Mutagenetix > Incidental Mutation

Incidental Mutation 'R5119:Fsip2'

392780

Institutional Source

Beutler Lab

Gene Symbol

Fsip2

Ensembl Gene

ENSMUSG00000075249

Gene Name

fibrous sheath-interacting protein 2

Synonyms

OTTMUSG00000013335

MMRRC Submission

042707-MU

Accession Numbers

Genbank: XM_913669; MGI: 2664111

Essential gene?

Probably non essential (E-score: 0.174) question?

Stock #

R5119 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

82943634-83008937 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 82988191 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 4756 (D4756V)

Ref Sequence

ENSEMBL: ENSMUSP00000120314 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000143764]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000132967

SMART Domains

Protein: ENSMUSP00000122350
Gene: ENSMUSG00000075249

Domain	Start	End	E-Value	Type
low complexity region	22	38	N/A	INTRINSIC
low complexity region	79	90	N/A	INTRINSIC
low complexity region	381	392	N/A	INTRINSIC
low complexity region	411	430	N/A	INTRINSIC
low complexity region	735	746	N/A	INTRINSIC
low complexity region	953	962	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000143764
AA Change: D4756V

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000120314
Gene: ENSMUSG00000075249
AA Change: D4756V

Domain	Start	End	E-Value	Type
coiled coil region	271	297	N/A	INTRINSIC
low complexity region	544	561	N/A	INTRINSIC
low complexity region	586	597	N/A	INTRINSIC
low complexity region	882	895	N/A	INTRINSIC
low complexity region	925	939	N/A	INTRINSIC
low complexity region	1115	1120	N/A	INTRINSIC
low complexity region	1531	1545	N/A	INTRINSIC
low complexity region	2044	2057	N/A	INTRINSIC
low complexity region	2507	2523	N/A	INTRINSIC
low complexity region	2564	2575	N/A	INTRINSIC
low complexity region	2866	2877	N/A	INTRINSIC
low complexity region	2896	2915	N/A	INTRINSIC
low complexity region	3220	3231	N/A	INTRINSIC
low complexity region	3438	3447	N/A	INTRINSIC
Pfam:FSIP2	4045	4408	3.5e-42	PFAM
Pfam:FSIP2	4375	4613	7.7e-26	PFAM
Pfam:FSIP2	4622	4932	4.3e-17	PFAM
Pfam:FSIP2	4903	5454	7e-27	PFAM
low complexity region	5507	5522	N/A	INTRINSIC
low complexity region	5769	5780	N/A	INTRINSIC
low complexity region	5834	5846	N/A	INTRINSIC
low complexity region	5851	5867	N/A	INTRINSIC
Pfam:FSIP2	5998	6867	N/A	PFAM
low complexity region	6977	6990	N/A	INTRINSIC

Meta Mutation Damage Score

0.3745

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.1%

Validation Efficiency

100% (127/127)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. [provided by RefSeq, Aug 2016]

