Mutagenetix > Incidental Mutation

Incidental Mutation 'R5038:Mycbp2'

393129

Institutional Source

Beutler Lab

Gene Symbol

Mycbp2

Ensembl Gene

ENSMUSG00000033004

Gene Name

MYC binding protein 2

Synonyms

C130061D10Rik, Phr1, Pam

MMRRC Submission

042628-MU

Accession Numbers

Genbank: NM_207215; MGI: 2179432

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R5038 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

103113411-103346814 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 103296939 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Histidine at position 372 (R372H)

Ref Sequence

ENSEMBL: ENSMUSP00000124601 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000159855] [ENSMUST00000160758]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000159855
AA Change: R405H

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000124710
Gene: ENSMUSG00000033004
AA Change: R405H

Domain	Start	End	E-Value	Type
low complexity region	5	27	N/A	INTRINSIC
low complexity region	47	55	N/A	INTRINSIC
low complexity region	100	127	N/A	INTRINSIC
low complexity region	178	191	N/A	INTRINSIC
Pfam:RCC1_2	683	712	1.4e-10	PFAM
low complexity region	737	750	N/A	INTRINSIC
low complexity region	793	815	N/A	INTRINSIC
Pfam:RCC1_2	942	971	5.5e-10	PFAM
Pfam:RCC1	958	1006	4.8e-15	PFAM
Pfam:PHR	1235	1385	8.2e-44	PFAM
Pfam:PHR	1723	1880	1.4e-43	PFAM
low complexity region	1935	1948	N/A	INTRINSIC
low complexity region	2182	2195	N/A	INTRINSIC
Pfam:Filamin	2261	2431	7.5e-9	PFAM
Pfam:SH3_3	2472	2539	4.1e-9	PFAM
internal_repeat_3	2612	2679	1.69e-7	PROSPERO
low complexity region	2701	2710	N/A	INTRINSIC
low complexity region	2884	2917	N/A	INTRINSIC
low complexity region	2970	2984	N/A	INTRINSIC
coiled coil region	3263	3290	N/A	INTRINSIC
low complexity region	3352	3365	N/A	INTRINSIC
low complexity region	3418	3433	N/A	INTRINSIC
low complexity region	3678	3695	N/A	INTRINSIC
APC10	3810	3968	1.11e-18	SMART
low complexity region	4103	4115	N/A	INTRINSIC
low complexity region	4190	4212	N/A	INTRINSIC
Blast:BBOX	4327	4370	7e-7	BLAST
RING	4496	4546	5.35e-5	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000160758
AA Change: R372H

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000124601
Gene: ENSMUSG00000033004
AA Change: R372H

Domain	Start	End	E-Value	Type
low complexity region	14	22	N/A	INTRINSIC
low complexity region	67	94	N/A	INTRINSIC
low complexity region	145	158	N/A	INTRINSIC
Pfam:RCC1_2	650	679	1e-10	PFAM
low complexity region	704	717	N/A	INTRINSIC
low complexity region	760	782	N/A	INTRINSIC
Pfam:RCC1_2	909	938	1.5e-9	PFAM
Pfam:RCC1	925	973	1.3e-15	PFAM
Pfam:PHR	1202	1353	1.6e-50	PFAM
Pfam:PHR	1690	1848	3.1e-58	PFAM
low complexity region	1902	1915	N/A	INTRINSIC
low complexity region	2149	2162	N/A	INTRINSIC
Pfam:Filamin	2228	2398	7.6e-9	PFAM
Pfam:SH3_3	2439	2507	2.3e-10	PFAM
internal_repeat_3	2554	2621	2e-7	PROSPERO
low complexity region	2643	2652	N/A	INTRINSIC
low complexity region	2774	2807	N/A	INTRINSIC
low complexity region	2860	2874	N/A	INTRINSIC
coiled coil region	3153	3180	N/A	INTRINSIC
low complexity region	3242	3255	N/A	INTRINSIC
low complexity region	3308	3323	N/A	INTRINSIC
low complexity region	3568	3585	N/A	INTRINSIC
APC10	3700	3858	1.11e-18	SMART
low complexity region	3993	4005	N/A	INTRINSIC
low complexity region	4080	4102	N/A	INTRINSIC
Blast:BBOX	4217	4260	7e-7	BLAST
RING	4386	4436	5.35e-5	SMART

Meta Mutation Damage Score

0.0720

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.7%
20x: 93.5%

Validation Efficiency

94% (64/68)

MGI Phenotype

PHENOTYPE: Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance. [provided by MGI curators]

Allele List at MGI

All alleles(10) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5) Chemically induced(3)

