Incidental Mutation 'IGL02837:Or9s13'
ID 391891
Institutional Source Beutler Lab
Gene Symbol Or9s13
Ensembl Gene ENSMUSG00000061616
Gene Name olfactory receptor family 9 subfamily S member 13
Synonyms GA_x6K02T2R7CC-81134096-81133095, Olfr12, MOR208-5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # IGL02837 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 92547603-92548723 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 92548404 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 259 (Y259H)
Ref Sequence ENSEMBL: ENSMUSP00000150858 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081274] [ENSMUST00000213247]
AlphaFold Q60894
Predicted Effect possibly damaging
Transcript: ENSMUST00000081274
AA Change: Y259H

PolyPhen 2 Score 0.728 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000080027
Gene: ENSMUSG00000061616
AA Change: Y259H

DomainStartEndE-ValueType
transmembrane domain 13 30 N/A INTRINSIC
Pfam:7tm_4 38 314 8e-53 PFAM
Pfam:7tm_1 48 297 1.3e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213247
AA Change: Y259H

PolyPhen 2 Score 0.728 (Sensitivity: 0.86; Specificity: 0.92)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 0.0%
  • 3x: 0.0%
  • 10x: 0.0%
  • 20x: 0.0%
Validation Efficiency 98% (56/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf1 C T 17: 36,268,473 (GRCm39) V786I probably benign Het
Adamts13 A G 2: 26,881,432 (GRCm39) N803S probably benign Het
Ago4 C G 4: 126,391,093 (GRCm39) G730R possibly damaging Het
Amn T A 12: 111,238,333 (GRCm39) M55K possibly damaging Het
Apob A T 12: 8,055,102 (GRCm39) Y1334F probably damaging Het
Arl14ep A C 2: 106,799,574 (GRCm39) L89R probably damaging Het
Bcam T G 7: 19,498,111 (GRCm39) E304A probably damaging Het
Car10 A T 11: 93,488,077 (GRCm39) Y258F probably damaging Het
Cerk T A 15: 86,028,896 (GRCm39) K82* probably null Het
Chac2 T C 11: 30,927,496 (GRCm39) N141S probably damaging Het
Clpx T G 9: 65,231,541 (GRCm39) L556R probably damaging Het
Csgalnact2 T C 6: 118,101,364 (GRCm39) I55V probably benign Het
Cul1 T C 6: 47,500,139 (GRCm39) V650A probably benign Het
Dnah5 A T 15: 28,269,546 (GRCm39) E895D probably benign Het
Dnah9 T C 11: 65,765,022 (GRCm39) K3841E probably damaging Het
Dpys A G 15: 39,720,701 (GRCm39) S20P probably damaging Het
Fat1 G A 8: 45,470,471 (GRCm39) V1490I probably benign Het
Flg2 T G 3: 93,109,044 (GRCm39) C357W probably damaging Het
Flt1 T A 5: 147,591,980 (GRCm39) D494V probably benign Het
Fpr-rs4 T A 17: 18,242,513 (GRCm39) D173E probably benign Het
Gm2666 G T 1: 85,412,824 (GRCm39) noncoding transcript Het
Gm3867 C A 9: 36,169,096 (GRCm39) noncoding transcript Het
Gm5436 A T 12: 84,305,374 (GRCm39) noncoding transcript Het
Kit G A 5: 75,799,668 (GRCm39) V467I probably benign Het
Krtap4-16 A G 11: 99,741,863 (GRCm39) V179A unknown Het
Lrp8 C A 4: 107,718,478 (GRCm39) H693Q probably benign Het
Lrrc49 A G 9: 60,517,605 (GRCm39) S75P probably benign Het
Ltbp4 C A 7: 27,013,806 (GRCm39) V1068L probably damaging Het
Magel2 C T 7: 62,028,008 (GRCm39) P304L possibly damaging Het
Muc19 T A 15: 91,766,850 (GRCm39) noncoding transcript Het
