Incidental Mutation 'R0443:Kcnk15'
ID 39261
Institutional Source Beutler Lab
Gene Symbol Kcnk15
Ensembl Gene ENSMUSG00000035238
Gene Name potassium channel, subfamily K, member 15
Synonyms KCNK11, KT3.3, TASK5, KCNK14
MMRRC Submission 038644-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R0443 (G1)
Quality Score 210
Status Validated (trace)
Chromosome 2
Chromosomal Location 163695670-163700794 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 163700243 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 161 (T161A)
Ref Sequence ENSEMBL: ENSMUSP00000048326 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044734] [ENSMUST00000044798] [ENSMUST00000109396]
AlphaFold B2RVL1
Predicted Effect probably benign
Transcript: ENSMUST00000044734
SMART Domains Protein: ENSMUSP00000045637
Gene: ENSMUSG00000035226

DomainStartEndE-ValueType
C2 129 232 1.42e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000044798
AA Change: T161A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000048326
Gene: ENSMUSG00000035238
AA Change: T161A

DomainStartEndE-ValueType
Pfam:Ion_trans_2 78 153 1.2e-20 PFAM
Pfam:Ion_trans_2 184 267 1.2e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109396
AA Change: T142A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000105023
Gene: ENSMUSG00000035238
AA Change: T142A

DomainStartEndE-ValueType
Pfam:Ion_trans_2 62 134 5.2e-21 PFAM
Pfam:Ion_trans_2 165 248 1.6e-17 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 95.6%
Validation Efficiency 96% (52/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr3b G T 5: 26,053,409 (GRCm39) R246L probably damaging Het
Adam18 T C 8: 25,119,653 (GRCm39) probably null Het
Ankhd1 A G 18: 36,777,652 (GRCm39) S1612G possibly damaging Het
Caskin1 C T 17: 24,724,374 (GRCm39) A1054V probably damaging Het
Casz1 T C 4: 149,033,368 (GRCm39) V1380A possibly damaging Het
Ccn2 T C 10: 24,471,701 (GRCm39) probably benign Het
Cnot6l T G 5: 96,239,604 (GRCm39) probably benign Het
Crat T C 2: 30,293,640 (GRCm39) probably benign Het
Cux2 C T 5: 122,025,500 (GRCm39) R56H possibly damaging Het
Dst A G 1: 34,333,631 (GRCm39) probably null Het
Dync2h1 G T 9: 7,167,244 (GRCm39) probably null Het
Epg5 T C 18: 77,999,118 (GRCm39) probably benign Het
Ergic3 G A 2: 155,858,707 (GRCm39) V278M probably benign Het
Fam20b A T 1: 156,509,023 (GRCm39) D396E probably benign Het
Gapvd1 A G 2: 34,594,633 (GRCm39) probably benign Het
Golga1 A T 2: 38,908,453 (GRCm39) S749T probably damaging Het
Gsdma2 C T 11: 98,548,514 (GRCm39) T255I probably damaging Het
Itga1 T A 13: 115,128,996 (GRCm39) D554V probably benign Het
Itgam C T 7: 127,680,806 (GRCm39) A245V probably damaging Het
Map3k19 A T 1: 127,750,152 (GRCm39) N1066K probably benign Het
Ms4a6b A G 19: 11,499,044 (GRCm39) I53V possibly damaging Het
Mtf1 C T 4: 124,718,075 (GRCm39) probably benign Het
Neb T C 2: 52,051,489 (GRCm39) probably null Het
Nop9 A G 14: 55,991,205 (GRCm39) S621G probably benign Het
Or1e19 A G 11: 73,316,581 (GRCm39) V76A probably damaging Het
Or5p60 A G 7: 107,724,023 (GRCm39) V149A probably benign Het
Or9a2 T A 6: 41,748,829 (GRCm39) I135F possibly damaging Het
Pacs1 A T 19: 5,322,611 (GRCm39) Y102* probably null Het
Pcdhb10 A C 18: 37,545,485 (GRCm39) D187A probably damaging Het
Pih1d2 A G 9: 50,532,403 (GRCm39) R170G possibly damaging Het
Pikfyve A G 1: 65,235,865 (GRCm39) H179R probably damaging Het
Pknox1 A G 17: 31,811,193 (GRCm39) S156G probably damaging Het
Prkcz T A 4: 155,353,597 (GRCm39) D250V probably damaging Het
Psg16 T A 7: 16,829,088 (GRCm39) I224N probably benign Het
Ro60 A G 1: 143,641,661 (GRCm39) probably benign Het
Slc25a40 T A 5: 8,497,348 (GRCm39) S229T probably benign Het
Slc43a2 T C 11: 75,435,493 (GRCm39) probably benign Het
Snrnp40 C G 4: 130,271,836 (GRCm39) probably null Het
Tas2r129 G T 6: 132,928,159 (GRCm39) C32F probably benign Het
Tfap2d C T 1: 19,174,591 (GRCm39) R15C possibly damaging Het
Tonsl T C 15: 76,523,884 (GRCm39) S39G probably benign Het
Trpc2 A G 7: 101,742,727 (GRCm39) probably benign Het
Ttc17 A G 2: 94,208,439 (GRCm39) F144S probably benign Het
Twnk G T 19: 44,996,578 (GRCm39) G337V possibly damaging Het
Uvssa A G 5: 33,546,168 (GRCm39) R180G possibly damaging Het
Vmn1r197 T A 13: 22,512,241 (GRCm39) I54K possibly damaging Het
Vmn1r71 G A 7: 10,482,238 (GRCm39) T84I probably benign Het
Zbtb49 T C 5: 38,358,174 (GRCm39) E693G probably benign Het
Other mutations in Kcnk15
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0389:Kcnk15 UTSW 2 163,700,243 (GRCm39) missense probably benign 0.00
R1472:Kcnk15 UTSW 2 163,700,127 (GRCm39) missense probably damaging 1.00
R3722:Kcnk15 UTSW 2 163,700,214 (GRCm39) missense probably damaging 1.00
R3732:Kcnk15 UTSW 2 163,695,733 (GRCm39) missense probably benign 0.08
R3732:Kcnk15 UTSW 2 163,695,733 (GRCm39) missense probably benign 0.08
R4403:Kcnk15 UTSW 2 163,700,538 (GRCm39) missense probably damaging 1.00
R7090:Kcnk15 UTSW 2 163,700,637 (GRCm39) missense probably benign
R7588:Kcnk15 UTSW 2 163,700,226 (GRCm39) missense probably damaging 1.00
R8318:Kcnk15 UTSW 2 163,700,189 (GRCm39) missense probably damaging 1.00
R8987:Kcnk15 UTSW 2 163,700,217 (GRCm39) missense probably damaging 1.00
R9144:Kcnk15 UTSW 2 163,700,451 (GRCm39) missense probably benign 0.01
R9184:Kcnk15 UTSW 2 163,700,606 (GRCm39) missense probably benign 0.01
R9589:Kcnk15 UTSW 2 163,700,127 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTCCTCCACTGGGCAAAATTCTG -3'
(R):5'- ATCTCTCTGCAACGCCACGAAG -3'

Sequencing Primer
(F):5'- TGGCCCAACTGAATTCTGAG -3'
(R):5'- AAGTCGCCGAAGCCTATG -3'
Posted On 2013-05-23