Mutagenetix > Incidental Mutation

Incidental Mutation 'R5106:Tenm4'

392626

Institutional Source

Beutler Lab

Gene Symbol

Tenm4

Ensembl Gene

ENSMUSG00000048078

Gene Name

teneurin transmembrane protein 4

Synonyms

l7Rn3, Doc4, Ten-m4, ELM2, l(7)-3Rn, Odz4

MMRRC Submission

042694-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R5106 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

95820453-96560300 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 96492356 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 1061 (S1061P)

Ref Sequence

ENSEMBL: ENSMUSP00000102784 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107162] [ENSMUST00000107165] [ENSMUST00000107166]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000107162
AA Change: S1097P

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000102780
Gene: ENSMUSG00000048078
AA Change: S1097P

Domain	Start	End	E-Value	Type
Pfam:Ten_N	10	410	5.6e-195	PFAM
transmembrane domain	411	433	N/A	INTRINSIC
EGF_like	637	665	3.43e1	SMART
EGF	668	696	2.29e1	SMART
EGF	701	730	1.88e-1	SMART
EGF	733	762	1.13e1	SMART
EGF	767	797	2.39e1	SMART
EGF	800	828	4.32e-1	SMART
EGF	831	859	6.02e0	SMART
EGF	862	894	9.93e-1	SMART
low complexity region	900	914	N/A	INTRINSIC
Pfam:RHS_repeat	2327	2380	5.5e-7	PFAM
Pfam:Tox-GHH	2740	2818	5.2e-34	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000107165
AA Change: S1098P

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000102783
Gene: ENSMUSG00000048078
AA Change: S1098P

Domain	Start	End	E-Value	Type
Pfam:Ten_N	36	402	1.1e-171	PFAM
transmembrane domain	403	425	N/A	INTRINSIC
EGF_like	629	657	3.43e1	SMART
EGF	660	688	2.29e1	SMART
EGF	693	722	1.88e-1	SMART
EGF	725	754	1.13e1	SMART
EGF	759	789	2.39e1	SMART
EGF	792	820	4.32e-1	SMART
EGF	823	851	6.02e0	SMART
EGF	863	895	9.93e-1	SMART
low complexity region	901	915	N/A	INTRINSIC
Pfam:RHS_repeat	2335	2368	1.6e-7	PFAM
Pfam:Tox-GHH	2749	2826	1.8e-32	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000107166
AA Change: S1061P

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000102784
Gene: ENSMUSG00000048078
AA Change: S1061P

Domain	Start	End	E-Value	Type
Pfam:Ten_N	35	193	1.4e-83	PFAM
Pfam:Ten_N	187	365	5e-78	PFAM
transmembrane domain	366	388	N/A	INTRINSIC
EGF_like	592	620	3.43e1	SMART
EGF	623	651	2.29e1	SMART
EGF	656	685	1.88e-1	SMART
EGF	688	717	1.13e1	SMART
EGF	722	752	2.39e1	SMART
EGF	755	783	4.32e-1	SMART
EGF	786	814	6.02e0	SMART
EGF	826	858	9.93e-1	SMART
low complexity region	864	878	N/A	INTRINSIC
Pfam:RHS_repeat	2298	2351	3.8e-7	PFAM
Pfam:Tox-GHH	2711	2789	3.9e-34	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147659

