUSP00000125081
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
|
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000160518
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000160518
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160934
|
| SMART Domains |
Protein: ENSMUSP00000123859
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
|
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161964
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161964
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000162485
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000162485
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000162777
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000162777
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000192205
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.1%
|
| Validation Efficiency |
97% (61/63) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 49 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actbl2 |
T |
A |
13: 111,392,127 (GRCm39) |
M154K |
probably benign |
Het |
| Ank |
T |
C |
15: 27,590,439 (GRCm39) |
V341A |
probably benign |
Het |
| Bnip3 |
T |
A |
7: 138,499,848 (GRCm39) |
|
probably benign |
Het |
| C1galt1 |
A |
G |
6: 7,863,931 (GRCm39) |
K4E |
possibly damaging |
Het |
| Cbs |
T |
A |
17: 31,834,456 (GRCm39) |
Q511L |
possibly damaging |
Het |
| Ccdc117 |
T |
C |
11: 5,484,897 (GRCm39) |
H109R |
possibly damaging |
Het |
| Cdh4 |
T |
A |
2: 179,523,742 (GRCm39) |
V440D |
possibly damaging |
Het |
| Cnot4 |
T |
C |
6: 35,054,962 (GRCm39) |
N109S |
probably damaging |
Het |
| Dact2 |
A |
T |
17: 14,416,114 (GRCm39) |
S695R |
probably benign |
Het |
| Defa21 |
A |
T |
8: 21,516,381 (GRCm39) |
E75V |
probably damaging |
Het |
| Dimt1 |
A |
G |
13: 107,093,630 (GRCm39) |
D274G |
probably null |
Het |
| Dstyk |
G |
T |
1: 132,377,062 (GRCm39) |
V223L |
probably benign |
Het |
| Dync1h1 |
T |
A |
12: 110,584,444 (GRCm39) |
S616T |
possibly damaging |
Het |
| Fer1l6 |
A |
T |
15: 58,515,769 (GRCm39) |
I1619F |
probably benign |
Het |
| Gm4744 |
T |
A |
6: 40,926,341 (GRCm39) |
Y83F |
probably null |
Het |
| Gm4787 |
G |
C |
12: 81,424,604 (GRCm39) |
T518S |
probably benign |
Het |
| Hpx |
T |
G |
7: 105,240,971 (GRCm39) |
Y434S |
probably damaging |
Het |
| Ints4 |
A |
G |
7: 97,158,981 (GRCm39) |
D451G |
probably benign |
Het |
| Itgb4 |
A |
T |
11: 115,879,417 (GRCm39) |
|
probably benign |
Het |
| Jph1 |
T |
A |
1: 17,161,615 (GRCm39) |
N349I |
possibly damaging |
Het |
| Klrg1 |
A |
G |
6: 122,259,694 (GRCm39) |
L26P |
probably benign |
Het |
| M1ap |
A |
C |
6: 82,980,813 (GRCm39) |
D233A |
probably damaging |
Het |
| Mfng |
C |
T |
15: 78,648,588 (GRCm39) |
R163H |
probably benign |
Het |
| Mycbp2 |
A |
G |
14: 103,393,946 (GRCm39) |
S2762P |
probably benign |
Het |
| Myh11 |
T |
A |
16: 14,023,489 (GRCm39) |
Q1556L |
probably damaging |
Het |
| N4bp2 |
A |
G |
5: 65,972,123 (GRCm39) |
D1428G |
probably damaging |
Het |
| Ndc80 |
A |
C |
17: 71,815,760 (GRCm39) |
C342G |
probably benign |
Het |
| Nxn |
A |
C |
11: 76,165,356 (GRCm39) |
Y199* |
probably null |
Het |
| Or6c206 |
T |
A |
10: 129,097,707 (GRCm39) |
N292K |
probably benign |
Het |
| Or7c19 |
C |
T |
8: 85,957,835 (GRCm39) |
A237V |
probably benign |
Het |
| Or8j3b |
A |
G |
2: 86,205,234 (GRCm39) |
I174T |
probably damaging |
Het |
| Pacs1 |
A |
G |
19: 5,192,299 (GRCm39) |
F691L |
probably benign |
Het |
| Pcdhga12 |
T |
C |
18: 37,899,864 (GRCm39) |
V232A |
probably benign |
Het |
| Pik3cb |
A |
T |
9: 98,936,113 (GRCm39) |
M773K |
probably damaging |
Het |
| Plxnb1 |
T |
C |
9: 108,943,723 (GRCm39) |
Y1937H |
probably damaging |
Het |
| Ppfia2 |
C |
A |
10: 106,693,304 (GRCm39) |
T603N |
probably benign |
Het |
| Psg22 |
A |
G |
7: 18,453,662 (GRCm39) |
Y119C |
probably damaging |
Het |
| Saraf |
G |
T |
8: 34,628,412 (GRCm39) |
R86L |
probably damaging |
Het |