Allele List at MGI

Other mutations in this stock

Total: 120 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930470P17Rik	C	A	2: 170,579,585	G125V	unknown	Het
Actr6	A	T	10: 89,725,855	L143Q	probably damaging	Het
Adamts18	A	G	8: 113,699,010	Y1207H	probably benign	Het
Adamts5	T	A	16: 85,899,578	R230S	probably benign	Het
Adat2	A	T	10: 13,556,906	N51Y	probably damaging	Het
Adgrv1	T	C	13: 81,419,427	Y5209C	possibly damaging	Het
Ahnak	G	T	19: 9,013,644	M4097I	probably benign	Het
Akap13	A	G	7: 75,687,252	T820A	probably damaging	Het
Als2cl	C	T	9: 110,890,819	R492C	probably damaging	Het
Aox3	G	A	1: 58,188,524		probably null	Het
Arid4b	G	A	13: 14,164,281	V446M	probably benign	Het
Armc2	A	G	10: 41,922,148	L794P	probably damaging	Het
Atp6v0a1	T	A	11: 101,020,515	M80K	probably benign	Het
Aup1	T	C	6: 83,055,134	V94A	probably damaging	Het
Bank1	A	T	3: 136,234,682	I180K	possibly damaging	Het
Becn1	A	G	11: 101,291,395	L116P	probably damaging	Het
Bsg	A	G	10: 79,710,223		probably benign	Het
Camk2a	A	T	18: 60,943,136		probably benign	Het
Ccdc180	A	G	4: 45,914,603	E706G	possibly damaging	Het
Cdk8	A	T	5: 146,283,627		probably null	Het
Cpne4	A	G	9: 104,901,521		probably null	Het
Cspp1	T	A	1: 10,126,463	N900K	probably damaging	Het
Cyp2c38	C	A	19: 39,460,621	G96V	probably damaging	Het
Dhx40	A	G	11: 86,776,636	I261T	probably damaging	Het
Dnah10	T	C	5: 124,779,258	F2038L	probably damaging	Het
Dnah7a	A	T	1: 53,698,692	D27E	probably benign	Het
Dock10	A	T	1: 80,567,994		probably null	Het
Dst	A	T	1: 34,195,969	K3710*	probably null	Het
Dtl	G	T	1: 191,541,506	A430D	probably damaging	Het
Ece2	T	C	16: 20,618,631	L241P	probably damaging	Het
Ecel1	T	A	1: 87,151,139	Y526F	probably benign	Het
Enpp2	T	A	15: 54,870,305	R420*	probably null	Het
Epb41	A	C	4: 131,937,436		probably benign	Het
Eppin	T	C	2: 164,589,451	Y85C	probably damaging	Het
Fam171a2	G	A	11: 102,438,733	A400V	probably damaging	Het
Fam71b	G	A	11: 46,407,036	G389D	probably damaging	Het
Fem1c	A	C	18: 46,506,369	C189G	probably damaging	Het
Frmd4b	A	G	6: 97,300,314	V560A	probably benign	Het
Gabbr1	T	C	17: 37,048,438	S102P	probably damaging	Het
Gm28042	G	A	2: 120,034,643	A250T	probably damaging	Het
Gm42877	T	C	14: 54,075,521		probably benign	Het
Gm9762	A	T	3: 78,966,400		noncoding transcript	Het
Gpr183	G	T	14: 121,954,863	T82N	possibly damaging	Het
Gps2	A	G	11: 69,914,791	K45R	probably benign	Het
Gramd2	A	G	9: 59,714,320		probably benign	Het
Grap2	G	A	15: 80,646,144	R155Q	possibly damaging	Het
Hsdl1	T	A	8: 119,565,867	Y203F	possibly damaging	Het
Ifi204	A	T	1: 173,755,668	I328N	probably damaging	Het
Igsf3	T	A	3: 101,439,361		probably null	Het
Il1rap	T	C	16: 26,624,199	I15T	probably benign	Het
Il23r	A	T	6: 67,466,316	C268S	probably damaging	Het
Irx4	A	G	13: 73,268,921	T479A	probably benign	Het
Kcnk7	G	A	19: 5,706,324	V193I	probably benign	Het
Kcnt1	G	T	2: 25,909,322		probably benign	Het
Kif13b	T	G	14: 64,757,453	C885G	probably benign	Het
Kif21b	C	A	1: 136,163,100	D1215E	probably benign	Het
Klhdc2	A	G	12: 69,296,962		probably benign	Het
Kmt2d	G	A	15: 98,847,194		probably benign	Het
Lama4	A	G	10: 39,048,054	N486S	probably benign	Het
Ldah	G	A	12: 8,227,237	A58T	probably benign	Het
Lrrc24	T	C	15: 76,716,000	Q313R	probably benign	Het
Luzp1	A	G	4: 136,543,397	D977G	possibly damaging	Het
Mrgpra4	A	G	7: 47,981,718	L45P	probably damaging	Het
Mrps28	C	T	3: 8,923,696	G34D	possibly damaging	Het
Myh8	A	G	11: 67,298,358	E1120G	probably damaging	Het
Myt1l	A	G	12: 29,832,303	E499G	unknown	Het
Ncan	C	T	8: 70,115,025	E146K	probably damaging	Het
Nlgn1	A	T	3: 25,433,794	D763E	probably damaging	Het
Olfr1259	A	T	2: 89,943,803	I104N	possibly damaging	Het
Olfr1474	C	T	19: 13,471,546	T192I	probably benign	Het
Olfr157	G	T	4: 43,836,433	A19D	probably benign	Het
Olfr23	A	T	11: 73,940,552	Y102F	possibly damaging	Het
Olfr742	T	C	14: 50,515,509	F102L	probably benign	Het
Olfr765	T	A	10: 129,046,842	I74F	possibly damaging	Het
Pak6	A	T	2: 118,694,548	I552F	probably damaging	Het
Pcbp1	G	A	6: 86,524,915	A334V	probably damaging	Het
Pclaf	T	C	9: 65,890,780	V32A	probably benign	Het
Pga5	T	A	19: 10,676,689	H50L	probably benign	Het
Phyhipl	A	T	10: 70,569,074	D56E	probably damaging	Het
Pik3ap1	C	T	19: 41,281,976	R758H	probably benign	Het
Plekha1	A	G	7: 130,905,364		probably benign	Het
Plekhm1	A	T	11: 103,387,315	N318K	possibly damaging	Het
Ppargc1b	G	A	18: 61,307,654	A731V	probably benign	Het
Pptc7	T	C	5: 122,313,781	V100A	possibly damaging	Het
Prl7a1	A	T	13: 27,633,581	H233Q	possibly damaging	Het
Prpf40a	A	G	2: 53,144,849	F776L	probably damaging	Het
Prrc2c	T	C	1: 162,705,440		probably benign	Het
Psmb1	T	C	17: 15,498,262	M1V	probably null	Het
Ptpn3	A	G	4: 57,218,513	F650S	possibly damaging	Het
Ranbp17	A	T	11: 33,404,181	*577R	probably null	Het
Reln	T	A	5: 21,971,870	N1933Y	probably benign	Het
Rgl2	T	A	17: 33,937,120	H727Q	probably benign	Het
Rhpn2	A	G	7: 35,371,124	T160A	probably damaging	Het
Rlf	G	A	4: 121,147,455	H1443Y	probably damaging	Het
Rpgrip1l	T	C	8: 91,280,816	E382G	probably damaging	Het
Rxrb	T	C	17: 34,033,588	S50P	probably benign	Het
Scn4b	A	T	9: 45,147,758	E109V	probably damaging	Het
Scrib	C	T	15: 76,051,753		probably null	Het
Slc22a29	A	T	19: 8,217,830	V147D	probably damaging	Het
Slc4a4	A	T	5: 88,954,862	E53V	probably null	Het
Slx4	A	G	16: 4,001,199	S37P	possibly damaging	Het
Spag9	G	A	11: 94,122,722	G1127D	probably damaging	Het
Srek1	T	A	13: 103,752,556		probably benign	Het
Supt5	G	T	7: 28,316,370	P849Q	probably damaging	Het
Tex14	T	C	11: 87,433,813	S2P	probably damaging	Het
Them7	A	G	2: 105,378,808	T158A	probably benign	Het
Tldc1	A	C	8: 119,768,143	L292R	probably damaging	Het
Tll2	A	G	19: 41,130,509	V260A	possibly damaging	Het
Tlr6	A	G	5: 64,954,301	V421A	probably benign	Het
Tmc3	T	G	7: 83,615,010	C649G	probably damaging	Het
Tnn	A	G	1: 160,120,552	W864R	probably damaging	Het
Tsc2	A	C	17: 24,603,280	V1095G	probably benign	Het
Vmn1r124	C	T	7: 21,260,247	G124D	probably damaging	Het
Vmn2r116	T	C	17: 23,387,164	V350A	probably benign	Het
Vps13d	A	G	4: 145,105,898	S2813P	possibly damaging	Het
Wrap53	T	A	11: 69,563,932	M204L	possibly damaging	Het
Zfp277	A	G	12: 40,328,688	V390A	possibly damaging	Het
Zfp687	A	T	3: 95,011,676	S262T	probably benign	Het
Zfp831	T	A	2: 174,705,310	S1429T	probably benign	Het
Znfx1	G	A	2: 167,065,387		probably benign	Het