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930512M02Rik	A	T	11: 11,589,375		probably null	Het
Abtb2	G	T	2: 103,567,063	G113C	probably damaging	Het
Acsm5	A	G	7: 119,534,811	T272A	probably damaging	Het
Adprhl2	C	T	4: 126,317,309	E272K	possibly damaging	Het
Agbl5	G	A	5: 30,903,059	R141Q	probably damaging	Het
Atp7b	A	C	8: 22,028,456	I122S	possibly damaging	Het
B230219D22Rik	T	C	13: 55,699,475	Y134H	probably damaging	Het
Bnc1	A	G	7: 81,968,714	S868P	probably damaging	Het
Camta1	T	C	4: 151,145,469	E302G	probably damaging	Het
Car1	A	G	3: 14,770,873	Y129H	probably damaging	Het
Cdh22	T	C	2: 165,142,277	T352A	probably benign	Het
Ckmt2	T	C	13: 91,861,163	E215G	probably benign	Het
Cyb5r4	T	G	9: 87,059,077		probably null	Het
Dhrs13	A	G	11: 78,032,430		probably benign	Het
Dsg1c	G	A	18: 20,264,844	A34T	probably benign	Het
Epb41l1	T	C	2: 156,521,410	V613A	probably benign	Het
Fam114a1	A	G	5: 65,009,045	M240V	probably damaging	Het
Gm15455	T	C	1: 33,838,176		noncoding transcript	Het
Herc1	T	G	9: 66,476,460		probably benign	Het
Ifna11	T	C	4: 88,820,077	V40A	probably benign	Het
Ifna15	T	C	4: 88,558,029	N73D	probably benign	Het
Imp4	A	T	1: 34,442,935	L45F	probably damaging	Het
Jak3	G	A	8: 71,686,058	A967T	probably damaging	Het
Krtap19-2	A	T	16: 88,874,028	Y76*	probably null	Het
Map4k5	A	T	12: 69,824,614	N492K	probably damaging	Het
Nos2	G	A	11: 78,922,314	S16N	probably benign	Het
Nr2c2	A	G	6: 92,139,822	T2A	probably damaging	Het
Nup188	T	C	2: 30,309,220	Y267H	probably damaging	Het
Nxph2	G	A	2: 23,321,544		probably null	Het
Olfr1446	T	A	19: 12,890,406	H57L	probably damaging	Het
Olfr1461	T	A	19: 13,165,591	D192E	probably benign	Het
Olfr1505	T	A	19: 13,919,458	V146E	possibly damaging	Het
Otof	C	T	5: 30,384,439	E761K	possibly damaging	Het
Pik3r1	C	T	13: 101,689,444	R37Q	probably damaging	Het
Pkn3	T	C	2: 30,085,281		probably null	Het
Pold3	A	G	7: 100,121,383	V14A	probably damaging	Het
Ptpn14	T	C	1: 189,786,886	S38P	probably damaging	Het
Raf1	G	A	6: 115,620,235	Q35*	probably null	Het
Rps3a1	C	A	3: 86,138,031	E251D	probably benign	Het
Scd1	C	T	19: 44,401,709	V207M	probably damaging	Het
Shq1	A	G	6: 100,630,993	V319A	probably benign	Het
Slc4a8	T	C	15: 100,795,821	Y416H	probably damaging	Het
Slco1a5	C	T	6: 142,266,364	G90D	probably damaging	Het
Slco1a5	T	C	6: 142,262,637	T143A	probably benign	Het
Snx9	T	C	17: 5,887,073	V30A	probably benign	Het
Spdya	T	C	17: 71,588,566		probably benign	Het
Stat1	A	T	1: 52,123,209	N75I	probably damaging	Het
Sv2b	A	T	7: 75,157,425	M159K	probably damaging	Het
Tdh	A	T	14: 63,496,126	Y89*	probably null	Het
Tmc7	A	G	7: 118,543,365	F600S	probably damaging	Het
Trpa1	T	A	1: 14,910,866	H104L	probably damaging	Het
Ttn	G	A	2: 76,848,640		probably benign	Het
Vmn1r113	A	G	7: 20,787,494	I70M	possibly damaging	Het
Vmn1r171	A	G	7: 23,632,763	M138V	probably benign	Het
Zfc3h1	G	A	10: 115,404,211	V550I	probably benign	Het
Zfp335	G	T	2: 164,910,644	S60*	probably null	Het
Zfp7	T	C	15: 76,891,810	M684T	probably benign	Het
Zfp984	T	A	4: 147,755,446	H316L	probably damaging	Het
Zmym2	T	A	14: 56,956,180	Y1151N	possibly damaging	Het