| Sh3bgrl2 |
T |
C |
9: 83,430,542 (GRCm39) |
S11P |
possibly damaging |
Het |
| Slc39a4 |
C |
T |
15: 76,498,283 (GRCm39) |
D385N |
probably damaging |
Het |
| St13 |
G |
C |
15: 81,283,786 (GRCm39) |
R4G |
probably benign |
Het |
| Stpg3 |
T |
C |
2: 25,104,576 (GRCm39) |
N13S |
probably damaging |
Het |
| Taf1a |
T |
A |
1: 183,177,273 (GRCm39) |
D50E |
possibly damaging |
Het |
| Tlr1 |
T |
A |
5: 65,083,024 (GRCm39) |
N518Y |
probably damaging |
Het |
| Tomm70a |
T |
A |
16: 56,942,514 (GRCm39) |
L97Q |
probably benign |
Het |
| Vmn2r97 |
T |
A |
17: 19,168,173 (GRCm39) |
V809E |
probably damaging |
Het |
| Vps13d |
T |
C |
4: 144,882,852 (GRCm39) |
I914V |
probably benign |
Het |
| Zfyve26 |
A |
T |
12: 79,333,097 (GRCm39) |
H291Q |
probably damaging |
Het |
| Zmynd15 |
G |
T |
11: 70,353,387 (GRCm39) |
C334F |
probably damaging |
Het |
|
| Other mutations in Tnik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Tnik
|
APN |
3 |
28,708,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00726:Tnik
|
APN |
3 |
28,587,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01022:Tnik
|
APN |
3 |
28,679,377 (GRCm39) |
splice site |
probably null |
|
|
IGL01145:Tnik
|
APN |
3 |
28,658,316 (GRCm39) |
intron |
probably benign |
|
|
IGL01664:Tnik
|
APN |
3 |
28,692,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01843:Tnik
|
APN |
3 |
28,625,007 (GRCm39) |
splice site |
probably null |
|
|
IGL02378:Tnik
|
APN |
3 |
28,692,608 (GRCm39) |
nonsense |
probably null |
|
|
IGL02448:Tnik
|
APN |
3 |
28,675,226 (GRCm39) |
missense |
probably null |
0.01 |
|
IGL02756:Tnik
|
APN |
3 |
28,596,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Tnik
|
APN |
3 |
28,720,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
delightful
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hottie
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
Knockout
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Looker
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
Lovely
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
Usher
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0135:Tnik
|
UTSW |
3 |
28,661,394 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0418:Tnik
|
UTSW |
3 |
28,625,029 (GRCm39) |
nonsense |
probably null |
|
|
R0540:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0549:Tnik
|
UTSW |
3 |
28,625,069 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0556:Tnik
|
UTSW |
3 |
28,679,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0586:Tnik
|
UTSW |
3 |
28,631,510 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0842:Tnik
|
UTSW |
3 |
28,648,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1068:Tnik
|
UTSW |
3 |
28,587,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1171:Tnik
|
UTSW |
3 |
28,587,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1597:Tnik
|
UTSW |
3 |
28,658,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Tnik
|
UTSW |
3 |
28,719,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1652:Tnik
|
UTSW |
3 |
28,658,442 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1996:Tnik
|
UTSW |
3 |
28,719,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2333:Tnik
|
UTSW |
3 |
28,587,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Tnik
|
UTSW |
3 |
28,700,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Tnik
|
UTSW |
3 |
28,722,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3774:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3775:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4007:Tnik
|
UTSW |
3 |
28,658,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4119:Tnik
|
UTSW |
3 |
28,720,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4209:Tnik
|
UTSW |
3 |
28,413,214 (GRCm39) |
splice site |
probably benign |
|
|
R4441:Tnik
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4611:Tnik
|
UTSW |
3 |
28,596,249 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4714:Tnik
