Incidental Mutation 'R5118:Micall2'
ID 392733
Institutional Source Beutler Lab
Gene Symbol Micall2
Ensembl Gene ENSMUSG00000036718
Gene Name MICAL-like 2
Synonyms MICAL-L2, Jrab, A930021H16Rik
MMRRC Submission 042706-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.352) question?
Stock # R5118 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 139692451-139722091 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 139702202 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 347 (T347M)
Ref Sequence ENSEMBL: ENSMUSP00000039707 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044642] [ENSMUST00000170773]
AlphaFold Q3TN34
Predicted Effect probably damaging
Transcript: ENSMUST00000044642
AA Change: T347M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000039707
Gene: ENSMUSG00000036718
AA Change: T347M

DomainStartEndE-ValueType
CH 3 102 4.34e-20 SMART
LIM 187 241 1.62e-5 SMART
low complexity region 242 253 N/A INTRINSIC
low complexity region 326 344 N/A INTRINSIC
low complexity region 428 489 N/A INTRINSIC
low complexity region 502 518 N/A INTRINSIC
low complexity region 728 746 N/A INTRINSIC
low complexity region 755 770 N/A INTRINSIC
DUF3585 840 980 3.1e-63 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000165645
Predicted Effect unknown
Transcript: ENSMUST00000170773
AA Change: T264M
SMART Domains Protein: ENSMUSP00000127937
Gene: ENSMUSG00000036718
AA Change: T264M

