Incidental Mutation 'IGL02796:Zfp263'
ID 392042
Institutional Source Beutler Lab
Gene Symbol Zfp263
Ensembl Gene ENSMUSG00000022529
Gene Name zinc finger protein 263
Synonyms mFPM315, NT2, 1200014J04Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # IGL02796 (G1)
Quality Score 112
Status Validated
Chromosome 16
Chromosomal Location 3561957-3568654 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 3564740 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 252 (E252K)
Ref Sequence ENSEMBL: ENSMUSP00000023176 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023176] [ENSMUST00000161630] [ENSMUST00000162207]
AlphaFold Q8CF60
Predicted Effect probably benign
Transcript: ENSMUST00000023176
AA Change: E252K

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000023176
Gene: ENSMUSG00000022529
AA Change: E252K

DomainStartEndE-ValueType
SCAN 39 151 5.15e-71 SMART
KRAB 219 279 1.86e-9 SMART
ZnF_C2H2 378 400 1.45e-2 SMART
ZnF_C2H2 434 456 3.11e-2 SMART
ZnF_C2H2 462 484 1.2e-3 SMART
ZnF_C2H2 490 512 6.52e-5 SMART
ZnF_C2H2 518 540 1.98e-4 SMART
ZnF_C2H2 572 594 2.4e-3 SMART
ZnF_C2H2 600 622 4.87e-4 SMART
ZnF_C2H2 628 650 1.1e-2 SMART
ZnF_C2H2 656 678 1.72e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159060
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159425
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159469
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160923
Predicted Effect probably benign
Transcript: ENSMUST00000161630
SMART Domains Protein: ENSMUSP00000123725
Gene: ENSMUSG00000022529

DomainStartEndE-ValueType
SCAN 39 143 1.61e-63 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162207
SMART Domains Protein: ENSMUSP00000124433
Gene: ENSMUSG00000022529