|
UTSW |
3 |
28,648,226 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4772:Tnik
|
UTSW |
3 |
28,661,359 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4829:Tnik
|
UTSW |
3 |
28,593,690 (GRCm39) |
intron |
probably benign |
|
|
R4839:Tnik
|
UTSW |
3 |
28,650,224 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4898:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Tnik
|
UTSW |
3 |
28,704,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5307:Tnik
|
UTSW |
3 |
28,596,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tnik
|
UTSW |
3 |
28,596,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5375:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5459:Tnik
|
UTSW |
3 |
28,715,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Tnik
|
UTSW |
3 |
28,666,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5749:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5780:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5837:Tnik
|
UTSW |
3 |
28,722,202 (GRCm39) |
unclassified |
probably benign |
|
|
R5969:Tnik
|
UTSW |
3 |
28,675,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6244:Tnik
|
UTSW |
3 |
28,704,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Tnik
|
UTSW |
3 |
28,631,649 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6457:Tnik
|
UTSW |
3 |
28,593,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Tnik
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6473:Tnik
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R6737:Tnik
|
UTSW |
3 |
28,650,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7049:Tnik
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
R7237:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7267:Tnik
|
UTSW |
3 |
28,700,776 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7445:Tnik
|
UTSW |
3 |
28,718,058 (GRCm39) |
splice site |
probably null |
|
|
R7499:Tnik
|
UTSW |
3 |
28,684,743 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7629:Tnik
|
UTSW |
3 |
28,715,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7654:Tnik
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7886:Tnik
|
UTSW |
3 |
28,720,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8096:Tnik
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8210:Tnik
|
UTSW |
3 |
28,658,482 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8233:Tnik
|
UTSW |
3 |
28,609,086 (GRCm39) |
missense |
unknown |
|
|
R8386:Tnik
|
UTSW |
3 |
28,317,823 (GRCm39) |
missense |
unknown |
|
|
R8399:Tnik
|
UTSW |
3 |
28,548,159 (GRCm39) |
missense |
unknown |
|
|
R8490:Tnik
|
UTSW |
3 |
28,650,321 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8539:Tnik
|
UTSW |
3 |
28,596,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8751:Tnik
|
UTSW |
3 |
28,666,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8804:Tnik
|
UTSW |
3 |
28,648,202 (GRCm39) |
missense |
unknown |
|
|
R8966:Tnik
|
UTSW |
3 |
28,587,044 (GRCm39) |
missense |
unknown |
|
|
R8998:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8999:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Tnik
|
UTSW |
3 |
28,692,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9284:Tnik
|
UTSW |
3 |
28,593,570 (GRCm39) |
missense |
unknown |
|
|
R9290:Tnik
|
UTSW |
3 |
28,675,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Tnik
|
UTSW |
3 |
28,684,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Tnik
|
UTSW |
3 |
28,649,093 (GRCm39) |
missense |
unknown |
|
|
X0022:Tnik
|
UTSW |
3 |
28,722,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnik
|
UTSW |
3 |
28,661,477 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Tnik
|
UTSW |
3 |
28,658,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAAGCAGAGTAATCCCTGGCC -3'
(R):5'- GCAACAACTCACAGCATTTGTTTAC -3'
Sequencing Primer
(F):5'- AGAGTAATCCCTGGCCTCTCTTTG -3'
(R):5'- CAAGTGTCAGTCACAGAC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation