Incidental Mutation 'R5103:Or8d2b'
ID 392491
Institutional Source Beutler Lab
Gene Symbol Or8d2b
Ensembl Gene ENSMUSG00000064333
Gene Name olfactory receptor family 8 subfamily D member 2D
Synonyms MOR171-8, Olfr926, GA_x6K02T2PVTD-32573036-32573962
MMRRC Submission 042691-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R5103 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 38788474-38789400 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 38788872 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 133 (M133I)
Ref Sequence ENSEMBL: ENSMUSP00000077405 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078289]
AlphaFold Q9EQ98
Predicted Effect probably damaging
Transcript: ENSMUST00000078289
AA Change: M133I

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000077405
Gene: ENSMUSG00000064333
AA Change: M133I

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 2.9e-53 PFAM
Pfam:7TM_GPCR_Srsx 32 282 8.6e-7 PFAM
Pfam:7tm_1 38 287 1.6e-20 PFAM
Meta Mutation Damage Score 0.2199 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.5%
Validation Efficiency 99% (82/83)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl5 G A 5: 31,051,345 (GRCm39) R518H probably damaging Het
Agfg1 T C 1: 82,871,288 (GRCm39) S486P probably damaging Het
Arhgap18 A G 10: 26,745,978 (GRCm39) D283G probably damaging Het
Asb1 A G 1: 91,480,066 (GRCm39) N162S possibly damaging Het
Capn1 A G 19: 6,059,140 (GRCm39) Y274H probably damaging Het
Cdk5 A T 5: 24,627,833 (GRCm39) V30E probably damaging Het
Cep290 T G 10: 100,374,882 (GRCm39) L1376W probably damaging Het
Crybg1 T A 10: 43,873,944 (GRCm39) T1055S probably damaging Het
Cyp2c70 A G 19: 40,149,076 (GRCm39) Y357H probably damaging Het
Dlx6 AGG AG 6: 6,865,180 (GRCm39) probably null Het
Eml6 T A 11: 29,800,905 (GRCm39) E367V possibly damaging Het
Emp1 A G 6: 135,358,073 (GRCm39) T140A probably benign Het
Ergic3 T C 2: 155,850,545 (GRCm39) V74A probably benign Het
Fancm A T 12: 65,152,632 (GRCm39) L1029F probably damaging Het
Fank1 C A 7: 133,478,570 (GRCm39) C210* probably null Het
Fbxo31 T C 8: 122,279,101 (GRCm39) D462G probably damaging Het
Frem1 G A 4: 82,909,849 (GRCm39) A736V probably benign Het
Fshr T C 17: 89,404,796 (GRCm39) T56A possibly damaging Het
Gm5901 A T 7: 105,026,589 (GRCm39) probably null Het
Golga2 A G 2: 32,193,758 (GRCm39) E458G probably benign Het
Grik2 T A 10: 49,372,205 (GRCm39) I335F probably benign Het
Grin1 T A 2: 25,200,433 (GRCm39) M230L probably benign Het
Gtf2f1 C T 17: 57,311,519 (GRCm39) G297D probably damaging Het
H2-T5 T C 17: 36,472,577 (GRCm39) probably benign Het
Hacd1 T C 2: 14,045,724 (GRCm39) T136A probably damaging Het
Hdac5 T A 11: 102,087,109 (GRCm39) S24C probably damaging Het
Jtb T C 3: 90,139,394 (GRCm39) probably benign Het
Kif1a C T 1: 92,974,418 (GRCm39) G979E probably damaging Het
Mark2 T C 19: 7,261,868 (GRCm39) M345V probably damaging Het
Mfsd14b A G 13: 65,234,907 (GRCm39) V90A possibly damaging Het
Micu1 T C 10: 59,624,806 (GRCm39) Y283H possibly damaging Het
Mmp2 C T 8: 93,558,413 (GRCm39) R161* probably null Het
Mrpl2 G A 17: 46,960,964 (GRCm39) R286Q probably benign Het
Msh5 T C 17: 35,248,215 (GRCm39) I783V possibly damaging Het
Myo3b T A 2: 69,926,747 (GRCm39) F65I probably benign Het
Nat10 C A 2: 103,587,605 (GRCm39) V37L probably damaging Het
Nlrp1a T A 11: 70,990,352 (GRCm39) T967S probably damaging Het
Nolc1 A T 19: 46,070,103 (GRCm39) K291* probably null Het
Or1j18 A T 2: 36,624,680 (GRCm39) T116S probably benign Het
Or2n1c A C 17: 38,519,208 (GRCm39) E24A possibly damaging Het
Or8u8 C A 2: 86,011,960 (GRCm39) R165L probably benign Het
Paip1 A G 13: 119,574,515 (GRCm39) E70G possibly damaging Het
Palmd T A 3: 116,721,070 (GRCm39) E127V probably damaging Het
Paqr6 T A 3: 88,275,024 (GRCm39) C262* probably null Het
Pdcd11 A G 19: 47,112,893 (GRCm39) H1301R probably benign Het
Plce1 C A 19: 38,755,659 (GRCm39) D1896E probably damaging Het
Ppib A G 9: 65,968,747 (GRCm39) probably null Het
Pzp C T 6: 128,479,192 (GRCm39) V654M probably benign Het
Rab26 T C 17: 24,753,071 (GRCm39) probably benign Het