Other mutations in Mycbp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Mycbp2	APN	14	103,223,050 (GRCm38)	missense	probably damaging	1.00
IGL00518:Mycbp2	APN	14	103,155,808 (GRCm38)	missense	probably damaging	1.00
IGL00650:Mycbp2	APN	14	103,143,228 (GRCm38)	missense	probably damaging	0.97
IGL00653:Mycbp2	APN	14	103,143,228 (GRCm38)	missense	probably damaging	0.97
IGL00742:Mycbp2	APN	14	103,201,352 (GRCm38)	missense	probably damaging	1.00
IGL00755:Mycbp2	APN	14	103,194,621 (GRCm38)	missense	possibly damaging	0.72
IGL00793:Mycbp2	APN	14	103,126,753 (GRCm38)	missense	possibly damaging	0.77
IGL00916:Mycbp2	APN	14	103,291,283 (GRCm38)	splice site	probably benign
IGL00960:Mycbp2	APN	14	103,229,384 (GRCm38)	missense	possibly damaging	0.95
IGL00977:Mycbp2	APN	14	103,172,642 (GRCm38)	missense	probably damaging	0.98
IGL01349:Mycbp2	APN	14	103,122,547 (GRCm38)	missense	probably damaging	0.98
IGL01369:Mycbp2	APN	14	103,155,510 (GRCm38)	missense	possibly damaging	0.61
IGL01410:Mycbp2	APN	14	103,229,492 (GRCm38)	splice site	probably null
IGL01586:Mycbp2	APN	14	103,140,869 (GRCm38)	critical splice donor site	probably null
IGL01593:Mycbp2	APN	14	103,291,287 (GRCm38)	critical splice donor site	probably null
IGL01693:Mycbp2	APN	14	103,127,979 (GRCm38)	missense	probably damaging	0.99
IGL01730:Mycbp2	APN	14	103,135,204 (GRCm38)	nonsense	probably null
IGL01820:Mycbp2	APN	14	103,188,501 (GRCm38)	missense	probably damaging	1.00
IGL01974:Mycbp2	APN	14	103,143,211 (GRCm38)	missense	possibly damaging	0.88
IGL02071:Mycbp2	APN	14	103,154,907 (GRCm38)	nonsense	probably null
IGL02178:Mycbp2	APN	14	103,224,366 (GRCm38)	missense	probably benign	0.01
IGL02324:Mycbp2	APN	14	103,242,207 (GRCm38)	missense	probably damaging	1.00
IGL02442:Mycbp2	APN	14	103,314,375 (GRCm38)	missense	probably benign
IGL02607:Mycbp2	APN	14	103,285,273 (GRCm38)	missense	probably damaging	1.00
IGL02679:Mycbp2	APN	14	103,205,185 (GRCm38)	missense	probably benign
IGL02702:Mycbp2	APN	14	103,220,124 (GRCm38)	missense	probably benign	0.01
IGL02709:Mycbp2	APN	14	103,155,261 (GRCm38)	missense	probably damaging	0.97
IGL02736:Mycbp2	APN	14	103,114,242 (GRCm38)	splice site	probably benign
IGL02866:Mycbp2	APN	14	103,129,992 (GRCm38)	missense	probably damaging	0.98
IGL02939:Mycbp2	APN	14	103,177,279 (GRCm38)	missense	probably benign
IGL03082:Mycbp2	APN	14	103,204,369 (GRCm38)	missense	probably benign	0.23
IGL03142:Mycbp2	APN	14	103,298,776 (GRCm38)	missense	probably damaging	0.99
IGL03155:Mycbp2	APN	14	103,155,453 (GRCm38)	missense	probably benign	0.06
IGL03236:Mycbp2	APN	14	103,298,698 (GRCm38)	missense	probably damaging	0.99
IGL03256:Mycbp2	APN	14	103,188,589 (GRCm38)	missense	possibly damaging	0.92
IGL03303:Mycbp2	APN	14	103,247,758 (GRCm38)	missense	probably damaging	1.00
compost	UTSW	14	103,156,453 (GRCm38)	missense	probably damaging	1.00
decompose	UTSW	14	103,219,979 (GRCm38)	missense	probably benign	0.12
moulder	UTSW	14	103,188,592 (GRCm38)	missense	probably damaging	1.00
N/A - 293:Mycbp2	UTSW	14	103,224,462 (GRCm38)	splice site	probably benign
R0040:Mycbp2	UTSW	14	103,224,272 (GRCm38)	missense	probably benign	0.11
R0040:Mycbp2	UTSW	14	103,224,272 (GRCm38)	missense	probably benign	0.11
R0057:Mycbp2	UTSW	14	103,152,142 (GRCm38)	missense	probably damaging	0.97
R0063:Mycbp2	UTSW	14	103,156,634 (GRCm38)	unclassified	probably benign
