Incidental Mutation 'R5121:Pappa2'
| ID |
392975 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pappa2
|
| Ensembl Gene |
ENSMUSG00000073530 |
| Gene Name |
pappalysin 2 |
| Synonyms |
pregnancy-associated plasma preproprotein-A2, placenta-specific 3, pregnancy-associated plasma protein-E, PAPP-A2, PLAC3, Pappe |
| MMRRC Submission |
042709-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5121 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
158711727-158980490 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 158838627 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 1128
(M1128L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124022
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159861]
|
| AlphaFold |
E9PZ87 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159860
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159861
AA Change: M1128L
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000124022
Gene: ENSMUSG00000073530
AA Change: M1128L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Laminin_G_3
|
271 |
440 |
1.2e-25 |
PFAM |
|
NL
|
572 |
614 |
2.81e-5 |
SMART |
|
Pfam:Peptidase_M43
|
669 |
832 |
1.5e-12 |
PFAM |
|
Blast:FN3
|
844 |
1103 |
1e-169 |
BLAST |
|
low complexity region
|
1130 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1361 |
1370 |
N/A |
INTRINSIC |
|
CCP
|
1394 |
1457 |
4.97e0 |
SMART |
|
CCP
|
1462 |
1519 |
4.81e-1 |
SMART |
|
CCP
|
1523 |
1588 |
2.58e-4 |
SMART |
|
CCP
|
1593 |
1644 |
1.13e0 |
SMART |
|
NL
|
1720 |
1757 |
2.66e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160206
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.1%
- 20x: 91.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acvr1c |
A |
G |
2: 58,281,650 |
I234T |
probably damaging |
Het |
| Adam24 |
A |
G |
8: 40,679,511 |
E6G |
probably damaging |
Het |
| Amz1 |
A |
G |
5: 140,744,164 |
D151G |
probably benign |
Het |
| Arhgap24 |
T |
C |
5: 102,841,335 |
L10P |
probably damaging |
Het |
| Arhgap25 |
T |
G |
6: 87,532,864 |
N8T |
probably benign |
Het |
| Arsi |
T |
G |
18: 60,917,439 |
F465V |
probably damaging |
Het |
| Atp2c1 |
A |
G |
9: 105,448,825 |
V293A |
probably damaging |
Het |
| Bzw2 |
A |
G |
12: 36,104,351 |
L340P |
probably damaging |
Het |
| Camkmt |
C |
T |
17: 85,096,581 |
T77I |
probably benign |
Het |
| Camsap1 |
G |
T |
2: 25,935,550 |
Q1375K |
probably benign |
Het |
| Catsper2 |
G |
T |
2: 121,397,123 |
|
probably null |
Het |
| Cd163 |
T |
C |
6: 124,317,989 |
C671R |
probably damaging |
Het |
| Cdk7 |
T |
C |
13: 100,717,684 |
|
probably null |
Het |
| Cfi |
C |
T |
3: 129,873,077 |
P483L |
probably damaging |
Het |
| Chn2 |
C |
T |
6: 54,218,561 |
L72F |
possibly damaging |
Het |
| Cntn2 |
C |
A |
1: 132,517,060 |
E363* |
probably null |
Het |
| Crebbp |
T |
C |
16: 4,093,511 |
E999G |
probably damaging |
Het |
| Cspp1 |
T |
A |
1: 10,126,463 |
N900K |
probably damaging |
Het |
| Cts3 |
A |
C |
13: 61,567,595 |
I141M |
probably benign |
Het |
| Cwc27 |
A |
T |
13: 104,804,353 |
V166D |
probably damaging |
Het |
| Defb26 |
T |
C |
2: 152,508,165 |
E65G |
possibly damaging |
Het |
| Dnah8 |
A |
G |
17: 30,810,353 |
T4099A |
probably benign |
Het |
| Eml6 |
A |
G |
11: 29,744,606 |
F1953L |
probably benign |
Het |
| Etl4 |
T |
A |
2: 20,340,111 |
|
probably null |
Het |
| Fbln1 |
A |
G |
15: 85,237,671 |
E331G |
probably damaging |
Het |
| Gabra4 |
G |
A |
5: 71,572,203 |
H76Y |
probably benign |
Het |
| Gcat |
T |
C |
15: 79,035,282 |
V149A |
probably damaging |
Het |
| Glp2r |
A |
T |
11: 67,722,100 |
|
probably null |
Het |
| Gm572 |
T |
C |
4: 148,666,845 |
|
probably null |
Het |
| Golgb1 |
T |
C |
16: 36,919,258 |
V2653A |
probably damaging |
Het |
| Grap2 |
G |
A |
15: 80,646,144 |
R155Q |
possibly damaging |
Het |
| Gspt1 |
T |
A |
16: 11,223,301 |