Other mutations in Fsip2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Fsip2	APN	2	82990386	missense	probably benign	0.18
IGL00557:Fsip2	APN	2	82991313	missense	possibly damaging	0.53
IGL01343:Fsip2	APN	2	82999819	missense	possibly damaging	0.53
IGL01387:Fsip2	APN	2	82992982	missense	possibly damaging	0.71
IGL01523:Fsip2	APN	2	82977519	missense	probably benign
IGL01554:Fsip2	APN	2	82977278	missense	possibly damaging	0.68
IGL01650:Fsip2	APN	2	82991086	missense	probably benign	0.33
IGL01809:Fsip2	APN	2	82978347	missense	possibly damaging	0.80
IGL01826:Fsip2	APN	2	82982639	missense	probably benign	0.18
IGL01830:Fsip2	APN	2	82984929	missense	probably benign
IGL01918:Fsip2	APN	2	82992138	missense	possibly damaging	0.71
IGL01932:Fsip2	APN	2	82994005	missense	possibly damaging	0.71
IGL01989:Fsip2	APN	2	82993867	missense	probably damaging	0.99
IGL02096:Fsip2	APN	2	82991860	missense	possibly damaging	0.85
IGL02153:Fsip2	APN	2	82978721	missense	probably benign
IGL02155:Fsip2	APN	2	82998352	missense	probably benign
IGL02219:Fsip2	APN	2	82977830	missense	probably benign	0.07
IGL02248:Fsip2	APN	2	82982772	missense	possibly damaging	0.73
IGL02316:Fsip2	APN	2	82978793	missense	probably benign
IGL02478:Fsip2	APN	2	82984392	missense	probably benign	0.00
IGL02504:Fsip2	APN	2	82978855	missense	possibly damaging	0.83
IGL02572:Fsip2	APN	2	82992003	missense	probably benign	0.32
IGL02625:Fsip2	APN	2	82949492	missense	probably benign	0.00
IGL02665:Fsip2	APN	2	82993063	missense	probably damaging	1.00
IGL02668:Fsip2	APN	2	82998318	missense	probably benign	0.06
IGL02676:Fsip2	APN	2	82982157	missense	possibly damaging	0.53
IGL02717:Fsip2	APN	2	82951026	splice site	probably benign
IGL02805:Fsip2	APN	2	82993495	missense	probably benign	0.01
IGL02943:Fsip2	APN	2	82992357	missense	probably benign	0.32
IGL02965:Fsip2	APN	2	82983054	missense	probably benign	0.33
IGL03001:Fsip2	APN	2	82990624	intron	probably benign
IGL03076:Fsip2	APN	2	82982138	missense	possibly damaging	0.96
IGL03229:Fsip2	APN	2	82978076	missense	possibly damaging	0.86
IGL03353:Fsip2	APN	2	82977393	missense	possibly damaging	0.85
IGL03401:Fsip2	APN	2	82990470	missense	probably benign
bubblegum	UTSW	2	82992840	missense	probably benign	0.16
Dao	UTSW	2	82993150	missense	probably damaging	0.97
engulf	UTSW	2	82984776	missense	probably damaging	0.98
envelope	UTSW	2	82980741	missense	probably benign	0.07
gladius	UTSW	2	82981949	missense	possibly damaging	0.68
glove	UTSW	2	82978394	missense	possibly damaging	0.85
Katana	UTSW	2	82989516	missense	probably benign	0.07
scarf	UTSW	2	82986891	missense	probably benign
Sock	UTSW	2	82998180	missense	probably benign	0.00
swaddle	UTSW	2	82983428	missense	possibly damaging	0.93
wrap	UTSW	2	82986820	missense	probably benign	0.04
Wrapper	UTSW	2	82990086	missense	possibly damaging	0.71
D4186:Fsip2	UTSW	2	82988412	missense	probably benign	0.32
FR4976:Fsip2	UTSW	2	82984362	critical splice acceptor site	probably benign
FR4976:Fsip2	UTSW	2	82984365	critical splice acceptor site	probably benign
PIT4382001:Fsip2	UTSW	2	82990852	missense	possibly damaging	0.86
R0017:Fsip2	UTSW	2	82992072	missense	probably damaging	0.98
R0017:Fsip2	UTSW	2	82992072	missense	probably damaging	0.98
R0021:Fsip2	UTSW	2	82999857	splice site	probably benign
R0054:Fsip2	UTSW	2	82976608	missense	probably damaging	0.96
R0054:Fsip2	UTSW	2	82986955	missense	possibly damaging	0.85
R0054:Fsip2	UTSW	2	82986955	missense	possibly damaging	0.85
R0104:Fsip2	UTSW	2	82978973	missense	possibly damaging	0.91
R0104:Fsip2	UTSW	2	82978973	missense	possibly damaging	0.91
R0127:Fsip2	UTSW	2	82984925	missense	probably benign	0.28
R0131:Fsip2	UTSW	2	82991121	missense	probably benign
R0149:Fsip2	UTSW	2	82975505	missense	possibly damaging	0.93
R0167:Fsip2	UTSW	2	82980807	missense	possibly damaging	0.53
R0190:Fsip2	UTSW	2	82985177	missense	possibly damaging	0.73
R0323:Fsip2	UTSW	2	82985896	missense	probably benign	0.33
R0358:Fsip2	UTSW	2	82983333	missense	possibly damaging	0.56
R0361:Fsip2	UTSW	2	82975505	missense	possibly damaging	0.93
R0369:Fsip2	UTSW	2	82984564	missense	probably benign	0.33
R0394:Fsip2	UTSW	2	82991075	missense	possibly damaging	0.70
R0532:Fsip2	UTSW	2	82977785	missense	probably benign	0.33
R0595:Fsip2	UTSW	2	82946952	missense	probably damaging	0.99
R0613:Fsip2	UTSW	2	82993795	missense	probably damaging	0.99