DomainStartEndE-ValueType
SCOP:d1bkra_ 1 25 9e-5 SMART
Blast:DUF3585 1 45 2e-7 BLAST
LIM 104 158 1.62e-5 SMART
low complexity region 159 170 N/A INTRINSIC
low complexity region 243 261 N/A INTRINSIC
low complexity region 345 406 N/A INTRINSIC
low complexity region 419 435 N/A INTRINSIC
low complexity region 645 663 N/A INTRINSIC
low complexity region 672 687 N/A INTRINSIC
DUF3585 757 897 3.1e-63 SMART
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.7%
Validation Efficiency 96% (52/54)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Adamts2 A G 11: 50,672,696 (GRCm39) E648G probably damaging Het
Ankrd55 A G 13: 112,492,473 (GRCm39) S187G probably benign Het
Cd44 C A 2: 102,695,715 (GRCm39) E52D probably damaging Het
Col6a5 T A 9: 105,814,204 (GRCm39) I603F unknown Het
Dmxl2 C A 9: 54,368,271 (GRCm39) R233L probably damaging Het
Dop1a T C 9: 86,388,312 (GRCm39) F429L probably damaging Het
Epsti1 T G 14: 78,224,122 (GRCm39) probably null Het
Erfe G T 1: 91,298,438 (GRCm39) probably null Het
Galnt5 A G 2: 57,905,015 (GRCm39) D526G probably damaging Het
Gatd1 A T 7: 140,986,719 (GRCm39) probably benign Het
Gm1330 T C 2: 148,844,906 (GRCm39) probably benign Het
Gm6181 G A 7: 52,405,364 (GRCm39) noncoding transcript Het
Irak2 T A 6: 113,642,772 (GRCm39) V68D probably benign Het
Kdm1a A G 4: 136,284,669 (GRCm39) probably benign Het
Kidins220 C A 12: 25,042,296 (GRCm39) Q198K probably damaging Het
Lgr5 A G 10: 115,288,244 (GRCm39) V728A possibly damaging Het
Mrap2 T C 9: 87,064,756 (GRCm39) F166L possibly damaging Het
Msh3 A T 13: 92,445,942 (GRCm39) probably benign Het
Mul1 T A 4: 138,166,660 (GRCm39) L238Q probably damaging Het
Nuak1 G T 10: 84,210,848 (GRCm39) H413Q probably benign Het
Or10j27 T C 1: 172,958,484 (GRCm39) Q100R possibly damaging Het
Pcnt C T 10: 76,248,002 (GRCm39) A931T probably damaging Het
Pramel20 T C 4: 143,297,697 (GRCm39) L39P probably damaging Het
Pramel34 T A 5: 93,785,656 (GRCm39) D208V probably benign Het
Psmb4 T C 3: 94,792,253 (GRCm39) Y223C probably damaging Het
Rbm15b G T 9: 106,763,301 (GRCm39) A289E possibly damaging Het
Reg3b T A 6: 78,349,111 (GRCm39) V79E probably damaging Het
Rsl1 A G 13: 67,330,045 (GRCm39) I164M probably damaging Het
Rtp1 T C 16: 23,250,285 (GRCm39) F217L probably benign Het
Sfmbt1 T C 14: 30,512,727 (GRCm39) L360P probably damaging Het
Sorbs2 T C 8: 46,248,822 (GRCm39) V611A probably damaging Het
Tenm4 T A 7: 96,542,293 (GRCm39) D1935E probably damaging Het
Tep1 T C 14: 51,093,044 (GRCm39) probably null Het
Tmppe T G 9: 114,234,549 (GRCm39) S283A probably benign Het
Tmtc1 A G 6: 148,171,485 (GRCm39) probably benign Het
Trp63 T C 16: 25,707,760 (GRCm39) I552T unknown Het
Tspan2 C A 3: 102,657,151 (GRCm39) D45E probably benign Het
Tut4 T A 4: 108,377,489 (GRCm39) D966E possibly damaging Het
Ubr1 T C 2: 120,712,745 (GRCm39) E1396G probably benign Het
Usp17lc A T 7: 103,067,868 (GRCm39) T388S probably benign Het
Wdr46 T C 17: 34,167,811 (GRCm39) V508A possibly damaging Het
Zfp462 T A 4: 55,010,667 (GRCm39) Y878N probably damaging Het
Zfp703 C T 8: 27,469,233 (GRCm39) P299L probably damaging Het
Zfp954 T A 7: 7,118,714 (GRCm39) T277S probably benign Het
Other mutations in Micall2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Micall2 APN 5 139,703,311 (GRCm39) critical splice acceptor site probably null
IGL00496:Micall2 APN 5 139,702,083 (GRCm39) missense probably benign 0.01
IGL02641:Micall2 APN 5 139,705,094 (GRCm39) missense probably damaging 1.00
IGL03245:Micall2 APN 5 139,705,014 (GRCm39) missense probably damaging 1.00
IGL03252:Micall2 APN 5 139,702,481 (GRCm39) missense probably benign 0.01
R1214:Micall2 UTSW 5 139,697,396 (GRCm39) missense probably damaging 0.97
R1468:Micall2 UTSW 5 139,705,097 (GRCm39) missense probably damaging 1.00
R1468:Micall2 UTSW 5 139,705,097 (GRCm39) missense probably damaging 1.00
R1831:Micall2 UTSW 5 139,702,508 (GRCm39) missense probably benign 0.09
R1833:Micall2 UTSW 5 139,702,508 (GRCm39) missense probably benign 0.09
R1969:Micall2 UTSW 5 139,721,885 (GRCm39) missense probably damaging 1.00
R2023:Micall2 UTSW 5 139,703,266 (GRCm39) missense possibly damaging 0.51
R2060:Micall2 UTSW 5 139,697,317 (GRCm39) missense probably damaging 0.98
R2330:Micall2 UTSW 5 139,703,270 (GRCm39) missense probably damaging 1.00
R3820:Micall2 UTSW 5 139,701,611 (GRCm39) missense possibly damaging 0.92
R4299:Micall2 UTSW 5 139,695,226 (GRCm39) intron probably benign
R4334:Micall2 UTSW 5 139,699,105 (GRCm39) missense probably damaging 1.00
R4451:Micall2 UTSW 5 139,692,852 (GRCm39) missense probably damaging 1.00
R4769:Micall2 UTSW 5 139,692,641 (GRCm39) missense probably damaging 0.97
R4911:Micall2 UTSW 5 139,702,580 (GRCm39) missense probably damaging 1.00
R4996:Micall2 UTSW 5 139,696,344 (GRCm39) missense probably benign 0.31
R5155:Micall2 UTSW 5 139,695,986 (GRCm39) missense probably damaging 1.00
R5475:Micall2 UTSW 5 139,702,224 (GRCm39) missense probably damaging 1.00
R5750:Micall2 UTSW 5 139,701,456 (GRCm39) splice site probably null
R5998:Micall2 UTSW 5 139,692,666 (GRCm39) critical splice acceptor site probably null
R6181:Micall2 UTSW 5 139,702,506 (GRCm39) missense probably benign 0.41
R6852:Micall2 UTSW 5 139,701,548 (GRCm39) missense possibly damaging 0.90
R7046:Micall2 UTSW 5 139,694,699 (GRCm39) unclassified probably benign
R7395:Micall2 UTSW 5 139,702,124 (GRCm39) missense possibly damaging 0.78
R8514:Micall2 UTSW 5 139,701,977 (GRCm39) missense probably damaging 1.00
R8889:Micall2 UTSW 5 139,703,254 (GRCm39) missense probably damaging 0.98
R8892:Micall2 UTSW 5 139,703,254 (GRCm39) missense probably damaging 0.98
R8960:Micall2 UTSW 5 139,702,025 (GRCm39) missense probably benign 0.23
R9060:Micall2 UTSW 5 139,705,035 (GRCm39) missense probably damaging 1.00
R9209:Micall2 UTSW 5 139,696,170 (GRCm39) missense unknown
R9227:Micall2 UTSW 5 139,701,827 (GRCm39) missense unknown
R9230:Micall2 UTSW 5 139,701,827 (GRCm39) missense unknown
R9260:Micall2 UTSW 5 139,695,453 (GRCm39) missense unknown
R9452:Micall2 UTSW 5 139,703,311 (GRCm39) critical splice acceptor site probably null
Z1088:Micall2 UTSW 5 139,702,050 (GRCm39) missense probably benign 0.12
Z1088:Micall2 UTSW 5 139,692,649 (GRCm39) missense probably damaging 1.00
Z1177:Micall2 UTSW 5 139,696,057 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CCGCTGTGTTTGAAGACTCTGAG -3'
(R):5'- TCTCATGGACGGTTCAGGAG -3'

Sequencing Primer
(F):5'- AGACTCTGAGTTCAAGTTGAGC -3'
(R):5'- CTGAGGGTCAGGACAGCAGC -3'
Posted On 2016-06-15