Meta Mutation Damage Score

0.1256

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 95.9%
20x: 91.0%

Validation Efficiency

100% (62/62)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
PHENOTYPE: Various ENU-induced alleles cause prenatal lethality associated with impaired mesoderm development and lead to pleiotropic phenotypes. The most severe alleles cause failure of gastrulation and somitogenesis while the least severe one allows survival to adulthood with runting of variable penetrance. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
C1qtnf2	G	A	11: 43,376,880 (GRCm39)	R84Q	possibly damaging	Het
Carmil2	T	A	8: 106,420,638 (GRCm39)		probably null	Het
Cenpf	A	T	1: 189,416,005 (GRCm39)	C107S	probably benign	Het
Cideb	T	C	14: 55,991,982 (GRCm39)	M191V	probably benign	Het
Cope	C	A	8: 70,763,097 (GRCm39)	R213S	possibly damaging	Het
Ctcf	T	C	8: 106,408,130 (GRCm39)		probably benign	Het
Daam2	T	C	17: 49,783,489 (GRCm39)	Y647C	probably damaging	Het
Dlg2	T	C	7: 92,091,894 (GRCm39)	Y920H	probably damaging	Het
Dnase1l1	C	T	X: 73,320,644 (GRCm39)		probably null	Het
Fdps	C	A	3: 89,006,710 (GRCm39)	R127L	probably damaging	Het
G6pd2	C	T	5: 61,967,695 (GRCm39)	T490I	probably benign	Het
Gm6401	A	G	14: 41,787,463 (GRCm39)	M121T	probably damaging	Het
Gnl2	T	C	4: 124,947,329 (GRCm39)		probably null	Het
Gprc5c	G	T	11: 114,755,093 (GRCm39)	V257L	possibly damaging	Het
Gtf2a1l	A	G	17: 89,002,073 (GRCm39)	S310G	possibly damaging	Het
Igdcc4	T	C	9: 65,031,983 (GRCm39)	F500L	probably damaging	Het
Lgr4	A	T	2: 109,827,940 (GRCm39)	H207L	probably damaging	Het
Llcfc1	A	G	6: 41,662,310 (GRCm39)	M105V	probably benign	Het
Macroh2a1	A	G	13: 56,236,106 (GRCm39)	V213A	possibly damaging	Het
Map2k3	A	G	11: 60,832,708 (GRCm39)	K18E	probably damaging	Het
Mccc1	T	A	3: 36,026,713 (GRCm39)	D528V	probably benign	Het
Nedd4l	C	T	18: 65,326,376 (GRCm39)	T568M	probably damaging	Het
Nr3c1	A	C	18: 39,619,654 (GRCm39)	I211S	possibly damaging	Het
Nudt5	C	T	2: 5,859,640 (GRCm39)		probably benign	Het
Or2ag20	T	A	7: 106,464,595 (GRCm39)	M136K	probably damaging	Het
Or5d46	T	C	2: 88,170,454 (GRCm39)	Y182H	probably benign	Het
Or6c202	T	C	10: 128,996,106 (GRCm39)	Y249C	probably damaging	Het
Or9k2b	A	T	10: 130,016,177 (GRCm39)	S191T	probably benign	Het
Pcid2	A	T	8: 13,129,648 (GRCm39)	F326I	probably damaging	Het
Pcnt	A	T	10: 76,237,278 (GRCm39)	I1336N	probably damaging	Het
Pomk	T	C	8: 26,476,404 (GRCm39)	D50G	probably benign	Het
Ppp2r2a	T	C	14: 67,260,546 (GRCm39)	Y244C	probably damaging	Het
Ptprz1	A	G	6: 23,000,027 (GRCm39)	T706A	probably benign	Het
Rad54l	G	A	4: 115,956,961 (GRCm39)		probably benign	Het
Raph1	T	C	1: 60,572,459 (GRCm39)	D36G	probably damaging	Het
Rgs7	A	G	1: 174,904,416 (GRCm39)	S166P	possibly damaging	Het
Rnf183	C	G	4: 62,346,465 (GRCm39)	R111P	probably damaging	Het
Rp1l1	A	T	14: 64,265,395 (GRCm39)	D327V	probably damaging	Het
Rpl3l	A	G	17: 24,951,411 (GRCm39)	Y156C	probably damaging	Het
Slc25a54	G	T	3: 109,020,180 (GRCm39)	C398F	probably benign	Het
Slc39a2	A	G	14: 52,132,988 (GRCm39)	*310W	probably null	Het
Slit3	T	C	11: 35,503,194 (GRCm39)	C464R	probably damaging	Het
Smu1	A	T	4: 40,743,104 (GRCm39)	F345I	possibly damaging	Het
Ssc5d	T	A	7: 4,939,664 (GRCm39)	V700E	probably benign	Het
Stxbp3	T	C	3: 108,702,243 (GRCm39)	Y521C	probably benign	Het
Thoc5	T	C	11: 4,860,630 (GRCm39)	S103P	probably damaging	Het
Tmem221	A	G	8: 72,008,522 (GRCm39)	F173L	probably benign	Het
Trit1	T	C	4: 122,948,106 (GRCm39)		probably benign	Het
Ttc23l	G	T	15: 10,551,636 (GRCm39)	T30K	possibly damaging	Het
Vmn2r106	T	C	17: 20,499,395 (GRCm39)		probably null	Het
Vmn2r38	C	A	7: 9,078,169 (GRCm39)	V738L	possibly damaging	Het
Zfp160	T	A	17: 21,247,023 (GRCm39)	H524Q	probably damaging	Het
Zfp791	T	A	8: 85,837,259 (GRCm39)	K202*	probably null	Het
Zfp985	T	A	4: 147,668,612 (GRCm39)	S493R	probably damaging	Het
Zkscan7	T	C	9: 122,725,198 (GRCm39)		probably benign	Het
Zwilch	A	C	9: 64,060,866 (GRCm39)	F329V	probably damaging	Het