R0097:Mycbp2	UTSW	14	103,155,762 (GRCm38)	missense	probably damaging	1.00
R0097:Mycbp2	UTSW	14	103,155,762 (GRCm38)	missense	probably damaging	1.00
R0268:Mycbp2	UTSW	14	103,314,325 (GRCm38)	nonsense	probably null
R0388:Mycbp2	UTSW	14	103,156,667 (GRCm38)	missense	probably benign	0.01
R0410:Mycbp2	UTSW	14	103,135,133 (GRCm38)	missense	probably damaging	1.00
R0530:Mycbp2	UTSW	14	103,182,459 (GRCm38)	missense	probably damaging	1.00
R0591:Mycbp2	UTSW	14	103,196,391 (GRCm38)	unclassified	probably benign
R0671:Mycbp2	UTSW	14	103,194,588 (GRCm38)	missense	possibly damaging	0.95
R0755:Mycbp2	UTSW	14	103,174,794 (GRCm38)	missense	probably damaging	1.00
R0817:Mycbp2	UTSW	14	103,229,418 (GRCm38)	missense	probably damaging	0.99
R0818:Mycbp2	UTSW	14	103,229,418 (GRCm38)	missense	probably damaging	0.99
R0819:Mycbp2	UTSW	14	103,229,418 (GRCm38)	missense	probably damaging	0.99
R0881:Mycbp2	UTSW	14	103,220,013 (GRCm38)	missense	probably benign
R0903:Mycbp2	UTSW	14	103,275,857 (GRCm38)	missense	probably damaging	0.99
R0940:Mycbp2	UTSW	14	103,262,693 (GRCm38)	unclassified	probably benign
R0961:Mycbp2	UTSW	14	103,184,835 (GRCm38)	missense	probably damaging	1.00
R1004:Mycbp2	UTSW	14	103,140,917 (GRCm38)	missense	probably benign	0.00
R1138:Mycbp2	UTSW	14	103,174,826 (GRCm38)	missense	possibly damaging	0.84
R1170:Mycbp2	UTSW	14	103,200,152 (GRCm38)	nonsense	probably null
R1211:Mycbp2	UTSW	14	103,120,563 (GRCm38)	missense	probably benign	0.31
R1268:Mycbp2	UTSW	14	103,208,782 (GRCm38)	missense	probably damaging	1.00
R1298:Mycbp2	UTSW	14	103,155,898 (GRCm38)	missense	probably damaging	1.00
R1341:Mycbp2	UTSW	14	103,298,867 (GRCm38)	splice site	probably benign
R1469:Mycbp2	UTSW	14	103,188,520 (GRCm38)	missense	probably damaging	0.99
R1469:Mycbp2	UTSW	14	103,188,520 (GRCm38)	missense	probably damaging	0.99
R1513:Mycbp2	UTSW	14	103,204,389 (GRCm38)	missense	probably damaging	1.00
R1528:Mycbp2	UTSW	14	103,232,597 (GRCm38)	missense	possibly damaging	0.91
R1564:Mycbp2	UTSW	14	103,169,851 (GRCm38)	splice site	probably null
R1565:Mycbp2	UTSW	14	103,252,509 (GRCm38)	missense	possibly damaging	0.82
R1656:Mycbp2	UTSW	14	103,247,758 (GRCm38)	missense	probably damaging	1.00
R1694:Mycbp2	UTSW	14	103,227,511 (GRCm38)	missense	probably damaging	1.00
R1709:Mycbp2	UTSW	14	103,224,416 (GRCm38)	missense	probably damaging	1.00
R1728:Mycbp2	UTSW	14	103,155,178 (GRCm38)	missense	probably damaging	0.98
R1751:Mycbp2	UTSW	14	103,248,405 (GRCm38)	missense	probably damaging	0.98
R1767:Mycbp2	UTSW	14	103,248,405 (GRCm38)	missense	probably damaging	0.98
R1772:Mycbp2	UTSW	14	103,182,419 (GRCm38)	missense	probably damaging	1.00
R1784:Mycbp2	UTSW	14	103,155,178 (GRCm38)	missense	probably damaging	0.98
R1823:Mycbp2	UTSW	14	103,252,509 (GRCm38)	missense	possibly damaging	0.82
R1824:Mycbp2	UTSW	14	103,252,509 (GRCm38)	missense	possibly damaging	0.82
R1844:Mycbp2	UTSW	14	103,155,714 (GRCm38)	missense	possibly damaging	0.94
R1916:Mycbp2	UTSW	14	103,184,883 (GRCm38)	missense	probably damaging	1.00
R1944:Mycbp2	UTSW	14	103,229,404 (GRCm38)	missense	probably damaging	1.00
R1983:Mycbp2	UTSW	14	103,145,971 (GRCm38)	missense	probably damaging	0.97
R2002:Mycbp2	UTSW	14	103,248,403 (GRCm38)	missense	probably damaging	0.98
R2031:Mycbp2	UTSW	14	103,188,592 (GRCm38)	missense	probably damaging	1.00
R2035:Mycbp2	UTSW	14	103,260,239 (GRCm38)	missense	probably damaging	1.00
