Mutagenetix > Incidental Mutation

Incidental Mutation 'R5123:Vmn2r17'

393394

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r17

Ensembl Gene

ENSMUSG00000091879

Gene Name

vomeronasal 2, receptor 17

Synonyms

EG384221

MMRRC Submission

042711-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.112) question?

Stock #

R5123 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

109567879-109601253 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 109575774 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 215 (D215G)

Ref Sequence

ENSEMBL: ENSMUSP00000131450 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171841]

AlphaFold

E9PYF5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171841
AA Change: D215G

PolyPhen 2 Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000131450
Gene: ENSMUSG00000091879
AA Change: D215G

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	76	465	7e-26	PFAM
Pfam:NCD3G	508	562	3.5e-18	PFAM
Pfam:7tm_3	593	830	4.8e-55	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.6%
20x: 93.5%

Validation Efficiency

98% (53/54)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca3	G	A	17: 24,603,434 (GRCm39)	G542D	possibly damaging	Het
Adh6b	A	G	3: 138,063,450 (GRCm39)	Y343C	probably damaging	Het
Adsl	T	A	15: 80,836,495 (GRCm39)		probably null	Het
Apob	T	A	12: 8,057,630 (GRCm39)		probably null	Het
Atp6ap1l	T	A	13: 91,047,017 (GRCm39)		probably benign	Het
Cacnb3	A	G	15: 98,537,750 (GRCm39)	D74G	probably damaging	Het
Cfap251	A	G	5: 123,411,696 (GRCm39)		probably benign	Het
Clca3a2	T	A	3: 144,512,104 (GRCm39)	D544V	probably damaging	Het
Col3a1	G	A	1: 45,372,756 (GRCm39)		probably benign	Het
D7Ertd443e	A	G	7: 133,951,397 (GRCm39)		probably null	Het
Dscam	T	C	16: 96,573,637 (GRCm39)	D775G	probably damaging	Het
Eif2b3	T	A	4: 116,879,408 (GRCm39)	M16K	probably damaging	Het
Eml5	T	C	12: 98,840,771 (GRCm39)	Y281C	probably damaging	Het
Epha2	T	A	4: 141,036,176 (GRCm39)	L204Q	possibly damaging	Het
Filip1l	A	C	16: 57,391,025 (GRCm39)	I538L	possibly damaging	Het
Gcnt2	T	A	13: 41,071,831 (GRCm39)	V158D	probably damaging	Het
Gnaq	A	G	19: 16,309,449 (GRCm39)	N162S	probably benign	Het
Haus5	A	T	7: 30,353,651 (GRCm39)	N575K	probably benign	Het
Hjurp	A	T	1: 88,202,772 (GRCm39)	Y71N	possibly damaging	Het
Igsf5	A	G	16: 96,174,279 (GRCm39)	D103G	probably damaging	Het
Myo10	A	G	15: 25,726,569 (GRCm39)	D297G	possibly damaging	Het
Net1	C	T	13: 3,936,623 (GRCm39)	R314H	probably damaging	Het
Or4b1c	C	A	2: 90,126,512 (GRCm39)	R231L	probably benign	Het
Or4k51	T	A	2: 111,584,897 (GRCm39)	V101D	probably damaging	Het
Pcsk4	C	A	10: 80,157,979 (GRCm39)	Q586H	probably null	Het
Pramel11	A	T	4: 143,623,706 (GRCm39)	M156K	probably benign	Het
Prss1	A	G	6: 41,440,131 (GRCm39)	D156G	possibly damaging	Het
Rnf133	A	T	6: 23,649,259 (GRCm39)	N266K	probably damaging	Het
Setd2	G	T	9: 110,446,595 (GRCm39)	A2482S	possibly damaging	Het
Sgo2a	A	T	1: 58,055,726 (GRCm39)	S637C	probably damaging	Het
Slc2a5	C	A	4: 150,224,262 (GRCm39)	S290*	probably null	Het
Spata6	T	G	4: 111,625,992 (GRCm39)	H120Q	possibly damaging	Het
Stk11	G	A	10: 79,963,775 (GRCm39)	V194I	probably damaging	Het
Tkt	T	C	14: 30,287,603 (GRCm39)	V199A	probably benign	Het
Traf3	G	A	12: 111,209,952 (GRCm39)	V183M	possibly damaging	Het
Trappc11	T	C	8: 47,966,437 (GRCm39)	Y483C	probably damaging	Het
Trappc9	T	C	15: 72,785,215 (GRCm39)		probably benign	Het
Trim59	T	C	3: 68,945,067 (GRCm39)	H91R	probably benign	Het
Ttc21a	A	G	9: 119,781,278 (GRCm39)	S484G	probably benign	Het
Usp13	A	T	3: 32,969,947 (GRCm39)	H691L	probably benign	Het
Vmn1r238	T	C	18: 3,123,243 (GRCm39)	Y57C	probably benign	Het
Vmn2r111	T	A	17: 22,790,124 (GRCm39)	Q294L	possibly damaging	Het
Zfp280b	A	G	10: 75,875,183 (GRCm39)	D354G	probably benign	Het
Zfp607a	A	G	7: 27,578,523 (GRCm39)	H531R	probably damaging	Het
Zfp74	A	T	7: 29,634,158 (GRCm39)	C517S	probably damaging	Het

