|Institutional Source||Beutler Lab|
|Gene Name||cyclin-dependent kinase 7|
|Synonyms||Cdkn7, Crk4, CRK4 PK (CDC2-related-kinase-4 protein kinase)|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R5121 (G1)|
|Chromosomal Location||100702631-100730939 bp(-) (GRCm38)|
|Type of Mutation||critical splice acceptor site|
|DNA Base Change (assembly)||T to C at 100717684 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000088845 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000091299] [ENSMUST00000091299] [ENSMUST00000225990]|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for null allele exhibit abnormal trophoblast layer morphology, abnormal inner cell mass apoptosis, and complete embryonic lethality during peri-implantation stages. Homoyzgous null MEFs display absent fibroblast proliferation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cdk7||
(F):5'- TGGCCTTCCTGGAATACAAAG -3'
(R):5'- GCACAGCATTGCTTACCACC -3'
(F):5'- GCAAGACTCTCACAGATAGATGGATC -3'
(R):5'- TGGAACTCACTCTGTAGACCAGG -3'