Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02837:Fpr-rs4'

391938

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs4

Ensembl Gene

ENSMUSG00000048062

Gene Name

formyl peptide receptor, related sequence 4

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

IGL02837 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

18241995-18242966 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18242513 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 173 (D173E)

Ref Sequence

ENSEMBL: ENSMUSP00000093311 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095651]

AlphaFold

A4FUQ5

Predicted Effect

probably benign
Transcript: ENSMUST00000095651
AA Change: D173E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000093311
Gene: ENSMUSG00000048062
AA Change: D173E

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	4.9e-35	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 0.0%
3x: 0.0%
10x: 0.0%
20x: 0.0%

Validation Efficiency

98% (56/57)

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcf1	C	T	17: 36,268,473 (GRCm39)	V786I	probably benign	Het
Adamts13	A	G	2: 26,881,432 (GRCm39)	N803S	probably benign	Het
Ago4	C	G	4: 126,391,093 (GRCm39)	G730R	possibly damaging	Het
Amn	T	A	12: 111,238,333 (GRCm39)	M55K	possibly damaging	Het
Apob	A	T	12: 8,055,102 (GRCm39)	Y1334F	probably damaging	Het
Arl14ep	A	C	2: 106,799,574 (GRCm39)	L89R	probably damaging	Het
Bcam	T	G	7: 19,498,111 (GRCm39)	E304A	probably damaging	Het
Car10	A	T	11: 93,488,077 (GRCm39)	Y258F	probably damaging	Het
Cerk	T	A	15: 86,028,896 (GRCm39)	K82*	probably null	Het
Chac2	T	C	11: 30,927,496 (GRCm39)	N141S	probably damaging	Het
Clpx	T	G	9: 65,231,541 (GRCm39)	L556R	probably damaging	Het
Csgalnact2	T	C	6: 118,101,364 (GRCm39)	I55V	probably benign	Het
Cul1	T	C	6: 47,500,139 (GRCm39)	V650A	probably benign	Het
Dnah5	A	T	15: 28,269,546 (GRCm39)	E895D	probably benign	Het
Dnah9	T	C	11: 65,765,022 (GRCm39)	K3841E	probably damaging	Het
Dpys	A	G	15: 39,720,701 (GRCm39)	S20P	probably damaging	Het
Fat1	G	A	8: 45,470,471 (GRCm39)	V1490I	probably benign	Het
Flg2	T	G	3: 93,109,044 (GRCm39)	C357W	probably damaging	Het
Flt1	T	A	5: 147,591,980 (GRCm39)	D494V	probably benign	Het
Gm2666	G	T	1: 85,412,824 (GRCm39)		noncoding transcript	Het
Gm3867	C	A	9: 36,169,096 (GRCm39)		noncoding transcript	Het
Gm5436	A	T	12: 84,305,374 (GRCm39)		noncoding transcript	Het
Kit	G	A	5: 75,799,668 (GRCm39)	V467I	probably benign	Het
Krtap4-16	A	G	11: 99,741,863 (GRCm39)	V179A	unknown	Het
Lrp8	C	A	4: 107,718,478 (GRCm39)	H693Q	probably benign	Het
Lrrc49	A	G	9: 60,517,605 (GRCm39)	S75P	probably benign	Het
Ltbp4	C	A	7: 27,013,806 (GRCm39)	V1068L	probably damaging	Het
Magel2	C	T	7: 62,028,008 (GRCm39)	P304L	possibly damaging	Het
Muc19	T	A	15: 91,766,850 (GRCm39)		noncoding transcript	Het
Npas3	T	C	12: 53,993,980 (GRCm39)	V175A	possibly damaging	Het
Nr1h4	A	T	10: 89,352,342 (GRCm39)	H8Q	probably benign	Het
Ntsr2	G	A	12: 16,703,876 (GRCm39)	V126M	probably damaging	Het
Odf2	A	T	2: 29,816,725 (GRCm39)	T725S	probably damaging	Het
Or52e19b	C	T	7: 103,032,822 (GRCm39)	C129Y	probably damaging	Het
Or5h17	C	T	16: 58,820,909 (GRCm39)	P287L	probably damaging	Het
Or9s13	T	C	1: 92,548,404 (GRCm39)	Y259H	possibly damaging	Het
Pgr	T	C	9: 8,946,639 (GRCm39)		probably benign	Het
Pik3c2g	T	A	6: 139,603,562 (GRCm39)	C249*	probably null	Het
Plcd3	C	T	11: 102,961,929 (GRCm39)	V726M	possibly damaging	Het
Prl8a1	A	G	13: 27,759,617 (GRCm39)	L140P	probably damaging	Het
Prpf6	C	A	2: 181,264,056 (GRCm39)	D239E	probably damaging	Het
Rcc1	C	T	4: 132,065,067 (GRCm39)	R139H	probably benign	Het
Rimbp2	G	T	5: 128,874,809 (GRCm39)	Q268K	probably damaging	Het
Rps19-ps13	A	T	18: 40,859,447 (GRCm39)		noncoding transcript	Het
Sema4c	C	A	1: 36,591,965 (GRCm39)	G266V	probably damaging	Het
Sema4g	T	C	19: 44,985,150 (GRCm39)	F156S	probably damaging	Het
Speer4c1	A	C	5: 15,919,214 (GRCm39)		probably benign	Het
Speer4f1	G	T	5: 17,685,381 (GRCm39)	L225F	unknown	Het
Thrap3	T	C	4: 126,059,157 (GRCm39)		probably benign	Het
Tnfrsf8	T	C	4: 144,995,568 (GRCm39)	E497G	probably benign	Het
Trim3	T	C	7: 105,261,863 (GRCm39)	N631S	probably damaging	Het
Trim45	C	T	3: 100,838,943 (GRCm39)		probably benign	Het
Wdr43	A	G	17: 71,949,731 (GRCm39)	D445G	probably benign	Het