DomainStartEndE-ValueType
ZnF_C2H2 90 112 1.45e-2 SMART
ZnF_C2H2 146 168 3.11e-2 SMART
ZnF_C2H2 174 196 1.2e-3 SMART
ZnF_C2H2 202 224 6.52e-5 SMART
ZnF_C2H2 230 252 1.98e-4 SMART
ZnF_C2H2 284 306 2.4e-3 SMART
ZnF_C2H2 312 334 4.87e-4 SMART
ZnF_C2H2 340 362 1.1e-2 SMART
ZnF_C2H2 368 390 1.72e-4 SMART
Meta Mutation Damage Score 0.0641 question?
Coding Region Coverage
  • 1x: 0.0%
  • 3x: 0.0%
  • 10x: 0.0%
  • 20x: 0.0%
Validation Efficiency 98% (50/51)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl5 A T 19: 55,266,601 (GRCm39) K86* probably null Het
Ambp C A 4: 63,072,169 (GRCm39) probably benign Het
Atp6v0d2 A T 4: 19,887,324 (GRCm39) M208K probably damaging Het
Brinp1 C G 4: 68,680,427 (GRCm39) R701P probably damaging Het
Btnl9 T C 11: 49,060,008 (GRCm39) D580G probably damaging Het
Cand1 A T 10: 119,049,543 (GRCm39) L401H probably damaging Het
Ccdc66 T C 14: 27,208,523 (GRCm39) E577G possibly damaging Het
Ccdc93 C A 1: 121,418,895 (GRCm39) D483E probably damaging Het
Cd38 T C 5: 44,063,555 (GRCm39) L216P probably damaging Het
Cdr1 C T X: 60,228,087 (GRCm39) D360N possibly damaging Het
Cibar2 C T 8: 120,904,138 (GRCm39) probably benign Het
Col9a3 G T 2: 180,255,955 (GRCm39) D443Y probably damaging Het
Cpt1b C T 15: 89,309,005 (GRCm39) V66I probably benign Het
Cyp8b1 T A 9: 121,744,564 (GRCm39) Y256F probably benign Het
Dennd10 A G 19: 60,806,081 (GRCm39) probably benign Het
Dync1i1 A G 6: 5,757,385 (GRCm39) N48S probably benign Het
Ehd3 T A 17: 74,123,396 (GRCm39) L133Q probably damaging Het
Eif6 C A 2: 155,668,068 (GRCm39) R57L probably damaging Het
Fcgbp T A 7: 27,800,576 (GRCm39) probably benign Het
Fgl1 C T 8: 41,650,095 (GRCm39) A229T probably benign Het
Flg2 C T 3: 93,110,920 (GRCm39) R983W unknown Het
Gdf7 A T 12: 8,351,666 (GRCm39) S90T unknown Het
Ggta1 T C 2: 35,303,329 (GRCm39) probably benign Het
Gm44859 C T 19: 12,014,112 (GRCm39) probably benign Het
Grin2a T C 16: 9,402,972 (GRCm39) E838G possibly damaging Het
Grin2c A G 11: 115,141,543 (GRCm39) probably benign Het
Grm1 T C 10: 10,565,411 (GRCm39) T966A probably benign Het
Gtpbp1 A G 15: 79,601,186 (GRCm39) I468M possibly damaging Het
Gucy1b2 G A 14: 62,645,143 (GRCm39) P639S probably benign Het
Hat1 T C 2: 71,250,700 (GRCm39) probably null Het
Hira A T 16: 18,744,404 (GRCm39) I374F probably benign Het
Htt C A 5: 35,034,826 (GRCm39) Q2024K probably benign Het
Kcnj6 A G 16: 94,633,778 (GRCm39) M111T probably benign Het
Loxhd1 T A 18: 77,456,811 (GRCm39) probably benign Het
Lrif1 T A 3: 106,642,752 (GRCm39) M619K probably benign Het
Lrrc8b G A 5: 105,629,211 (GRCm39) G519D probably damaging Het
Map3k7 A G 4: 31,979,692 (GRCm39) probably benign Het
Or2ah1 T C 2: 85,653,933 (GRCm39) I206T probably benign Het
Or4d6 T A 19: 12,086,248 (GRCm39) I221F possibly damaging Het
P2ry12 T C 3: 59,125,302 (GRCm39) I124M probably damaging Het
Paxbp1 A G 16: 90,822,182 (GRCm39) probably benign Het
Polb A T 8: 23,121,474 (GRCm39) I257N probably damaging Het
Psg27 A T 7: 18,295,875 (GRCm39) V190E probably benign Het
Rabgap1 T A 2: 37,362,318 (GRCm39) N54K probably damaging Het
Sacm1l T A 9: 123,377,989 (GRCm39) W90R possibly damaging Het
Snrpb2 A T 2: 142,906,487 (GRCm39) M1L probably benign Het
Spata31d1d A G 13: 59,876,057 (GRCm39) Y493H possibly damaging Het
Speer4c1 A C 5: 15,919,214 (GRCm39) probably benign Het
Spocd1 A G 4: 129,841,548 (GRCm39) probably benign Het
Tbc1d5 G T 17: 51,273,652 (GRCm39) H123Q probably damaging Het
Ttn T C 2: 76,608,445 (GRCm39) N17826S probably damaging Het
Tubgcp6 A G 15: 89,006,593 (GRCm39) I143T probably benign Het
Usp48 A G 4: 137,338,029 (GRCm39) Y268C probably damaging Het
Zfhx4 G A 3: 5,464,599 (GRCm39) V1586M probably damaging Het
Zfp146 C T 7: 29,861,983 (GRCm39) V20I probably benign Het
Other mutations in Zfp263
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00489:Zfp263 APN 16 3,563,710 (GRCm39) missense probably benign 0.00
IGL01112:Zfp263 APN 16 3,566,776 (GRCm39) missense probably benign 0.09
IGL02049:Zfp263 APN 16 3,562,482 (GRCm39) missense probably damaging 0.97
IGL02534:Zfp263 APN 16 3,564,279 (GRCm39) unclassified probably benign
IGL02674:Zfp263 APN 16 3,564,629 (GRCm39) unclassified probably benign
IGL03065:Zfp263 APN 16 3,564,344 (GRCm39) missense probably benign
IGL03105:Zfp263 APN 16 3,566,824 (GRCm39) missense probably damaging 1.00
IGL03153:Zfp263 APN 16 3,564,744 (GRCm39) missense possibly damaging 0.56
R1201:Zfp263 UTSW 16 3,567,294 (GRCm39) missense probably damaging 1.00
R1414:Zfp263 UTSW 16 3,567,160 (GRCm39) missense probably damaging 1.00
R1448:Zfp263 UTSW 16 3,564,323 (GRCm39) missense probably benign 0.18
R3085:Zfp263 UTSW 16 3,567,580 (GRCm39) missense probably damaging 1.00
R4368:Zfp263 UTSW 16 3,562,770 (GRCm39) unclassified probably benign
R4989:Zfp263 UTSW 16 3,566,992 (GRCm39) missense probably damaging 1.00
R5072:Zfp263 UTSW 16 3,564,704 (GRCm39) missense possibly damaging 0.84
R5073:Zfp263 UTSW 16 3,564,704 (GRCm39) missense possibly damaging 0.84
R5074:Zfp263 UTSW 16 3,564,704 (GRCm39) missense possibly damaging 0.84
R5122:Zfp263 UTSW 16 3,567,719 (GRCm39) missense probably damaging 0.99
R5705:Zfp263 UTSW 16 3,564,318 (GRCm39) missense probably benign 0.00
R6140:Zfp263 UTSW 16 3,566,081 (GRCm39) missense probably benign 0.10
R6879:Zfp263 UTSW 16 3,567,719 (GRCm39) missense probably damaging 0.99
R7133:Zfp263 UTSW 16 3,567,255 (GRCm39) nonsense probably null
R7216:Zfp263 UTSW 16 3,562,435 (GRCm39) missense probably damaging 1.00
R8517:Zfp263 UTSW 16 3,564,760 (GRCm39) critical splice donor site probably null
R8822:Zfp263 UTSW 16 3,562,004 (GRCm39) unclassified probably benign
R9130:Zfp263 UTSW 16 3,567,701 (GRCm39) missense probably benign 0.06
R9172:Zfp263 UTSW 16 3,567,323 (GRCm39) missense probably benign 0.22
R9512:Zfp263 UTSW 16 3,564,306 (GRCm39) missense probably damaging 1.00
R9616:Zfp263 UTSW 16 3,567,482 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACATGAGTTTTCTTGGCACTCATG -3'
(R):5'- GTCTATCAACTGTGCCATTTGG -3'

Sequencing Primer
(F):5'- GGCACTCATGTGTTTTAACCC -3'
(R):5'- TCATGTCCAGTAGGTGTG -3'
Posted On 2016-06-08