Mutagenetix > Incidental Mutation

Incidental Mutation 'R5106:Vmn2r38'

392624

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r38

Ensembl Gene

ENSMUSG00000095773

Gene Name

vomeronasal 2, receptor 38

Synonyms

MMRRC Submission

042694-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R5106 (G1)

Quality Score

Status

Not validated

Chromosome

Chromosomal Location

9073835-9097881 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 9075170 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 738 (V738L)

Ref Sequence

ENSEMBL: ENSMUSP00000104194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108554]

AlphaFold

G3UYA8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000108554
AA Change: V738L

PolyPhen 2 Score 0.848 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000104194
Gene: ENSMUSG00000095773
AA Change: V738L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	3.5e-33	PFAM
Pfam:NCD3G	512	565	1.4e-20	PFAM
Pfam:7tm_3	598	833	6.4e-54	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 95.9%
20x: 91.0%

Validation Efficiency

100% (62/62)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
C1qtnf2	G	A	11: 43,486,053	R84Q	possibly damaging	Het
Carmil2	T	A	8: 105,694,006		probably null	Het
Cenpf	A	T	1: 189,683,808	C107S	probably benign	Het
Cideb	T	C	14: 55,754,525	M191V	probably benign	Het
Cope	C	A	8: 70,310,447	R213S	possibly damaging	Het
Ctcf	T	C	8: 105,681,498		probably benign	Het
Daam2	T	C	17: 49,476,461	Y647C	probably damaging	Het
Dlg2	T	C	7: 92,442,686	Y920H	probably damaging	Het
Dnase1l1	C	T	X: 74,277,038		probably null	Het
Fdps	C	A	3: 89,099,403	R127L	probably damaging	Het
G6pd2	C	T	5: 61,810,352	T490I	probably benign	Het
Gm6401	A	G	14: 41,965,506	M121T	probably damaging	Het
Gnl2	T	C	4: 125,053,536		probably null	Het
Gprc5c	G	T	11: 114,864,267	V257L	possibly damaging	Het
Gtf2a1l	A	G	17: 88,694,645	S310G	possibly damaging	Het
H2afy	A	G	13: 56,088,293	V213A	possibly damaging	Het
Igdcc4	T	C	9: 65,124,701	F500L	probably damaging	Het
Lgr4	A	T	2: 109,997,595	H207L	probably damaging	Het
Llcfc1	A	G	6: 41,685,376	M105V	probably benign	Het
Map2k3	A	G	11: 60,941,882	K18E	probably damaging	Het
Mccc1	T	A	3: 35,972,564	D528V	probably benign	Het
Nedd4l	C	T	18: 65,193,305	T568M	probably damaging	Het
Nr3c1	A	C	18: 39,486,601	I211S	possibly damaging	Het
Nudt5	C	T	2: 5,854,829		probably benign	Het
Olfr1176	T	C	2: 88,340,110	Y182H	probably benign	Het
Olfr704	T	A	7: 106,865,388	M136K	probably damaging	Het
Olfr771	T	C	10: 129,160,237	Y249C	probably damaging	Het
Olfr826	A	T	10: 130,180,308	S191T	probably benign	Het
Pcid2	A	T	8: 13,079,648	F326I	probably damaging	Het
Pcnt	A	T	10: 76,401,444	I1336N	probably damaging	Het
Pomk	T	C	8: 25,986,376	D50G	probably benign	Het
Ppp2r2a	T	C	14: 67,023,097	Y244C	probably damaging	Het
Ptprz1	A	G	6: 23,000,028	T706A	probably benign	Het
Rad54l	G	A	4: 116,099,764		probably benign	Het
Raph1	T	C	1: 60,533,300	D36G	probably damaging	Het
Rgs7	A	G	1: 175,076,850	S166P	possibly damaging	Het
Rnf183	C	G	4: 62,428,228	R111P	probably damaging	Het
Rp1l1	A	T	14: 64,027,946	D327V	probably damaging	Het
Rpl3l	A	G	17: 24,732,437	Y156C	probably damaging	Het
Slc25a54	G	T	3: 109,112,864	C398F	probably benign	Het
Slc39a2	A	G	14: 51,895,531	*310W	probably null	Het
Slit3	T	C	11: 35,612,367	C464R	probably damaging	Het
Smu1	A	T	4: 40,743,104	F345I	possibly damaging	Het
Ssc5d	T	A	7: 4,936,665	V700E	probably benign	Het
Stxbp3	T	C	3: 108,794,927	Y521C	probably benign	Het
Tenm4	T	C	7: 96,843,149	S1061P	probably damaging	Het
Thoc5	T	C	11: 4,910,630	S103P	probably damaging	Het
Tmem221	A	G	8: 71,555,878	F173L	probably benign	Het
Trit1	T	C	4: 123,054,313		probably benign	Het
Ttc23l	G	T	15: 10,551,550	T30K	possibly damaging	Het
Vmn2r106	T	C	17: 20,279,133		probably null	Het
Zfp160	T	A	17: 21,026,761	H524Q	probably damaging	Het
Zfp791	T	A	8: 85,110,630	K202*	probably null	Het
Zfp985	T	A	4: 147,584,155	S493R	probably damaging	Het
Zkscan7	T	C	9: 122,896,133		probably benign	Het
Zwilch	A	C	9: 64,153,584	F329V	probably damaging	Het

Other mutations in Vmn2r38

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02805:Vmn2r38	APN	7	9075547	missense	probably damaging	0.99
IGL03199:Vmn2r38	APN	7	9075376	missense	probably damaging	1.00
R1619:Vmn2r38	UTSW	7	9075533	missense	probably damaging	1.00
R3154:Vmn2r38	UTSW	7	9094690	missense	probably benign	0.03
R3909:Vmn2r38	UTSW	7	9075554	missense	probably damaging	1.00
R4302:Vmn2r38	UTSW	7	9097563	splice site	probably null
R5187:Vmn2r38	UTSW	7	9097572	missense	probably benign	0.03
R5575:Vmn2r38	UTSW	7	9075636	nonsense	probably null
R5653:Vmn2r38	UTSW	7	9097765	start codon destroyed	probably null	1.00
R6156:Vmn2r38	UTSW	7	9094612	missense	probably damaging	0.99
R6970:Vmn2r38	UTSW	7	9075341	nonsense	probably null
R7107:Vmn2r38	UTSW	7	9090729	missense	probably benign	0.00
R7231:Vmn2r38	UTSW	7	9097638	missense	possibly damaging	0.88
R7419:Vmn2r38	UTSW	7	9075355	missense	probably damaging	1.00
R7963:Vmn2r38	UTSW	7	9092855	missense	probably benign	0.17
R8788:Vmn2r38	UTSW	7	9075483	missense	probably benign	0.02
R9639:Vmn2r38	UTSW	7	9075064	missense	probably damaging	0.96
R9773:Vmn2r38	UTSW	7	9094807	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACCTTGCCCTTGGTGCTATG -3'
(R):5'- ACAGTCACTGTGGTTCTTGC -3'

Sequencing Primer
(F):5'- CCCTTGGTGCTATGGTAGACAG -3'
(R):5'- GGTTCTTGCTTTCAAAGTCACAGAC -3'

Posted On

2016-06-15