Other mutations in Tenm4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00228:Tenm4	APN	7	96,517,216 (GRCm39)	missense	probably benign	0.00
IGL00468:Tenm4	APN	7	96,523,679 (GRCm39)	missense	probably damaging	0.98
IGL00519:Tenm4	APN	7	96,454,345 (GRCm39)	splice site	probably benign
IGL00979:Tenm4	APN	7	96,378,598 (GRCm39)	missense	probably damaging	0.96
IGL01401:Tenm4	APN	7	96,523,474 (GRCm39)	missense	probably damaging	1.00
IGL01459:Tenm4	APN	7	96,378,592 (GRCm39)	missense	probably damaging	1.00
IGL01519:Tenm4	APN	7	96,544,384 (GRCm39)	missense	probably damaging	1.00
IGL01545:Tenm4	APN	7	96,523,510 (GRCm39)	missense	probably benign	0.00
IGL01579:Tenm4	APN	7	96,512,709 (GRCm39)	missense	probably benign	0.00
IGL01587:Tenm4	APN	7	96,512,709 (GRCm39)	missense	probably benign	0.00
IGL01625:Tenm4	APN	7	96,534,565 (GRCm39)	missense	probably damaging	1.00
IGL01655:Tenm4	APN	7	96,202,931 (GRCm39)	missense	probably damaging	1.00
IGL01683:Tenm4	APN	7	96,534,611 (GRCm39)	missense	possibly damaging	0.84
IGL01728:Tenm4	APN	7	96,545,271 (GRCm39)	missense	probably damaging	1.00
IGL01732:Tenm4	APN	7	96,544,716 (GRCm39)	missense	probably damaging	1.00
IGL01924:Tenm4	APN	7	96,544,419 (GRCm39)	missense	probably damaging	1.00
IGL01966:Tenm4	APN	7	96,202,757 (GRCm39)	missense	probably damaging	1.00
IGL02177:Tenm4	APN	7	96,544,869 (GRCm39)	missense	probably benign	0.40
IGL02207:Tenm4	APN	7	96,523,323 (GRCm39)	missense	possibly damaging	0.85
IGL02269:Tenm4	APN	7	96,473,029 (GRCm39)	missense	probably damaging	1.00
IGL02274:Tenm4	APN	7	96,503,941 (GRCm39)	missense	probably damaging	1.00
IGL02375:Tenm4	APN	7	96,353,344 (GRCm39)	missense	possibly damaging	0.52
IGL02415:Tenm4	APN	7	96,523,281 (GRCm39)	missense	probably damaging	0.98
IGL02472:Tenm4	APN	7	96,423,383 (GRCm39)	unclassified	probably benign
IGL02656:Tenm4	APN	7	96,534,640 (GRCm39)	missense	probably damaging	1.00
IGL02678:Tenm4	APN	7	96,545,426 (GRCm39)	missense	probably damaging	1.00
IGL02829:Tenm4	APN	7	96,544,205 (GRCm39)	nonsense	probably null
IGL02863:Tenm4	APN	7	96,522,913 (GRCm39)	missense	probably damaging	1.00
IGL03145:Tenm4	APN	7	96,492,175 (GRCm39)	missense	probably damaging	0.98
IGL03153:Tenm4	APN	7	96,522,969 (GRCm39)	missense	probably damaging	1.00
principium	UTSW	7	96,446,688 (GRCm39)	missense	probably damaging	0.98
toccata	UTSW	7	96,552,196 (GRCm39)	critical splice donor site	probably null
P0026:Tenm4	UTSW	7	96,523,734 (GRCm39)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,542,133 (GRCm39)	missense	probably damaging	1.00
R0097:Tenm4	UTSW	7	96,542,133 (GRCm39)	missense	probably damaging	1.00
R0140:Tenm4	UTSW	7	96,545,259 (GRCm39)	missense	possibly damaging	0.78
R0164:Tenm4	UTSW	7	96,378,547 (GRCm39)	splice site	probably benign
R0277:Tenm4	UTSW	7	96,344,157 (GRCm39)	missense	possibly damaging	0.54
R0323:Tenm4	UTSW	7	96,344,157 (GRCm39)	missense	possibly damaging	0.54
R0362:Tenm4	UTSW	7	96,421,242 (GRCm39)	nonsense	probably null
R0381:Tenm4	UTSW	7	96,555,088 (GRCm39)	missense	probably damaging	1.00