I533L |
probably damaging |
Het |
| Gypa |
A |
T |
8: 80,496,348 |
Y27F |
unknown |
Het |
| Hipk4 |
G |
A |
7: 27,529,492 |
V456I |
probably benign |
Het |
| Homer2 |
A |
T |
7: 81,649,563 |
D51E |
probably benign |
Het |
| Hspa1b |
A |
T |
17: 34,958,004 |
V335E |
possibly damaging |
Het |
| Ift122 |
A |
G |
6: 115,912,534 |
T827A |
probably benign |
Het |
| Igkv1-35 |
T |
C |
6: 70,011,135 |
N58S |
probably benign |
Het |
| Kat6b |
A |
T |
14: 21,619,258 |
H297L |
probably damaging |
Het |
| Kirrel3 |
G |
T |
9: 35,013,305 |
G296W |
probably damaging |
Het |
| Klhl17 |
A |
G |
4: 156,230,625 |
V525A |
probably benign |
Het |
| Lrrn1 |
G |
T |
6: 107,569,207 |
R655S |
possibly damaging |
Het |
| Ltk |
T |
C |
2: 119,753,227 |
N256D |
probably damaging |
Het |
| Mill2 |
G |
A |
7: 18,856,666 |
G209S |
probably benign |
Het |
| Mmp27 |
A |
T |
9: 7,581,368 |
H544L |
probably benign |
Het |
| Mphosph10 |
A |
G |
7: 64,389,596 |
S209P |
probably damaging |
Het |
| Mphosph8 |
A |
T |
14: 56,676,546 |
K415* |
probably null |
Het |
| Myb |
T |
A |
10: 21,126,238 |
M616L |
probably benign |
Het |
| Myo15b |
C |
T |
11: 115,886,054 |
R867W |
probably damaging |
Het |
| Myo18b |
A |
T |
5: 112,874,480 |
|
probably benign |
Het |
| Nip7 |
A |
G |
8: 107,056,957 |
E8G |
possibly damaging |
Het |
| Olfr1318 |
A |
T |
2: 112,156,286 |
M112L |
possibly damaging |
Het |
| Olfr368 |
T |
G |
2: 37,332,589 |
F281V |
probably damaging |
Het |
| Olfr38 |
T |
A |
6: 42,762,997 |
L315* |
probably null |
Het |
| Olfr677 |
A |
G |
7: 105,056,482 |
T79A |
possibly damaging |
Het |
| Olfr711 |
T |
C |
7: 106,972,231 |
I38V |
probably benign |
Het |
| Optn |
T |
A |
2: 5,046,106 |
I155F |
probably benign |
Het |
| Papolb |
A |
T |
5: 142,528,837 |
H350Q |
probably benign |
Het |
| Pcdhb5 |
T |
A |
18: 37,321,117 |
N183K |
probably benign |
Het |
| Pde12 |
G |
T |
14: 26,669,422 |
S44* |
probably null |
Het |
| Peg3 |
T |
C |
7: 6,710,289 |
K645E |
probably benign |
Het |
| Pkd1 |
C |
T |
17: 24,573,463 |
R1375C |
probably benign |
Het |
| Plekha5 |
G |
A |
6: 140,579,474 |
E21K |
probably damaging |
Het |
| Plk2 |
C |
T |
13: 110,399,424 |
P554L |
probably benign |
Het |
| Pnkp |
C |
T |
7: 44,862,403 |
S113L |
probably damaging |
Het |
| Polg |
A |
T |
7: 79,464,605 |
W203R |
probably damaging |
Het |
| Ppcdc |
A |
G |
9: 57,421,163 |
V65A |
possibly damaging |
Het |
| Ppm1m |
T |
A |
9: 106,195,805 |
Q353L |
probably benign |
Het |
| Ppp1r13l |
G |
C |
7: 19,370,095 |
R167P |
probably damaging |
Het |
| Ppp1r9b |
T |
A |
11: 94,996,653 |
V497E |
probably damaging |
Het |
| Prpf6 |
T |
A |
2: 181,636,043 |
H399Q |
probably benign |
Het |
| Psg25 |
T |
A |
7: 18,526,536 |
I146F |
possibly damaging |
Het |
| Rasgef1c |
A |
T |
11: 49,960,429 |
Q116L |
probably damaging |
Het |
| Rbbp9 |
A |
G |
2: 144,550,756 |
V8A |
possibly damaging |
Het |
| Rfk |
T |
C |
19: 17,399,566 |
F144S |
probably damaging |
Het |
| Rfwd3 |
A |
C |
8: 111,282,753 |
|
probably null |
Het |
| Rhpn1 |
T |
C |
15: 75,709,260 |
I117T |
probably damaging |
Het |
| Sars2 |
A |
T |
7: 28,747,908 |
N244Y |
probably damaging |
Het |
| Scnn1b |
A |
T |
7: 121,902,887 |
H256L |
probably benign |
Het |
| Sgcz |
G |
A |
8: 37,539,667 |
T195I |
probably damaging |
Het |
| Sh3gl2 |
T |
A |
4: 85,379,257 |
H157Q |
probably benign |
Het |
| Spen |
T |
A |
4: 141,476,099 |
Q1739L |
probably benign |
Het |
| Susd1 |
G |
T |
4: 59,379,657 |
S323R |
possibly damaging |
Het |
| Szt2 |
T |
C |
4: 118,385,444 |
E1482G |
possibly damaging |
Het |
| Tex15 |
A |
T |
8: 33,571,766 |
K408I |
probably damaging |
Het |
| Tex33 |
C |
T |
15: 78,386,173 |
E132K |
probably benign |
Het |
| Trem1 |
T |
A |
17: 48,232,836 |
F14L |
probably null |
Het |
| Trim26 |
G |
T |
17: 36,851,066 |
E126* |
probably null |
