Incidental Mutation 'IGL02799:Dcp1a'
ID 392304
Institutional Source Beutler Lab
Gene Symbol Dcp1a
Ensembl Gene ENSMUSG00000021962
Gene Name decapping mRNA 1A
Synonyms SMIF, Mitc1, 1110066A22Rik, D14Ertd817e, 4930568L04Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.262) question?
Stock # IGL02799 (G1)
Quality Score 145
Status Validated
Chromosome 14
Chromosomal Location 30201613-30249013 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 30241636 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000022535 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022535] [ENSMUST00000225196] [ENSMUST00000225286]
AlphaFold Q91YD3
Predicted Effect probably null
Transcript: ENSMUST00000022535
SMART Domains Protein: ENSMUSP00000022535
Gene: ENSMUSG00000021962

DomainStartEndE-ValueType
Pfam:DCP1 28 144 1.8e-44 PFAM
low complexity region 327 343 N/A INTRINSIC
low complexity region 457 472 N/A INTRINSIC
Pfam:mRNA_decap_C 559 601 6.3e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223568
Predicted Effect probably benign
Transcript: ENSMUST00000223658
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223754
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224692
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224810
Predicted Effect probably benign
Transcript: ENSMUST00000225196
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225124
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225923
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225655
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225806
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225521
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225243
Predicted Effect probably benign
Transcript: ENSMUST00000225286
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225934
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225407
Meta Mutation Damage Score 0.9493 question?
Coding Region Coverage
  • 1x: 0.0%
  • 3x: 0.0%
  • 10x: 0.0%
  • 20x: 0.0%
Validation Efficiency 99% (67/68)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Add2 A G 6: 86,083,234 (GRCm39) N444S possibly damaging Het
Atp2b2 A T 6: 113,739,813 (GRCm39) Y823* probably null Het
Atp2c1 A C 9: 105,290,242 (GRCm39) probably benign Het
Capns1 A T 7: 29,891,644 (GRCm39) D133E probably benign Het
Cast A G 13: 74,884,871 (GRCm39) V361A probably damaging Het
Cd69 G A 6: 129,245,223 (GRCm39) probably benign Het
Celsr2 T A 3: 108,321,378 (GRCm39) D478V probably damaging Het
Cenpf T C 1: 189,391,849 (GRCm39) E661G probably damaging Het
Chrna1 A G 2: 73,404,985 (GRCm39) probably benign Het
Clec5a C A 6: 40,554,983 (GRCm39) V138F probably damaging Het
Ctsj T A 13: 61,151,634 (GRCm39) I95F probably benign Het
Dcaf1 T A 9: 106,735,139 (GRCm39) S696T probably benign Het
Dnajc14 C T 10: 128,642,725 (GRCm39) P216S possibly damaging Het
Dst T C 1: 34,218,930 (GRCm39) I1790T possibly damaging Het
Ehmt1 A T 2: 24,705,818 (GRCm39) H789Q probably damaging Het
Exoc7 A T 11: 116,192,007 (GRCm39) L188Q probably damaging Het
Faap100 A G 11: 120,261,561 (GRCm39) L823P probably damaging Het
Fdxacb1 T A 9: 50,683,896 (GRCm39) S620T probably benign Het
Fhl2 C T 1: 43,167,562 (GRCm39) R177Q probably benign Het
Gars1 C A 6: 55,040,084 (GRCm39) T337K probably damaging Het
Ggta1 A T 2: 35,312,211 (GRCm39) F56I probably damaging Het
Gm10715 A C 9: 3,038,062 (GRCm39) probably benign Het
Gpr108 T A 17: 57,544,482 (GRCm39) I343F probably damaging Het
Gpr12 T A 5: 146,520,629 (GRCm39) I98F possibly damaging Het
Hk2 A G 6: 82,737,219 (GRCm39) L3P probably damaging Het
Imp4 C A 1: 34,479,258 (GRCm39) probably benign Het
Insrr G A 3: 87,720,888 (GRCm39) V1049M probably damaging Het
Klhl24 T C 16: 19,933,331 (GRCm39) V314A probably damaging Het
Krt32 A T 11: 99,978,733 (GRCm39) V107D possibly damaging Het
Krtap5-1 G A 7: 141,850,242 (GRCm39) Q189* probably null Het
Lrrc9 A G 12: 72,553,178 (GRCm39) E1360G probably damaging Het
Mdc1 G T 17: 36,157,083 (GRCm39) L163F possibly damaging Het
Mroh1 T G 15: 76,276,661 (GRCm39) probably null Het
Myh8 A G 11: 67,192,418 (GRCm39) probably benign Het
Ndufab1 A T 7: 121,692,949 (GRCm39) probably benign Het
Nek3 A G 8: 22,648,735 (GRCm39) probably benign Het