R2048:Mycbp2	UTSW	14	103,232,524 (GRCm38)	critical splice donor site	probably null
R2061:Mycbp2	UTSW	14	103,287,260 (GRCm38)	missense	probably damaging	0.99
R2113:Mycbp2	UTSW	14	103,220,076 (GRCm38)	missense	probably damaging	0.99
R2128:Mycbp2	UTSW	14	103,201,230 (GRCm38)	missense	probably benign	0.01
R2134:Mycbp2	UTSW	14	103,208,893 (GRCm38)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,208,893 (GRCm38)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,145,942 (GRCm38)	missense	probably benign
R2146:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2147:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2148:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2150:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2163:Mycbp2	UTSW	14	103,169,855 (GRCm38)	critical splice donor site	probably null
R2248:Mycbp2	UTSW	14	103,169,859 (GRCm38)	missense	possibly damaging	0.50
R2265:Mycbp2	UTSW	14	103,262,749 (GRCm38)	missense	probably benign	0.39
R2272:Mycbp2	UTSW	14	103,144,338 (GRCm38)	missense	probably null	0.66
R2379:Mycbp2	UTSW	14	103,174,950 (GRCm38)	missense	probably benign
R2495:Mycbp2	UTSW	14	103,200,118 (GRCm38)	missense	probably damaging	0.99
R2508:Mycbp2	UTSW	14	103,131,245 (GRCm38)	missense	probably damaging	0.99
R2510:Mycbp2	UTSW	14	103,155,255 (GRCm38)	missense	probably damaging	0.96
R2851:Mycbp2	UTSW	14	103,144,333 (GRCm38)	missense	probably damaging	0.99
R2852:Mycbp2	UTSW	14	103,144,333 (GRCm38)	missense	probably damaging	0.99
R2965:Mycbp2	UTSW	14	103,297,358 (GRCm38)	missense	probably benign	0.00
R3156:Mycbp2	UTSW	14	103,208,743 (GRCm38)	splice site	probably benign
R3404:Mycbp2	UTSW	14	103,200,114 (GRCm38)	missense	probably damaging	0.99
R3410:Mycbp2	UTSW	14	103,135,117 (GRCm38)	missense	probably damaging	1.00
R3429:Mycbp2	UTSW	14	103,229,430 (GRCm38)	missense	probably damaging	1.00
R3706:Mycbp2	UTSW	14	103,156,414 (GRCm38)	missense	probably benign	0.31
R3772:Mycbp2	UTSW	14	103,133,788 (GRCm38)	missense	possibly damaging	0.82
R3778:Mycbp2	UTSW	14	103,197,285 (GRCm38)	missense	probably damaging	0.99
R3883:Mycbp2	UTSW	14	103,295,250 (GRCm38)	missense	probably damaging	0.97
R3884:Mycbp2	UTSW	14	103,295,250 (GRCm38)	missense	probably damaging	0.97
R3887:Mycbp2	UTSW	14	103,174,797 (GRCm38)	missense	probably damaging	0.98
R3923:Mycbp2	UTSW	14	103,126,713 (GRCm38)	missense	probably damaging	1.00
R3926:Mycbp2	UTSW	14	103,204,500 (GRCm38)	missense	probably damaging	1.00
R3959:Mycbp2	UTSW	14	103,295,252 (GRCm38)	missense	probably benign	0.00
R3966:Mycbp2	UTSW	14	103,138,725 (GRCm38)	splice site	probably benign
R4021:Mycbp2	UTSW	14	103,152,157 (GRCm38)	missense	probably damaging	0.97
R4363:Mycbp2	UTSW	14	103,248,457 (GRCm38)	missense	probably damaging	1.00
R4405:Mycbp2	UTSW	14	103,123,445 (GRCm38)	missense	probably damaging	1.00
R4407:Mycbp2	UTSW	14	103,287,228 (GRCm38)	missense	probably damaging	1.00
R4410:Mycbp2	UTSW	14	103,135,266 (GRCm38)	missense	probably damaging	1.00
R4434:Mycbp2	UTSW	14	103,133,789 (GRCm38)	missense	probably damaging	0.99
R4448:Mycbp2	UTSW	14	103,188,502 (GRCm38)	missense	possibly damaging	0.89
R4452:Mycbp2	UTSW	14	103,155,658 (GRCm38)	missense	probably damaging	0.99
R4573:Mycbp2	UTSW	14	103,346,297 (GRCm38)	missense	probably benign	0.05
R4589:Mycbp2	UTSW	14	103,177,313 (GRCm38)	missense	probably benign	0.04