R0420:Tenm4	UTSW	7	96,522,973 (GRCm39)	missense	possibly damaging	0.85
R0426:Tenm4	UTSW	7	96,427,058 (GRCm39)	missense	probably damaging	1.00
R0513:Tenm4	UTSW	7	96,544,830 (GRCm39)	missense	probably benign	0.35
R0624:Tenm4	UTSW	7	96,423,227 (GRCm39)	missense	probably damaging	1.00
R0837:Tenm4	UTSW	7	96,545,482 (GRCm39)	splice site	probably benign
R1037:Tenm4	UTSW	7	96,446,688 (GRCm39)	missense	probably damaging	0.98
R1172:Tenm4	UTSW	7	96,497,251 (GRCm39)	missense	probably damaging	1.00
R1422:Tenm4	UTSW	7	96,199,258 (GRCm39)	missense	probably damaging	0.99
R1427:Tenm4	UTSW	7	96,492,255 (GRCm39)	missense	probably benign	0.42
R1462:Tenm4	UTSW	7	96,353,360 (GRCm39)	missense	probably damaging	1.00
R1462:Tenm4	UTSW	7	96,353,360 (GRCm39)	missense	probably damaging	1.00
R1597:Tenm4	UTSW	7	96,552,196 (GRCm39)	critical splice donor site	probably null
R1701:Tenm4	UTSW	7	96,552,096 (GRCm39)	missense	probably damaging	1.00
R1707:Tenm4	UTSW	7	96,537,892 (GRCm39)	missense	probably damaging	1.00
R1809:Tenm4	UTSW	7	96,522,987 (GRCm39)	missense	probably benign	0.17
R1812:Tenm4	UTSW	7	96,545,147 (GRCm39)	missense	probably damaging	1.00
R1895:Tenm4	UTSW	7	96,385,015 (GRCm39)	missense	probably damaging	1.00
R1933:Tenm4	UTSW	7	96,544,533 (GRCm39)	missense	probably damaging	1.00
R1946:Tenm4	UTSW	7	96,385,015 (GRCm39)	missense	probably damaging	1.00
R2108:Tenm4	UTSW	7	96,555,497 (GRCm39)	missense	probably damaging	1.00
R2151:Tenm4	UTSW	7	96,552,054 (GRCm39)	missense	probably damaging	1.00
R2247:Tenm4	UTSW	7	96,555,216 (GRCm39)	missense	probably benign	0.03
R2329:Tenm4	UTSW	7	96,545,069 (GRCm39)	missense	probably benign	0.00
R2893:Tenm4	UTSW	7	96,544,197 (GRCm39)	missense	probably damaging	1.00
R2990:Tenm4	UTSW	7	96,542,332 (GRCm39)	splice site	probably null
R3409:Tenm4	UTSW	7	96,544,367 (GRCm39)	missense	probably damaging	1.00
R3410:Tenm4	UTSW	7	96,501,737 (GRCm39)	missense	probably damaging	0.99
R3411:Tenm4	UTSW	7	96,501,737 (GRCm39)	missense	probably damaging	0.99
R3440:Tenm4	UTSW	7	96,202,723 (GRCm39)	missense	probably benign	0.00
R3441:Tenm4	UTSW	7	96,202,723 (GRCm39)	missense	probably benign	0.00
R3719:Tenm4	UTSW	7	96,512,770 (GRCm39)	missense	possibly damaging	0.92
R3772:Tenm4	UTSW	7	96,344,087 (GRCm39)	missense	probably damaging	1.00
R3773:Tenm4	UTSW	7	96,344,087 (GRCm39)	missense	probably damaging	1.00
R4093:Tenm4	UTSW	7	96,544,979 (GRCm39)	missense	probably damaging	1.00
R4439:Tenm4	UTSW	7	96,545,022 (GRCm39)	missense	probably benign	0.01
R4441:Tenm4	UTSW	7	96,545,022 (GRCm39)	missense	probably benign	0.01
R4510:Tenm4	UTSW	7	96,544,070 (GRCm39)	missense	probably benign
R4511:Tenm4	UTSW	7	96,544,070 (GRCm39)	missense	probably benign
R4543:Tenm4	UTSW	7	96,545,022 (GRCm39)	missense	probably benign	0.01
R4645:Tenm4	UTSW	7	96,544,949 (GRCm39)	missense	probably damaging	1.00
R4701:Tenm4	UTSW	7	96,544,556 (GRCm39)	missense	probably damaging	1.00
R4707:Tenm4	UTSW	7	96,423,253 (GRCm39)	missense	probably damaging	0.99