R0614:Fsip2	UTSW	2	82977533	missense	probably benign	0.15
R0619:Fsip2	UTSW	2	82944140	missense	probably damaging	1.00
R0626:Fsip2	UTSW	2	82988958	missense	probably benign	0.06
R0644:Fsip2	UTSW	2	82976897	missense	probably benign	0.02
R0661:Fsip2	UTSW	2	82986169	missense	possibly damaging	0.92
R0680:Fsip2	UTSW	2	82991359	missense	possibly damaging	0.73
R0688:Fsip2	UTSW	2	82982339	missense	probably benign	0.18
R0881:Fsip2	UTSW	2	82986273	missense	possibly damaging	0.52
R0919:Fsip2	UTSW	2	82985484	missense	possibly damaging	0.53
R0973:Fsip2	UTSW	2	82977092	missense	probably benign	0.05
R0973:Fsip2	UTSW	2	82977092	missense	probably benign	0.05
R0974:Fsip2	UTSW	2	82977092	missense	probably benign	0.05
R0976:Fsip2	UTSW	2	82998031	missense	possibly damaging	0.92
R1025:Fsip2	UTSW	2	82989436	nonsense	probably null
R1026:Fsip2	UTSW	2	82988461	missense	possibly damaging	0.52
R1140:Fsip2	UTSW	2	82975034	missense	probably damaging	0.99
R1170:Fsip2	UTSW	2	82991500	missense	possibly damaging	0.72
R1180:Fsip2	UTSW	2	82975226	missense	probably damaging	0.99
R1188:Fsip2	UTSW	2	82975017	missense	possibly damaging	0.96
R1226:Fsip2	UTSW	2	82981011	missense	probably damaging	0.96
R1248:Fsip2	UTSW	2	82989763	missense	possibly damaging	0.93
R1273:Fsip2	UTSW	2	82989408	missense	possibly damaging	0.92
R1323:Fsip2	UTSW	2	82985752	missense	probably damaging	1.00
R1323:Fsip2	UTSW	2	82985752	missense	probably damaging	1.00
R1356:Fsip2	UTSW	2	82989745	missense	probably benign	0.38
R1413:Fsip2	UTSW	2	82988418	missense	possibly damaging	0.93
R1430:Fsip2	UTSW	2	82998063	missense	possibly damaging	0.71
R1475:Fsip2	UTSW	2	82987195	missense	probably damaging	0.99
R1489:Fsip2	UTSW	2	82979811	missense	probably benign
R1520:Fsip2	UTSW	2	82980714	missense	possibly damaging	0.96
R1543:Fsip2	UTSW	2	82981587	missense	possibly damaging	0.91
R1581:Fsip2	UTSW	2	82986282	missense	probably damaging	0.98
R1590:Fsip2	UTSW	2	82982787	missense	probably benign	0.26
R1646:Fsip2	UTSW	2	82978517	missense	probably benign	0.07
R1678:Fsip2	UTSW	2	82986345	missense	probably benign
R1700:Fsip2	UTSW	2	82991737	missense	probably benign	0.33
R1717:Fsip2	UTSW	2	82974945	missense	possibly damaging	0.68
R1741:Fsip2	UTSW	2	82989912	missense	probably benign	0.32
R1760:Fsip2	UTSW	2	82984896	missense	probably benign	0.07
R1760:Fsip2	UTSW	2	82987711	missense	possibly damaging	0.71
R1760:Fsip2	UTSW	2	82999841	missense	possibly damaging	0.85
R1789:Fsip2	UTSW	2	82977562	missense	probably benign	0.00
R1850:Fsip2	UTSW	2	82984589	missense	possibly damaging	0.72
R1854:Fsip2	UTSW	2	82993257	missense	possibly damaging	0.84
R1888:Fsip2	UTSW	2	82944160	missense	probably benign	0.04
R1888:Fsip2	UTSW	2	82944160	missense	probably benign	0.04
R1905:Fsip2	UTSW	2	82983428	missense	possibly damaging	0.93
R1907:Fsip2	UTSW	2	82983428	missense	possibly damaging	0.93
R1920:Fsip2	UTSW	2	82986820	missense	probably benign	0.04
R1921:Fsip2	UTSW	2	82980783	nonsense	probably null
R1921:Fsip2	UTSW	2	82986820	missense	probably benign	0.04
R1931:Fsip2	UTSW	2	82986733	missense	probably damaging	0.99
R1934:Fsip2	UTSW	2	82980558	missense	possibly damaging	0.91
R1959:Fsip2	UTSW	2	82991550	missense	probably benign
R1965:Fsip2	UTSW	2	82992780	missense	possibly damaging	0.86
R1966:Fsip2	UTSW	2	82992780	missense	possibly damaging	0.86
R1983:Fsip2	UTSW	2	82979831	missense	probably benign
R1988:Fsip2	UTSW	2	82976517	missense	possibly damaging	0.56
R2016:Fsip2	UTSW	2	82982732	missense	possibly damaging	0.53
R2017:Fsip2	UTSW	2	82982732	missense	possibly damaging	0.53
R2026:Fsip2	UTSW	2	82989444	missense	possibly damaging	0.71
R2034:Fsip2	UTSW	2	82989494	missense	probably benign	0.43
R2037:Fsip2	UTSW	2	82978512	missense	probably damaging	0.99
R2070:Fsip2	UTSW	2	82976355	missense	probably damaging	0.98
R2072:Fsip2	UTSW	2	83008815	missense	possibly damaging	0.53
R2075:Fsip2	UTSW	2	82988579	missense	possibly damaging	0.85
R2143:Fsip2	UTSW	2	82990271	missense	possibly damaging	0.93
R2207:Fsip2	UTSW	2	82977479	missense	probably benign	0.02
R2256:Fsip2	UTSW	2	82962751	missense	probably benign	0.07
R2315:Fsip2	UTSW	2	82975093	missense	probably benign
R2344:Fsip2	UTSW	2	82989913	missense	possibly damaging	0.71
R2377:Fsip2	UTSW	2	82976249	missense	probably benign	0.29
R2403:Fsip2	UTSW	2	82980720	missense	possibly damaging	0.53
R2441:Fsip2	UTSW	2	82985341	missense	possibly damaging	0.53