Other mutations in Vmn2r17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00325:Vmn2r17	APN	5	109,575,858 (GRCm39)	missense	probably benign	0.15
IGL01457:Vmn2r17	APN	5	109,600,898 (GRCm39)	missense	probably benign	0.00
IGL01527:Vmn2r17	APN	5	109,601,006 (GRCm39)	missense	probably damaging	1.00
IGL01693:Vmn2r17	APN	5	109,600,384 (GRCm39)	missense	probably damaging	1.00
IGL01738:Vmn2r17	APN	5	109,577,364 (GRCm39)	missense	probably damaging	1.00
IGL01767:Vmn2r17	APN	5	109,567,903 (GRCm39)	missense	probably benign	0.01
IGL01932:Vmn2r17	APN	5	109,574,916 (GRCm39)	missense	probably benign	0.00
IGL01970:Vmn2r17	APN	5	109,575,813 (GRCm39)	missense	probably damaging	0.97
IGL02009:Vmn2r17	APN	5	109,600,714 (GRCm39)	missense	possibly damaging	0.67
IGL02365:Vmn2r17	APN	5	109,601,175 (GRCm39)	missense	probably damaging	1.00
IGL02385:Vmn2r17	APN	5	109,582,247 (GRCm39)	missense	probably damaging	1.00
IGL02457:Vmn2r17	APN	5	109,601,012 (GRCm39)	missense	probably damaging	1.00
IGL02646:Vmn2r17	APN	5	109,600,946 (GRCm39)	missense	probably damaging	1.00
IGL02741:Vmn2r17	APN	5	109,568,077 (GRCm39)	missense	probably benign
IGL03213:Vmn2r17	APN	5	109,582,256 (GRCm39)	critical splice donor site	probably null
IGL03216:Vmn2r17	APN	5	109,600,756 (GRCm39)	missense	probably damaging	1.00
IGL03342:Vmn2r17	APN	5	109,575,782 (GRCm39)	missense	probably damaging	1.00
IGL03408:Vmn2r17	APN	5	109,577,238 (GRCm39)	splice site	probably benign
R0349:Vmn2r17	UTSW	5	109,576,202 (GRCm39)	missense	probably damaging	1.00
R0418:Vmn2r17	UTSW	5	109,600,747 (GRCm39)	missense	probably damaging	1.00
R0800:Vmn2r17	UTSW	5	109,575,192 (GRCm39)	splice site	probably benign
R0836:Vmn2r17	UTSW	5	109,575,822 (GRCm39)	missense	possibly damaging	0.89
R1715:Vmn2r17	UTSW	5	109,576,110 (GRCm39)	missense	probably benign	0.00
R1738:Vmn2r17	UTSW	5	109,576,377 (GRCm39)	missense	probably benign	0.10
R1801:Vmn2r17	UTSW	5	109,576,344 (GRCm39)	missense	probably damaging	1.00
R2054:Vmn2r17	UTSW	5	109,600,352 (GRCm39)	missense	probably damaging	0.98
R2060:Vmn2r17	UTSW	5	109,575,075 (GRCm39)	missense	probably benign	0.00
R2192:Vmn2r17	UTSW	5	109,582,144 (GRCm39)	missense	possibly damaging	0.81
R2315:Vmn2r17	UTSW	5	109,575,897 (GRCm39)	missense	probably damaging	1.00
R2374:Vmn2r17	UTSW	5	109,575,104 (GRCm39)	missense	probably benign
R3612:Vmn2r17	UTSW	5	109,577,463 (GRCm39)	missense	probably benign	0.00
R3832:Vmn2r17	UTSW	5	109,576,262 (GRCm39)	missense	probably damaging	1.00
R4273:Vmn2r17	UTSW	5	109,600,832 (GRCm39)	missense	probably benign	0.44
R4494:Vmn2r17	UTSW	5	109,576,335 (GRCm39)	missense	probably damaging	1.00
R4597:Vmn2r17	UTSW	5	109,577,428 (GRCm39)	missense	probably benign	0.01
R4675:Vmn2r17	UTSW	5	109,575,049 (GRCm39)	missense	probably benign	0.00
R4701:Vmn2r17	UTSW	5	109,575,849 (GRCm39)	missense	probably damaging	0.99
R4754:Vmn2r17	UTSW	5	109,600,715 (GRCm39)	missense	probably damaging	0.99