Het |
| Trpv3 |
T |
C |
11: 73,277,834 |
|
probably null |
Het |
| Ttn |
T |
A |
2: 76,916,491 |
|
probably null |
Het |
| Ubap1 |
C |
T |
4: 41,379,688 |
L301F |
probably benign |
Het |
| Uchl1 |
T |
C |
5: 66,676,437 |
M12T |
probably benign |
Het |
| Vill |
C |
T |
9: 119,070,025 |
T253I |
possibly damaging |
Het |
| Vmn2r107 |
C |
T |
17: 20,355,753 |
T115I |
probably benign |
Het |
| Vmn2r98 |
T |
C |
17: 19,053,553 |
S21P |
probably benign |
Het |
| Wapl |
A |
G |
14: 34,677,162 |
K63E |
probably benign |
Het |
| Wnt2 |
T |
C |
6: 18,023,126 |
K175E |
possibly damaging |
Het |
| Zfp592 |
T |
C |
7: 81,023,561 |
L91P |
probably damaging |
Het |
| Zfp74 |
T |
C |
7: 29,932,507 |
|
probably null |
Het |
| Zglp1 |
A |
T |
9: 21,062,661 |
I243N |
probably benign |
Het |
| Zranb1 |
A |
G |
7: 132,950,187 |
E215G |
probably benign |
Het |
|
| Other mutations in Pappa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Pappa2
|
APN |
1 |
158,857,148 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01394:Pappa2
|
APN |
1 |
158,765,104 (GRCm38) |
splice site |
probably benign |
|
|
IGL01570:Pappa2
|
APN |
1 |
158,814,540 (GRCm38) |
nonsense |
probably null |
|
|
IGL01618:Pappa2
|
APN |
1 |
158,857,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01717:Pappa2
|
APN |
1 |
158,857,132 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01804:Pappa2
|
APN |
1 |
158,936,519 (GRCm38) |
missense |
probably benign |
|
|
IGL01904:Pappa2
|
APN |
1 |
158,783,941 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02116:Pappa2
|
APN |
1 |
158,845,125 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02174:Pappa2
|
APN |
1 |
158,761,618 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02302:Pappa2
|
APN |
1 |
158,715,001 (GRCm38) |
missense |
probably benign |
0.38 |
|
IGL02422:Pappa2
|
APN |
1 |
158,936,933 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02572:Pappa2
|
APN |
1 |
158,851,216 (GRCm38) |
missense |
probably benign |
|
|
IGL02659:Pappa2
|
APN |
1 |
158,936,794 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02887:Pappa2
|
APN |
1 |
158,782,259 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02981:Pappa2
|
APN |
1 |
158,851,144 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03128:Pappa2
|
APN |
1 |
158,936,484 (GRCm38) |
missense |
probably benign |
0.16 |
|
IGL03142:Pappa2
|
APN |
1 |
158,854,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03270:Pappa2
|
APN |
1 |
158,765,067 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
Fritas
|
UTSW |
1 |
158,847,963 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
Gulliver
|
UTSW |
1 |
158,857,136 (GRCm38) |
missense |
probably null |
1.00 |
|
Lilliputian
|
UTSW |
1 |
158,716,990 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Lilliputian2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
lilliputian3
|
UTSW |
1 |
158,782,403 (GRCm38) |
splice site |
probably null |
|
|
Pitzel
|
UTSW |
1 |
158,956,645 (GRCm38) |
missense |
probably damaging |
1.00 |
|
shrink
|
UTSW |
1 |
158,763,192 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,714,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,714,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0172:Pappa2
|
UTSW |
1 |
158,854,849 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0194:Pappa2
|
UTSW |
1 |
158,765,101 (GRCm38) |
splice site |
probably benign |
|
|
R0418:Pappa2
|
UTSW |
1 |
158,716,990 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0421:Pappa2
|
UTSW |
1 |
158,848,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0441:Pappa2
|
UTSW |
1 |
158,763,058 (GRCm38) |
unclassified |
probably benign |
|
|
R0602:Pappa2
|
UTSW |
1 |
158,763,055 (GRCm38) |
unclassified |
probably benign |
|
|
R0630:Pappa2
|
UTSW |
1 |
158,832,773 (GRCm38) |
missense |
probably benign |