R2504:Fsip2	UTSW	2	82979610	missense	possibly damaging	0.86
R2510:Fsip2	UTSW	2	82986438	missense	probably benign
R2511:Fsip2	UTSW	2	82951657	missense	probably damaging	1.00
R2511:Fsip2	UTSW	2	82986438	missense	probably benign
R2512:Fsip2	UTSW	2	82978167	missense	probably benign	0.04
R2568:Fsip2	UTSW	2	82990431	missense	probably benign	0.14
R2656:Fsip2	UTSW	2	82979045	missense	possibly damaging	0.83
R2883:Fsip2	UTSW	2	82991524	missense	possibly damaging	0.86
R3417:Fsip2	UTSW	2	82986510	missense	possibly damaging	0.51
R3431:Fsip2	UTSW	2	82992010	missense	possibly damaging	0.85
R3441:Fsip2	UTSW	2	82986727	missense	probably benign	0.00
R3605:Fsip2	UTSW	2	82984909	missense	probably benign	0.28
R3620:Fsip2	UTSW	2	82980258	missense	probably benign	0.00
R3621:Fsip2	UTSW	2	82980258	missense	probably benign	0.00
R3726:Fsip2	UTSW	2	82988967	missense	possibly damaging	0.84
R3755:Fsip2	UTSW	2	82978217	missense	probably benign	0.26
R3789:Fsip2	UTSW	2	82982714	missense	probably damaging	0.96
R3836:Fsip2	UTSW	2	82950946	missense	probably damaging	1.00
R3844:Fsip2	UTSW	2	82989606	missense	possibly damaging	0.52
R3846:Fsip2	UTSW	2	82986415	missense	possibly damaging	0.52
R3861:Fsip2	UTSW	2	82984776	missense	probably damaging	0.98
R3981:Fsip2	UTSW	2	82958662	missense	probably benign	0.08
R4014:Fsip2	UTSW	2	82983518	missense	probably benign
R4042:Fsip2	UTSW	2	82983552	missense	probably benign	0.02
R4075:Fsip2	UTSW	2	82982901	missense	probably benign	0.26
R4154:Fsip2	UTSW	2	82987069	missense	possibly damaging	0.71
R4210:Fsip2	UTSW	2	82975149	missense	probably damaging	0.99
R4211:Fsip2	UTSW	2	82975149	missense	probably damaging	0.99
R4327:Fsip2	UTSW	2	82987059	missense	probably benign	0.25
R4332:Fsip2	UTSW	2	82977857	missense	probably benign	0.00
R4440:Fsip2	UTSW	2	82991206	missense	possibly damaging	0.85
R4454:Fsip2	UTSW	2	82990776	missense	possibly damaging	0.70
R4455:Fsip2	UTSW	2	82990776	missense	possibly damaging	0.70
R4457:Fsip2	UTSW	2	82990776	missense	possibly damaging	0.70
R4458:Fsip2	UTSW	2	82990776	missense	possibly damaging	0.70
R4540:Fsip2	UTSW	2	82951665	missense	probably benign
R4549:Fsip2	UTSW	2	82989628	missense	probably damaging	0.99
R4558:Fsip2	UTSW	2	82984953	missense	possibly damaging	0.73
R4573:Fsip2	UTSW	2	82986166	missense	possibly damaging	0.71
R4583:Fsip2	UTSW	2	82978673	missense	probably benign	0.33
R4618:Fsip2	UTSW	2	82987759	missense	probably benign
R4700:Fsip2	UTSW	2	82987029	missense	probably benign	0.32
R4716:Fsip2	UTSW	2	82974859	missense	probably damaging	0.96
R4739:Fsip2	UTSW	2	82975353	missense	possibly damaging	0.92
R4749:Fsip2	UTSW	2	82989285	missense	probably benign	0.06
R4791:Fsip2	UTSW	2	82982108	missense	possibly damaging	0.53
R4793:Fsip2	UTSW	2	82987700	nonsense	probably null
R4819:Fsip2	UTSW	2	82988442	missense	probably benign	0.06
R4832:Fsip2	UTSW	2	82990171	missense	possibly damaging	0.92
R4840:Fsip2	UTSW	2	82949395	missense	probably benign	0.01
R4840:Fsip2	UTSW	2	82985471	missense	probably benign	0.26
R4865:Fsip2	UTSW	2	82990951	missense	possibly damaging	0.86
R4876:Fsip2	UTSW	2	82974858	missense	possibly damaging	0.91
R4885:Fsip2	UTSW	2	82988094	missense	probably benign	0.02
R4911:Fsip2	UTSW	2	82981493	missense	possibly damaging	0.85
R4918:Fsip2	UTSW	2	82993770	missense	possibly damaging	0.51
R4936:Fsip2	UTSW	2	82985040	missense	probably benign	0.18
R4950:Fsip2	UTSW	2	82946932	missense	probably damaging	0.97
R4950:Fsip2	UTSW	2	82977414	missense	probably benign	0.03
R4959:Fsip2	UTSW	2	82984825	missense	probably benign	0.00
R4971:Fsip2	UTSW	2	82985878	missense	probably benign	0.38
R4973:Fsip2	UTSW	2	82984825	missense	probably benign	0.00
R4976:Fsip2	UTSW	2	82988191	missense	probably damaging	0.99
R5022:Fsip2	UTSW	2	82979429	missense	probably benign	0.33
R5027:Fsip2	UTSW	2	82989133	missense	possibly damaging	0.71
R5030:Fsip2	UTSW	2	82988492	missense	possibly damaging	0.85
R5048:Fsip2	UTSW	2	82993150	missense	probably damaging	0.97
R5096:Fsip2	UTSW	2	82991116	missense	probably benign	0.00
R5097:Fsip2	UTSW	2	82991985	missense	probably benign
R5138:Fsip2	UTSW	2	82981424	missense	probably benign	0.12
R5152:Fsip2	UTSW	2	82978572	missense	probably benign	0.43
R5174:Fsip2	UTSW	2	82980741	missense	probably benign	0.07
R5193:Fsip2	UTSW	2	82982994	missense	possibly damaging	0.53
R5245:Fsip2	UTSW	2	82993161	missense	probably benign	0.02
R5282:Fsip2	UTSW	2	82978581	missense	possibly damaging	0.61