R4714:Tenm4	UTSW	7	96,544,131 (GRCm39)	missense	probably damaging	1.00
R4742:Tenm4	UTSW	7	96,446,691 (GRCm39)	missense	probably damaging	0.99
R4784:Tenm4	UTSW	7	96,423,253 (GRCm39)	missense	probably damaging	0.99
R4785:Tenm4	UTSW	7	96,423,253 (GRCm39)	missense	probably damaging	0.99
R4801:Tenm4	UTSW	7	96,555,452 (GRCm39)	missense	probably damaging	0.97
R4802:Tenm4	UTSW	7	96,555,452 (GRCm39)	missense	probably damaging	0.97
R4880:Tenm4	UTSW	7	96,555,025 (GRCm39)	splice site	probably null
R5036:Tenm4	UTSW	7	96,501,768 (GRCm39)	missense	probably damaging	1.00
R5036:Tenm4	UTSW	7	96,343,997 (GRCm39)	missense	probably damaging	1.00
R5050:Tenm4	UTSW	7	96,544,995 (GRCm39)	missense	probably damaging	1.00
R5103:Tenm4	UTSW	7	96,492,164 (GRCm39)	missense	probably damaging	1.00
R5118:Tenm4	UTSW	7	96,542,293 (GRCm39)	missense	probably damaging	1.00
R5272:Tenm4	UTSW	7	96,523,410 (GRCm39)	missense	probably damaging	0.98
R5282:Tenm4	UTSW	7	96,486,538 (GRCm39)	missense	possibly damaging	0.90
R5403:Tenm4	UTSW	7	96,538,034 (GRCm39)	missense	probably damaging	1.00
R5404:Tenm4	UTSW	7	96,543,887 (GRCm39)	missense	probably damaging	1.00
R5567:Tenm4	UTSW	7	96,545,416 (GRCm39)	nonsense	probably null
R5590:Tenm4	UTSW	7	96,446,608 (GRCm39)	missense	possibly damaging	0.93
R5590:Tenm4	UTSW	7	96,446,607 (GRCm39)	missense	possibly damaging	0.73
R5597:Tenm4	UTSW	7	96,202,724 (GRCm39)	missense	probably benign	0.00
R5782:Tenm4	UTSW	7	96,542,246 (GRCm39)	missense	probably benign	0.00
R5861:Tenm4	UTSW	7	96,492,424 (GRCm39)	intron	probably benign
R5890:Tenm4	UTSW	7	96,552,067 (GRCm39)	missense	probably damaging	1.00
R5930:Tenm4	UTSW	7	96,503,926 (GRCm39)	missense	probably damaging	1.00
R5940:Tenm4	UTSW	7	96,495,102 (GRCm39)	missense	probably damaging	1.00
R6012:Tenm4	UTSW	7	96,171,640 (GRCm39)	intron	probably benign
R6060:Tenm4	UTSW	7	96,522,918 (GRCm39)	missense	probably damaging	1.00
R6104:Tenm4	UTSW	7	96,486,496 (GRCm39)	missense	probably damaging	0.97
R6283:Tenm4	UTSW	7	96,523,701 (GRCm39)	missense	probably benign	0.33
R6333:Tenm4	UTSW	7	96,423,331 (GRCm39)	missense	probably damaging	1.00
R6522:Tenm4	UTSW	7	96,492,251 (GRCm39)	missense	possibly damaging	0.88
R6616:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6746:Tenm4	UTSW	7	96,542,067 (GRCm39)	missense	probably damaging	1.00
R6751:Tenm4	UTSW	7	96,494,919 (GRCm39)	missense	possibly damaging	0.95
R6806:Tenm4	UTSW	7	96,461,166 (GRCm39)	missense	possibly damaging	0.95
R6807:Tenm4	UTSW	7	96,544,478 (GRCm39)	missense	probably damaging	1.00
R6807:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6809:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6810:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6811:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6853:Tenm4	UTSW	7	96,486,502 (GRCm39)	missense	possibly damaging	0.94
R6886:Tenm4	UTSW	7	96,446,599 (GRCm39)	missense	possibly damaging	0.85
R6920:Tenm4	UTSW	7	96,544,757 (GRCm39)	missense	probably damaging	1.00