|
|
R0760:Pappa2
|
UTSW |
1 |
158,716,961 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1146:Pappa2
|
UTSW |
1 |
158,854,982 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1146:Pappa2
|
UTSW |
1 |
158,854,982 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1243:Pappa2
|
UTSW |
1 |
158,845,100 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1413:Pappa2
|
UTSW |
1 |
158,936,554 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1502:Pappa2
|
UTSW |
1 |
158,957,288 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1599:Pappa2
|
UTSW |
1 |
158,857,172 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1689:Pappa2
|
UTSW |
1 |
158,957,398 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1750:Pappa2
|
UTSW |
1 |
158,763,150 (GRCm38) |
nonsense |
probably null |
|
|
R1772:Pappa2
|
UTSW |
1 |
158,814,368 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R1832:Pappa2
|
UTSW |
1 |
158,857,316 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1905:Pappa2
|
UTSW |
1 |
158,803,503 (GRCm38) |
splice site |
probably null |
|
|
R1914:Pappa2
|
UTSW |
1 |
158,750,563 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2013:Pappa2
|
UTSW |
1 |
158,834,928 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2037:Pappa2
|
UTSW |
1 |
158,956,644 (GRCm38) |
nonsense |
probably null |
|
|
R2118:Pappa2
|
UTSW |
1 |
158,857,266 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2268:Pappa2
|
UTSW |
1 |
158,857,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2269:Pappa2
|
UTSW |
1 |
158,857,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2347:Pappa2
|
UTSW |
1 |
158,765,043 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3024:Pappa2
|
UTSW |
1 |
158,936,225 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3706:Pappa2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
R3707:Pappa2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
R3708:Pappa2
|
UTSW |
1 |
158,834,918 (GRCm38) |
nonsense |
probably null |
|
|
R4600:Pappa2
|
UTSW |
1 |
158,814,445 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4737:Pappa2
|
UTSW |
1 |
158,957,012 (GRCm38) |
missense |
probably benign |
|
|
R4738:Pappa2
|
UTSW |
1 |
158,957,012 (GRCm38) |
missense |
probably benign |
|
|
R4739:Pappa2
|
UTSW |
1 |
158,957,012 (GRCm38) |
missense |
probably benign |
|
|
R4739:Pappa2
|
UTSW |
1 |
158,957,002 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4788:Pappa2
|
UTSW |
1 |
158,783,917 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4798:Pappa2
|
UTSW |
1 |
158,857,379 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4952:Pappa2
|
UTSW |
1 |
158,857,136 (GRCm38) |
missense |
probably null |
1.00 |
|
R5144:Pappa2
|
UTSW |
1 |
158,957,133 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5159:Pappa2
|
UTSW |
1 |
158,761,619 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5278:Pappa2
|
UTSW |
1 |
158,782,403 (GRCm38) |
splice site |
probably null |
|
|
R5428:Pappa2
|
UTSW |
1 |
158,814,785 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R5452:Pappa2
|
UTSW |
1 |
158,838,602 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5477:Pappa2
|
UTSW |
1 |
158,956,738 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5504:Pappa2
|
UTSW |
1 |
158,848,045 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5852:Pappa2
|
UTSW |
1 |
158,717,014 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6003:Pappa2
|
UTSW |
1 |
158,936,250 (GRCm38) |
missense |
probably benign |
0.23 |
|
R6129:Pappa2
|
UTSW |
1 |
158,714,997 (GRCm38) |
nonsense |
probably null |
|
|
R6137:Pappa2
|
UTSW |
1 |
158,871,543 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6374:Pappa2
|
UTSW |
1 |
158,956,645 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6472:Pappa2
|
UTSW |
1 |
158,834,799 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6804:Pappa2