R5323:Fsip2	UTSW	2	82988145	missense	possibly damaging	0.71
R5326:Fsip2	UTSW	2	82981863	missense	possibly damaging	0.84
R5378:Fsip2	UTSW	2	82989841	missense	possibly damaging	0.71
R5380:Fsip2	UTSW	2	82975398	missense	possibly damaging	0.91
R5396:Fsip2	UTSW	2	82990918	missense	probably benign	0.00
R5422:Fsip2	UTSW	2	82982228	missense	probably benign	0.00
R5481:Fsip2	UTSW	2	82979886	missense	probably benign	0.26
R5482:Fsip2	UTSW	2	82985310	missense	possibly damaging	0.80
R5513:Fsip2	UTSW	2	82950908	missense	probably damaging	1.00
R5513:Fsip2	UTSW	2	82950912	missense	probably benign	0.07
R5513:Fsip2	UTSW	2	82985198	missense	possibly damaging	0.72
R5536:Fsip2	UTSW	2	82987059	missense	probably benign	0.25
R5542:Fsip2	UTSW	2	82981863	missense	possibly damaging	0.84
R5553:Fsip2	UTSW	2	82962746	missense	probably benign
R5568:Fsip2	UTSW	2	82986564	missense	probably benign	0.25
R5581:Fsip2	UTSW	2	82998128	missense	possibly damaging	0.84
R5664:Fsip2	UTSW	2	82988095	missense	probably benign	0.05
R5672:Fsip2	UTSW	2	82987494	nonsense	probably null
R5712:Fsip2	UTSW	2	83008848	missense	possibly damaging	0.73
R5762:Fsip2	UTSW	2	82977916	missense	probably benign	0.33
R5772:Fsip2	UTSW	2	82984740	missense	probably benign
R5881:Fsip2	UTSW	2	82984441	missense	possibly damaging	0.72
R5919:Fsip2	UTSW	2	82992609	missense	possibly damaging	0.71
R5920:Fsip2	UTSW	2	82988508	nonsense	probably null
R5934:Fsip2	UTSW	2	82986748	missense	possibly damaging	0.86
R5938:Fsip2	UTSW	2	82977491	missense	probably benign	0.00
R5974:Fsip2	UTSW	2	82963313	missense	possibly damaging	0.68
R5991:Fsip2	UTSW	2	82990468	missense	probably benign	0.28
R6019:Fsip2	UTSW	2	82987939	missense	possibly damaging	0.52
R6020:Fsip2	UTSW	2	82992127	missense	probably damaging	0.99
R6056:Fsip2	UTSW	2	82985673	missense	probably benign	0.01
R6057:Fsip2	UTSW	2	82979433	missense	probably damaging	0.99
R6139:Fsip2	UTSW	2	82991044	missense	possibly damaging	0.85
R6145:Fsip2	UTSW	2	82993768	missense	possibly damaging	0.71
R6160:Fsip2	UTSW	2	82987945	nonsense	probably null
R6161:Fsip2	UTSW	2	82987257	missense	possibly damaging	0.80
R6166:Fsip2	UTSW	2	82980727	missense	probably benign	0.00
R6187:Fsip2	UTSW	2	82982454	missense	probably benign	0.33
R6196:Fsip2	UTSW	2	82989883	missense	possibly damaging	0.71
R6217:Fsip2	UTSW	2	82988418	missense	possibly damaging	0.93
R6276:Fsip2	UTSW	2	82980441	missense	possibly damaging	0.91
R6278:Fsip2	UTSW	2	82988898	missense	probably benign	0.16
R6349:Fsip2	UTSW	2	82993072	missense	probably benign	0.05
R6351:Fsip2	UTSW	2	82992684	missense	possibly damaging	0.51
R6401:Fsip2	UTSW	2	82990086	missense	possibly damaging	0.71
R6404:Fsip2	UTSW	2	82990086	missense	possibly damaging	0.71
R6405:Fsip2	UTSW	2	82990086	missense	possibly damaging	0.71
R6437:Fsip2	UTSW	2	82983492	missense	possibly damaging	0.73
R6478:Fsip2	UTSW	2	82990086	missense	possibly damaging	0.71
R6479:Fsip2	UTSW	2	82990086	missense	possibly damaging	0.71
R6480:Fsip2	UTSW	2	82990086	missense	possibly damaging	0.71
R6481:Fsip2	UTSW	2	82990086	missense	possibly damaging	0.71
R6521:Fsip2	UTSW	2	82990086	missense	possibly damaging	0.71
R6529:Fsip2	UTSW	2	82982313	missense	probably benign
R6621:Fsip2	UTSW	2	82989814	missense	possibly damaging	0.93
R6639:Fsip2	UTSW	2	82983227	missense	possibly damaging	0.85
R6649:Fsip2	UTSW	2	82967817	missense	possibly damaging	0.83
R6714:Fsip2	UTSW	2	82979534	missense	probably benign	0.01
R6714:Fsip2	UTSW	2	82990086	missense	possibly damaging	0.71
R6749:Fsip2	UTSW	2	82978394	missense	possibly damaging	0.85
R6765:Fsip2	UTSW	2	82986432	missense	probably benign
R6790:Fsip2	UTSW	2	82990939	missense	possibly damaging	0.53
R6793:Fsip2	UTSW	2	82989494	missense	probably benign	0.43
R6795:Fsip2	UTSW	2	82980959	missense	probably benign	0.08
R6818:Fsip2	UTSW	2	82985200	missense	probably benign	0.04
R6844:Fsip2	UTSW	2	82983625	missense	possibly damaging	0.72
R6848:Fsip2	UTSW	2	82982787	missense	probably benign	0.26
R6945:Fsip2	UTSW	2	82992840	missense	probably benign	0.16
R6950:Fsip2	UTSW	2	82985988	missense	probably benign	0.03
R6951:Fsip2	UTSW	2	82981949	missense	possibly damaging	0.68
R6974:Fsip2	UTSW	2	82978717	missense	probably damaging	0.96
R6987:Fsip2	UTSW	2	82948286	nonsense	probably null
R6989:Fsip2	UTSW	2	82976954	missense	probably benign	0.00
R7001:Fsip2	UTSW	2	82986925	missense	probably damaging	1.00