R4841:Vmn2r17	UTSW	5	109,582,246 (GRCm39)	missense	probably damaging	1.00
R4842:Vmn2r17	UTSW	5	109,582,246 (GRCm39)	missense	probably damaging	1.00
R4865:Vmn2r17	UTSW	5	109,574,985 (GRCm39)	missense	probably damaging	1.00
R4902:Vmn2r17	UTSW	5	109,601,220 (GRCm39)	missense	probably benign	0.14
R4989:Vmn2r17	UTSW	5	109,575,739 (GRCm39)	missense	probably benign	0.07
R5101:Vmn2r17	UTSW	5	109,576,217 (GRCm39)	missense	probably damaging	0.99
R5109:Vmn2r17	UTSW	5	109,577,342 (GRCm39)	missense	probably benign	0.06
R5474:Vmn2r17	UTSW	5	109,582,150 (GRCm39)	missense	probably damaging	1.00
R5485:Vmn2r17	UTSW	5	109,567,972 (GRCm39)	missense	probably benign	0.06
R5611:Vmn2r17	UTSW	5	109,576,030 (GRCm39)	missense	probably damaging	0.97
R5652:Vmn2r17	UTSW	5	109,577,430 (GRCm39)	missense	probably benign	0.10
R5717:Vmn2r17	UTSW	5	109,575,140 (GRCm39)	missense	possibly damaging	0.94
R5735:Vmn2r17	UTSW	5	109,600,716 (GRCm39)	missense	possibly damaging	0.67
R5766:Vmn2r17	UTSW	5	109,575,139 (GRCm39)	missense	possibly damaging	0.46
R6645:Vmn2r17	UTSW	5	109,576,247 (GRCm39)	missense	probably damaging	1.00
R6786:Vmn2r17	UTSW	5	109,575,695 (GRCm39)	missense	probably benign	0.30
R6821:Vmn2r17	UTSW	5	109,577,331 (GRCm39)	missense	probably damaging	1.00
R6979:Vmn2r17	UTSW	5	109,576,265 (GRCm39)	missense	possibly damaging	0.46
R6984:Vmn2r17	UTSW	5	109,600,533 (GRCm39)	missense	probably benign	0.10
R7269:Vmn2r17	UTSW	5	109,576,337 (GRCm39)	missense	possibly damaging	0.88
R7509:Vmn2r17	UTSW	5	109,575,695 (GRCm39)	missense	probably benign	0.30
R7736:Vmn2r17	UTSW	5	109,600,757 (GRCm39)	missense	probably benign	0.05
R7789:Vmn2r17	UTSW	5	109,600,831 (GRCm39)	missense	possibly damaging	0.77
R7814:Vmn2r17	UTSW	5	109,575,739 (GRCm39)	missense	probably benign	0.07
R7847:Vmn2r17	UTSW	5	109,568,063 (GRCm39)	missense	probably damaging	1.00
R7863:Vmn2r17	UTSW	5	109,568,035 (GRCm39)	missense	probably benign
R7893:Vmn2r17	UTSW	5	109,575,944 (GRCm39)	missense	probably benign	0.05
R8234:Vmn2r17	UTSW	5	109,601,235 (GRCm39)	missense	probably benign	0.01
R8382:Vmn2r17	UTSW	5	109,576,387 (GRCm39)	missense	probably benign	0.01
R8435:Vmn2r17	UTSW	5	109,576,172 (GRCm39)	missense	probably benign	0.01
R8465:Vmn2r17	UTSW	5	109,600,691 (GRCm39)	missense	probably damaging	0.99
R8555:Vmn2r17	UTSW	5	109,600,810 (GRCm39)	missense	probably damaging	0.99
R8900:Vmn2r17	UTSW	5	109,575,863 (GRCm39)	missense	probably benign	0.25
R9293:Vmn2r17	UTSW	5	109,600,712 (GRCm39)	missense	probably damaging	1.00
R9308:Vmn2r17	UTSW	5	109,600,505 (GRCm39)	missense	probably damaging	0.98
R9378:Vmn2r17	UTSW	5	109,575,732 (GRCm39)	missense	possibly damaging	0.94
R9597:Vmn2r17	UTSW	5	109,575,669 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACAAGCACATTACTTATGGGGATG -3'
(R):5'- TGCCCATCTTCTAAAGCTGAC -3'

Sequencing Primer
(F):5'- ACATTACTTATGGGGATGTTTAATCC -3'
(R):5'- CCATCTTCTAAAGCTGACTTCTAGAG -3'

Posted On

2016-06-15