Npas3 T C 12: 53,993,980 (GRCm39) V175A possibly damaging Het
Nr1h4 A T 10: 89,352,342 (GRCm39) H8Q probably benign Het
Ntsr2 G A 12: 16,703,876 (GRCm39) V126M probably damaging Het
Odf2 A T 2: 29,816,725 (GRCm39) T725S probably damaging Het
Or52e19b C T 7: 103,032,822 (GRCm39) C129Y probably damaging Het
Or5h17 C T 16: 58,820,909 (GRCm39) P287L probably damaging Het
Pgr T C 9: 8,946,639 (GRCm39) probably benign Het
Pik3c2g T A 6: 139,603,562 (GRCm39) C249* probably null Het
Plcd3 C T 11: 102,961,929 (GRCm39) V726M possibly damaging Het
Prl8a1 A G 13: 27,759,617 (GRCm39) L140P probably damaging Het
Prpf6 C A 2: 181,264,056 (GRCm39) D239E probably damaging Het
Rcc1 C T 4: 132,065,067 (GRCm39) R139H probably benign Het
Rimbp2 G T 5: 128,874,809 (GRCm39) Q268K probably damaging Het
Rps19-ps13 A T 18: 40,859,447 (GRCm39) noncoding transcript Het
Sema4c C A 1: 36,591,965 (GRCm39) G266V probably damaging Het
Sema4g T C 19: 44,985,150 (GRCm39) F156S probably damaging Het
Speer4c1 A C 5: 15,919,214 (GRCm39) probably benign Het
Speer4f1 G T 5: 17,685,381 (GRCm39) L225F unknown Het
Thrap3 T C 4: 126,059,157 (GRCm39) probably benign Het
Tnfrsf8 T C 4: 144,995,568 (GRCm39) E497G probably benign Het
Trim3 T C 7: 105,261,863 (GRCm39) N631S probably damaging Het
Trim45 C T 3: 100,838,943 (GRCm39) probably benign Het
Wdr43 A G 17: 71,949,731 (GRCm39) D445G probably benign Het
Other mutations in Or9s13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01085:Or9s13 APN 1 92,547,921 (GRCm39) missense possibly damaging 0.88
IGL01309:Or9s13 APN 1 92,548,057 (GRCm39) missense probably damaging 1.00
IGL02025:Or9s13 APN 1 92,548,269 (GRCm39) missense probably benign 0.00
IGL02517:Or9s13 APN 1 92,548,183 (GRCm39) missense probably benign
R1394:Or9s13 UTSW 1 92,548,267 (GRCm39) missense probably benign 0.02
R1395:Or9s13 UTSW 1 92,548,267 (GRCm39) missense probably benign 0.02
R1590:Or9s13 UTSW 1 92,548,467 (GRCm39) missense possibly damaging 0.64
R1778:Or9s13 UTSW 1 92,548,342 (GRCm39) missense possibly damaging 0.94
R1924:Or9s13 UTSW 1 92,548,525 (GRCm39) missense probably damaging 1.00
R2011:Or9s13 UTSW 1 92,548,471 (GRCm39) missense probably benign 0.01
R3877:Or9s13 UTSW 1 92,547,805 (GRCm39) missense probably damaging 1.00
R5286:Or9s13 UTSW 1 92,548,084 (GRCm39) missense probably benign 0.38
R5513:Or9s13 UTSW 1 92,548,102 (GRCm39) missense probably benign
R5727:Or9s13 UTSW 1 92,547,900 (GRCm39) missense probably benign 0.00
R5905:Or9s13 UTSW 1 92,547,864 (GRCm39) missense possibly damaging 0.49
R5921:Or9s13 UTSW 1 92,548,344 (GRCm39) missense probably benign 0.01
R7614:Or9s13 UTSW 1 92,548,183 (GRCm39) missense probably damaging 0.99
R7959:Or9s13 UTSW 1 92,548,029 (GRCm39) missense probably damaging 0.96
R8073:Or9s13 UTSW 1 92,547,806 (GRCm39) missense probably damaging 1.00
R8161:Or9s13 UTSW 1 92,548,078 (GRCm39) missense probably benign 0.00
R8680:Or9s13 UTSW 1 92,547,643 (GRCm39) missense probably benign 0.10
Predicted Primers PCR Primer
(F):5'- ACCACTTCTACTGTGATGTGC -3'
(R):5'- AGGCTGTGTCTCTGTCCTAAC -3'

Sequencing Primer
(F):5'- GCACGGCTCTCAATGAACTC -3'
(R):5'- GTCCTAACCTCTGCAGAGC -3'
Posted On 2016-06-08