R7002:Fsip2	UTSW	2	82989343	missense	possibly damaging	0.86
R7016:Fsip2	UTSW	2	82990635	missense	probably benign	0.25
R7066:Fsip2	UTSW	2	82990891	missense	possibly damaging	0.86
R7067:Fsip2	UTSW	2	82980734	missense	possibly damaging	0.85
R7077:Fsip2	UTSW	2	82983152	missense	probably benign	0.18
R7099:Fsip2	UTSW	2	82987624	missense	probably benign
R7126:Fsip2	UTSW	2	82983141	missense	possibly damaging	0.53
R7156:Fsip2	UTSW	2	82982741	missense	probably benign	0.00
R7165:Fsip2	UTSW	2	82981197	missense	possibly damaging	0.77
R7171:Fsip2	UTSW	2	82986227	nonsense	probably null
R7189:Fsip2	UTSW	2	82993237	missense	possibly damaging	0.92
R7217:Fsip2	UTSW	2	82989068	missense	possibly damaging	0.85
R7222:Fsip2	UTSW	2	82983671	missense	probably benign
R7228:Fsip2	UTSW	2	82992307	missense	possibly damaging	0.93
R7238:Fsip2	UTSW	2	82982140	missense	possibly damaging	0.72
R7244:Fsip2	UTSW	2	82993263	missense	possibly damaging	0.92
R7251:Fsip2	UTSW	2	82979081	missense	possibly damaging	0.95
R7259:Fsip2	UTSW	2	82982130	missense	possibly damaging	0.85
R7291:Fsip2	UTSW	2	82980519	missense	possibly damaging	0.91
R7316:Fsip2	UTSW	2	82989691	missense	possibly damaging	0.93
R7323:Fsip2	UTSW	2	82989516	missense	probably benign	0.07
R7335:Fsip2	UTSW	2	82983118	missense	probably benign
R7343:Fsip2	UTSW	2	82979367	missense	probably benign	0.07
R7346:Fsip2	UTSW	2	82998180	missense	probably benign	0.00
R7389:Fsip2	UTSW	2	82988796	missense	possibly damaging	0.51
R7391:Fsip2	UTSW	2	82990319	missense	possibly damaging	0.70
R7397:Fsip2	UTSW	2	82985257	missense	possibly damaging	0.53
R7426:Fsip2	UTSW	2	82980097	missense	probably damaging	0.98
R7450:Fsip2	UTSW	2	82951680	missense	probably benign	0.30
R7538:Fsip2	UTSW	2	82988550	missense	possibly damaging	0.86
R7542:Fsip2	UTSW	2	82984852	missense	possibly damaging	0.96
R7549:Fsip2	UTSW	2	82993993	missense	probably damaging	0.99
R7564:Fsip2	UTSW	2	82989017	missense	probably benign	0.02
R7565:Fsip2	UTSW	2	82949512	missense	probably damaging	0.97
R7583:Fsip2	UTSW	2	82975241	missense	probably benign	0.12
R7641:Fsip2	UTSW	2	82986912	nonsense	probably null
R7655:Fsip2	UTSW	2	82977542	missense	possibly damaging	0.91
R7656:Fsip2	UTSW	2	82977542	missense	possibly damaging	0.91
R7665:Fsip2	UTSW	2	82981805	missense	probably benign	0.03
R7672:Fsip2	UTSW	2	82990111	missense	possibly damaging	0.93
R7764:Fsip2	UTSW	2	82980908	missense	possibly damaging	0.93
R7790:Fsip2	UTSW	2	82988379	missense	probably benign
R7811:Fsip2	UTSW	2	82998453	missense	possibly damaging	0.93
R7838:Fsip2	UTSW	2	82976700	missense	probably benign	0.00
R7873:Fsip2	UTSW	2	82949512	missense	probably damaging	0.97
R7902:Fsip2	UTSW	2	82977824	missense	possibly damaging	0.72
R7920:Fsip2	UTSW	2	82951021	missense	possibly damaging	0.94
R7959:Fsip2	UTSW	2	82985776	missense	possibly damaging	0.51
R8009:Fsip2	UTSW	2	82988449	missense	possibly damaging	0.85
R8031:Fsip2	UTSW	2	82986891	missense	probably benign
R8034:Fsip2	UTSW	2	82989355	missense	possibly damaging	0.92
R8037:Fsip2	UTSW	2	82985978	missense	possibly damaging	0.72
R8110:Fsip2	UTSW	2	82958673	missense	probably benign	0.00
R8117:Fsip2	UTSW	2	82992952	missense	possibly damaging	0.86
R8138:Fsip2	UTSW	2	82975797	missense	possibly damaging	0.83
R8175:Fsip2	UTSW	2	82984744	missense	probably benign	0.06
R8175:Fsip2	UTSW	2	82987677	missense	probably benign	0.16
R8182:Fsip2	UTSW	2	82976607	missense	probably damaging	0.99
R8206:Fsip2	UTSW	2	82990464	missense	possibly damaging	0.85
R8229:Fsip2	UTSW	2	82978143	missense	possibly damaging	0.63
R8239:Fsip2	UTSW	2	82989343	missense	possibly damaging	0.71
R8245:Fsip2	UTSW	2	82981002	missense	possibly damaging	0.79
R8303:Fsip2	UTSW	2	82988380	missense	probably benign	0.00
R8336:Fsip2	UTSW	2	82990755	missense	possibly damaging	0.53
R8347:Fsip2	UTSW	2	82987854	missense	probably benign	0.16
R8351:Fsip2	UTSW	2	82991895	missense	possibly damaging	0.73
R8352:Fsip2	UTSW	2	82984593	missense	probably benign
R8419:Fsip2	UTSW	2	82978619	missense	probably damaging	0.96
R8431:Fsip2	UTSW	2	82981566	missense	probably damaging	1.00
R8439:Fsip2	UTSW	2	82977086	missense	probably benign	0.24
R8452:Fsip2	UTSW	2	82984593	missense	probably benign
R8459:Fsip2	UTSW	2	82979678	missense	possibly damaging	0.95
R8465:Fsip2	UTSW	2	82979940	missense	probably benign	0.26
R8473:Fsip2	UTSW	2	82946992	missense	probably damaging	0.99