Ngly1 A T 14: 16,260,636 (GRCm38) I107L probably benign Het
Nkain4 A T 2: 180,577,728 (GRCm39) probably null Het
Nsd2 T A 5: 34,022,132 (GRCm39) probably benign Het
Or4n4 A G 14: 50,518,801 (GRCm39) I303T probably benign Het
Or5e1 A T 7: 108,354,830 (GRCm39) M256L probably benign Het
Or5t9 A T 2: 86,659,300 (GRCm39) H68L probably damaging Het
Or7e166 T A 9: 19,624,314 (GRCm39) Y64N probably damaging Het
Or8b12 T A 9: 37,657,805 (GRCm39) I125N probably damaging Het
Pcnt G A 10: 76,248,417 (GRCm39) Q901* probably null Het
Pctp C A 11: 89,881,913 (GRCm39) W81C probably damaging Het
Pik3r5 A T 11: 68,386,773 (GRCm39) I801F probably damaging Het
Ptprj A T 2: 90,299,942 (GRCm39) N193K probably benign Het
Rab11fip1 A T 8: 27,642,788 (GRCm39) D670E probably benign Het
Racgap1 T C 15: 99,530,628 (GRCm39) K201E probably benign Het
Ranbp2 T C 10: 58,316,086 (GRCm39) F2269L probably damaging Het
Rint1 C A 5: 24,024,478 (GRCm39) A760D possibly damaging Het
Ryr2 G A 13: 11,680,848 (GRCm39) P3166S probably damaging Het
Snap29 A G 16: 17,240,367 (GRCm39) N158D probably benign Het
Speer4c1 A C 5: 15,919,214 (GRCm39) probably benign Het
St6galnac1 G T 11: 116,657,473 (GRCm39) probably benign Het
Strc G A 2: 121,209,717 (GRCm39) T202I probably damaging Het
Stxbp4 A G 11: 90,385,426 (GRCm39) probably null Het
Syne1 A T 10: 5,309,059 (GRCm39) M650K probably damaging Het
Tbc1d2b C T 9: 90,105,487 (GRCm39) probably benign Het
Tcfl5 A T 2: 180,280,419 (GRCm39) I328N possibly damaging Het
Tenm2 A G 11: 36,164,235 (GRCm39) Y337H probably damaging Het
Tgfbr2 T C 9: 115,939,204 (GRCm39) K233E possibly damaging Het
Tnk2 T C 16: 32,484,699 (GRCm39) probably benign Het
Trbv13-2 A G 6: 41,098,471 (GRCm39) probably benign Het
Tut4 T C 4: 108,370,725 (GRCm39) Y875H probably benign Het
Usp6nl T A 2: 6,432,360 (GRCm39) probably benign Het
Vmn2r62 A G 7: 42,437,396 (GRCm39) S363P possibly damaging Het
Vnn3 T C 10: 23,727,869 (GRCm39) I93T possibly damaging Het
Ylpm1 A G 12: 85,091,258 (GRCm39) D1108G probably damaging Het
Zbtb17 G A 4: 141,190,691 (GRCm39) G170S probably benign Het
Zfyve26 T C 12: 79,320,084 (GRCm39) E1087G probably benign Het
Other mutations in Dcp1a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01653:Dcp1a APN 14 30,227,528 (GRCm39) missense possibly damaging 0.52
IGL02698:Dcp1a APN 14 30,227,499 (GRCm39) splice site probably benign
R0240:Dcp1a UTSW 14 30,206,551 (GRCm39) splice site probably benign
R0387:Dcp1a UTSW 14 30,241,636 (GRCm39) critical splice donor site probably null
R0646:Dcp1a UTSW 14 30,224,842 (GRCm39) missense probably damaging 1.00
R1781:Dcp1a UTSW 14 30,235,032 (GRCm39) missense probably benign 0.37
R1843:Dcp1a UTSW 14 30,240,940 (GRCm39) missense probably damaging 0.99
R2111:Dcp1a UTSW 14 30,241,327 (GRCm39) missense probably benign 0.00
R3176:Dcp1a UTSW 14 30,227,499 (GRCm39) splice site probably benign
R4948:Dcp1a UTSW 14 30,201,724 (GRCm39) missense probably damaging 1.00
R5541:Dcp1a UTSW 14 30,224,796 (GRCm39) missense probably damaging 1.00
R6178:Dcp1a UTSW 14 30,245,261 (GRCm39) makesense probably null
R7767:Dcp1a UTSW 14 30,201,775 (GRCm39) critical splice donor site probably null
R7818:Dcp1a UTSW 14 30,201,678 (GRCm39) missense probably damaging 0.99
R8248:Dcp1a UTSW 14 30,244,883 (GRCm39) missense possibly damaging 0.87
R8248:Dcp1a UTSW 14 30,201,555 (GRCm39) intron probably benign
R8250:Dcp1a UTSW 14 30,244,883 (GRCm39) missense possibly damaging 0.87
R8271:Dcp1a UTSW 14 30,244,883 (GRCm39) missense possibly damaging 0.87
R8297:Dcp1a UTSW 14 30,244,883 (GRCm39) missense possibly damaging 0.87
R8302:Dcp1a UTSW 14 30,244,883 (GRCm39) missense possibly damaging 0.87
R8326:Dcp1a UTSW 14 30,241,527 (GRCm39) nonsense probably null
R8333:Dcp1a UTSW 14 30,244,883 (GRCm39) missense possibly damaging 0.87
R8818:Dcp1a UTSW 14 30,240,899 (GRCm39) missense possibly damaging 0.64
R9554:Dcp1a UTSW 14 30,201,691 (GRCm39) missense probably benign 0.01
R9599:Dcp1a UTSW 14 30,241,497 (GRCm39) missense probably benign
R9641:Dcp1a UTSW 14 30,241,132 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACTCAGGTTGACCCCACAG -3'
(R):5'- GCGTACAAGTCTACATGCCAAG -3'

Sequencing Primer
(F):5'- GGTTGACCCCACAGCATGAC -3'
(R):5'- GTCTACATGCCAAGATCAGTTACAG -3'
Posted On 2016-06-09