Incidental Mutation 'IGL03047:Il36g'
ID 392212
Institutional Source Beutler Lab
Gene Symbol Il36g
Ensembl Gene ENSMUSG00000044103
Gene Name interleukin 36G
Synonyms IL-36gamma, If36g, Il1f9
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # IGL03047 (G1)
Quality Score 52
Status Validated
Chromosome 2
Chromosomal Location 24076488-24083579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 24082719 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 165 (A165T)
Ref Sequence ENSEMBL: ENSMUSP00000053391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057567]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000057567
AA Change: A165T

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000053391
Gene: ENSMUSG00000044103
AA Change: A165T

DomainStartEndE-ValueType
IL1 43 190 7.91e-5 SMART
Meta Mutation Damage Score 0.7957 question?
Coding Region Coverage
  • 1x: 0.0%
  • 3x: 0.0%
  • 10x: 0.0%
  • 20x: 0.0%
Validation Efficiency 98% (41/42)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900092C05Rik T A 7: 12,246,568 (GRCm39) H21Q possibly damaging Het
4933427D14Rik A G 11: 72,057,552 (GRCm39) I749T possibly damaging Het
Adam22 A G 5: 8,132,220 (GRCm39) S869P probably damaging Het
Add3 A G 19: 53,231,022 (GRCm39) T566A probably benign Het
Asic3 A C 5: 24,618,788 (GRCm39) M27L probably benign Het
Atp2c1 T A 9: 105,398,206 (GRCm39) probably benign Het
Cabin1 A T 10: 75,535,934 (GRCm39) probably benign Het
Ccr7 C T 11: 99,036,160 (GRCm39) R254H probably benign Het
Cdk2ap1 G T 5: 124,486,753 (GRCm39) A63E possibly damaging Het
Cfap70 T C 14: 20,498,646 (GRCm39) T14A possibly damaging Het
Cldn11 T A 3: 31,217,256 (GRCm39) F141L probably damaging Het
Comp G T 8: 70,827,559 (GRCm39) A107S possibly damaging Het
Cyp2b23 A T 7: 26,380,892 (GRCm39) probably benign Het
Cyp2c68 T G 19: 39,722,904 (GRCm39) I215L probably benign Het
Cyp4f17 T A 17: 32,743,023 (GRCm39) I232K possibly damaging Het
Dram2 T G 3: 106,480,345 (GRCm39) F219L probably damaging Het
Fam186a G A 15: 99,843,589 (GRCm39) A885V unknown Het
Fbxo42 A G 4: 140,926,853 (GRCm39) T378A possibly damaging Het
Frmpd1 T A 4: 45,283,993 (GRCm39) V938E probably damaging Het
Gramd1c C A 16: 43,808,610 (GRCm39) L489F probably damaging Het
Il17ra T C 6: 120,458,187 (GRCm39) I446T probably damaging Het
Kcne4 G T 1: 78,795,495 (GRCm39) V48F possibly damaging Het
Ly6g6c T A 17: 35,288,325 (GRCm39) probably null Het
Mars2 A G 1: 55,278,032 (GRCm39) Y545C probably benign Het
Mmp12 T G 9: 7,357,797 (GRCm39) probably benign Het
Mthfd1l T A 10: 3,930,409 (GRCm39) probably benign Het
Nop14 C T 5: 34,817,358 (GRCm39) R11K possibly damaging Het
Npas3 T A 12: 53,878,470 (GRCm39) probably benign Het
Odf2 A T 2: 29,810,907 (GRCm39) probably benign Het
Or2y1d A G 11: 49,321,794 (GRCm39) M164V probably benign Het
Or5p73 T C 7: 108,064,983 (GRCm39) S151P probably damaging Het
Or5w16 A G 2: 87,577,338 (GRCm39) Y266C possibly damaging Het
Or6s1 A G 14: 51,308,613 (GRCm39) I79T possibly damaging Het
Otud7b T C 3: 96,058,301 (GRCm39) probably benign Het
Plcg1 T C 2: 160,596,799 (GRCm39) Y747H probably damaging Het
Runx1t1 G A 4: 13,865,882 (GRCm39) V357I probably damaging Het
Seh1l C G 18: 67,922,520 (GRCm39) T291R probably damaging Het
Speer4c1 A C 5: 15,919,214 (GRCm39) probably benign Het
Sulf2 G T 2: 165,922,814 (GRCm39) probably null Het
Tent4a C A 13: 69,651,030 (GRCm39) D369Y probably damaging Het
Tex14 C T 11: 87,427,530 (GRCm39) S1174F probably damaging Het
Tm9sf4 A G 2: 153,003,326 (GRCm39) probably benign Het
Vmn2r7 G A 3: 64,614,639 (GRCm39) H392Y possibly damaging Het
Zfhx4 T A 3: 5,308,793 (GRCm39) V673D probably damaging Het
Other mutations in Il36g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02027:Il36g APN 2 24,082,797 (GRCm39) missense probably benign 0.06
IGL03190:Il36g APN 2 24,077,272 (GRCm39) nonsense probably null
R2384:Il36g UTSW 2 24,082,660 (GRCm39) missense probably benign 0.43
R5158:Il36g UTSW 2 24,082,798 (GRCm39) missense probably damaging 0.99
R5916:Il36g UTSW 2 24,082,806 (GRCm39) makesense probably null
R6875:Il36g UTSW 2 24,078,633 (GRCm39) critical splice acceptor site probably null
R8187:Il36g UTSW 2 24,082,617 (GRCm39) missense probably damaging 1.00
R8357:Il36g UTSW 2 24,078,661 (GRCm39) missense probably benign 0.45
R8457:Il36g UTSW 2 24,078,661 (GRCm39) missense probably benign 0.45
Predicted Primers PCR Primer
(F):5'- TGCCTATCAGTAGTGTCTATCTTTG -3'
(R):5'- CCCACCGACTTTGGAGTATG -3'

Sequencing Primer
(F):5'- ATCAGTAGTGTCTATCTTTGTTCATG -3'
(R):5'- AGATAATGTTGGTCCTGCTTACC -3'
Posted On 2016-06-09