R4621:Mycbp2	UTSW	14	103,219,979 (GRCm38)	missense	probably benign	0.12
R4622:Mycbp2	UTSW	14	103,219,979 (GRCm38)	missense	probably benign	0.12
R4729:Mycbp2	UTSW	14	103,188,591 (GRCm38)	missense	probably damaging	1.00
R4770:Mycbp2	UTSW	14	103,219,944 (GRCm38)	missense	probably benign	0.41
R4790:Mycbp2	UTSW	14	103,229,437 (GRCm38)	missense	probably damaging	1.00
R4884:Mycbp2	UTSW	14	103,211,295 (GRCm38)	missense	probably damaging	1.00
R4885:Mycbp2	UTSW	14	103,145,946 (GRCm38)	missense	possibly damaging	0.86
R4956:Mycbp2	UTSW	14	103,287,239 (GRCm38)	missense	probably damaging	0.99
R4980:Mycbp2	UTSW	14	103,260,385 (GRCm38)	splice site	probably null
R4994:Mycbp2	UTSW	14	103,169,994 (GRCm38)	missense	probably benign
R5029:Mycbp2	UTSW	14	103,156,510 (GRCm38)	missense	probably benign	0.21
R5044:Mycbp2	UTSW	14	103,139,235 (GRCm38)	critical splice donor site	probably null
R5231:Mycbp2	UTSW	14	103,346,214 (GRCm38)	critical splice donor site	probably null
R5305:Mycbp2	UTSW	14	103,346,321 (GRCm38)	missense	probably benign	0.00
R5322:Mycbp2	UTSW	14	103,185,683 (GRCm38)	critical splice acceptor site	probably null
R5376:Mycbp2	UTSW	14	103,242,432 (GRCm38)	nonsense	probably null
R5414:Mycbp2	UTSW	14	103,306,261 (GRCm38)	missense	probably damaging	1.00
R5453:Mycbp2	UTSW	14	103,201,401 (GRCm38)	missense	probably damaging	0.99
R5462:Mycbp2	UTSW	14	103,200,126 (GRCm38)	missense	probably damaging	1.00
R5499:Mycbp2	UTSW	14	103,242,179 (GRCm38)	missense	probably damaging	1.00
R5502:Mycbp2	UTSW	14	103,173,814 (GRCm38)	missense	probably damaging	1.00
R5524:Mycbp2	UTSW	14	103,295,237 (GRCm38)	missense	probably damaging	1.00
R5533:Mycbp2	UTSW	14	103,282,645 (GRCm38)	nonsense	probably null
R5569:Mycbp2	UTSW	14	103,135,243 (GRCm38)	missense	probably damaging	1.00
R5574:Mycbp2	UTSW	14	103,142,767 (GRCm38)	missense	possibly damaging	0.94
R5579:Mycbp2	UTSW	14	103,291,333 (GRCm38)	missense	probably damaging	0.98
R5590:Mycbp2	UTSW	14	103,123,355 (GRCm38)	missense	probably damaging	1.00
R5592:Mycbp2	UTSW	14	103,194,677 (GRCm38)	missense	probably benign	0.02
R5643:Mycbp2	UTSW	14	103,287,334 (GRCm38)	missense	probably damaging	1.00
R5644:Mycbp2	UTSW	14	103,287,334 (GRCm38)	missense	probably damaging	1.00
R5645:Mycbp2	UTSW	14	103,188,615 (GRCm38)	critical splice acceptor site	probably null
R5645:Mycbp2	UTSW	14	103,188,608 (GRCm38)	missense	probably damaging	1.00
R5646:Mycbp2	UTSW	14	103,169,910 (GRCm38)	missense	probably benign	0.09
R5648:Mycbp2	UTSW	14	103,291,342 (GRCm38)	missense	probably damaging	1.00
R5651:Mycbp2	UTSW	14	103,282,665 (GRCm38)	missense	probably null	0.99
R5668:Mycbp2	UTSW	14	103,120,519 (GRCm38)	missense	possibly damaging	0.62
R5745:Mycbp2	UTSW	14	103,156,453 (GRCm38)	missense	possibly damaging	0.94
R5751:Mycbp2	UTSW	14	103,148,550 (GRCm38)	missense	probably damaging	0.99
R5756:Mycbp2	UTSW	14	103,133,974 (GRCm38)	missense	probably damaging	0.99
R5837:Mycbp2	UTSW	14	103,124,403 (GRCm38)	missense	probably damaging	1.00
R5984:Mycbp2	UTSW	14	103,126,684 (GRCm38)	missense	probably damaging	0.98
R6005:Mycbp2	UTSW	14	103,156,723 (GRCm38)	missense	probably benign
R6063:Mycbp2	UTSW	14	103,135,146 (GRCm38)	missense	probably damaging	1.00
R6091:Mycbp2	UTSW	14	103,223,046 (GRCm38)	missense	probably damaging	1.00
R6120:Mycbp2	UTSW	14	103,275,887 (GRCm38)	missense	probably benign	0.01