R6937:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R6939:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7011:Tenm4	UTSW	7	96,545,342 (GRCm39)	nonsense	probably null
R7033:Tenm4	UTSW	7	96,544,430 (GRCm39)	nonsense	probably null
R7040:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7083:Tenm4	UTSW	7	96,544,556 (GRCm39)	missense	probably damaging	1.00
R7238:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7239:Tenm4	UTSW	7	96,385,020 (GRCm39)	missense	possibly damaging	0.47
R7239:Tenm4	UTSW	7	96,202,703 (GRCm39)	missense	probably benign	0.01
R7337:Tenm4	UTSW	7	96,523,333 (GRCm39)	missense	probably benign	0.44
R7400:Tenm4	UTSW	7	96,344,010 (GRCm39)	missense	probably damaging	0.97
R7407:Tenm4	UTSW	7	96,423,194 (GRCm39)	missense	possibly damaging	0.89
R7449:Tenm4	UTSW	7	96,523,420 (GRCm39)	missense	possibly damaging	0.65
R7473:Tenm4	UTSW	7	96,423,353 (GRCm39)	missense	probably damaging	1.00
R7477:Tenm4	UTSW	7	96,495,015 (GRCm39)	missense	probably damaging	0.99
R7489:Tenm4	UTSW	7	96,486,521 (GRCm39)	missense	possibly damaging	0.90
R7498:Tenm4	UTSW	7	96,497,224 (GRCm39)	missense	probably damaging	1.00
R7562:Tenm4	UTSW	7	96,538,021 (GRCm39)	missense	probably damaging	1.00
R7615:Tenm4	UTSW	7	96,495,133 (GRCm39)	missense	probably damaging	1.00
R7624:Tenm4	UTSW	7	96,545,192 (GRCm39)	missense	possibly damaging	0.95
R7626:Tenm4	UTSW	7	96,542,221 (GRCm39)	missense	probably damaging	1.00
R7690:Tenm4	UTSW	7	96,512,740 (GRCm39)	missense	probably benign	0.00
R7692:Tenm4	UTSW	7	96,544,610 (GRCm39)	missense	probably damaging	1.00
R7748:Tenm4	UTSW	7	96,543,909 (GRCm39)	missense	probably damaging	1.00
R7763:Tenm4	UTSW	7	96,544,899 (GRCm39)	missense	probably benign	0.38
R7792:Tenm4	UTSW	7	96,423,221 (GRCm39)	missense	possibly damaging	0.54
R7855:Tenm4	UTSW	7	96,523,081 (GRCm39)	missense	probably damaging	1.00
R7868:Tenm4	UTSW	7	96,555,587 (GRCm39)	missense	possibly damaging	0.79
R7878:Tenm4	UTSW	7	96,501,564 (GRCm39)	missense	probably damaging	1.00
R7997:Tenm4	UTSW	7	96,523,512 (GRCm39)	missense	probably benign	0.44
R8017:Tenm4	UTSW	7	96,353,248 (GRCm39)	missense	probably damaging	1.00
R8019:Tenm4	UTSW	7	96,353,248 (GRCm39)	missense	probably damaging	1.00
R8054:Tenm4	UTSW	7	96,378,553 (GRCm39)	splice site	probably benign
R8061:Tenm4	UTSW	7	96,501,663 (GRCm39)	missense	probably damaging	1.00
R8108:Tenm4	UTSW	7	96,503,935 (GRCm39)	missense	probably benign	0.39
R8140:Tenm4	UTSW	7	96,544,383 (GRCm39)	missense	probably damaging	1.00
R8214:Tenm4	UTSW	7	96,544,614 (GRCm39)	missense	probably damaging	1.00
R8258:Tenm4	UTSW	7	96,517,198 (GRCm39)	missense	probably damaging	1.00
R8259:Tenm4	UTSW	7	96,517,198 (GRCm39)	missense	probably damaging	1.00
R8364:Tenm4	UTSW	7	96,421,313 (GRCm39)	critical splice donor site	probably null
R8542:Tenm4	UTSW	7	96,461,139 (GRCm39)	missense	probably damaging	0.99
R8669:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8670:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8683:Tenm4	UTSW	7	96,552,064 (GRCm39)	missense	probably damaging	0.99
