Incidental Mutation 'R0442:Rexo5'
ID 39218
Institutional Source Beutler Lab
Gene Symbol Rexo5
Ensembl Gene ENSMUSG00000030924
Gene Name RNA exonuclease 5
Synonyms 2610020H08Rik
MMRRC Submission 038643-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.132) question?
Stock # R0442 (G1)
Quality Score 222
Status Validated
Chromosome 7
Chromosomal Location 119393229-119448166 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 119442508 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 542 (L542P)
Ref Sequence ENSEMBL: ENSMUSP00000102130 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033218] [ENSMUST00000084644] [ENSMUST00000106520] [ENSMUST00000133758]
AlphaFold D3YW29
Predicted Effect probably benign
Transcript: ENSMUST00000033218
SMART Domains Protein: ENSMUSP00000033218
Gene: ENSMUSG00000030924

DomainStartEndE-ValueType
low complexity region 105 116 N/A INTRINSIC
low complexity region 123 134 N/A INTRINSIC
Pfam:RNase_T 225 330 1.4e-12 PFAM
Blast:RRM 424 463 5e-17 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000084644
AA Change: L349P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000081694
Gene: ENSMUSG00000030924
AA Change: L349P

DomainStartEndE-ValueType
EXOIII 31 189 2.72e-29 SMART
RRM 298 367 3.23e-9 SMART
Blast:RRM 393 437 2e-22 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000106520
AA Change: L542P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102130
Gene: ENSMUSG00000030924
AA Change: L542P

