Incidental Mutation 'R5043:Or1n2'
ID 393283
Institutional Source Beutler Lab
Gene Symbol Or1n2
Ensembl Gene ENSMUSG00000055088
Gene Name olfactory receptor family 1 subfamily N member 2
Synonyms GA_x6K02T2NLDC-33601476-33602429, MOR127-4, Olfr354
MMRRC Submission 042633-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.172) question?
Stock # R5043 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 36796960-36797913 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 36796977 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 6 (R6S)
Ref Sequence ENSEMBL: ENSMUSP00000149298 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068475] [ENSMUST00000217479]
AlphaFold Q8VGJ8
Predicted Effect probably benign
Transcript: ENSMUST00000068475
AA Change: R6S

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000068986
Gene: ENSMUSG00000055088
AA Change: R6S

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 2.1e-62 PFAM
Pfam:7tm_1 44 293 2.9e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121665
Predicted Effect probably benign
Transcript: ENSMUST00000217479
AA Change: R6S

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218102
Meta Mutation Damage Score 0.1261 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.4%
Validation Efficiency 98% (44/45)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik T A 5: 144,980,910 (GRCm39) Y106* probably null Het
Acsbg3 A G 17: 57,192,198 (GRCm39) Y587C probably damaging Het
Akap12 G C 10: 4,305,047 (GRCm39) G619A probably damaging Het
Arhgap29 A G 3: 121,767,653 (GRCm39) K32E probably benign Het
Capg T A 6: 72,535,237 (GRCm39) Y253* probably null Het
Cntnap3 A T 13: 64,942,162 (GRCm39) F189L probably damaging Het
Cp T C 3: 20,028,081 (GRCm39) S496P probably benign Het
Cxcl11 T C 5: 92,511,011 (GRCm39) probably null Het
Dennd3 T C 15: 73,399,785 (GRCm39) L217P probably benign Het
Dip2c G T 13: 9,601,863 (GRCm39) R274L possibly damaging Het
Dnah12 C T 14: 26,606,147 (GRCm39) S3776L probably damaging Het
Emcn A G 3: 137,097,362 (GRCm39) T94A possibly damaging Het
Fnip2 A T 3: 79,400,174 (GRCm39) Y397* probably null Het
Gabrp T C 11: 33,518,072 (GRCm39) N79D probably benign Het
Glmp T G 3: 88,233,983 (GRCm39) probably benign Het
Gm5921 C T 9: 115,267,087 (GRCm39) noncoding transcript Het
Gm6483 A G 8: 19,743,686 (GRCm39) T104A probably benign Het
Ifi206 A T 1: 173,314,284 (GRCm39) M52K probably damaging Het
Iqcc T C 4: 129,512,070 (GRCm39) probably benign Het
Klra2 T A 6: 131,197,135 (GRCm39) H288L probably benign Het
Myo5b T C 18: 74,771,224 (GRCm39) probably null Het
Nisch A G 14: 30,898,422 (GRCm39) probably benign Het
Nlrp4c A G 7: 6,069,824 (GRCm39) N575S probably benign Het
Or8b49 A G 9: 38,506,137 (GRCm39) I207V probably damaging Het
Phlda1 T A 10: 111,343,152 (GRCm39) L296Q unknown Het
Pramel19 T C 4: 101,797,721 (GRCm39) F40L possibly damaging Het
Rab36 G A 10: 74,886,837 (GRCm39) E182K probably benign Het
Rasa3 G A 8: 13,620,368 (GRCm39) T767M possibly damaging Het
Serpinb11 G A 1: 107,297,195 (GRCm39) V24M probably damaging Het
Slc7a14 T G 3: 31,291,615 (GRCm39) N221T probably damaging Het
Smg6 T C 11: 74,820,721 (GRCm39) S331P possibly damaging Het
Snx1 C T 9: 66,004,718 (GRCm39) A183T probably benign Het
Srpk2 T C 5: 23,729,515 (GRCm39) T375A probably benign Het
Tecpr1 T C 5: 144,134,672 (GRCm39) probably null Het
Topaz1 A T 9: 122,577,469 (GRCm39) E126D probably benign Het
Ugt2b1 C G 5: 87,065,503 (GRCm39) C512S possibly damaging Het
Ugt2b37 C T 5: 87,399,719 (GRCm39) W263* probably null Het
Utp20 A T 10: 88,634,608 (GRCm39) M750K possibly damaging Het
Yeats2 A T 16: 20,027,215 (GRCm39) Q822L probably damaging Het
Zfp609 T C 9: 65,608,109 (GRCm39) Y1257C probably damaging Het
Other mutations in Or1n2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01942:Or1n2 APN 2 36,797,869 (GRCm39) missense probably benign
IGL02573:Or1n2 APN 2 36,797,566 (GRCm39) missense probably damaging 1.00
P0027:Or1n2 UTSW 2 36,797,582 (GRCm39) missense probably benign 0.00
R0040:Or1n2 UTSW 2 36,797,470 (GRCm39) missense probably damaging 1.00
R0610:Or1n2 UTSW 2 36,797,671 (GRCm39) missense probably damaging 1.00
R0760:Or1n2 UTSW 2 36,797,233 (GRCm39) missense probably benign 0.25
R1727:Or1n2 UTSW 2 36,797,405 (GRCm39) missense probably benign 0.00
R2972:Or1n2 UTSW 2 36,797,416 (GRCm39) missense probably benign 0.03
R4671:Or1n2 UTSW 2 36,797,405 (GRCm39) missense probably benign 0.00
R4750:Or1n2 UTSW 2 36,797,728 (GRCm39) missense probably benign 0.13
R5400:Or1n2 UTSW 2 36,797,833 (GRCm39) missense probably damaging 1.00
R5543:Or1n2 UTSW 2 36,797,369 (GRCm39) missense possibly damaging 0.75
R5792:Or1n2 UTSW 2 36,797,113 (GRCm39) missense probably benign 0.00
R6639:Or1n2 UTSW 2 36,797,690 (GRCm39) missense probably damaging 1.00
R6876:Or1n2 UTSW 2 36,797,834 (GRCm39) missense probably damaging 1.00
R7965:Or1n2 UTSW 2 36,796,953 (GRCm39) start gained probably benign
R8351:Or1n2 UTSW 2 36,797,149 (GRCm39) missense probably benign 0.00
R8859:Or1n2 UTSW 2 36,797,516 (GRCm39) missense possibly damaging 0.63
T0722:Or1n2 UTSW 2 36,797,582 (GRCm39) missense probably benign 0.00
Z1176:Or1n2 UTSW 2 36,797,713 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TTCCAGTGATACTCAGGCATG -3'
(R):5'- TGGGTACTGATGCAGAAGTG -3'

Sequencing Primer
(F):5'- AGGCATGTTCCTGGGCAAG -3'
(R):5'- GCATCAGTTAAGGAGAGATTTGC -3'
Posted On 2016-06-15