R6129:Mycbp2	UTSW	14	103,285,400 (GRCm38)	missense	probably benign	0.21
R6147:Mycbp2	UTSW	14	103,155,509 (GRCm38)	nonsense	probably null
R6161:Mycbp2	UTSW	14	103,298,747 (GRCm38)	missense	probably damaging	1.00
R6187:Mycbp2	UTSW	14	103,147,017 (GRCm38)	missense	probably damaging	1.00
R6208:Mycbp2	UTSW	14	103,295,228 (GRCm38)	missense	probably benign	0.11
R6228:Mycbp2	UTSW	14	103,260,229 (GRCm38)	missense	probably benign	0.24
R6301:Mycbp2	UTSW	14	103,155,426 (GRCm38)	missense	probably damaging	1.00
R6311:Mycbp2	UTSW	14	103,262,740 (GRCm38)	missense	possibly damaging	0.93
R6329:Mycbp2	UTSW	14	103,155,852 (GRCm38)	missense	probably benign	0.00
R6439:Mycbp2	UTSW	14	103,155,475 (GRCm38)	missense	probably benign	0.00
R6462:Mycbp2	UTSW	14	103,136,557 (GRCm38)	critical splice donor site	probably null
R6528:Mycbp2	UTSW	14	103,142,881 (GRCm38)	missense	probably damaging	0.99
R6736:Mycbp2	UTSW	14	103,191,567 (GRCm38)	missense	probably null	1.00
R6821:Mycbp2	UTSW	14	103,139,409 (GRCm38)	missense	probably damaging	1.00
R6851:Mycbp2	UTSW	14	103,260,194 (GRCm38)	critical splice donor site	probably null
R6948:Mycbp2	UTSW	14	103,285,267 (GRCm38)	missense	possibly damaging	0.94
R6977:Mycbp2	UTSW	14	103,154,906 (GRCm38)	missense	probably damaging	0.99
R6985:Mycbp2	UTSW	14	103,206,681 (GRCm38)	missense	possibly damaging	0.79
R7035:Mycbp2	UTSW	14	103,174,981 (GRCm38)	missense	probably benign
R7054:Mycbp2	UTSW	14	103,156,098 (GRCm38)	missense	possibly damaging	0.90
R7108:Mycbp2	UTSW	14	103,122,603 (GRCm38)	missense	probably damaging	1.00
R7117:Mycbp2	UTSW	14	103,154,077 (GRCm38)	missense	probably benign	0.21
R7137:Mycbp2	UTSW	14	103,282,679 (GRCm38)	missense	possibly damaging	0.94
R7169:Mycbp2	UTSW	14	103,260,200 (GRCm38)	missense	possibly damaging	0.78
R7218:Mycbp2	UTSW	14	103,133,846 (GRCm38)	missense	probably benign
R7234:Mycbp2	UTSW	14	103,215,337 (GRCm38)	missense	probably damaging	0.98
R7238:Mycbp2	UTSW	14	103,156,297 (GRCm38)	missense	probably damaging	1.00
R7244:Mycbp2	UTSW	14	103,208,909 (GRCm38)	missense	probably damaging	0.98
R7265:Mycbp2	UTSW	14	103,197,243 (GRCm38)	critical splice donor site	probably null
R7286:Mycbp2	UTSW	14	103,120,591 (GRCm38)	missense	probably damaging	1.00
R7332:Mycbp2	UTSW	14	103,197,357 (GRCm38)	missense	probably damaging	0.97
R7332:Mycbp2	UTSW	14	103,156,453 (GRCm38)	missense	probably damaging	1.00
R7384:Mycbp2	UTSW	14	103,276,393 (GRCm38)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,243,128 (GRCm38)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,152,191 (GRCm38)	missense	probably damaging	1.00
R7409:Mycbp2	UTSW	14	103,288,744 (GRCm38)	missense	probably damaging	1.00
R7486:Mycbp2	UTSW	14	103,197,254 (GRCm38)	missense	probably damaging	0.97
R7643:Mycbp2	UTSW	14	103,346,265 (GRCm38)	missense	probably benign
R7661:Mycbp2	UTSW	14	103,212,623 (GRCm38)	missense	probably damaging	1.00
R7663:Mycbp2	UTSW	14	103,191,609 (GRCm38)	missense	probably damaging	0.99
R7730:Mycbp2	UTSW	14	103,123,355 (GRCm38)	missense	probably damaging	0.99
R7757:Mycbp2	UTSW	14	103,191,619 (GRCm38)	missense	probably damaging	1.00
R7773:Mycbp2	UTSW	14	103,248,404 (GRCm38)	missense	probably damaging	0.97
R7787:Mycbp2	UTSW	14	103,127,097 (GRCm38)	missense	probably damaging	1.00
R7822:Mycbp2	UTSW	14	103,139,415 (GRCm38)	missense	probably benign	0.00
R7838:Mycbp2	UTSW	14	103,177,293 (GRCm38)	missense	probably benign	0.10