R8703:Fsip2	UTSW	2	82991527	missense	probably damaging	0.98
R8711:Fsip2	UTSW	2	82984902	missense	possibly damaging	0.53
R8713:Fsip2	UTSW	2	82981109	missense	probably damaging	1.00
R8789:Fsip2	UTSW	2	82985478	missense	possibly damaging	0.73
R8805:Fsip2	UTSW	2	82983109	missense	possibly damaging	0.46
R8840:Fsip2	UTSW	2	82991262	missense	probably benign	0.03
R8855:Fsip2	UTSW	2	82980177	missense	probably benign	0.04
R8866:Fsip2	UTSW	2	82980177	missense	probably benign	0.04
R8875:Fsip2	UTSW	2	82990438	missense	possibly damaging	0.95
R8883:Fsip2	UTSW	2	82979180	missense	possibly damaging	0.68
R8903:Fsip2	UTSW	2	82977337	missense	possibly damaging	0.83
R8907:Fsip2	UTSW	2	82986640	missense	probably benign	0.20
R8912:Fsip2	UTSW	2	82980594	missense	probably benign
R8926:Fsip2	UTSW	2	82993583	missense	possibly damaging	0.84
R8991:Fsip2	UTSW	2	82985026	missense	probably benign	0.33
R9014:Fsip2	UTSW	2	82976554	missense	probably benign	0.32
R9014:Fsip2	UTSW	2	82986731	missense	possibly damaging	0.71
R9039:Fsip2	UTSW	2	82998201	missense	probably benign	0.32
R9054:Fsip2	UTSW	2	82975836	missense	possibly damaging	0.68
R9114:Fsip2	UTSW	2	82976957	missense	probably benign	0.00
R9124:Fsip2	UTSW	2	82985759	missense	probably benign	0.00
R9131:Fsip2	UTSW	2	82982826	missense	probably benign
R9149:Fsip2	UTSW	2	82982030	missense	possibly damaging	0.86
R9180:Fsip2	UTSW	2	82985230	missense	possibly damaging	0.96
R9192:Fsip2	UTSW	2	82987500	missense	probably benign	0.06
R9216:Fsip2	UTSW	2	82990081	missense	probably damaging	0.99
R9218:Fsip2	UTSW	2	82992718	missense	probably damaging	0.97
R9222:Fsip2	UTSW	2	82985614	missense	probably benign	0.00
R9262:Fsip2	UTSW	2	82977318	missense	probably benign	0.00
R9340:Fsip2	UTSW	2	82988260	missense	possibly damaging	0.71
R9342:Fsip2	UTSW	2	82988403	missense	possibly damaging	0.71
R9368:Fsip2	UTSW	2	82980695	missense	possibly damaging	0.68
R9372:Fsip2	UTSW	2	82992412	missense	possibly damaging	0.71
R9385:Fsip2	UTSW	2	82989449	missense	possibly damaging	0.84
R9432:Fsip2	UTSW	2	82975563	missense	probably damaging	0.98
R9434:Fsip2	UTSW	2	82986358	missense	possibly damaging	0.71
R9445:Fsip2	UTSW	2	82975788	missense	probably damaging	0.99
R9472:Fsip2	UTSW	2	82986941	missense	possibly damaging	0.85
R9496:Fsip2	UTSW	2	82962718	missense	probably benign
R9523:Fsip2	UTSW	2	82977628	missense	probably damaging	0.99
R9567:Fsip2	UTSW	2	82967829	missense	probably benign
R9636:Fsip2	UTSW	2	82990219	missense	possibly damaging	0.52
R9643:Fsip2	UTSW	2	82991640	missense	possibly damaging	0.53
R9680:Fsip2	UTSW	2	82988928	missense	probably benign	0.32
R9695:Fsip2	UTSW	2	82975882	missense	probably benign
R9705:Fsip2	UTSW	2	82993290	missense	probably benign
R9739:Fsip2	UTSW	2	82993552	missense	possibly damaging	0.71
R9751:Fsip2	UTSW	2	82987897	missense	probably benign	0.00
R9761:Fsip2	UTSW	2	82991650	missense	probably benign	0.00
R9798:Fsip2	UTSW	2	82979881	nonsense	probably null
RF003:Fsip2	UTSW	2	82991521	missense	probably benign	0.02
RF005:Fsip2	UTSW	2	82992532	missense	probably benign	0.04
RF008:Fsip2	UTSW	2	82977840	missense	probably benign
RF028:Fsip2	UTSW	2	82994008	frame shift	probably null
RF029:Fsip2	UTSW	2	82994008	frame shift	probably null
RF036:Fsip2	UTSW	2	82984363	critical splice acceptor site	probably benign
RF038:Fsip2	UTSW	2	82994008	frame shift	probably null
RF062:Fsip2	UTSW	2	82984363	critical splice acceptor site	probably benign
X0018:Fsip2	UTSW	2	82982507	nonsense	probably null
X0020:Fsip2	UTSW	2	82951020	missense	probably damaging	1.00
X0025:Fsip2	UTSW	2	82954946	missense	possibly damaging	0.70
X0027:Fsip2	UTSW	2	82976778	missense	probably benign	0.35
X0066:Fsip2	UTSW	2	82987463	missense	possibly damaging	0.51
Z1088:Fsip2	UTSW	2	82975448	missense	probably damaging	0.96
Z1088:Fsip2	UTSW	2	82987653	missense	possibly damaging	0.86
Z1088:Fsip2	UTSW	2	82988634	missense	possibly damaging	0.85
Z1176:Fsip2	UTSW	2	82989665	missense	probably benign	0.02
Z1177:Fsip2	UTSW	2	82946960	missense	probably damaging	0.99
Z1177:Fsip2	UTSW	2	82984524	missense	probably damaging	0.98
Z1177:Fsip2	UTSW	2	82987203	missense	possibly damaging	0.71

Predicted Primers

PCR Primer
(F):5'- GAACGGTTGAGTTTATCCCCAG -3'
(R):5'- AATGTCCTACACTGGAATCTGATGG -3'

Sequencing Primer
(F):5'- ACGGTTGAGTTTATCCCCAGTAGAAG -3'
(R):5'- CACTGGAATCTGATGGATTTATCTG -3'

Posted On

2016-06-15