R8691:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8692:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8714:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8716:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8735:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8736:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8737:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8738:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8738:Tenm4	UTSW	7	96,523,047 (GRCm39)	missense	probably damaging	1.00
R8739:Tenm4	UTSW	7	96,555,148 (GRCm39)	missense	probably benign
R8776:Tenm4	UTSW	7	96,544,239 (GRCm39)	missense	probably damaging	1.00
R8776-TAIL:Tenm4	UTSW	7	96,544,239 (GRCm39)	missense	probably damaging	1.00
R8777:Tenm4	UTSW	7	96,545,244 (GRCm39)	missense	probably damaging	1.00
R8777-TAIL:Tenm4	UTSW	7	96,545,244 (GRCm39)	missense	probably damaging	1.00
R8817:Tenm4	UTSW	7	96,523,335 (GRCm39)	missense	probably benign	0.01
R8851:Tenm4	UTSW	7	96,501,710 (GRCm39)	missense	probably damaging	1.00
R8913:Tenm4	UTSW	7	96,351,952 (GRCm39)	splice site	probably benign
R8977:Tenm4	UTSW	7	96,461,177 (GRCm39)	missense	probably damaging	1.00
R9100:Tenm4	UTSW	7	96,495,061 (GRCm39)	missense	probably damaging	1.00
R9136:Tenm4	UTSW	7	96,473,125 (GRCm39)	missense	possibly damaging	0.69
R9163:Tenm4	UTSW	7	96,473,080 (GRCm39)	missense	probably damaging	1.00
R9188:Tenm4	UTSW	7	96,421,234 (GRCm39)	missense	probably damaging	1.00
R9195:Tenm4	UTSW	7	96,542,126 (GRCm39)	missense	probably damaging	1.00
R9217:Tenm4	UTSW	7	96,534,646 (GRCm39)	missense	probably damaging	1.00
R9344:Tenm4	UTSW	7	96,545,352 (GRCm39)	missense	probably damaging	1.00
R9414:Tenm4	UTSW	7	96,545,367 (GRCm39)	missense	probably benign
R9466:Tenm4	UTSW	7	96,199,252 (GRCm39)	missense	possibly damaging	0.79
R9559:Tenm4	UTSW	7	96,473,056 (GRCm39)	missense	probably benign
R9626:Tenm4	UTSW	7	96,545,345 (GRCm39)	missense	probably damaging	1.00
R9673:Tenm4	UTSW	7	96,517,196 (GRCm39)	missense	probably damaging	1.00
R9676:Tenm4	UTSW	7	96,544,638 (GRCm39)	missense	probably damaging	1.00
R9678:Tenm4	UTSW	7	96,386,619 (GRCm39)	missense	possibly damaging	0.94
R9775:Tenm4	UTSW	7	96,555,761 (GRCm39)	missense	possibly damaging	0.92
R9790:Tenm4	UTSW	7	96,538,046 (GRCm39)	missense	probably damaging	1.00
R9791:Tenm4	UTSW	7	96,538,046 (GRCm39)	missense	probably damaging	1.00
R9803:Tenm4	UTSW	7	96,202,685 (GRCm39)	missense	probably damaging	1.00
X0021:Tenm4	UTSW	7	96,523,116 (GRCm39)	nonsense	probably null
X0026:Tenm4	UTSW	7	96,517,294 (GRCm39)	missense	probably damaging	0.98
X0066:Tenm4	UTSW	7	96,544,001 (GRCm39)	missense	probably damaging	1.00
X0066:Tenm4	UTSW	7	96,497,237 (GRCm39)	missense	probably damaging	1.00
Z1176:Tenm4	UTSW	7	96,555,121 (GRCm39)	missense	probably benign	0.00
Z1177:Tenm4	UTSW	7	96,512,792 (GRCm39)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- TCACAAATGGCGGCATCTC -3'
(R):5'- CCATGGTGCGATTTGGTAAAG -3'

Sequencing Primer
(F):5'- CCATCATCTTGAGATTCGAAAGGGC -3'
(R):5'- GCGATTTGGTAAAGTGGGC -3'

Posted On

2016-06-15