R7841:Mycbp2	UTSW	14	103,146,831 (GRCm38)	critical splice donor site	probably null
R7858:Mycbp2	UTSW	14	103,156,305 (GRCm38)	missense	probably damaging	1.00
R7873:Mycbp2	UTSW	14	103,156,146 (GRCm38)	missense	probably damaging	1.00
R7911:Mycbp2	UTSW	14	103,200,185 (GRCm38)	missense	probably damaging	0.99
R7942:Mycbp2	UTSW	14	103,155,238 (GRCm38)	missense	probably damaging	0.99
R7951:Mycbp2	UTSW	14	103,215,462 (GRCm38)	missense	probably damaging	0.99
R7958:Mycbp2	UTSW	14	103,129,964 (GRCm38)	missense	probably benign	0.00
R8235:Mycbp2	UTSW	14	103,198,674 (GRCm38)	missense	probably damaging	0.99
R8246:Mycbp2	UTSW	14	103,155,204 (GRCm38)	missense	probably damaging	0.99
R8338:Mycbp2	UTSW	14	103,135,265 (GRCm38)	missense	probably damaging	1.00
R8343:Mycbp2	UTSW	14	103,160,675 (GRCm38)	splice site	probably null
R8361:Mycbp2	UTSW	14	103,138,814 (GRCm38)	missense	probably damaging	1.00
R8490:Mycbp2	UTSW	14	103,208,831 (GRCm38)	missense	probably benign	0.00
R8524:Mycbp2	UTSW	14	103,155,459 (GRCm38)	missense	probably benign	0.23
R8525:Mycbp2	UTSW	14	103,212,719 (GRCm38)	missense	probably damaging	1.00
R8711:Mycbp2	UTSW	14	103,169,994 (GRCm38)	missense	probably benign	0.08
R8735:Mycbp2	UTSW	14	103,223,150 (GRCm38)	missense	probably damaging	0.99
R8825:Mycbp2	UTSW	14	103,229,435 (GRCm38)	missense	probably damaging	1.00
R8928:Mycbp2	UTSW	14	103,156,345 (GRCm38)	missense	probably benign
R8974:Mycbp2	UTSW	14	103,124,421 (GRCm38)	missense	probably damaging	1.00
R8987:Mycbp2	UTSW	14	103,208,796 (GRCm38)	missense	probably damaging	1.00
R9021:Mycbp2	UTSW	14	103,314,316 (GRCm38)	missense	probably benign	0.08
R9062:Mycbp2	UTSW	14	103,242,360 (GRCm38)	missense	probably benign	0.00
R9077:Mycbp2	UTSW	14	103,232,538 (GRCm38)	missense	probably damaging	1.00
R9208:Mycbp2	UTSW	14	103,295,228 (GRCm38)	missense	probably benign	0.01
R9285:Mycbp2	UTSW	14	103,197,317 (GRCm38)	missense	probably damaging	0.97
R9290:Mycbp2	UTSW	14	103,188,524 (GRCm38)	missense	probably damaging	0.99
R9362:Mycbp2	UTSW	14	103,260,206 (GRCm38)	missense	probably damaging	0.97
R9520:Mycbp2	UTSW	14	103,260,269 (GRCm38)	missense	probably benign	0.02
R9557:Mycbp2	UTSW	14	103,135,261 (GRCm38)	missense	probably benign	0.03
R9639:Mycbp2	UTSW	14	103,196,381 (GRCm38)	missense	probably damaging	1.00
R9666:Mycbp2	UTSW	14	103,134,038 (GRCm38)	missense	probably damaging	0.98
R9732:Mycbp2	UTSW	14	103,211,313 (GRCm38)	missense	probably damaging	1.00
R9736:Mycbp2	UTSW	14	103,197,416 (GRCm38)	missense	probably damaging	0.96
R9739:Mycbp2	UTSW	14	103,282,793 (GRCm38)	missense	probably benign	0.11
R9755:Mycbp2	UTSW	14	103,314,370 (GRCm38)	missense	probably benign
X0024:Mycbp2	UTSW	14	103,146,942 (GRCm38)	missense	probably damaging	1.00
Z1176:Mycbp2	UTSW	14	103,346,249 (GRCm38)	missense	probably benign
Z1176:Mycbp2	UTSW	14	103,156,637 (GRCm38)	missense	probably benign	0.06
Z1177:Mycbp2	UTSW	14	103,169,873 (GRCm38)	missense	possibly damaging	0.83
Z1177:Mycbp2	UTSW	14	103,135,123 (GRCm38)	missense	probably damaging	1.00
Z1177:Mycbp2	UTSW	14	103,127,063 (GRCm38)	critical splice donor site	probably null

Predicted Primers

PCR Primer
(F):5'- CAGGCTTGAAATTGAACGACTG -3'
(R):5'- AACTCAGTATTGATTGTACCCTGG -3'

Sequencing Primer
(F):5'- GAACGACTGATGAATTCTGACTTTG -3'
(R):5'- CAGTATTGATTGTACCCTGGTTCTAG -3'

Posted On

2016-06-15