DomainStartEndE-ValueType
low complexity region 105 116 N/A INTRINSIC
low complexity region 123 134 N/A INTRINSIC
EXOIII 223 381 2.72e-29 SMART
RRM 491 560 3.23e-9 SMART
RRM 586 661 3.28e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000133758
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138689
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151248
Predicted Effect probably benign
Transcript: ENSMUST00000208789
Predicted Effect probably benign
Transcript: ENSMUST00000207042
Meta Mutation Damage Score 0.3937 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.5%
  • 10x: 93.4%
  • 20x: 81.2%
Validation Efficiency 99% (70/71)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 T A 1: 25,435,551 (GRCm39) N816Y probably damaging Het
Arfgef3 T C 10: 18,553,563 (GRCm39) probably benign Het
Cd200 T A 16: 45,217,518 (GRCm39) S58C probably damaging Het
Cep128 C T 12: 91,233,545 (GRCm39) E508K probably damaging Het
Dnah2 C A 11: 69,339,368 (GRCm39) L3046F probably damaging Het
Duox2 T C 2: 122,119,813 (GRCm39) N872D probably benign Het
Fam90a1a C T 8: 22,453,074 (GRCm39) T143I probably benign Het
Fdft1 T C 14: 63,400,798 (GRCm39) T112A probably benign Het
Gimap9 G T 6: 48,655,000 (GRCm39) G196* probably null Het
Grhl1 G A 12: 24,662,169 (GRCm39) R536Q probably damaging Het
Gtpbp3 T A 8: 71,944,135 (GRCm39) V293E probably damaging Het
Hcn3 A T 3: 89,058,847 (GRCm39) F251Y probably damaging Het
Hectd4 T A 5: 121,462,045 (GRCm39) C971S possibly damaging Het
Helz2 T A 2: 180,874,002 (GRCm39) D2164V probably damaging Het
Hif1an T G 19: 44,554,451 (GRCm39) L188R probably damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Iqgap3 C T 3: 88,023,266 (GRCm39) P519L probably damaging Het
Jakmip1 T G 5: 37,292,897 (GRCm39) probably null Het
Klra1 T C 6: 130,349,835 (GRCm39) Y201C probably damaging Het
Minpp1 T C 19: 32,471,348 (GRCm39) F299L possibly damaging Het
Myb A G 10: 21,002,095 (GRCm39) S749P probably benign Het
Myo3b T C 2: 70,069,305 (GRCm39) probably null Het
Naip1 T A 13: 100,581,024 (GRCm39) R74S probably benign Het
Nt5m A G 11: 59,765,445 (GRCm39) T158A possibly damaging Het
Obscn A T 11: 58,893,000 (GRCm39) probably benign Het
Or5af1 T A 11: 58,722,257 (GRCm39) Y92* probably null Het
Or5b119 T G 19: 13,457,412 (GRCm39) D50A probably damaging Het
Or6c210 T C 10: 129,495,693 (GRCm39) I6T probably benign Het
Otogl T A 10: 107,712,716 (GRCm39) T543S probably damaging Het
Pds5b T C 5: 150,640,009 (GRCm39) probably benign Het
Plekhm1 A G 11: 103,288,000 (GRCm39) M49T possibly damaging Het
Rabl6 A T 2: 25,477,534 (GRCm39) S305R probably damaging Het
Rad54b G A 4: 11,609,480 (GRCm39) probably benign Het
Rad54b C A 4: 11,610,362 (GRCm39) R660S probably benign Het
Rp1 C T 1: 4,416,970 (GRCm39) D1381N probably benign Het
Scnn1a T G 6: 125,316,100 (GRCm39) M346R probably damaging Het
Sirpb1c A G 3: 15,856,710 (GRCm39) I380T probably benign Het
Snrnp40 C G 4: 130,271,836 (GRCm39) probably null Het
Sstr3 A T 15: 78,424,597 (GRCm39) L50Q probably damaging Het
St3gal6 C A 16: 58,293,816 (GRCm39) A238S probably damaging Het
St3gal6 G T 16: 58,293,818 (GRCm39) A237E probably damaging Het
Sun5 T C 2: 153,712,872 (GRCm39) D16G possibly damaging Het
Svil A T 18: 5,046,870 (GRCm39) T39S probably damaging Het
Taar1 A G 10: 23,796,380 (GRCm39) Y26C possibly damaging Het
Ugt1a1 AT A 1: 88,140,093 (GRCm39) probably null Het
Use1 T C 8: 71,819,702 (GRCm39) probably benign Het
Usp54 T C 14: 20,657,277 (GRCm39) Y7C probably damaging Het
Zbtb37 A G 1: 160,859,918 (GRCm39) F129S possibly damaging Het
Zfhx2 T C 14: 55,304,357 (GRCm39) H1209R possibly damaging Het
Zfp28 T C 7: 6,397,998 (GRCm39) L811P probably damaging Het
Zfp616 T C 11: 73,975,321 (GRCm39) I530T possibly damaging Het
Other mutations in Rexo5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01308:Rexo5 APN 7 119,433,499 (GRCm39) missense probably damaging 1.00
R0347:Rexo5 UTSW 7 119,423,119 (GRCm39) critical splice donor site probably null
R0589:Rexo5 UTSW 7 119,444,606 (GRCm39) missense probably benign 0.00
R0980:Rexo5 UTSW 7 119,423,035 (GRCm39) missense probably damaging 1.00
R1465:Rexo5 UTSW 7 119,400,581 (GRCm39) critical splice donor site probably null
R1465:Rexo5 UTSW 7 119,400,581 (GRCm39) critical splice donor site probably null
R1505:Rexo5 UTSW 7 119,398,826 (GRCm39) nonsense probably null
R1775:Rexo5 UTSW 7 119,444,634 (GRCm39) missense probably benign 0.00
R1911:Rexo5 UTSW 7 119,398,867 (GRCm39) missense probably damaging 1.00
R1996:Rexo5 UTSW 7 119,423,080 (GRCm39) missense probably damaging 1.00
R4168:Rexo5 UTSW 7 119,426,621 (GRCm39) intron probably benign
R4169:Rexo5 UTSW 7 119,426,621 (GRCm39) intron probably benign
R4402:Rexo5 UTSW 7 119,433,599 (GRCm39) missense possibly damaging 0.82
R4486:Rexo5 UTSW 7 119,424,800 (GRCm39) missense probably benign 0.00
R4620:Rexo5 UTSW 7 119,426,526 (GRCm39) missense probably benign 0.37
R4621:Rexo5 UTSW 7 119,418,722 (GRCm39) missense probably benign 0.19
R4865:Rexo5 UTSW 7 119,400,553 (GRCm39) nonsense probably null
R4884:Rexo5 UTSW 7 119,424,774 (GRCm39) nonsense probably null
R5171:Rexo5 UTSW 7 119,423,002 (GRCm39) missense probably damaging 1.00
R5209:Rexo5 UTSW 7 119,433,522 (GRCm39) nonsense probably null
R5266:Rexo5 UTSW 7 119,443,660 (GRCm39) missense probably benign 0.00
R5463:Rexo5 UTSW 7 119,433,526 (GRCm39) missense probably damaging 1.00
R5579:Rexo5 UTSW 7 119,433,626 (GRCm39) critical splice donor site probably null
R6163:Rexo5 UTSW 7 119,404,470 (GRCm39) missense probably damaging 1.00
R6305:Rexo5 UTSW 7 119,427,348 (GRCm39) missense probably damaging 1.00
R7144:Rexo5 UTSW 7 119,404,414 (GRCm39) missense probably damaging 1.00
R7282:Rexo5 UTSW 7 119,417,636 (GRCm39) missense probably damaging 0.97
R8143:Rexo5 UTSW 7 119,433,484 (GRCm39) splice site probably null
R8379:Rexo5 UTSW 7 119,433,508 (GRCm39) missense probably benign 0.03
R8550:Rexo5 UTSW 7 119,400,568 (GRCm39) missense probably benign 0.01
R8841:Rexo5 UTSW 7 119,448,011 (GRCm39) missense probably benign 0.00
R9133:Rexo5 UTSW 7 119,444,667 (GRCm39) missense probably damaging 1.00
R9287:Rexo5 UTSW 7 119,402,025 (GRCm39) missense probably damaging 1.00
R9404:Rexo5 UTSW 7 119,400,542 (GRCm39) missense probably damaging 1.00
R9499:Rexo5 UTSW 7 119,404,480 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCCTGTGCCATACATGAATGACC -3'
(R):5'- GCCATGTAGAACAGACCTTCCATGC -3'

Sequencing Primer
(F):5'- CTTGTACTACCATAACAGTGGGC -3'
(R):5'- TGTAGAACAGACCTTCCATGCATAAG -3'
Posted On 2013-05-23