Recql4 A G 15: 76,590,956 (GRCm39) L468P probably damaging Het
Retreg1 C T 15: 25,968,540 (GRCm39) Q65* probably null Het
Rhpn1 C T 15: 75,586,064 (GRCm39) T659I possibly damaging Het
Rmc1 A G 18: 12,322,319 (GRCm39) I591V probably benign Het
Slc12a5 C A 2: 164,834,353 (GRCm39) H791Q probably damaging Het
Slc40a1 G A 1: 45,958,155 (GRCm39) Q93* probably null Het
Slc4a1 T C 11: 102,244,087 (GRCm39) M681V possibly damaging Het
Slc6a9 T A 4: 117,725,352 (GRCm39) F493L probably benign Het
Smc2 A G 4: 52,459,033 (GRCm39) E476G probably damaging Het
Smco4 G T 9: 15,456,090 (GRCm39) E59* probably null Het
Sparcl1 C T 5: 104,233,629 (GRCm39) M573I probably damaging Het
Stat4 T A 1: 52,111,054 (GRCm39) L167Q probably damaging Het
Sult1e1 C A 5: 87,724,091 (GRCm39) V289L probably benign Het
Tbc1d4 C A 14: 101,696,318 (GRCm39) E877* probably null Het
Tenm4 A T 7: 96,492,164 (GRCm39) I1033F probably damaging Het
Tppp2 T A 14: 52,156,909 (GRCm39) F95L probably benign Het
Trappc14 A G 5: 138,260,562 (GRCm39) V288A probably benign Het
Vmn2r41 G A 7: 8,141,341 (GRCm39) L708F probably benign Het
Washc5 G A 15: 59,222,018 (GRCm39) P126L probably damaging Het
Xkr4 T C 1: 3,740,911 (GRCm39) I221V probably benign Het
Xkr5 T C 8: 18,983,659 (GRCm39) R628G probably benign Het
Zfp207 T C 11: 80,282,736 (GRCm39) L233P probably damaging Het
Zfp827 T A 8: 79,797,032 (GRCm39) C373S probably damaging Het
Other mutations in Or8d2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01886:Or8d2b APN 9 38,788,844 (GRCm39) missense probably damaging 0.97
IGL02315:Or8d2b APN 9 38,789,353 (GRCm39) missense probably damaging 1.00
IGL02626:Or8d2b APN 9 38,788,784 (GRCm39) missense probably benign 0.05
IGL03001:Or8d2b APN 9 38,789,374 (GRCm39) missense probably benign
IGL03085:Or8d2b APN 9 38,788,959 (GRCm39) missense probably benign
R0365:Or8d2b UTSW 9 38,788,481 (GRCm39) missense probably benign 0.00
R0600:Or8d2b UTSW 9 38,789,111 (GRCm39) missense probably damaging 0.99
R0708:Or8d2b UTSW 9 38,788,571 (GRCm39) missense probably damaging 0.97
R1178:Or8d2b UTSW 9 38,789,051 (GRCm39) missense probably damaging 1.00
R1762:Or8d2b UTSW 9 38,789,081 (GRCm39) missense probably damaging 0.98
R1856:Or8d2b UTSW 9 38,788,892 (GRCm39) missense possibly damaging 0.58
R1924:Or8d2b UTSW 9 38,789,147 (GRCm39) missense probably damaging 1.00
R2267:Or8d2b UTSW 9 38,789,359 (GRCm39) missense probably benign 0.00
R3729:Or8d2b UTSW 9 38,788,547 (GRCm39) missense probably damaging 1.00
R4290:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4292:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4293:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4295:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4973:Or8d2b UTSW 9 38,789,400 (GRCm39) makesense probably null
R5026:Or8d2b UTSW 9 38,789,195 (GRCm39) missense possibly damaging 0.95
R5086:Or8d2b UTSW 9 38,789,087 (GRCm39) missense probably damaging 1.00
R5817:Or8d2b UTSW 9 38,788,673 (GRCm39) missense probably damaging 1.00
R5998:Or8d2b UTSW 9 38,789,165 (GRCm39) missense probably damaging 0.99
R6101:Or8d2b UTSW 9 38,788,604 (GRCm39) missense possibly damaging 0.95
R6105:Or8d2b UTSW 9 38,788,604 (GRCm39) missense possibly damaging 0.95
R6176:Or8d2b UTSW 9 38,788,673 (GRCm39) missense probably damaging 1.00
R6403:Or8d2b UTSW 9 38,788,538 (GRCm39) missense probably damaging 0.97
R8116:Or8d2b UTSW 9 38,789,026 (GRCm39) missense probably damaging 0.98
R8144:Or8d2b UTSW 9 38,788,662 (GRCm39) missense probably damaging 1.00
R8972:Or8d2b UTSW 9 38,789,150 (GRCm39) missense probably benign 0.00
R9520:Or8d2b UTSW 9 38,789,039 (GRCm39) missense probably benign 0.22
R9550:Or8d2b UTSW 9 38,788,937 (GRCm39) missense probably benign 0.00
R9614:Or8d2b UTSW 9 38,789,281 (GRCm39) missense probably damaging 0.98
RF014:Or8d2b UTSW 9 38,789,196 (GRCm39) missense probably benign 0.14
X0022:Or8d2b UTSW 9 38,788,952 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- CCTCTGTCATTACACCAAAGATG -3'
(R):5'- ATGACAGCCAGTGTAGGTGC -3'

Sequencing Primer
(F):5'- CAAAGATGTTGGTGAACTTTGTATG -3'
(R):5'- AGGTGCTAGGGTATTAACTCCACC -3'
Posted On 2016-06-15