|Institutional Source||Beutler Lab|
|Gene Name||major vault protein|
|Synonyms||LRP, VAULT1, 2310009M24Rik|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5031 (G1)|
|Chromosomal Location||126986860-127014621 bp(-) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||A to C at 126993616 bp (GRCm38)|
|Amino Acid Change||Tyrosine to Stop codon at position 374 (Y374*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000127250 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000133172] [ENSMUST00000165096]|
|AlphaFold||no structure available at present|
AA Change: Y374*
AA Change: Y374*
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (52/52)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
PHENOTYPE: Targeted disruption of this gene does not induce hypersensitivity to various cytostatic agents. Homozygotes are viable, healthy and phenotypically normal and exhibit unimpaired dendritic cell maturation and function. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mvp||
(F):5'- GCTGTATGAGTCTTCTCCCAAC -3'
(R):5'- TATGGCCAGAGAGACACCATG -3'
(F):5'- GTATGAGTCTTCTCCCAACCTGCC -3'
(R):5'- CCACTAGGGAGAGAAGTCCTTTTTC -3'