|
UTSW |
1 |
158,936,868 (GRCm38) |
missense |
probably benign |
0.24 |
|
R7020:Pappa2
|
UTSW |
1 |
158,848,009 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7051:Pappa2
|
UTSW |
1 |
158,957,183 (GRCm38) |
missense |
unknown |
|
|
R7082:Pappa2
|
UTSW |
1 |
158,763,119 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R7111:Pappa2
|
UTSW |
1 |
158,956,526 (GRCm38) |
missense |
probably benign |
0.38 |
|
R7213:Pappa2
|
UTSW |
1 |
158,936,886 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7575:Pappa2
|
UTSW |
1 |
158,814,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7587:Pappa2
|
UTSW |
1 |
158,851,131 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7826:Pappa2
|
UTSW |
1 |
158,936,440 (GRCm38) |
nonsense |
probably null |
|
|
R7957:Pappa2
|
UTSW |
1 |
158,761,561 (GRCm38) |
nonsense |
probably null |
|
|
R8007:Pappa2
|
UTSW |
1 |
158,782,304 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8050:Pappa2
|
UTSW |
1 |
158,848,400 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8063:Pappa2
|
UTSW |
1 |
158,936,556 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R8068:Pappa2
|
UTSW |
1 |
158,935,985 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R8128:Pappa2
|
UTSW |
1 |
158,936,664 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R8264:Pappa2
|
UTSW |
1 |
158,854,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8317:Pappa2
|
UTSW |
1 |
158,764,960 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8499:Pappa2
|
UTSW |
1 |
158,936,522 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8744:Pappa2
|
UTSW |
1 |
158,783,917 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R8793:Pappa2
|
UTSW |
1 |
158,851,161 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8932:Pappa2
|
UTSW |
1 |
158,763,192 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9004:Pappa2
|
UTSW |
1 |
158,936,948 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R9004:Pappa2
|
UTSW |
1 |
158,936,409 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9088:Pappa2
|
UTSW |
1 |
158,936,357 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9191:Pappa2
|
UTSW |
1 |
158,857,418 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9243:Pappa2
|
UTSW |
1 |
158,936,193 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9280:Pappa2
|
UTSW |
1 |
158,847,963 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R9301:Pappa2
|
UTSW |
1 |
158,845,044 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9306:Pappa2
|
UTSW |
1 |
158,936,922 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9367:Pappa2
|
UTSW |
1 |
158,956,972 (GRCm38) |
missense |
probably benign |
0.40 |
|
R9471:Pappa2
|
UTSW |
1 |
158,814,459 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9544:Pappa2
|
UTSW |
1 |
158,957,247 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9680:Pappa2
|
UTSW |
1 |
158,782,248 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R9762:Pappa2
|
UTSW |
1 |
158,857,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9774:Pappa2
|
UTSW |
1 |
158,848,350 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9776:Pappa2
|
UTSW |
1 |
158,783,911 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0058:Pappa2
|
UTSW |
1 |
158,814,397 (GRCm38) |
missense |
probably null |
|
|
X0061:Pappa2
|
UTSW |
1 |
158,936,618 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,956,933 (GRCm38) |
missense |
probably benign |
|
|
Z1176:Pappa2
|
UTSW |
1 |
158,814,816 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,814,814 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTTCAATCATCATTAAGACACAGGAC -3'
(R):5'- TAGGAATTCCCACAACACTCTG -3'
Sequencing Primer
(F):5'- TTAAGACACAGGACACTAACAGTTC -3'
(R):5'- AATACTAATCTACCATTTTGCTGACC -3'
|
| Posted On |
2016-06-15 |
Incidental Mutation