Other mutations in Fpr-rs4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00539:Fpr-rs4	APN	17	18,242,188 (GRCm39)	missense	probably damaging	1.00
IGL01064:Fpr-rs4	APN	17	18,242,779 (GRCm39)	missense	probably damaging	1.00
IGL01626:Fpr-rs4	APN	17	18,242,493 (GRCm39)	missense	probably damaging	0.97
IGL02544:Fpr-rs4	APN	17	18,242,473 (GRCm39)	missense	probably benign
R0179:Fpr-rs4	UTSW	17	18,242,289 (GRCm39)	nonsense	probably null
R0383:Fpr-rs4	UTSW	17	18,242,359 (GRCm39)	missense	probably damaging	1.00
R0686:Fpr-rs4	UTSW	17	18,242,613 (GRCm39)	missense	probably benign	0.05
R1551:Fpr-rs4	UTSW	17	18,242,589 (GRCm39)	missense	possibly damaging	0.89
R1956:Fpr-rs4	UTSW	17	18,242,518 (GRCm39)	missense	probably damaging	0.97
R2040:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2041:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2043:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2045:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2048:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2092:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2093:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R2136:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R3624:Fpr-rs4	UTSW	17	18,242,596 (GRCm39)	frame shift	probably null
R4684:Fpr-rs4	UTSW	17	18,242,446 (GRCm39)	missense	probably damaging	1.00
R6076:Fpr-rs4	UTSW	17	18,242,317 (GRCm39)	missense	probably damaging	1.00
R6247:Fpr-rs4	UTSW	17	18,242,748 (GRCm39)	missense	probably benign	0.00
R6639:Fpr-rs4	UTSW	17	18,242,394 (GRCm39)	nonsense	probably null
R6757:Fpr-rs4	UTSW	17	18,242,394 (GRCm39)	nonsense	probably null
R8703:Fpr-rs4	UTSW	17	18,242,332 (GRCm39)	missense	probably damaging	0.99
R9007:Fpr-rs4	UTSW	17	18,242,416 (GRCm39)	missense	probably damaging	1.00
R9318:Fpr-rs4	UTSW	17	18,242,217 (GRCm39)	missense	probably benign
R9357:Fpr-rs4	UTSW	17	18,242,211 (GRCm39)	missense	probably damaging	0.97
R9435:Fpr-rs4	UTSW	17	18,242,391 (GRCm39)	missense	probably benign	0.00
Z1088:Fpr-rs4	UTSW	17	18,242,956 (GRCm39)	missense	probably benign	0.16
Z1088:Fpr-rs4	UTSW	17	18,242,181 (GRCm39)	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- ACATCATCTCAATGGTCATGAGAG -3'
(R):5'- TGCAGATCTTGGCAGCCATG -3'

Sequencing Primer
(F):5'- CATGAGAGGAAAATGGCTTTTTGG -3'
(R):5'- ATCTTGGCAGCCATGAGTCCATAG -3'

Posted On

2016-06-08